Linshang Chemical
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4-Chloronitrosobenzene
Linshang Chemical
|
HS Code |
950296 |
| Chemical Formula | C6H4ClNO |
| Molar Mass | 143.55 g/mol |
| Appearance | Yellow - orange solid |
| Odor | Pungent |
| Melting Point | 37 - 40 °C |
| Boiling Point | 234 - 235 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like benzene, toluene |
| Density | 1.34 g/cm³ |
| Stability | Unstable, decomposes on exposure to light and heat |
| Hazard Class | Toxic, irritant |
As an accredited 4-Chloronitrosobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloronitrosobenzene packaged in a sealed chemical - grade bottle. |
| Storage | 4 - Chloronitrosobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably in a corrosion - resistant material. Store it separately from oxidizing agents, reducing agents, and combustibles to prevent potential reactions. Ensure proper labeling for easy identification and safety. |
| Shipping | 4 - Chloronitrosobenzene is a hazardous chemical. Shipping must comply with strict regulations. It should be properly packaged in approved containers, labeled clearly, and transported by carriers licensed for such hazardous substances. |
Competitive 4-Chloronitrosobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 4-chloronitrosobenzene?
4-chloronitrosobenzene is p-chloro-nitrosobenzene. Although its main use is not recorded in Tiangong Kaiwu, it can be known from today's chemical knowledge. P-chloro-nitrosobenzene is a key intermediate in the field of organic synthesis. It can participate in a variety of chemical reactions to prepare other nitrogenous or chlorine-containing organic compounds.
In dye synthesis, it can be used as a starting material. Through a series of reactions, specific functional groups are introduced to construct dye molecules with special structures and colors. Because it contains nitroso and chlorine atoms, the two have different activities. They can be cleverly combined with other reagents through reactions such as nucleophilic substitution and electrophilic addition, so as to customize the color and fastness of dyes.
In the field of medicinal chemistry, p-chloro-nitrosobenzene is also useful. By chemical modification, it can be converted into bioactive compounds or used as lead compounds for the development of new drugs. Nitroso and chlorine atoms can be modified to fit specific targets, providing various possibilities for drug design.
In addition, in the field of materials science, it may be used to create organic materials with special properties. If its structural units are introduced into the polymer chain by polymerization, the material can be endowed with new electrical, optical or mechanical properties, which is expected to be applied to electronic devices, optical materials and so on.
In dye synthesis, it can be used as a starting material. Through a series of reactions, specific functional groups are introduced to construct dye molecules with special structures and colors. Because it contains nitroso and chlorine atoms, the two have different activities. They can be cleverly combined with other reagents through reactions such as nucleophilic substitution and electrophilic addition, so as to customize the color and fastness of dyes.
In the field of medicinal chemistry, p-chloro-nitrosobenzene is also useful. By chemical modification, it can be converted into bioactive compounds or used as lead compounds for the development of new drugs. Nitroso and chlorine atoms can be modified to fit specific targets, providing various possibilities for drug design.
In addition, in the field of materials science, it may be used to create organic materials with special properties. If its structural units are introduced into the polymer chain by polymerization, the material can be endowed with new electrical, optical or mechanical properties, which is expected to be applied to electronic devices, optical materials and so on.
What are the physical properties of 4-chloronitrosobenzene?
4-Chloro-nitrosobenzene is one of the organic compounds. It has specific physical properties, which are described as follows:
- ** Properties **: At room temperature, it is mostly yellow to brown crystalline. The appearance of this color is derived from the specific functional groups and electronic transition characteristics of its molecular structure. Its crystalline morphology is regular, reflecting the orderly arrangement of intermolecular forces.
- ** Melting point **: about 32-33 ° C. The value of the melting point is determined by the interaction force between molecules. At this temperature, the molecule is energized enough to overcome the lattice energy and cause the solid state to turn into a liquid state. This property is an important indicator in the separation, purification and identification of substances.
- ** Boiling point **: about 230 ° C. The boiling point characterizes the temperature when the vapor pressure of a liquid is equal to the ambient atmospheric pressure. The boiling point value of 4-chloronitrobenzene is related to its intermolecular attractive forces, such as van der Waals force, dipole-dipole interaction, etc. Higher boiling points indicate that the intermolecular forces are stronger, and more energy is required for gasification.
