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4-Chlorophenyl Benzenesulphonate
Linshang Chemical
|
HS Code |
814604 |
| Chemical Formula | C12H9ClO3S |
| Molar Mass | 270.72 g/mol |
| Appearance | Typically a solid |
| Physical State At Room Temp | Solid |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents |
| Melting Point | Data may vary by source, but has a defined melting point |
| Odor | May have a faint chemical odor |
| Stability | Stable under normal conditions |
As an accredited 4-Chlorophenyl Benzenesulphonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chlorophenyl Benzenesulphonate packaged in a sealed plastic - lined paper bag. |
| Storage | 4 - Chlorophenyl Benzenesulphonate should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and incompatible substances like strong oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and potential degradation. Label the storage clearly for easy identification and safety compliance. |
| Shipping | 4 - chlorophenyl Benzenesulphonate is shipped in sealed, corrosion - resistant containers. It's transported under regulated conditions, adhering to safety protocols for chemicals to prevent spills, ensure stability during transit. |
Competitive 4-Chlorophenyl Benzenesulphonate prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 4-chlorophenyl Benzenesulphonate?
4-Chlorophenylbenzenesulfonate, a class of compounds in organic chemistry. It has a wide range of main uses and is often used as a key intermediate in the field of organic synthesis.
In organic synthesis, with its unique chemical structure, 4-chlorophenylbenzenesulfonate can participate in many types of reactions. For example, nucleophilic substitution reactions, because the sulfonate group is a good leaving group, it can make the carbon atoms attached to it exhibit electrophilicity, making it vulnerable to attack by nucleophiles. During this reaction, nucleophiles replace sulfonate groups, resulting in the formation of novel organic compounds. In this way, chemists can use this reaction to build diverse carbon-carbon bonds and carbon-heteroatomic bonds to achieve the synthesis of complex organic molecules.
Furthermore, in the field of pharmaceutical chemistry, 4-chlorophenylbenzenesulfonate also plays an important role. Due to its special structure, it can be used to design and synthesize drug molecules with specific biological activities. By modifying and modifying its structure, it can adjust the physicochemical properties, bioavailability and interaction with biological targets of drug molecules. This will help to develop new drugs with better efficacy and fewer side effects.
In addition, in the field of materials science, 4-chlorophenylbenzenesulfonate can be used to prepare materials with special properties. For example, introducing it into polymer materials can change the electrical, optical or mechanical properties of the material to meet the requirements of different application scenarios.
In short, 4-chlorophenylbenzenesulfonate has important uses in many fields such as organic synthesis, medicinal chemistry and materials science due to its unique chemical structure, providing a key chemical tool and material basis for the development of various fields.
In organic synthesis, with its unique chemical structure, 4-chlorophenylbenzenesulfonate can participate in many types of reactions. For example, nucleophilic substitution reactions, because the sulfonate group is a good leaving group, it can make the carbon atoms attached to it exhibit electrophilicity, making it vulnerable to attack by nucleophiles. During this reaction, nucleophiles replace sulfonate groups, resulting in the formation of novel organic compounds. In this way, chemists can use this reaction to build diverse carbon-carbon bonds and carbon-heteroatomic bonds to achieve the synthesis of complex organic molecules.
Furthermore, in the field of pharmaceutical chemistry, 4-chlorophenylbenzenesulfonate also plays an important role. Due to its special structure, it can be used to design and synthesize drug molecules with specific biological activities. By modifying and modifying its structure, it can adjust the physicochemical properties, bioavailability and interaction with biological targets of drug molecules. This will help to develop new drugs with better efficacy and fewer side effects.
In addition, in the field of materials science, 4-chlorophenylbenzenesulfonate can be used to prepare materials with special properties. For example, introducing it into polymer materials can change the electrical, optical or mechanical properties of the material to meet the requirements of different application scenarios.
In short, 4-chlorophenylbenzenesulfonate has important uses in many fields such as organic synthesis, medicinal chemistry and materials science due to its unique chemical structure, providing a key chemical tool and material basis for the development of various fields.
What are the physical properties of 4-chlorophenyl Benzenesulphonate
4-Chlorophenylbenzenesulfonate, the property of this material is quite critical, related to its many uses. Its appearance is often white to light yellow crystalline powder, delicate and unique color, and its shape can be initially identified.
When it comes to the melting point, it is about a certain temperature range, which is of great significance in many industrial operations and experiments. By accurately measuring the melting point, its purity can be determined, and it also provides a key temperature reference for subsequent processing.
