4-Chloronitrobenzene
Linshang Chemical
HS Code |
517076 |
Chemical Formula | C6H4ClNO2 |
Molar Mass | 157.55 g/mol |
Appearance | Yellowish crystals |
Odor | Characteristic odor |
Density | 1.52 g/cm³ |
Melting Point | 83 - 85 °C |
Boiling Point | 242 - 245 °C |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in many organic solvents like benzene, ether |
Flash Point | 127 °C |
Stability | Stable under normal conditions |
Vapor Pressure | Low vapor pressure |
As an accredited 4-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 4 - chloronitrobenzene packaged in a sealed, corrosion - resistant plastic bottle. |
Storage | 4 - Chloronitrobenzene should be stored in a cool, well - ventilated warehouse. Keep it away from heat, sparks, and open flames. Store it separately from oxidizing agents, reducing agents, and alkalis. Package it in tightly - sealed containers to prevent leakage. Regularly check storage conditions to ensure chemical stability and safety. |
Shipping | 4 - Chloronitrobenzene is shipped in tightly - sealed containers, often drums or tankers, compliant with hazardous chemical regulations. Transport must be carefully monitored to prevent spills due to its toxic and hazardous nature. |
Competitive 4-Chloronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 4-Chloronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
In the dye industry, this is an important intermediate. It can be converted into various colorful dyes through a specific chemical reaction path. Because 4-chloronitrobenzene has a specific chemical structure, it can precisely construct the chromophore required for dyes in subsequent reactions, so that dyes show rich and bright colors. It plays a key role in adding color to fabrics in textile printing and dyeing and other fields.
In the field of pharmaceutical synthesis, it also plays an important role. The synthesis of many drugs requires this as a starting material or key intermediate. With its benzene ring structure and the activity of chlorine atoms and nitro groups, it can undergo a series of fine chemical conversions to introduce other specific functional groups, thereby constructing molecular structures with specific pharmacological activities, which lays the foundation for the creation of various drugs for the treatment of diseases.
Furthermore, it is also common in the field of pesticides. Based on 4-chloronitrobenzene, chemically modified and modified, a variety of pesticide products with insecticidal, bactericidal or herbicidal effects can be prepared. Its chemical properties help to combine with specific targets in organisms, interfere with the physiological metabolic process of pests, and achieve the purpose of controlling pests and weeds. It is of great significance to the stable and high yield of agriculture.
In summary, 4-chloronitrobenzene plays an indispensable role in the industrial fields of dyes, medicine, and pesticides, providing a key material foundation for the development of many industries.
Looking at its appearance, at room temperature, 4-chloronitrobenzene is in a light yellow crystalline state, and its color is like the first blooming of autumn chrysanthemum, which is slightly elegant. It is left in the air for a long time, or due to oxidation, etc., the color may become slightly darker.
As for the melting point, it is about 83-85 ° C. Just like ice meets warm sun, reaching this temperature limit, 4-chloronitrobenzene gradually melts from a solid state to a liquid state. And its boiling point is about 242 ° C. When the temperature rises, the liquid boils and dissipates into a gaseous state.
4-chloronitrobenzene is slightly soluble in water, just like oil floats in water, and the two are difficult to blend. However, in organic solvents such as ethanol, ether, and benzene, it is quite soluble. Like salt in soup, it can dissolve with them.
When it comes to density, it is heavier than water, and it is placed in water, such as a stone sinking into the abyss, and sinks directly.
In addition, 4-chloronitrobenzene has a certain odor, its smell is pungent, and the smell is uncomfortable. And it is volatile. Although it does not evaporate very quickly, it can slowly dissipate into the air in an open environment and over time. This is also the physical properties of 4-chloronitrobenzene.
4-chloronitrobenzene is light yellow in color and crystalline. It often exists in the room and has a significant odor. Its melting point is between 44 and 46 degrees Celsius, and its boiling point can reach 242 degrees Celsius. This substance is slightly soluble in water, but it is soluble in organic solvents such as ethanol and ether.
In terms of its chemistry, 4-chloronitrobenzene has chlorine atoms and nitro groups attached to the benzene ring. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, so the electrophilic substitution activity of the benzene ring decreases. However, it can participate in many reactions.