- ** Solubility **: Slightly soluble in water. Because of its polar chlorine and nitroso functional groups in the molecule, it can form a certain hydrogen bond with water molecules; however, it also contains a non-polar benzene ring structure, which restricts its solubility in water and has limited solubility. However, in organic solvents such as ethanol, ether, and benzene, it has good solubility. Due to the principle of similar phase dissolution, the organic solvent is compatible with the force between the molecules of 4-chloro-nitrosobenzene, which is conducive to the dispersion of the solute in the solvent.
- ** Volatility **: has a certain volatility. At room temperature and pressure, some molecules obtain enough energy to escape from the solid surface and enter the gas phase. Its volatility is affected by temperature, pressure and intermolecular forces. Higher temperature and lower pressure can increase its volatility.
The physical properties of 4-chloro-nitrosobenzene are the basis for its application in chemical industry, scientific research and other fields. Its specific melting point and boiling point assist in the separation and purification of substances; its solubility determines the choice of medium involved in the reaction; and its volatility needs to be taken into account during storage and use to ensure safety and efficiency.
- ** Properties **: At room temperature, it is mostly yellow to brown crystalline. The appearance of this color is derived from the specific functional groups and electronic transition characteristics of its molecular structure. Its crystalline morphology is regular, reflecting the orderly arrangement of intermolecular forces.
- ** Melting point **: about 32-33 ° C. The value of the melting point is determined by the interaction force between molecules. At this temperature, the molecule is energized enough to overcome the lattice energy and cause the solid state to turn into a liquid state. This property is an important indicator in the separation, purification and identification of substances.
- ** Boiling point **: about 230 ° C. The boiling point characterizes the temperature when the vapor pressure of a liquid is equal to the ambient atmospheric pressure. The boiling point value of 4-chloronitrobenzene is related to its intermolecular attractive forces, such as van der Waals force, dipole-dipole interaction, etc. Higher boiling points indicate that the intermolecular forces are stronger, and more energy is required for gasification.
- ** Solubility **: Slightly soluble in water. Because of its polar chlorine and nitroso functional groups in the molecule, it can form a certain hydrogen bond with water molecules; however, it also contains a non-polar benzene ring structure, which restricts its solubility in water and has limited solubility. However, in organic solvents such as ethanol, ether, and benzene, it has good solubility. Due to the principle of similar phase dissolution, the organic solvent is compatible with the force between the molecules of 4-chloro-nitrosobenzene, which is conducive to the dispersion of the solute in the solvent.
- ** Volatility **: has a certain volatility. At room temperature and pressure, some molecules obtain enough energy to escape from the solid surface and enter the gas phase. Its volatility is affected by temperature, pressure and intermolecular forces. Higher temperature and lower pressure can increase its volatility.
The physical properties of 4-chloro-nitrosobenzene are the basis for its application in chemical industry, scientific research and other fields. Its specific melting point and boiling point assist in the separation and purification of substances; its solubility determines the choice of medium involved in the reaction; and its volatility needs to be taken into account during storage and use to ensure safety and efficiency.
What are the chemical properties of 4-chloronitrosobenzene?
4-Chloro-nitrosobenzene is also an organic compound. It is active and has a variety of special chemical properties.
In this substance, the chlorine atom and the nitroso group are connected to the benzene ring. Nitroso (-NO) has a unique electronic effect, which changes the electron cloud density distribution of the benzene ring. Among its chemical properties, electrophilic substitution reaction is quite important. The edge nitroso group is an electron-withdrawing group, which reduces the electron cloud density of the adjacent and para-position of the benzene ring, and the meta-position is relatively high, so the electrophilic reagent is easy to attack the meta-position.
And because it contains nitroso groups, it is oxidizing. The nitrogen atom in the nitroso group is + 3 valent, which can obtain electrons and be reduced. Under the action of suitable reducing agents, the nitroso group can be converted into other groups such as amino group (-NH -2).
Furthermore, the chlorine atom in 4-chloro-nitrosobenzene is also active. In the nucleophilic substitution reaction, the chlorine atom can be replaced by a variety of nucleophilic substitution reagents, such as hydroxyl (-OH), amino group, etc., to form corresponding substitution products. This is because the chlorine atom is connected to the benzene ring, and affected by the benzene ring, the C-Cl bond has a certain polarity, which is conducive to the attack of nucleophilic reagents.
