Linshang Chemical
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4-Methylsulfuryl Chlorobenzene
Linshang Chemical
|
HS Code |
641966 |
| Chemical Formula | C7H7ClO2S |
| Molecular Weight | 190.65 |
| Appearance | Colorless to light yellow liquid |
| Odor | Pungent odor |
| Boiling Point | Around 245 - 247 °C |
| Density | Approx. 1.37 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like benzene, toluene |
| Flash Point | Around 110 °C |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 4-Methylsulfuryl Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - methylsulfuryl Chlorobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 4 - Methylsulfuryl Chlorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it may be flammable. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to chemical reactions. Store it separately from incompatible substances like oxidizing agents. |
| Shipping | 4 - Methylsulfuryl Chlorobenzene is a chemical. For shipping, it must be in proper, leak - proof containers. Follow all hazardous material regulations, with clear labels indicating its nature to ensure safe transportation. |
Competitive 4-Methylsulfuryl Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Methylsulfuryl Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4-methylsulfuryl Chlorobenzene?
4-Methylsulfonyl chlorobenzene has a wide range of main uses. This substance is a crucial intermediate in the field of organic synthesis.
Gein 4-methylsulfonyl chlorobenzene has a unique structure, in which the sulfonyl chloride group has high activity and is easy to react with many nucleophiles. This is the key to building various carbon-sulfur bonds, carbon-oxygen bonds and carbon-nitrogen bonds in organic synthesis. In the field of pharmaceutical chemistry, it is often used as a starting material. After a series of delicate chemical reactions, drug molecules with specific biological activities can be synthesized. For example, in the preparation of some antibacterial and anti-inflammatory drugs, 4-methylsulfonyl chlorobenzene is used to introduce key structural fragments to optimize the pharmacological properties and efficacy of the drug.
In the field of materials science, it also has its place. It can be used to participate in polymerization reactions to prepare polymer materials with special properties. Due to the presence of sulfonyl groups, polymer materials can be endowed with good thermal stability, chemical stability and unique electrical properties. For example, in the synthesis of some high-performance engineering plastics, the introduction of 4-methylsulfonyl chlorobenzene-derived structural units can significantly improve the mechanical properties and chemical resistance of plastics, thus meeting the stringent requirements of high-end industrial applications.
Furthermore, in the field of fine chemicals, 4-methylsulfonyl chlorobenzene is also commonly used in the synthesis of various fine chemicals, such as dyes, fragrances and surfactants. In dye synthesis, by skillfully using its reactive groups, dyes with bright colors and excellent fastness can be prepared; in fragrance synthesis, it can add a unique chemical structure to fragrance molecules, thereby improving the aroma characteristics and durability of fragrances; and in the synthesis of surfactants, the surfactants involved in the synthesis often have better emulsification, dispersion and wetting properties, and are widely used in daily chemical, textile and other industries.
Gein 4-methylsulfonyl chlorobenzene has a unique structure, in which the sulfonyl chloride group has high activity and is easy to react with many nucleophiles. This is the key to building various carbon-sulfur bonds, carbon-oxygen bonds and carbon-nitrogen bonds in organic synthesis. In the field of pharmaceutical chemistry, it is often used as a starting material. After a series of delicate chemical reactions, drug molecules with specific biological activities can be synthesized. For example, in the preparation of some antibacterial and anti-inflammatory drugs, 4-methylsulfonyl chlorobenzene is used to introduce key structural fragments to optimize the pharmacological properties and efficacy of the drug.
In the field of materials science, it also has its place. It can be used to participate in polymerization reactions to prepare polymer materials with special properties. Due to the presence of sulfonyl groups, polymer materials can be endowed with good thermal stability, chemical stability and unique electrical properties. For example, in the synthesis of some high-performance engineering plastics, the introduction of 4-methylsulfonyl chlorobenzene-derived structural units can significantly improve the mechanical properties and chemical resistance of plastics, thus meeting the stringent requirements of high-end industrial applications.
Furthermore, in the field of fine chemicals, 4-methylsulfonyl chlorobenzene is also commonly used in the synthesis of various fine chemicals, such as dyes, fragrances and surfactants. In dye synthesis, by skillfully using its reactive groups, dyes with bright colors and excellent fastness can be prepared; in fragrance synthesis, it can add a unique chemical structure to fragrance molecules, thereby improving the aroma characteristics and durability of fragrances; and in the synthesis of surfactants, the surfactants involved in the synthesis often have better emulsification, dispersion and wetting properties, and are widely used in daily chemical, textile and other industries.
