Linshang Chemical
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4-Fluoro-2-Iodochlorobenzene
Linshang Chemical
|
HS Code |
170997 |
| Chemical Formula | C6H3ClF I |
| Molecular Weight | 260.44 |
| Appearance | Liquid (usually) |
| Boiling Point | Data may vary, around 190 - 200 °C (estimated) |
| Melting Point | Data may vary |
| Density | Data may vary |
| Solubility | Soluble in organic solvents like dichloromethane, etc. (general trend) |
| Vapor Pressure | Low vapor pressure (estimated for a relatively high - boiling organic compound) |
| Flash Point | Data may vary |
| Stability | Stable under normal conditions; can react with strong oxidizing agents |
As an accredited 4-Fluoro-2-Iodochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - fluoro - 2 - iodochlorobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 4 - fluoro - 2 - iodochlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and strong oxidizing agents. Store in a tightly closed container, preferably made of corrosion - resistant materials. Label the container clearly. This storage method helps prevent decomposition, reactivity, and potential hazards associated with the chemical. |
| Shipping | 4 - fluoro - 2 - iodochlorobenzene is shipped in sealed, corrosion - resistant containers. Compliance with chemical transportation regulations is ensured. Shipment is carefully monitored to maintain stability during transit. |
Competitive 4-Fluoro-2-Iodochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Fluoro-2-Iodochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-fluoro-2-iodochlorobenzene?
4-Fluoro-2-iodochlorobenzene is one of the organohalogenated aromatic hydrocarbons. It has unique chemical properties, which are related to many reactions and various chemical properties.
When it comes to chemical activity, the halogen atom above the benzene ring has a great impact on its properties. Fluorine atoms have high electronegativity, which can reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. And fluorine atoms have small volume and small steric resistance. In some reactions, it can affect the reaction process and product structure.
Although the electronegativity of iodine atoms is not as good as that of fluorine, its atomic radius is large, and the C-I bond energy is relatively small, which is prone to heterocracking, resulting in its activity in nucleophilic substitution and other reactions. Chlorine atoms also have similar effects, which change the electron cloud density of the benzene ring, but their activity is different from that of fluorine and iodine.
In the electrophilic substitution reaction, the position of the substituent entering the benzene ring of this compound is affected by the localization effect due to the influence of fluorine, iodine and chlorine atoms. Fluorine and chlorine are ortho-para-sites, but the ratio of ortho-substitution products may be different due to the strong electron-absorbing induction effect of fluorine; although iodine is also an ortho-para-site site, its electronic effect and spatial effect are combined to make the reaction regioselectivity unique.
In nucleophilic substitution reaction, the activity of C-I bond makes iodine atoms easily replaced by nucleophilic reagents, and a variety of derivatives can be formed. However, due to the existence of benzene ring conjugation system, the reaction conditions are different from the nucleophilic substitution of ordinary halogenated hydrocarbons, and specific catalysts and reaction environments are often required.
Because it is a halogenated aromatic hydrocarbon, it has a certain stability. However, under high temperature, light or specific catalysts, it can also undergo various conversions, or become a raw material for more complex organic compounds, which is important in the field of organic synthesis.
When it comes to chemical activity, the halogen atom above the benzene ring has a great impact on its properties. Fluorine atoms have high electronegativity, which can reduce the electron cloud density of the benzene ring and weaken the electrophilic substitution activity of the benzene ring. And fluorine atoms have small volume and small steric resistance. In some reactions, it can affect the reaction process and product structure.
Although the electronegativity of iodine atoms is not as good as that of fluorine, its atomic radius is large, and the C-I bond energy is relatively small, which is prone to heterocracking, resulting in its activity in nucleophilic substitution and other reactions. Chlorine atoms also have similar effects, which change the electron cloud density of the benzene ring, but their activity is different from that of fluorine and iodine.
In the electrophilic substitution reaction, the position of the substituent entering the benzene ring of this compound is affected by the localization effect due to the influence of fluorine, iodine and chlorine atoms. Fluorine and chlorine are ortho-para-sites, but the ratio of ortho-substitution products may be different due to the strong electron-absorbing induction effect of fluorine; although iodine is also an ortho-para-site site, its electronic effect and spatial effect are combined to make the reaction regioselectivity unique.
In nucleophilic substitution reaction, the activity of C-I bond makes iodine atoms easily replaced by nucleophilic reagents, and a variety of derivatives can be formed. However, due to the existence of benzene ring conjugation system, the reaction conditions are different from the nucleophilic substitution of ordinary halogenated hydrocarbons, and specific catalysts and reaction environments are often required.