And 4-chloro-nitrosobenzene contains a conju Although the conjugated system reduces the molecular energy and has certain stability, the special properties of nitroso and chlorine atoms enable them to participate in various chemical reactions under specific conditions, exhibiting active chemical behaviors.
In this substance, the chlorine atom and the nitroso group are connected to the benzene ring. Nitroso (-NO) has a unique electronic effect, which changes the electron cloud density distribution of the benzene ring. Among its chemical properties, electrophilic substitution reaction is quite important. The edge nitroso group is an electron-withdrawing group, which reduces the electron cloud density of the adjacent and para-position of the benzene ring, and the meta-position is relatively high, so the electrophilic reagent is easy to attack the meta-position.
And because it contains nitroso groups, it is oxidizing. The nitrogen atom in the nitroso group is + 3 valent, which can obtain electrons and be reduced. Under the action of suitable reducing agents, the nitroso group can be converted into other groups such as amino group (-NH -2).
Furthermore, the chlorine atom in 4-chloro-nitrosobenzene is also active. In the nucleophilic substitution reaction, the chlorine atom can be replaced by a variety of nucleophilic substitution reagents, such as hydroxyl (-OH), amino group, etc., to form corresponding substitution products. This is because the chlorine atom is connected to the benzene ring, and affected by the benzene ring, the C-Cl bond has a certain polarity, which is conducive to the attack of nucleophilic reagents.
And 4-chloro-nitrosobenzene contains a conju Although the conjugated system reduces the molecular energy and has certain stability, the special properties of nitroso and chlorine atoms enable them to participate in various chemical reactions under specific conditions, exhibiting active chemical behaviors.
What is the preparation method of 4-chloronitrosobenzene?
4-Chloronitrobenzene is also an organic compound. The method of its preparation is mostly described in ancient books.
First take benzene as the group, to obtain 4-chloronitrobenzene, chlorobenzene is often used as the starting material. The method of nitrification of chlorobenzene can introduce nitro groups. Nitrification is done by using mixed acid (mixture of sulfuric acid and nitric acid) as the reagent. At a suitable temperature, chlorobenzene and mixed acid should be responded to. In this step, 4-chloronitrobenzene is obtained. Due to the change in the density of the electron cloud on the benzene ring, the adjacent position of the chlorine atom is affected by the nitro group, which causes its chemical properties to be abnormal.
Next, 4-chloronitrobenzene needs to In the past, it was mostly a combination of metals and acids. For example, iron and hydrochloric acid were used as agents to gradually reduce the nitro group of 4-chloronitrobenzene to an amino group, resulting in 4-chloroaniline.
Then, 4-chloroaniline is changed by diazotization and nitrosation. During diazotization, 4-chloroaniline is made into diazo salt at low temperature (usually 0-5 ° C) with sodium nitrite and hydrochloric acid. Nitrosation is added with nitrous acid reagents to convert diazo salt, resulting in 4-chloronitrosobenzene. Although this preparation path is complicated, every step is based on the principles of organic chemistry, through many ingenuity and practice, and is a common method for preparing 4-chloro-nitrosobenzene in the past.
First take benzene as the group, to obtain 4-chloronitrobenzene, chlorobenzene is often used as the starting material. The method of nitrification of chlorobenzene can introduce nitro groups. Nitrification is done by using mixed acid (mixture of sulfuric acid and nitric acid) as the reagent. At a suitable temperature, chlorobenzene and mixed acid should be responded to. In this step, 4-chloronitrobenzene is obtained. Due to the change in the density of the electron cloud on the benzene ring, the adjacent position of the chlorine atom is affected by the nitro group, which causes its chemical properties to be abnormal.
Next, 4-chloronitrobenzene needs to In the past, it was mostly a combination of metals and acids. For example, iron and hydrochloric acid were used as agents to gradually reduce the nitro group of 4-chloronitrobenzene to an amino group, resulting in 4-chloroaniline.
Then, 4-chloroaniline is changed by diazotization and nitrosation. During diazotization, 4-chloroaniline is made into diazo salt at low temperature (usually 0-5 ° C) with sodium nitrite and hydrochloric acid. Nitrosation is added with nitrous acid reagents to convert diazo salt, resulting in 4-chloronitrosobenzene. Although this preparation path is complicated, every step is based on the principles of organic chemistry, through many ingenuity and practice, and is a common method for preparing 4-chloro-nitrosobenzene in the past.