In terms of solubility, it shows a certain solubility in organic solvents, such as common ethanol and acetone. This property determines its dispersion and reaction ability in various solution systems. In the field of synthetic chemistry, it provides a basis for the preparation of suitable reaction media. In terms of stability,
is relatively stable under conventional environmental conditions. In case of extreme conditions such as high temperature and strong acid and alkali, its chemical structure is easily damaged, triggering decomposition reactions. This requires that environmental factors must be paid attention to during storage and transportation to ensure that its quality is not damaged. The physical properties of
4-chlorophenylbenzenesulfonate are of great significance in many fields such as chemical industry and materials science, laying a solid foundation for its rational application and in-depth research.
When it comes to the melting point, it is about a certain temperature range, which is of great significance in many industrial operations and experiments. By accurately measuring the melting point, its purity can be determined, and it also provides a key temperature reference for subsequent processing.
In terms of solubility, it shows a certain solubility in organic solvents, such as common ethanol and acetone. This property determines its dispersion and reaction ability in various solution systems. In the field of synthetic chemistry, it provides a basis for the preparation of suitable reaction media. In terms of stability,
is relatively stable under conventional environmental conditions. In case of extreme conditions such as high temperature and strong acid and alkali, its chemical structure is easily damaged, triggering decomposition reactions. This requires that environmental factors must be paid attention to during storage and transportation to ensure that its quality is not damaged. The physical properties of
4-chlorophenylbenzenesulfonate are of great significance in many fields such as chemical industry and materials science, laying a solid foundation for its rational application and in-depth research.
What are the chemical properties of 4-chlorophenyl Benzenesulphonate
4-Chlorophenylbenzenesulfonate, this is an organic compound. Its chemical properties are unique and have the following numbers.
Its hydrolytic properties, under suitable acid and alkali conditions, 4-chlorophenylbenzenesulfonate can be hydrolyzed. In an alkaline environment, hydroxide ions nucleophilically attack the carbon atoms of the sulfonate group, causing the sulfonate bond to break, generating 4-chlorophenol and benzenesulfonate. This hydrolysis reaction rate is affected by factors such as the concentration of the base and temperature. When the temperature increases, the reaction rate is often accelerated; when the concentration of the base increases, the hydrolysis reaction is also accelerated.
For its nucleophilic substitution ability, benzenesulfonate group is a good leaving group, and 4-chlorophenylbenzenesulfonate is prone to nucleophilic substitution. Nucleophilic reagents such as alcohols and amines can attack the carbon atoms connected to the benzenesulfonate group and replace the benzenesulfonate group. For example, alcohol nucleophiles react with them to obtain corresponding ether compounds; amine nucleophiles generate substituted amine derivatives. This reactivity is related to the nucleophilicity of nucleophiles, and reagents with strong nucleophilicity are more likely to react.
In terms of stability, 4-chlorophenylbenzenesulfonate is relatively stable under normal conditions. In case of high temperature, strong acid base or specific catalyst, the stability is affected. High temperature can cause the vibration of intramolecular chemical bonds to intensify, making the sulfonate bond more prone to fracture; strong acid base directly participates in the chemical reaction and destroys its structural stability.
In addition, although the chlorine atom in 4-chlorophenylbenzenesulfonate is not as active as the halogen atom in halogenated alkanes, it can also participate in the reaction under specific conditions. For example, under the action of strong bases and suitable catalysts, an elimination reaction can occur to remove hydrogen chloride and form unsaturated bonds.
In short, 4-chlorophenylbenzenesulfonate has rich chemical properties, hydrolysis, nucleophilic substitution and other reaction characteristics. It has important uses in the field of organic synthesis and can help synthesize a variety of organic compounds.
Its hydrolytic properties, under suitable acid and alkali conditions, 4-chlorophenylbenzenesulfonate can be hydrolyzed. In an alkaline environment, hydroxide ions nucleophilically attack the carbon atoms of the sulfonate group, causing the sulfonate bond to break, generating 4-chlorophenol and benzenesulfonate. This hydrolysis reaction rate is affected by factors such as the concentration of the base and temperature. When the temperature increases, the reaction rate is often accelerated; when the concentration of the base increases, the hydrolysis reaction is also accelerated.
For its nucleophilic substitution ability, benzenesulfonate group is a good leaving group, and 4-chlorophenylbenzenesulfonate is prone to nucleophilic substitution. Nucleophilic reagents such as alcohols and amines can attack the carbon atoms connected to the benzenesulfonate group and replace the benzenesulfonate group. For example, alcohol nucleophiles react with them to obtain corresponding ether compounds; amine nucleophiles generate substituted amine derivatives. This reactivity is related to the nucleophilicity of nucleophiles, and reagents with strong nucleophilicity are more likely to react.