Because it is a halogenated aromatic hydrocarbon, it has a certain stability. However, under high temperature, light or specific catalysts, it can also undergo various conversions, or become a raw material for more complex organic compounds, which is important in the field of organic synthesis.
What are the main uses of 4-fluoro-2-iodochlorobenzene?
4-Fluoro-2-iodochlorobenzene is an organic compound with a wide range of uses. In the field of medicine, it is often used as a key intermediate in the synthesis of many drugs. The atoms such as fluorine, iodine, and chlorine attached to the genbenzene ring can endow the compound with specific physical, chemical properties and biological activities, helping the drug to better achieve specific therapeutic effects. For example, in the synthesis of some antibacterial and antiviral drugs, it may be used as a starting material to construct complex structures with precise pharmacological effects through subsequent series of chemical reactions.
In the field of materials science, 4-fluoro-2-iodochlorobenzene also has important applications. It can be used to prepare polymer materials with special properties, because the halogen atoms contained can participate in the polymerization reaction, thereby regulating the properties of polymer materials, such as improving the heat resistance and chemical corrosion resistance of the material, or imparting specific photoelectric properties to the material. For example, in the preparation of organic optoelectronic materials, introducing them into polymers as structural units is expected to improve the absorption and emission ability of materials to specific wavelengths of light, and play a role in organic light emitting diodes (OLEDs), solar cells and other fields.
Furthermore, in the field of organic synthetic chemistry, it is an extremely important synthetic building block. Due to the differences in the activity of different halogen atoms on the benzene ring, one of the halogen atoms can be selectively involved in the reaction according to specific reaction requirements, so as to construct organic compounds with diverse structures, providing an effective way for the synthesis of various complex natural products and functional molecules. For example, through palladium-catalyzed cross-coupling reactions, it reacts with different organometallic reagents to achieve the construction of carbon-carbon bonds and carbon-heteroatom bonds, expanding the structural complexity and diversity of organic molecules.
In the field of materials science, 4-fluoro-2-iodochlorobenzene also has important applications. It can be used to prepare polymer materials with special properties, because the halogen atoms contained can participate in the polymerization reaction, thereby regulating the properties of polymer materials, such as improving the heat resistance and chemical corrosion resistance of the material, or imparting specific photoelectric properties to the material. For example, in the preparation of organic optoelectronic materials, introducing them into polymers as structural units is expected to improve the absorption and emission ability of materials to specific wavelengths of light, and play a role in organic light emitting diodes (OLEDs), solar cells and other fields.
Furthermore, in the field of organic synthetic chemistry, it is an extremely important synthetic building block. Due to the differences in the activity of different halogen atoms on the benzene ring, one of the halogen atoms can be selectively involved in the reaction according to specific reaction requirements, so as to construct organic compounds with diverse structures, providing an effective way for the synthesis of various complex natural products and functional molecules. For example, through palladium-catalyzed cross-coupling reactions, it reacts with different organometallic reagents to achieve the construction of carbon-carbon bonds and carbon-heteroatom bonds, expanding the structural complexity and diversity of organic molecules.
What are 4-fluoro-2-iodochlorobenzene synthesis methods?
There are several common methods for synthesizing 4-fluoro-2-iodochlorobenzene.
One is the halogenation reaction method. First, take a suitable aromatic compound, such as chlorobenzene as the starting material. Under specific reaction conditions, the chlorobenzene and the fluorine-containing reagent undergo an electrophilic substitution reaction, and fluorine atoms are introduced to generate fluorochlorobenzene derivatives. Then, on the basis of this derivative, it is reacted with the iodine-containing reagent. By electrophilic substitution or other suitable halogenation reaction mechanism, iodine atoms are successfully introduced, and then 4-fluoro-2-iodochlorobenzene is obtained. In this process, many factors such as reaction temperature, reactant ratio and reaction time need to be carefully regulated. If the temperature is too high or too low, both side reactions may increase, affecting the purity and yield of the product; improper proportion of reactants is not conducive to the formation of the target product.
The second is metal catalysis. With suitable metal catalysts, such as palladium, copper and other catalysts. First, the fluorohalogenated aromatic hydrocarbons and iodine-containing reagents are cross-coupled under the synergistic action of metal catalysts and ligands. Metal catalysts can activate the reactant molecules and promote the breaking of carbon-halogen bonds and the formation of new bonds. For example, using palladium-catalyzed halogenated aromatics cross-coupling reaction, selecting suitable palladium catalysts, ligands and bases, heating the reaction in a suitable organic solvent, so that fluoroaromatics can effectively react with iodine-substituted reagents, so as to achieve the purpose of synthesizing 4-fluoro-2-iodochlorobenzene. This method requires quite high reaction conditions. The choice and dosage of catalysts, the structure of ligands and the polarity of the reaction solvent all have a profound impact on the process and results of the reaction.
