Linshang Chemical
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4-Fluoro(Chloromethyl)Benzene
Linshang Chemical
|
HS Code |
344092 |
| Chemical Formula | C7H6ClF |
| Molecular Weight | 146.57 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 173 - 175 °C |
| Density | 1.195 g/cm³ |
| Flash Point | 61 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Odor | Characteristic odor |
As an accredited 4-Fluoro(Chloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - fluoro(chloromethyl)benzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - fluoro(chloromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames to prevent ignition. Keep it in a tightly sealed container to avoid leakage and vapor release. Store it separately from oxidizing agents, strong acids, and bases to prevent chemical reactions. Use appropriate secondary containment to handle any potential spills. |
| Shipping | 4 - fluoro(chloromethyl)benzene is shipped in specialized, tightly - sealed containers compliant with chemical transportation regulations. Shipment requires careful handling to prevent spills, with proper labeling indicating its hazardous nature. |
Competitive 4-Fluoro(Chloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Fluoro(Chloromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4-fluoro (chloromethyl) benzene?
4-Fluoro (chloromethyl) benzene is 4-fluoro (chloromethyl) benzene, which has a wide range of uses. In the field of organic synthesis, it is a key intermediate. Due to the characteristics of fluorine atoms and chloromethyl groups in its structure, it can undergo many chemical reactions to build a variety of complex organic molecules.
In the field of pharmaceutical research and development, it can be used to prepare compounds with specific biological activities. For example, by modifying its structure, or by obtaining drug molecules with affinity and inhibitory activity to specific disease targets, it is very helpful for the creation of new medicines.
In the field of materials science, 4-fluoro (chloromethyl) benzene can be used as a raw material for the synthesis of special functional materials. Through polymerization and other means, it may be able to prepare materials with unique electrical, optical or mechanical properties, which may have extraordinary applications in electronic devices, optical materials, etc.
In the field of pesticide chemistry, this can be used as a starting material, or can be synthesized into pesticide products with high insecticidal and bactericidal properties, contributing to agricultural pest control. Because of its halogen atom structure, it may endow pesticides with good stability and biological activity.
In the field of pharmaceutical research and development, it can be used to prepare compounds with specific biological activities. For example, by modifying its structure, or by obtaining drug molecules with affinity and inhibitory activity to specific disease targets, it is very helpful for the creation of new medicines.
In the field of materials science, 4-fluoro (chloromethyl) benzene can be used as a raw material for the synthesis of special functional materials. Through polymerization and other means, it may be able to prepare materials with unique electrical, optical or mechanical properties, which may have extraordinary applications in electronic devices, optical materials, etc.
In the field of pesticide chemistry, this can be used as a starting material, or can be synthesized into pesticide products with high insecticidal and bactericidal properties, contributing to agricultural pest control. Because of its halogen atom structure, it may endow pesticides with good stability and biological activity.
What are the physical properties of 4-fluoro (chloromethyl) benzene
4-Fluoro (chloromethyl) benzene, or 4-fluoro (chloromethyl) benzene, is one of the organic compounds. Its physical properties are quite unique and of great significance to organic synthesis chemistry.
Looking at its properties, under room temperature and pressure, 4-fluoro (chloromethyl) benzene is a colorless to light yellow liquid with a clear appearance and specific volatility. Its smell is pungent, and it can be felt obviously irritating when smelled.
The melting point is between -10 ° C and -5 ° C, while the boiling point is roughly in the range of 180 ° C to 185 ° C. Such melting-boiling point characteristics make it necessary to precisely control the temperature conditions when heating, cooling and separating them in conventional experiments and industrial operations.
The density of this substance is about 1.2 g/cm ³, which is heavier than water. Therefore, in the water-organic mixture system, 4-fluoro (chloromethyl) benzene will settle at the bottom. Its solubility is also characteristic. It is slightly soluble in water, but it can be miscible with most organic solvents such as ethanol, ether, acetone, etc. in any ratio. This solubility property plays a key role in the selection of solvents for organic reactions and the separation of products.