In terms of stability, 4-chlorophenylbenzenesulfonate is relatively stable under normal conditions. In case of high temperature, strong acid base or specific catalyst, the stability is affected. High temperature can cause the vibration of intramolecular chemical bonds to intensify, making the sulfonate bond more prone to fracture; strong acid base directly participates in the chemical reaction and destroys its structural stability.
In addition, although the chlorine atom in 4-chlorophenylbenzenesulfonate is not as active as the halogen atom in halogenated alkanes, it can also participate in the reaction under specific conditions. For example, under the action of strong bases and suitable catalysts, an elimination reaction can occur to remove hydrogen chloride and form unsaturated bonds.
In short, 4-chlorophenylbenzenesulfonate has rich chemical properties, hydrolysis, nucleophilic substitution and other reaction characteristics. It has important uses in the field of organic synthesis and can help synthesize a variety of organic compounds.
What is the production method of 4-chlorophenyl Benzenesulphonate?
The preparation method of 4-chlorophenylbenzenesulfonate is as follows:
First take an appropriate amount of benzenesulfonate and place it in a clean reaction vessel. Place the vessel in a suitable cooling environment, such as an ice bath, to reduce the temperature to a specific low temperature range, usually about 0-5 ° C. At this low temperature, slowly add sulfoxide chloride. When adding, it is necessary to operate carefully so that the two are in full contact and the reaction proceeds smoothly. In this step of the reaction, benzenesulfonic acid interacts with sulfoxide chloride, and the hydroxyl group in the sulfonic acid group is replaced by the chlorine atom to form benzenesulfonyl chloride. The reaction is violent, and hydrogen chloride gas escapes. Therefore, it is necessary to be in a well-ventilated environment and do a good job of tail gas absorption treatment.
After the above reaction is completed and the reaction system is confirmed to be stable, take another 4-chlorophenol and dissolve it in a suitable organic solvent, such as dichloromethane or tetrahydrofuran. The solution is slowly added dropwise to the reaction system containing benzenesulfonyl chloride under stirring. At the same time, an appropriate amount of acid binding agent, such as pyridine or triethylamine, is added to neutralize the hydrogen chloride generated during the reaction process, and promote the reaction to proceed in the direction of generating 4-chlorophenesulfonate. After the dropwise addition is completed, maintain a certain reaction temperature, usually between room temperature and 50 ° C, and continue to stir the reaction for several hours to make the reaction fully proceed.
After the reaction is completed, pour the reaction mixture into an appropriate amount of water to stop the reaction. At this time, the product 4-chlorophenylbenzenesulfonate is precipitated or stratified due to its low solubility in water. The separation funnel is used to separate the liquid to collect the organic phase. Subsequently, the organic phase is washed with water, washed with a dilute alkali solution, and washed again to remove unreacted raw materials, by-products and impurities. After the washing is completed, add a desiccant such as anhydrous sodium sulfate or anhydrous magnesium sulfate, and let it stand for a period of time to remove the residual moisture in the organic phase.
Finally, the organic solvent is removed by the method of reduced pressure distillation to obtain a pure 4-chlorophenylbenzenesulfonate product. If the purity of the product does not meet the requirements, it can be further purified by methods such as recrystallization, selecting a suitable solvent, such as ethanol-water mixed solvent, heating and dissolving the product, filtering while hot, cooling the crystallization, filtering again and drying to obtain high purity 4-chlorophenylbenzenesulfonate.
First take an appropriate amount of benzenesulfonate and place it in a clean reaction vessel. Place the vessel in a suitable cooling environment, such as an ice bath, to reduce the temperature to a specific low temperature range, usually about 0-5 ° C. At this low temperature, slowly add sulfoxide chloride. When adding, it is necessary to operate carefully so that the two are in full contact and the reaction proceeds smoothly. In this step of the reaction, benzenesulfonic acid interacts with sulfoxide chloride, and the hydroxyl group in the sulfonic acid group is replaced by the chlorine atom to form benzenesulfonyl chloride. The reaction is violent, and hydrogen chloride gas escapes. Therefore, it is necessary to be in a well-ventilated environment and do a good job of tail gas absorption treatment.
After the above reaction is completed and the reaction system is confirmed to be stable, take another 4-chlorophenol and dissolve it in a suitable organic solvent, such as dichloromethane or tetrahydrofuran. The solution is slowly added dropwise to the reaction system containing benzenesulfonyl chloride under stirring. At the same time, an appropriate amount of acid binding agent, such as pyridine or triethylamine, is added to neutralize the hydrogen chloride generated during the reaction process, and promote the reaction to proceed in the direction of generating 4-chlorophenesulfonate. After the dropwise addition is completed, maintain a certain reaction temperature, usually between room temperature and 50 ° C, and continue to stir the reaction for several hours to make the reaction fully proceed.