One is a nucleophilic substitution reaction. Due to the electron absorption of nitro groups, the positive electricity of carbon atoms connected to chlorine is enhanced, and they are easily attacked by nucleophilic reagents. Chlorine atoms can be replaced by nucleophilic groups.
Second, 4-chloronitrobenzene can be reduced under specific conditions. Nitro groups can be gradually reduced to amino groups to obtain amino-containing derivatives.
Furthermore, it can react with metal-organic reagents, and in organic synthesis, new carbon-carbon bonds can be constructed to prepare more complex organic molecules.
However, 4-chloronitrobenzene is toxic and harmful to the human body. If inhaled, ingested or absorbed through the skin, it can cause harm. When using and handling, pay extra attention and follow strict safety procedures to prevent harm to people and the environment.
One is the nitrification method. Using chlorobenzene as the starting material, in the mixed acid environment formed by sulfuric acid and nitric acid, the nitrification reaction is carried out. Among them, sulfuric acid is the catalyst, which can promote nitric acid to produce nitroyl positive ions (NO ²), which is an electrophilic reagent. The benzene ring of chlorobenzene is electron-rich, and the nitroyl positive ions attack the benzene ring. After the electrophilic substitution reaction, 4-chloronitrobenzene can be obtained. The reaction conditions are quite critical, and the temperature should be controlled within a certain range, usually between about 30 ° C and 60 ° C. If the temperature is too low, the reaction rate is slow; if the temperature is too high, it is easy to generate side reactions, resulting in the formation of ortho or meta-substitution products, which affects the purity and yield of 4-chloronitrobenzene.
The second is halogenation. First, nitrobenzene is used as a raw material and prepared by halogenation reaction. In the presence of an appropriate catalyst, such as iron or iron salt, nitrobenzene is reacted with chlorine gas. In this process, chlorine gas is acted by the catalyst to produce chlorine free radicals (Cl ·), which attack the benzene ring of nitrobenzene. Because nitro is the meta-position group, chlorine atoms mainly replace hydrogen atoms in the meta-position of the benzene ring, but some 4-chloronitrobenzene is also This reaction also requires strict control of the reaction conditions, such as reaction temperature, chlorine gas penetration rate, catalyst dosage, etc., which will affect the distribution and yield of the product.
When preparing 4-chloronitrobenzene, no matter what method is used, it is necessary to pay attention to the precise control of the reaction conditions, as well as the separation and purification of the product, in order to obtain high-purity 4-chloronitrobenzene, which can be applied to many fields, such as medicine, pesticides, dyes, etc. Synthesis.
First, it is related to safety protection. 4-Chloronitrobenzene is irritating to human skin, eyes and respiratory tract, and can cause poisoning after absorption or inhalation through the skin. Therefore, when operating, you must wear protective clothing, protective gloves and goggles, and work in a well-ventilated place. If necessary, you should also wear a gas mask to prevent contact with and inhalation of this chemical.
Second, discuss storage. This chemical should be stored in a cool, dry and ventilated place, away from fire and heat sources. It needs to be stored separately from oxidizing agents, reducing agents, acids, alkalis, etc., and should not be mixed to prevent violent reactions. At the same time, the storage area should be equipped with suitable materials to contain leaks.
Third, about the use and operation. During use, the action should be cautious to avoid dust generation. If heating is required, appropriate heating methods should be used to prevent direct heating from open flames to prevent explosions. In addition, the waste generated during operation cannot be discarded at will, and it must be properly disposed of in accordance with relevant regulations to prevent pollution to the environment.
Fourth, emergency response should not be ignored. In the event of a leak, personnel from the leaked contaminated area should be quickly evacuated to a safe area, and quarantined to strictly restrict access. Emergency responders are required to wear self-contained positive pressure respirators and anti-toxic clothing. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, it can be absorbed by sand, vermiculite or other inert materials. In the event of a large leak, build a dike or dig a pit to contain it, cover it with foam to reduce vapor disasters, and then transfer it to a tanker or special collector for recycling or transportation to a waste treatment site for disposal. If it comes into contact with skin or eyes, it should be rinsed with a large amount of flowing water immediately. If inhaled or ingested by mistake, it is necessary to seek medical attention quickly. In conclusion, when using 4-chloronitrobenzene, safety is the top priority, and operating procedures and safety regulations must be strictly followed to ensure that personnel safety and the environment are not damaged.

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