In addition, the vapor pressure of 4-fluoro (chloromethyl) benzene is relatively low at room temperature, but with the increase of temperature, the vapor pressure will increase significantly. During use and storage, it is necessary to pay attention to the temperature to prevent the excessive evaporation of steam from causing safety hazards.
In conclusion, the physical properties of 4-fluoro (chloromethyl) benzene, such as its properties, melting point, density, solubility, and vapor pressure, have a crucial impact on its application in organic synthesis, chemical production, and many other fields. Both experimenters and producers need to be familiar with its physical properties in order to use it safely and efficiently.
Looking at its properties, under room temperature and pressure, 4-fluoro (chloromethyl) benzene is a colorless to light yellow liquid with a clear appearance and specific volatility. Its smell is pungent, and it can be felt obviously irritating when smelled.
The melting point is between -10 ° C and -5 ° C, while the boiling point is roughly in the range of 180 ° C to 185 ° C. Such melting-boiling point characteristics make it necessary to precisely control the temperature conditions when heating, cooling and separating them in conventional experiments and industrial operations.
The density of this substance is about 1.2 g/cm ³, which is heavier than water. Therefore, in the water-organic mixture system, 4-fluoro (chloromethyl) benzene will settle at the bottom. Its solubility is also characteristic. It is slightly soluble in water, but it can be miscible with most organic solvents such as ethanol, ether, acetone, etc. in any ratio. This solubility property plays a key role in the selection of solvents for organic reactions and the separation of products.
In addition, the vapor pressure of 4-fluoro (chloromethyl) benzene is relatively low at room temperature, but with the increase of temperature, the vapor pressure will increase significantly. During use and storage, it is necessary to pay attention to the temperature to prevent the excessive evaporation of steam from causing safety hazards.
In conclusion, the physical properties of 4-fluoro (chloromethyl) benzene, such as its properties, melting point, density, solubility, and vapor pressure, have a crucial impact on its application in organic synthesis, chemical production, and many other fields. Both experimenters and producers need to be familiar with its physical properties in order to use it safely and efficiently.
What are the chemical properties of 4-fluoro (chloromethyl) benzene
4-Fluoro (chloromethyl) benzene, or 4-fluoro (chloromethyl) benzene, has unique chemical properties and is often important in the field of organic synthesis.
This substance has dual characteristics of halogenated hydrocarbons and halogenated aromatics. In its chloromethyl group, the chlorine atom is highly active and vulnerable to attack by nucleophiles. For example, in case of sodium alcohol, ether products can be generated by nucleophilic substitution; if it meets with sodium cyanide, the cyanyl group will replace the chlorine atom to obtain a benzene-based compound containing a cyanide group, which can be hydrolyzed into carboxylic acids later.
The fluorine atom on its benzene ring, although affected by the conjugation effect of the benzene ring, is less active than the chlorine of chloromethyl, but it can also participate in specific reactions. Due to the high electronegativity of fluorine atoms, the electron cloud density of the benzene ring will decrease, making the electrophilic substitution reaction more difficult, and the localization effect is unique. Many electrophilic reagents are guided into the counterposition of fluorine atoms.
4-fluoro (chloromethyl) benzene is relatively stable to heat and light. Under conventional conditions, without suitable reagents and conditions, it is difficult to change significantly. However, when high temperature or light is used, free radical reactions may be initiated, and chloromethyl may become the starting point of free radical reactions
This substance has good solubility in organic solvents such as dichloromethane and toluene, making it easy to carry out various organic reactions in solution systems. Its diverse chemical properties make it widely used in drug synthesis, material preparation and many other fields. It can be used as a key intermediate to construct complex organic compounds.
This substance has dual characteristics of halogenated hydrocarbons and halogenated aromatics. In its chloromethyl group, the chlorine atom is highly active and vulnerable to attack by nucleophiles. For example, in case of sodium alcohol, ether products can be generated by nucleophilic substitution; if it meets with sodium cyanide, the cyanyl group will replace the chlorine atom to obtain a benzene-based compound containing a cyanide group, which can be hydrolyzed into carboxylic acids later.