4-chloronitrosobenzene what are the precautions during use
4-Chloro-nitrosobenzene is one of the organic compounds. During its use, many matters need to be paid attention to.
The first priority is safety. This substance is toxic and irritating, or has great harm to human health. Therefore, when taking it, be sure to wear complete protective equipment, such as gas masks, protective gloves and protective clothing, to prevent it from coming into contact with the skin, respiratory tract, etc. If it is accidentally touched, rinse it with plenty of water immediately and seek medical treatment quickly.
Furthermore, 4-chloro-nitrosobenzene is more active in nature. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire, heat and strong oxidants, etc., to prevent dangerous reactions. Because it is volatile, the storage container must be tightly sealed to avoid leakage.
And because 4-chloro-nitrosobenzene is a chemical reagent, the established operating procedures and experimental requirements should be strictly followed when using it. The amount to be used should be accurately measured, and the operation process should be careful to prevent it from spilling and splashing. And the experimental environment should have good ventilation conditions to disperse harmful gases that may be generated.
In addition, after use, the remaining 4-chloro-nitrosobenzene should not be discarded at will. It is necessary to properly dispose of it in accordance with relevant regulations, or recycle it for reuse, or hand it over to a professional organization according to the hazardous waste disposal process, so as to avoid pollution to the environment. In short, the use of this substance should be done with caution, comprehensive protection, and operation in accordance with regulations to ensure safety and environmental harmlessness.
The first priority is safety. This substance is toxic and irritating, or has great harm to human health. Therefore, when taking it, be sure to wear complete protective equipment, such as gas masks, protective gloves and protective clothing, to prevent it from coming into contact with the skin, respiratory tract, etc. If it is accidentally touched, rinse it with plenty of water immediately and seek medical treatment quickly.
Furthermore, 4-chloro-nitrosobenzene is more active in nature. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire, heat and strong oxidants, etc., to prevent dangerous reactions. Because it is volatile, the storage container must be tightly sealed to avoid leakage.
And because 4-chloro-nitrosobenzene is a chemical reagent, the established operating procedures and experimental requirements should be strictly followed when using it. The amount to be used should be accurately measured, and the operation process should be careful to prevent it from spilling and splashing. And the experimental environment should have good ventilation conditions to disperse harmful gases that may be generated.
In addition, after use, the remaining 4-chloro-nitrosobenzene should not be discarded at will. It is necessary to properly dispose of it in accordance with relevant regulations, or recycle it for reuse, or hand it over to a professional organization according to the hazardous waste disposal process, so as to avoid pollution to the environment. In short, the use of this substance should be done with caution, comprehensive protection, and operation in accordance with regulations to ensure safety and environmental harmlessness.
What is the chemical structure of 4-chloronitrosobenzene?
4-chloronitrosobenzene is 4-chloro-nitrosobenzene, and its chemical structure is as follows. This substance belongs to the aromatic compound, and the benzene ring is used as the parent structure. On the benzene ring, there are two substituents. One is a chlorine atom (-Cl), and the other is a nitroso (-NO). The two are in the opposite position of the benzene ring, that is, they are separated by two carbon atoms, which are in a spatial position of 180 °. The benzene ring is a planar regular hexagonal structure composed of six carbon atoms connected by a conjugated large π bond, each carbon atom is connected to a hydrogen atom. The chlorine atom is connected to a specific carbon atom of the benzene ring by means of a carbon-chlorine covalent bond, and the nitroso group is connected to the opposite benzene ring carbon atom by a nitrogen-carbon covalent bond. In the nitroso group, the nitrogen atom and the oxygen atom are connected by a double bond, and the nitrogen atom has a single electron, which makes the compound have certain reactivity. This chemical structure endows 4-chloronitrobenzene with unique physical and chemical properties, and has specific uses and reaction characteristics in organic synthesis and other fields.
What are the main uses of 4-chloronitrosobenzene?
4-Chloro-nitrosobenzene is an organic compound. It has a wide range of uses and has important applications in many fields.
First, it is a key intermediate in the field of organic synthesis. Due to its unique structure, it can participate in many chemical reactions to build complex organic molecular structures. For example, it can react with nucleophiles to realize the transformation of functional groups, such as combining with nucleophiles containing nitrogen, oxygen, sulfur, etc., to form new chemical bonds, thereby preparing organic compounds with specific functions, such as certain pharmaceutical intermediates and special organic material precursors.