After the reaction is completed, pour the reaction mixture into an appropriate amount of water to stop the reaction. At this time, the product 4-chlorophenylbenzenesulfonate is precipitated or stratified due to its low solubility in water. The separation funnel is used to separate the liquid to collect the organic phase. Subsequently, the organic phase is washed with water, washed with a dilute alkali solution, and washed again to remove unreacted raw materials, by-products and impurities. After the washing is completed, add a desiccant such as anhydrous sodium sulfate or anhydrous magnesium sulfate, and let it stand for a period of time to remove the residual moisture in the organic phase.
Finally, the organic solvent is removed by the method of reduced pressure distillation to obtain a pure 4-chlorophenylbenzenesulfonate product. If the purity of the product does not meet the requirements, it can be further purified by methods such as recrystallization, selecting a suitable solvent, such as ethanol-water mixed solvent, heating and dissolving the product, filtering while hot, cooling the crystallization, filtering again and drying to obtain high purity 4-chlorophenylbenzenesulfonate.
What are the precautions when using 4-chlorophenyl Benzenesulphonate
4-Chlorophenylbenzenesulfonate is an important compound in organic chemistry. When using it, there are many precautions that cannot be ignored.
One is related to safety. This compound may be toxic and irritating, so it is necessary to strictly follow safety procedures when operating. Appropriate protective equipment, such as protective gloves, goggles, lab clothes, etc., must be worn to prevent skin contact with it or its entry into the eyes, and should be operated in a well-ventilated environment to avoid its volatile gas entering the body and harming health.
Second, pay attention to its chemical properties. 4-Chlorophenylbenzenesulfonate has specific reactivity and may react violently when exposed to certain chemicals. When using, specify its compatibility with other reagents used, consult relevant information in advance, and be familiar with possible chemical reactions. Avoid rash mixing and dangerous situations, such as explosions and fires.
Third, storage is also exquisite. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its stability or environmental factors, excessive humidity and temperature may cause it to deteriorate, affecting the use effect. And should be stored separately from oxidizing agents and reducing agents to prevent interaction and damage to quality.
Fourth, weighing and taking should be accurate. Because it often participates in chemical reactions, the accuracy of dosage depends on the success or failure of the reaction and the purity of the product. When taking it, it is advisable to use an accurate weighing instrument and use it according to the amount required by the experiment, which not only avoids waste, but also avoids abnormal reactions due to improper amounts.
Fifth, waste treatment should not be underestimated. The leftover materials and waste generated by the reaction after use should not be discarded at will. It needs to be properly disposed of in accordance with relevant environmental protection regulations and laboratory regulations to prevent environmental pollution. Either recycle and reuse, or dispose of according to specific methods to ensure environmental safety. In short, when using 4-chlorophenylbenzenesulfonate, care should be taken in terms of safety, chemical properties, storage, access and waste disposal to achieve the purpose of the experiment and ensure the safety of personnel and the environment.
One is related to safety. This compound may be toxic and irritating, so it is necessary to strictly follow safety procedures when operating. Appropriate protective equipment, such as protective gloves, goggles, lab clothes, etc., must be worn to prevent skin contact with it or its entry into the eyes, and should be operated in a well-ventilated environment to avoid its volatile gas entering the body and harming health.
Second, pay attention to its chemical properties. 4-Chlorophenylbenzenesulfonate has specific reactivity and may react violently when exposed to certain chemicals. When using, specify its compatibility with other reagents used, consult relevant information in advance, and be familiar with possible chemical reactions. Avoid rash mixing and dangerous situations, such as explosions and fires.
Third, storage is also exquisite. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its stability or environmental factors, excessive humidity and temperature may cause it to deteriorate, affecting the use effect. And should be stored separately from oxidizing agents and reducing agents to prevent interaction and damage to quality.
Fourth, weighing and taking should be accurate. Because it often participates in chemical reactions, the accuracy of dosage depends on the success or failure of the reaction and the purity of the product. When taking it, it is advisable to use an accurate weighing instrument and use it according to the amount required by the experiment, which not only avoids waste, but also avoids abnormal reactions due to improper amounts.
Fifth, waste treatment should not be underestimated. The leftover materials and waste generated by the reaction after use should not be discarded at will. It needs to be properly disposed of in accordance with relevant environmental protection regulations and laboratory regulations to prevent environmental pollution. Either recycle and reuse, or dispose of according to specific methods to ensure environmental safety. In short, when using 4-chlorophenylbenzenesulfonate, care should be taken in terms of safety, chemical properties, storage, access and waste disposal to achieve the purpose of the experiment and ensure the safety of personnel and the environment.
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