The fluorine atom on its benzene ring, although affected by the conjugation effect of the benzene ring, is less active than the chlorine of chloromethyl, but it can also participate in specific reactions. Due to the high electronegativity of fluorine atoms, the electron cloud density of the benzene ring will decrease, making the electrophilic substitution reaction more difficult, and the localization effect is unique. Many electrophilic reagents are guided into the counterposition of fluorine atoms.
4-fluoro (chloromethyl) benzene is relatively stable to heat and light. Under conventional conditions, without suitable reagents and conditions, it is difficult to change significantly. However, when high temperature or light is used, free radical reactions may be initiated, and chloromethyl may become the starting point of free radical reactions
This substance has good solubility in organic solvents such as dichloromethane and toluene, making it easy to carry out various organic reactions in solution systems. Its diverse chemical properties make it widely used in drug synthesis, material preparation and many other fields. It can be used as a key intermediate to construct complex organic compounds.
What is the preparation method of 4-fluoro (chloromethyl) benzene
4-Fluoro (chloromethyl) benzene. To prepare this substance, the following methods can be used.
First, p-fluorotoluene is used as the starting material and obtained by chlorination. Under the condition of light or the presence of an initiator, p-fluorotoluene reacts with chlorine gas. Because the methyl group is affected by the electronic effect of the benzene ring and the fluorine atom, its α-hydrogen has a certain activity. When illuminated, the chlorine molecule absorbs light energy and cleaves into a chlorine radical. The chlorine radical grabs the hydrogen atom on the p-fluorotoluene methyl group to form a benzyl radical. The benzyl radical reacts with the chlorine molecule to form 4-fluoro (chloromethyl) benzene and hydrogen chloride. This reaction condition is relatively mild and convenient to operate. However, it is necessary to pay attention to control the reaction conditions to prevent the formation of polychlorinated by-products. By controlling the amount of chlorine, reaction time and temperature, the selectivity of the product can be improved.
Furthermore, it can be prepared by reacting p-fluorobenzyl alcohol with chlorination reagents. Commonly used chlorination reagents such as thionyl chloride and phosphorus trichloride. Taking thionyl chloride as an example, when p-fluorobenzyl alcohol reacts with thionyl chloride, the oxygen atoms in the hydroxyl group of the alcohol attack the sulfur atoms of thionyl chloride, and through a series of rearrangement and elimination steps, 4-fluoro (chloromethyl) benzene is generated, and sulfur dioxide and hydrogen chloride gas are generated at the same time. This method has high reaction efficiency, the product is easy to separate and purify, and the gas by-products produced are also easy to handle, which is quite commonly used in organic synthesis.
Or starting from p-fluorobenzaldehyde, p-fluorobenzyl alcohol is obtained by reduction reaction first, and then the above chlorination reaction is carried out. p-fluorobenzaldehyde can be reduced to p-fluorobenzyl alcohol by suitable reducing agents, such as sodium borohydride and lithium aluminum hydride. Sodium borohydride is a milder reducing agent, which is safe and simple to operate. In a suitable solvent, p-fluorobenzaldehyde can be successfully reduced to p-fluorobenzyl alcohol, and then reacted with chlorination reagents to obtain the target product 4-fluoro (chloromethyl) benzene.
First, p-fluorotoluene is used as the starting material and obtained by chlorination. Under the condition of light or the presence of an initiator, p-fluorotoluene reacts with chlorine gas. Because the methyl group is affected by the electronic effect of the benzene ring and the fluorine atom, its α-hydrogen has a certain activity. When illuminated, the chlorine molecule absorbs light energy and cleaves into a chlorine radical. The chlorine radical grabs the hydrogen atom on the p-fluorotoluene methyl group to form a benzyl radical. The benzyl radical reacts with the chlorine molecule to form 4-fluoro (chloromethyl) benzene and hydrogen chloride. This reaction condition is relatively mild and convenient to operate. However, it is necessary to pay attention to control the reaction conditions to prevent the formation of polychlorinated by-products. By controlling the amount of chlorine, reaction time and temperature, the selectivity of the product can be improved.