What are the physical properties of 4-methylsulfuryl Chlorobenzene?
4-Methylsulfonyl chlorobenzene, which is a molecule in organic chemicals. It has specific physical properties and is widely used in the chemical industry.
In terms of its properties, under room temperature, 4-methylsulfonyl chlorobenzene is a colorless to light yellow liquid, which looks clear. Smell it, it has a pungent smell, which is unique and easy to perceive.
As for the boiling point, the boiling point of 4-methylsulfonyl chlorobenzene is quite high, between 270 ° C and 280 ° C. Such a high boiling point makes it able to maintain a liquid state in a high temperature environment and has good stability. Because of the strong intermolecular force, it requires more energy to boil it into a gaseous state.
In terms of melting point, the melting point of this substance is about -20 ° C. The relatively low melting point makes it liquid at room temperature or slightly higher temperature, which is convenient for various operations and reactions.
Solubility is also a key property. 4-Methylsulfonyl chlorobenzene is insoluble in water because its molecular structure has a relatively small polar part and a weak force with water molecules, so it is difficult to disperse in water. However, it is soluble in organic solvents such as ethanol, ether, and chloroform. There are similar interactions between organic solvent molecules and 4-methylsulfonyl chlorobenzene molecules, such as van der Waals forces, which can cause the two to mix and dissolve.
The density of 4-methylsulfonyl chlorobenzene is greater than that of water, about 1.35g/cm ³. Placing it in the same container as water shows that it sinks to the bottom of the water, which is of great significance in separation and identification.
The physical properties of 4-methylsulfonyl chlorobenzene have a profound impact on its storage, transportation and application in chemical reactions. Because of its pungent smell and certain toxicity, it is necessary to ensure that it is well sealed and placed in a cool and ventilated place during storage and transportation to prevent leakage from harming human body and the environment. And because of its solubility and density characteristics, in chemical production, suitable reaction solvents and separation methods can be selected accordingly to achieve efficient production processes.
In terms of its properties, under room temperature, 4-methylsulfonyl chlorobenzene is a colorless to light yellow liquid, which looks clear. Smell it, it has a pungent smell, which is unique and easy to perceive.
As for the boiling point, the boiling point of 4-methylsulfonyl chlorobenzene is quite high, between 270 ° C and 280 ° C. Such a high boiling point makes it able to maintain a liquid state in a high temperature environment and has good stability. Because of the strong intermolecular force, it requires more energy to boil it into a gaseous state.
In terms of melting point, the melting point of this substance is about -20 ° C. The relatively low melting point makes it liquid at room temperature or slightly higher temperature, which is convenient for various operations and reactions.
Solubility is also a key property. 4-Methylsulfonyl chlorobenzene is insoluble in water because its molecular structure has a relatively small polar part and a weak force with water molecules, so it is difficult to disperse in water. However, it is soluble in organic solvents such as ethanol, ether, and chloroform. There are similar interactions between organic solvent molecules and 4-methylsulfonyl chlorobenzene molecules, such as van der Waals forces, which can cause the two to mix and dissolve.
The density of 4-methylsulfonyl chlorobenzene is greater than that of water, about 1.35g/cm ³. Placing it in the same container as water shows that it sinks to the bottom of the water, which is of great significance in separation and identification.
The physical properties of 4-methylsulfonyl chlorobenzene have a profound impact on its storage, transportation and application in chemical reactions. Because of its pungent smell and certain toxicity, it is necessary to ensure that it is well sealed and placed in a cool and ventilated place during storage and transportation to prevent leakage from harming human body and the environment. And because of its solubility and density characteristics, in chemical production, suitable reaction solvents and separation methods can be selected accordingly to achieve efficient production processes.
What are the chemical properties of 4-methylsulfuryl Chlorobenzene?
4-Methylsulfonyl chlorobenzene, this material is unique. It is a useful raw material in organic synthesis. Depending on its physical properties, under room temperature, it may be a colorless to pale yellow liquid with a special odor. Its boiling point and melting point are fixed due to the molecular structure. The boiling point is about a specific temperature range, due to the intermolecular force and structure. This value is very critical when separating and purifying. The same is true for the melting point, which is the critical temperature for the transformation of solid and liquid substances.