Second, it is also of great value in the field of materials science. The materials obtained by its participation in the reaction may have unique physical and chemical properties. For example, in the synthesis of materials with special optical or electrical properties, 4-chloro-nitrosobenzene can be used as a starting material. After a series of reactions, the material is endowed with unique photoelectric properties, which may have potential applications in the manufacture of optoelectronic devices.
Furthermore, in the field of drug development, it participates in the synthesis of biologically active compounds as an intermediate. By chemically modifying and reacting it, molecules with pharmacological activity may be obtained, providing a basis for the development of new drugs. The modified product may have affinity and activity to specific biological targets, thus demonstrating the potential to treat diseases.
Overall, 4-chloro-nitrosobenzene, with its unique chemical properties, plays an indispensable role in many fields such as organic synthesis, materials science, and drug development, and has made significant contributions to the development of related fields.
First, it is a key intermediate in the field of organic synthesis. Due to its unique structure, it can participate in many chemical reactions to build complex organic molecular structures. For example, it can react with nucleophiles to realize the transformation of functional groups, such as combining with nucleophiles containing nitrogen, oxygen, sulfur, etc., to form new chemical bonds, thereby preparing organic compounds with specific functions, such as certain pharmaceutical intermediates and special organic material precursors.
Second, it is also of great value in the field of materials science. The materials obtained by its participation in the reaction may have unique physical and chemical properties. For example, in the synthesis of materials with special optical or electrical properties, 4-chloro-nitrosobenzene can be used as a starting material. After a series of reactions, the material is endowed with unique photoelectric properties, which may have potential applications in the manufacture of optoelectronic devices.
Furthermore, in the field of drug development, it participates in the synthesis of biologically active compounds as an intermediate. By chemically modifying and reacting it, molecules with pharmacological activity may be obtained, providing a basis for the development of new drugs. The modified product may have affinity and activity to specific biological targets, thus demonstrating the potential to treat diseases.
Overall, 4-chloro-nitrosobenzene, with its unique chemical properties, plays an indispensable role in many fields such as organic synthesis, materials science, and drug development, and has made significant contributions to the development of related fields.
What are the physical properties of 4-chloronitrosobenzene?
4-Chloro-nitrosobenzene is also an organic compound. It has specific physical properties, which are described in detail by you today.
Looking at its appearance, under room temperature, 4-chloro-nitrosobenzene is often a yellow to brown crystalline solid. This color state is easy to recognize with the naked eye, which is one of the characteristics of this material.
When it comes to the melting point, it is about 32-34 degrees Celsius. The melting point is not high, and it is easy to melt when heated. This property is of great significance for chemical operations, analysis and testing. If it involves the process of its preparation and purification, it is necessary to precisely control the temperature to prevent it from melting due to excessive temperature and affecting the purity and yield of the product.
In terms of boiling point, it is about 194-196 degrees Celsius. At this temperature, 4-chloronitrobenzene will change from liquid to gaseous state. In separation operations such as distillation, the boiling point data can be used as a key reference, and 4-chloronitrobenzene can be separated from other substances by suitable temperature.
Solubility is also an important physical property. 4-chloronitrobenzene is insoluble in water, because water is a polar solvent, while 4-chloronitrobenzene molecules are relatively weak in polarity. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it is soluble in organic solvents such as ethanol and ether, which facilitates its use in organic synthesis reactions. Suitable organic solvents can be selected to fully dissolve 4-chloro-nitrosobenzene, participate in the reaction, and improve the reaction efficiency.
In addition, 4-chloro-nitrosobenzene is volatile and will slowly evaporate in the air. When stored, it needs to be properly sealed to prevent its volatilization from causing changes in content, and because it has certain toxicity and irritation, volatile gases should also be paid attention to to to prevent harm to the human body and the environment.
Looking at its appearance, under room temperature, 4-chloro-nitrosobenzene is often a yellow to brown crystalline solid. This color state is easy to recognize with the naked eye, which is one of the characteristics of this material.
When it comes to the melting point, it is about 32-34 degrees Celsius. The melting point is not high, and it is easy to melt when heated. This property is of great significance for chemical operations, analysis and testing. If it involves the process of its preparation and purification, it is necessary to precisely control the temperature to prevent it from melting due to excessive temperature and affecting the purity and yield of the product.