Furthermore, a stepwise functional group conversion method can be tried. Starting from benzene derivatives with specific functional groups, some of them are converted into the desired halogen atoms through a series of reactions. For example, starting with a benzene compound with a convertible functional group, a specific functional group is first converted into a chlorine atom, then another functional group is converted into a fluorine atom through suitable reaction conditions, and finally an iodine atom is introduced. This process requires strict control of the selectivity and reaction conditions of each step to ensure that each step can be carried out efficiently and accurately, and the occurrence of side reactions is minimized, so that 4-fluoro-2-iodochlorobenzene can be successfully synthesized.
One is the halogenation reaction method. First, take a suitable aromatic compound, such as chlorobenzene as the starting material. Under specific reaction conditions, the chlorobenzene and the fluorine-containing reagent undergo an electrophilic substitution reaction, and fluorine atoms are introduced to generate fluorochlorobenzene derivatives. Then, on the basis of this derivative, it is reacted with the iodine-containing reagent. By electrophilic substitution or other suitable halogenation reaction mechanism, iodine atoms are successfully introduced, and then 4-fluoro-2-iodochlorobenzene is obtained. In this process, many factors such as reaction temperature, reactant ratio and reaction time need to be carefully regulated. If the temperature is too high or too low, both side reactions may increase, affecting the purity and yield of the product; improper proportion of reactants is not conducive to the formation of the target product.
The second is metal catalysis. With suitable metal catalysts, such as palladium, copper and other catalysts. First, the fluorohalogenated aromatic hydrocarbons and iodine-containing reagents are cross-coupled under the synergistic action of metal catalysts and ligands. Metal catalysts can activate the reactant molecules and promote the breaking of carbon-halogen bonds and the formation of new bonds. For example, using palladium-catalyzed halogenated aromatics cross-coupling reaction, selecting suitable palladium catalysts, ligands and bases, heating the reaction in a suitable organic solvent, so that fluoroaromatics can effectively react with iodine-substituted reagents, so as to achieve the purpose of synthesizing 4-fluoro-2-iodochlorobenzene. This method requires quite high reaction conditions. The choice and dosage of catalysts, the structure of ligands and the polarity of the reaction solvent all have a profound impact on the process and results of the reaction.
Furthermore, a stepwise functional group conversion method can be tried. Starting from benzene derivatives with specific functional groups, some of them are converted into the desired halogen atoms through a series of reactions. For example, starting with a benzene compound with a convertible functional group, a specific functional group is first converted into a chlorine atom, then another functional group is converted into a fluorine atom through suitable reaction conditions, and finally an iodine atom is introduced. This process requires strict control of the selectivity and reaction conditions of each step to ensure that each step can be carried out efficiently and accurately, and the occurrence of side reactions is minimized, so that 4-fluoro-2-iodochlorobenzene can be successfully synthesized.
4-fluoro-2-iodochlorobenzene what are the precautions during storage and transportation?
4-Fluoro-2-iodine-chlorobenzene is also an organic compound. When storing and transporting, many important items need careful attention.
First, storage, because it has a certain chemical activity, should be placed in a cool and dry place. Avoid open flames and hot topics to prevent chemical reactions, causing fire or explosion risk. If this substance is heated, the molecular activity will increase greatly, or cause unpredictable changes. In addition, it should be placed separately from oxidizing agents, strong bases and other substances. Due to its chemical properties, it may encounter oxidizing agents or cause severe oxidation reactions; when it encounters strong bases, or cause molecular structure changes, which will damage its quality and increase safety hazards. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or certain plastic materials, should be used to prevent corrosion of the container and leakage of substances.
As for transportation, it is necessary to follow relevant regulations and standards. Before transportation, the packaging must be firm and well sealed to prevent leakage due to bumps in the way. During the handling process, the operator should wear appropriate protective equipment, such as protective gloves, goggles, etc., to avoid skin and eye contact. Because the substance may be harmful to the human body, inadvertent contact may cause skin irritation, eye damage, etc. The transportation vehicle should also be equipped with emergency treatment equipment. If there is a leak, it can be dealt with in time. And the transportation route planning should avoid densely populated areas and water sources, so that in case of leakage, the harm can be reduced. In conclusion, every aspect of the storage and transportation of 4-fluoro-2-iodochlorobenzene is related to safety and quality, and must not be slack at all.