In terms of its chemical properties, the chlorine atoms on the chlorobenzene ring are quite active. Due to the influence of methylsulfonyl groups, the distribution of electron clouds changes, making it vulnerable to nucleophilic attack. In case of nucleophilic reagents such as sodium alcohol, a nucleophilic substitution reaction can occur, and the chlorine atom is replaced by an alkoxy group to form a new organic compound. This reaction has a wide range of uses in the construction of carbon-oxygen bonds.
Methyl sulfonyl group also has characteristics, and its sulfur atom is in a higher oxidation state and has a certain oxidation property. And this group can enhance molecular polarity and affect the solubility of compounds. In organic solvents, 4-methylsulfonyl chlorobenzene may have good solubility, which is conducive to the development of various organic reactions. Due to the stability of benzene ring and active groups in its structure, various functional groups can be introduced through a series of reactions to expand its application in the field of organic synthesis, such as drug synthesis and material preparation.
In terms of its chemical properties, the chlorine atoms on the chlorobenzene ring are quite active. Due to the influence of methylsulfonyl groups, the distribution of electron clouds changes, making it vulnerable to nucleophilic attack. In case of nucleophilic reagents such as sodium alcohol, a nucleophilic substitution reaction can occur, and the chlorine atom is replaced by an alkoxy group to form a new organic compound. This reaction has a wide range of uses in the construction of carbon-oxygen bonds.
Methyl sulfonyl group also has characteristics, and its sulfur atom is in a higher oxidation state and has a certain oxidation property. And this group can enhance molecular polarity and affect the solubility of compounds. In organic solvents, 4-methylsulfonyl chlorobenzene may have good solubility, which is conducive to the development of various organic reactions. Due to the stability of benzene ring and active groups in its structure, various functional groups can be introduced through a series of reactions to expand its application in the field of organic synthesis, such as drug synthesis and material preparation.
What are the preparation methods of 4-methylsulfuryl Chlorobenzene
4-Methylsulfonylchlorobenzene, there are many ways to prepare it.
First, 4-methylthiophenol can be used. First, 4-methylthiophenol is oxidized to 4-methylphenylsulfoxide under mild temperature conditions with an appropriate oxidizing agent, such as hydrogen peroxide, in a suitable solvent, such as glacial acetic acid. This process requires temperature control and monitoring of the reaction process to prevent excessive oxidation. Then, a stronger oxidizing agent, such as m-chloroperoxybenzoic acid, is further oxidized to 4-methylphenylsulfoxide. Finally, under the action of chlorination reagents such as phosphorus trichloride and thionyl chloride, 4-methyl sulfonyl chlorobenzene can be obtained by substituting the methyl ortho-hydrogen of 4-methylbenzene sulfone with chlorine under the condition of heating and refluxing.
Second, 4-methyl chlorobenzene is used as the starting material. First, through a sulfonation reaction, concentrated sulfuric acid or fuming sulfuric acid is used, and under heating conditions, the methyl group is introduced into the sulfonic acid group to form 4-methyl-4-chlorobenzene sulfonic acid. Subsequently, the sulfonic acid group is converted into a sulfonyl chloride group, which can be used as phosphorus pentachloride or phosphorus oxychloride. At a suitable reaction temperature, such as 80-120 ° C, the reaction is carried out
Third, toluene is used as the starting material. First, it is chlorinated, and in the presence of light or an initiator, it reacts with chlorine gas to obtain p-chlorotoluene. P-chlorotoluene is then oxidized to a suitable oxidizing agent, such as potassium permanganate. Under basic conditions, methyl is oxidized to a carboxyl group to obtain 4-chlorobenzoic acid. 4-chlorobenzoic acid is treated with sulfoxide chloride and converted to 4-chlorobenzoyl chloride. 4-chlorobenzoyl chloride reacts with sodium methyl mercaptan to form 4-chlorophenyl methyl sulfide. This sulfide is then oxidized. If it is oxidized with hydrogen peroxide, the sulfoxide is obtained first, and it is further oxidized to sulfone. Finally, 4-methylsulfonyl chlorob Each law has its advantages and disadvantages, and it is necessary to choose it according to actual needs and conditions.