Furthermore, it can be prepared by reacting p-fluorobenzyl alcohol with chlorination reagents. Commonly used chlorination reagents such as thionyl chloride and phosphorus trichloride. Taking thionyl chloride as an example, when p-fluorobenzyl alcohol reacts with thionyl chloride, the oxygen atoms in the hydroxyl group of the alcohol attack the sulfur atoms of thionyl chloride, and through a series of rearrangement and elimination steps, 4-fluoro (chloromethyl) benzene is generated, and sulfur dioxide and hydrogen chloride gas are generated at the same time. This method has high reaction efficiency, the product is easy to separate and purify, and the gas by-products produced are also easy to handle, which is quite commonly used in organic synthesis.
Or starting from p-fluorobenzaldehyde, p-fluorobenzyl alcohol is obtained by reduction reaction first, and then the above chlorination reaction is carried out. p-fluorobenzaldehyde can be reduced to p-fluorobenzyl alcohol by suitable reducing agents, such as sodium borohydride and lithium aluminum hydride. Sodium borohydride is a milder reducing agent, which is safe and simple to operate. In a suitable solvent, p-fluorobenzaldehyde can be successfully reduced to p-fluorobenzyl alcohol, and then reacted with chlorination reagents to obtain the target product 4-fluoro (chloromethyl) benzene.
What are the precautions for 4-fluoro (chloromethyl) benzene in storage and transportation?
For 4-fluoro (chloromethyl) benzene, many precautions should be paid attention to during storage and transportation. This substance has certain toxicity and irritation, which is related to personal safety and must not be ignored.
When storing, the first choice is the environment. When placed in a cool and ventilated warehouse, away from fire and heat sources. It is easy to evaporate due to heat, or cause chemical reactions, endangering safety. The temperature of the warehouse should be controlled within a reasonable range, and the humidity should also be appropriate to prevent it from deteriorating due to environmental factors. In addition, it should be stored separately from oxidants, alkalis, etc., and must not be mixed. This is because of its chemical activity, contact with other substances, or violent reaction, causing danger.
When transporting, you should also not slack off. It is necessary to ensure that the container is intact and sealed to prevent it from leaking. The transportation process should be smooth and avoid violent vibration and impact, otherwise the container may be damaged and the material leaks. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Once a leak occurs, it can be dealt with in time. And during transportation, you need to follow the specified route and do not stop in densely populated areas and residential areas to prevent leakage from endangering the safety of many people. Transportation personnel should also be familiar with the characteristics of this substance and emergency treatment methods, so that in case of emergencies, they can be disposed of quickly and properly to minimize the harm. In short, the storage and transportation of 4-fluoro (chloromethyl) benzene are all related to safety and must be done with caution.
When storing, the first choice is the environment. When placed in a cool and ventilated warehouse, away from fire and heat sources. It is easy to evaporate due to heat, or cause chemical reactions, endangering safety. The temperature of the warehouse should be controlled within a reasonable range, and the humidity should also be appropriate to prevent it from deteriorating due to environmental factors. In addition, it should be stored separately from oxidants, alkalis, etc., and must not be mixed. This is because of its chemical activity, contact with other substances, or violent reaction, causing danger.
When transporting, you should also not slack off. It is necessary to ensure that the container is intact and sealed to prevent it from leaking. The transportation process should be smooth and avoid violent vibration and impact, otherwise the container may be damaged and the material leaks. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Once a leak occurs, it can be dealt with in time. And during transportation, you need to follow the specified route and do not stop in densely populated areas and residential areas to prevent leakage from endangering the safety of many people. Transportation personnel should also be familiar with the characteristics of this substance and emergency treatment methods, so that in case of emergencies, they can be disposed of quickly and properly to minimize the harm. In short, the storage and transportation of 4-fluoro (chloromethyl) benzene are all related to safety and must be done with caution.
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