In terms of boiling point, it is about 194-196 degrees Celsius. At this temperature, 4-chloronitrobenzene will change from liquid to gaseous state. In separation operations such as distillation, the boiling point data can be used as a key reference, and 4-chloronitrobenzene can be separated from other substances by suitable temperature.
Solubility is also an important physical property. 4-chloronitrobenzene is insoluble in water, because water is a polar solvent, while 4-chloronitrobenzene molecules are relatively weak in polarity. According to the principle of "similar miscibility", the two are difficult to dissolve. However, it is soluble in organic solvents such as ethanol and ether, which facilitates its use in organic synthesis reactions. Suitable organic solvents can be selected to fully dissolve 4-chloro-nitrosobenzene, participate in the reaction, and improve the reaction efficiency.
In addition, 4-chloro-nitrosobenzene is volatile and will slowly evaporate in the air. When stored, it needs to be properly sealed to prevent its volatilization from causing changes in content, and because it has certain toxicity and irritation, volatile gases should also be paid attention to to to prevent harm to the human body and the environment.
What are 4-chloronitrosobenzene synthesis methods?
The synthesis of 4-chloronitrobenzene has always been studied by chemists. The way to synthesize this substance is not the same, and the advantages and disadvantages of each method are different. It should be selected according to the appropriate environment and needs.
One method can start with 4-chloroaniline. First dissolve 4-chloroaniline in an appropriate amount of dilute acid, such as hydrochloric acid, to make a salt solution. Slowly add an appropriate amount of sodium nitrite solution, and control its temperature at a low temperature, often in an ice bath, so that the temperature does not exceed 5 degrees Celsius. At that time, a diazotization reaction occurs, and 4-chloroaniline is then converted to 4-chlorodiazonium salt. Then, in the diazonium salt solution, an appropriate amount of reducing agent is added, such as the hydrochloric acid solution of stannous chloride. After reduction, 4-chloronitrobenzene can be obtained. Although this method is complicated, the reaction of diazotization and reduction is easier to control, and the yield is still considerable.
Another method uses 4-chlorobenzaldehyde as the starting material. Shilling 4-chlorobenzaldehyde reacts with hydroxylamine hydrochloride in an alkaline environment. The pH value is often adjusted with an aqueous solution of sodium hydroxide or sodium carbonate to make it alkaline. The two interact in phase to obtain 4-chlorobenzaldehyde oxime. Then, 4-chloronitrobenzene can also be obtained by dehydrating 4-chlorobenzaldehyde oxime with an appropriate dehydrating agent, such as acetic anhydride. The raw materials used in this way are relatively easy to purchase, but the dehydration step requires attention to the reaction conditions. If it is not properly controlled, it may cause side reactions, which will affect the purity and yield of the product.
Furthermore, there are those who use 4-chloronitrobenzene as a raw material. First, 4-chloronitrobenzene is reduced with an appropriate reducing agent, such as iron and hydrochloric acid, to obtain 4-chloronitrobenzene. The next step is the same as that of the first method from 4-chloronitrobenzene, and 4-chloronitrobenzene is obtained by diazotization and reduction. Although this method has undergone multiple steps of reaction, the raw material 4-chloronitrobenzene is quite common, and the technology of each step of reaction is well known, so it is a usable method.
The various methods for synthesizing 4-chloronitrobenzene have their own strengths, or the raw materials are easy to purchase, or the reaction is easy to control, or the yield is better. If you want to do a good job, you must carefully observe the needs, choose one and use it.
One method can start with 4-chloroaniline. First dissolve 4-chloroaniline in an appropriate amount of dilute acid, such as hydrochloric acid, to make a salt solution. Slowly add an appropriate amount of sodium nitrite solution, and control its temperature at a low temperature, often in an ice bath, so that the temperature does not exceed 5 degrees Celsius. At that time, a diazotization reaction occurs, and 4-chloroaniline is then converted to 4-chlorodiazonium salt. Then, in the diazonium salt solution, an appropriate amount of reducing agent is added, such as the hydrochloric acid solution of stannous chloride. After reduction, 4-chloronitrobenzene can be obtained. Although this method is complicated, the reaction of diazotization and reduction is easier to control, and the yield is still considerable.