First, 4-methylthiophenol can be used. First, 4-methylthiophenol is oxidized to 4-methylphenylsulfoxide under mild temperature conditions with an appropriate oxidizing agent, such as hydrogen peroxide, in a suitable solvent, such as glacial acetic acid. This process requires temperature control and monitoring of the reaction process to prevent excessive oxidation. Then, a stronger oxidizing agent, such as m-chloroperoxybenzoic acid, is further oxidized to 4-methylphenylsulfoxide. Finally, under the action of chlorination reagents such as phosphorus trichloride and thionyl chloride, 4-methyl sulfonyl chlorobenzene can be obtained by substituting the methyl ortho-hydrogen of 4-methylbenzene sulfone with chlorine under the condition of heating and refluxing.
Second, 4-methyl chlorobenzene is used as the starting material. First, through a sulfonation reaction, concentrated sulfuric acid or fuming sulfuric acid is used, and under heating conditions, the methyl group is introduced into the sulfonic acid group to form 4-methyl-4-chlorobenzene sulfonic acid. Subsequently, the sulfonic acid group is converted into a sulfonyl chloride group, which can be used as phosphorus pentachloride or phosphorus oxychloride. At a suitable reaction temperature, such as 80-120 ° C, the reaction is carried out
Third, toluene is used as the starting material. First, it is chlorinated, and in the presence of light or an initiator, it reacts with chlorine gas to obtain p-chlorotoluene. P-chlorotoluene is then oxidized to a suitable oxidizing agent, such as potassium permanganate. Under basic conditions, methyl is oxidized to a carboxyl group to obtain 4-chlorobenzoic acid. 4-chlorobenzoic acid is treated with sulfoxide chloride and converted to 4-chlorobenzoyl chloride. 4-chlorobenzoyl chloride reacts with sodium methyl mercaptan to form 4-chlorophenyl methyl sulfide. This sulfide is then oxidized. If it is oxidized with hydrogen peroxide, the sulfoxide is obtained first, and it is further oxidized to sulfone. Finally, 4-methylsulfonyl chlorob Each law has its advantages and disadvantages, and it is necessary to choose it according to actual needs and conditions.
What are the precautions for 4-methylsulfuryl Chlorobenzene during use?
4-Methylsulfonyl chlorobenzene is an important chemical in organic synthesis. During use, many things need to be paid attention to.
Bear the brunt of it, and safety protection should not be underestimated. Because of its toxicity and irritation, contact can cause skin, eye and respiratory damage. When taking it, you must wear protective clothing, protective gloves and goggles to ensure a well-ventilated environment to prevent inhalation of its volatile gases. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation.
Furthermore, its chemical properties also need to be treated with caution. 4-Methylsulfonyl chlorobenzene has high activity and is prone to react with many substances. When storing, be sure to keep away from strong oxidants, strong bases, etc., to avoid dangerous chemical reactions. During use, strictly control the reaction conditions, such as temperature, pH, reaction time, etc., which will affect the reaction process and product purity. If the temperature is too high, the reaction may go out of control and unnecessary by-products will be generated; if the reaction time is insufficient, or the reaction is incomplete, the yield of the product will be affected.
In addition, the operating specifications must not be lost. Accurate weighing and measurement to ensure the accuracy of the reaction. After the experiment is completed, properly dispose of the remaining substances and reaction waste, follow environmental protection requirements, and prevent environmental pollution.
In conclusion, when using 4-methylsulfonyl chlorobenzene, safety must be given top priority, and operating procedures must be strictly followed to ensure smooth operation and avoid accidents.
Bear the brunt of it, and safety protection should not be underestimated. Because of its toxicity and irritation, contact can cause skin, eye and respiratory damage. When taking it, you must wear protective clothing, protective gloves and goggles to ensure a well-ventilated environment to prevent inhalation of its volatile gases. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation.
Furthermore, its chemical properties also need to be treated with caution. 4-Methylsulfonyl chlorobenzene has high activity and is prone to react with many substances. When storing, be sure to keep away from strong oxidants, strong bases, etc., to avoid dangerous chemical reactions. During use, strictly control the reaction conditions, such as temperature, pH, reaction time, etc., which will affect the reaction process and product purity. If the temperature is too high, the reaction may go out of control and unnecessary by-products will be generated; if the reaction time is insufficient, or the reaction is incomplete, the yield of the product will be affected.
In addition, the operating specifications must not be lost. Accurate weighing and measurement to ensure the accuracy of the reaction. After the experiment is completed, properly dispose of the remaining substances and reaction waste, follow environmental protection requirements, and prevent environmental pollution.
In conclusion, when using 4-methylsulfonyl chlorobenzene, safety must be given top priority, and operating procedures must be strictly followed to ensure smooth operation and avoid accidents.
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