First, storage, because it has a certain chemical activity, should be placed in a cool and dry place. Avoid open flames and hot topics to prevent chemical reactions, causing fire or explosion risk. If this substance is heated, the molecular activity will increase greatly, or cause unpredictable changes. In addition, it should be placed separately from oxidizing agents, strong bases and other substances. Due to its chemical properties, it may encounter oxidizing agents or cause severe oxidation reactions; when it encounters strong bases, or cause molecular structure changes, which will damage its quality and increase safety hazards. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or certain plastic materials, should be used to prevent corrosion of the container and leakage of substances.
As for transportation, it is necessary to follow relevant regulations and standards. Before transportation, the packaging must be firm and well sealed to prevent leakage due to bumps in the way. During the handling process, the operator should wear appropriate protective equipment, such as protective gloves, goggles, etc., to avoid skin and eye contact. Because the substance may be harmful to the human body, inadvertent contact may cause skin irritation, eye damage, etc. The transportation vehicle should also be equipped with emergency treatment equipment. If there is a leak, it can be dealt with in time. And the transportation route planning should avoid densely populated areas and water sources, so that in case of leakage, the harm can be reduced. In conclusion, every aspect of the storage and transportation of 4-fluoro-2-iodochlorobenzene is related to safety and quality, and must not be slack at all.
What are the effects of 4-fluoro-2-iodochlorobenzene on the environment and human health?
4-Fluoro-2-iodochlorobenzene is a genus of organohalogenated aromatic hydrocarbons. It has an impact on the environment and human health, and cannot be ignored.
First of all, its impact on the environment. This substance has certain chemical stability and is difficult to degrade in the natural environment. If it flows into the soil, it can cause soil pollution, hinder the uptake of nutrients and moisture by plant roots, inhibit its growth, and even cause plants to wither. If it enters the water body, it will endanger aquatic organisms. It may be enriched by aquatic organisms, causing the accumulation of toxins in the organism, disturbing its physiological functions, such as affecting the reproductive and immune systems of fish, resulting in a decrease in the population. And because it persists in the environment, it can be transmitted and amplified through the food chain, posing a profound threat to the structure and function of the ecosystem.
As for the impact on human health, it should not be underestimated. It enters the human body through respiratory tract, skin contact or accidental ingestion. It contains halogen atoms, or interferes with the normal biochemical reactions of the human body. For example, halogen atoms can combine with biological macromolecules such as proteins and nucleic acids in the body to destroy their structure and function. Long-term exposure may damage the nervous system, causing dizziness, fatigue, memory loss, etc. And because of its potential carcinogenicity, or increase the risk of human cancer, such as induced liver cancer, lung cancer, etc. And it also affects the reproductive system, or causes germ cell mutation, affects fertility, and causes problems such as abnormal fetal development.
In summary, 4-fluoro-2-iodochlorobenzene is harmful to the environment and human health. During its production, use and disposal, careful precautions must be taken to reduce its adverse effects on the environment and human health.
First of all, its impact on the environment. This substance has certain chemical stability and is difficult to degrade in the natural environment. If it flows into the soil, it can cause soil pollution, hinder the uptake of nutrients and moisture by plant roots, inhibit its growth, and even cause plants to wither. If it enters the water body, it will endanger aquatic organisms. It may be enriched by aquatic organisms, causing the accumulation of toxins in the organism, disturbing its physiological functions, such as affecting the reproductive and immune systems of fish, resulting in a decrease in the population. And because it persists in the environment, it can be transmitted and amplified through the food chain, posing a profound threat to the structure and function of the ecosystem.
As for the impact on human health, it should not be underestimated. It enters the human body through respiratory tract, skin contact or accidental ingestion. It contains halogen atoms, or interferes with the normal biochemical reactions of the human body. For example, halogen atoms can combine with biological macromolecules such as proteins and nucleic acids in the body to destroy their structure and function. Long-term exposure may damage the nervous system, causing dizziness, fatigue, memory loss, etc. And because of its potential carcinogenicity, or increase the risk of human cancer, such as induced liver cancer, lung cancer, etc. And it also affects the reproductive system, or causes germ cell mutation, affects fertility, and causes problems such as abnormal fetal development.
In summary, 4-fluoro-2-iodochlorobenzene is harmful to the environment and human health. During its production, use and disposal, careful precautions must be taken to reduce its adverse effects on the environment and human health.
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