Another method uses 4-chlorobenzaldehyde as the starting material. Shilling 4-chlorobenzaldehyde reacts with hydroxylamine hydrochloride in an alkaline environment. The pH value is often adjusted with an aqueous solution of sodium hydroxide or sodium carbonate to make it alkaline. The two interact in phase to obtain 4-chlorobenzaldehyde oxime. Then, 4-chloronitrobenzene can also be obtained by dehydrating 4-chlorobenzaldehyde oxime with an appropriate dehydrating agent, such as acetic anhydride. The raw materials used in this way are relatively easy to purchase, but the dehydration step requires attention to the reaction conditions. If it is not properly controlled, it may cause side reactions, which will affect the purity and yield of the product.
Furthermore, there are those who use 4-chloronitrobenzene as a raw material. First, 4-chloronitrobenzene is reduced with an appropriate reducing agent, such as iron and hydrochloric acid, to obtain 4-chloronitrobenzene. The next step is the same as that of the first method from 4-chloronitrobenzene, and 4-chloronitrobenzene is obtained by diazotization and reduction. Although this method has undergone multiple steps of reaction, the raw material 4-chloronitrobenzene is quite common, and the technology of each step of reaction is well known, so it is a usable method.
The various methods for synthesizing 4-chloronitrobenzene have their own strengths, or the raw materials are easy to purchase, or the reaction is easy to control, or the yield is better. If you want to do a good job, you must carefully observe the needs, choose one and use it.
4-chloronitrosobenzene what are the precautions during use
4-Chloro-nitrosobenzene is a commonly used reagent in organic synthesis. When using, many matters need to be paid attention to.
First, this material is toxic and harmful to the human body. Or by inhalation, ingestion, skin contact and other ways into the human body, harming health. Therefore, when operating, it is necessary to strictly follow safety regulations, wear protective clothing, gloves and protective masks, and work in a well-ventilated place to prevent its volatile gas from being inhaled into the body.
Second, 4-chloro-nitrosobenzene is chemically active and has poor stability. It is easy to react with many substances, and can cause combustion and explosion in case of open flames, hot topics or. When storing, store in a cool, dry and ventilated place, away from fire and heat sources, and store separately from oxidants, acids, alkalis, etc., and avoid mixed storage.
Third, it may produce harmful waste during use. Disposal of such waste must be done in accordance with relevant environmental regulations, and cannot be dumped at will to avoid polluting the environment. It needs to be collected and handed over to a professional treatment agency for proper disposal.
Fourth, during operation, be careful to avoid contact with skin and eyes. In case of inadvertent contact, corresponding first aid measures should be taken immediately. If it comes into contact with the skin, rinse with a large amount of flowing water immediately; when entering the eyes, immediately lift the eyelids, rinse with flowing water or normal saline, and seek medical treatment immediately.
In short, when using 4-chloro nitrosobenzene, it is necessary to be familiar with its characteristics and strictly abide by safety and environmental protection guidelines to ensure the safety of the operation and the tranquility of the environment.
First, this material is toxic and harmful to the human body. Or by inhalation, ingestion, skin contact and other ways into the human body, harming health. Therefore, when operating, it is necessary to strictly follow safety regulations, wear protective clothing, gloves and protective masks, and work in a well-ventilated place to prevent its volatile gas from being inhaled into the body.
Second, 4-chloro-nitrosobenzene is chemically active and has poor stability. It is easy to react with many substances, and can cause combustion and explosion in case of open flames, hot topics or. When storing, store in a cool, dry and ventilated place, away from fire and heat sources, and store separately from oxidants, acids, alkalis, etc., and avoid mixed storage.
Third, it may produce harmful waste during use. Disposal of such waste must be done in accordance with relevant environmental regulations, and cannot be dumped at will to avoid polluting the environment. It needs to be collected and handed over to a professional treatment agency for proper disposal.
Fourth, during operation, be careful to avoid contact with skin and eyes. In case of inadvertent contact, corresponding first aid measures should be taken immediately. If it comes into contact with the skin, rinse with a large amount of flowing water immediately; when entering the eyes, immediately lift the eyelids, rinse with flowing water or normal saline, and seek medical treatment immediately.
In short, when using 4-chloro nitrosobenzene, it is necessary to be familiar with its characteristics and strictly abide by safety and environmental protection guidelines to ensure the safety of the operation and the tranquility of the environment.
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