Linshang Chemical
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4-Nitro-2-(Trifluoromethyl)Chlorobenzene
Linshang Chemical
|
HS Code |
489487 |
| Chemical Formula | C7H3ClF3NO2 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 200 - 210 °C |
| Density | Typically around 1.5 - 1.6 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | Caution: Flammable, flash point around 80 - 90 °C |
| Odor | Pungent odor |
As an accredited 4-Nitro-2-(Trifluoromethyl)Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - nitro - 2 - (trifluoromethyl)chlorobenzene packaged in air - tight glass bottles. |
| Storage | 4 - nitro - 2 - (trifluoromethyl)chlorobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | 4 - nitro - 2 - (trifluoromethyl)chlorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safety during transit, with proper labeling and handling procedures. |
Competitive 4-Nitro-2-(Trifluoromethyl)Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Nitro-2-(Trifluoromethyl)Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-nitro-2- (trifluoromethyl) chlorobenzene?
4-Nitro-2 - (trifluoromethyl) chlorobenzene is a kind of organic compound. Its physical properties are often solid, with specific melting points and boiling points, which can be purified and identified by specific means according to these characteristics.
In this compound, the nitro group is connected to the trifluoromethyl group and the chlorine atom. Nitro groups have strong electron-absorbing properties, which can significantly affect the distribution of molecular electron clouds, which in turn affects their chemical activity. Due to its electron-absorbing effect, the electron cloud density of the benzene ring decreases, making it difficult for electrophilic substitution reactions to occur. For example, in the aromatic electrophilic substitution reaction, the benzene ring has a certain electron cloud density to attract electrophilic reagents. However, due to the presence of nitro groups, the electron cloud density decreases, and it is more difficult for
Trifluoromethyl is also a strong electron-absorbing group. Its existence further enhances the molecular polarity and has a great impact on the physical and chemical properties of the compound. For example, in terms of solubility, it will change the solubility of the compound in different solvents. At the same time, trifluoromethyl has a significant effect on ortho-chlorine atoms, which will affect the activity of chlorine atoms.
Chlorine atoms as substituents, although they are power supply groups, their induced effect is electron-absorbing. In this molecule, they interact with the strong electron-absorbing nitro and trifluoromethyl groups to comprehensively affect the molecular chemical properties. In the nucleophilic substitution reaction, chlorine atoms can be used as leaving groups, and under suitable nucleophilic reagents and reaction conditions, they can be replaced by nucleophilic reagents to form new organic
In addition, the compound may have certain biological activity and toxicity due to its nitro and trifluoromethyl groups. In related research and applications, its safety and environmental impact need to be carefully considered. Its chemical properties are of great significance in the field of organic synthesis. It can be used as an intermediate for the preparation of various functional organic compounds. When synthesizing complex organic molecular structures, its characteristics can be used to achieve specific reaction steps.
In this compound, the nitro group is connected to the trifluoromethyl group and the chlorine atom. Nitro groups have strong electron-absorbing properties, which can significantly affect the distribution of molecular electron clouds, which in turn affects their chemical activity. Due to its electron-absorbing effect, the electron cloud density of the benzene ring decreases, making it difficult for electrophilic substitution reactions to occur. For example, in the aromatic electrophilic substitution reaction, the benzene ring has a certain electron cloud density to attract electrophilic reagents. However, due to the presence of nitro groups, the electron cloud density decreases, and it is more difficult for
Trifluoromethyl is also a strong electron-absorbing group. Its existence further enhances the molecular polarity and has a great impact on the physical and chemical properties of the compound. For example, in terms of solubility, it will change the solubility of the compound in different solvents. At the same time, trifluoromethyl has a significant effect on ortho-chlorine atoms, which will affect the activity of chlorine atoms.
Chlorine atoms as substituents, although they are power supply groups, their induced effect is electron-absorbing. In this molecule, they interact with the strong electron-absorbing nitro and trifluoromethyl groups to comprehensively affect the molecular chemical properties. In the nucleophilic substitution reaction, chlorine atoms can be used as leaving groups, and under suitable nucleophilic reagents and reaction conditions, they can be replaced by nucleophilic reagents to form new organic
In addition, the compound may have certain biological activity and toxicity due to its nitro and trifluoromethyl groups. In related research and applications, its safety and environmental impact need to be carefully considered. Its chemical properties are of great significance in the field of organic synthesis. It can be used as an intermediate for the preparation of various functional organic compounds. When synthesizing complex organic molecular structures, its characteristics can be used to achieve specific reaction steps.
What are the common uses of 4-nitro-2- (trifluoromethyl) chlorobenzene?
4-Nitro-2 - (trifluoromethyl) chlorobenzene is a fine chemical commonly used in organic synthesis. Its common uses involve many fields such as pharmaceuticals, pesticides, dyes, etc.
In the field of medicine, it is often used as a key intermediate. The nitro group, trifluoromethyl group and chlorine atoms attached to the benzene ring endow the molecule with unique physical and chemical properties and biological activities. By means of organic synthesis, its structure can be modified and modified to prepare various specific drugs. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, it is often used as a starting material. After multi-step reactions, specific functional groups are introduced to obtain the final product with the required pharmacological activity.
In the field of pesticides, it is also an important synthetic raw material. Due to its structural properties, compounds with high insecticidal, bactericidal or herbicidal properties can be derived. Such pesticides often have high selectivity and activity for specific target organisms, and have low residues in the environment, which meets the development requirements of modern green pesticides.
In the dye industry, 4-nitro-2- (trifluoromethyl) chlorobenzene can be used to construct the conjugate system of dye molecules. The phenyl ring and its substituents can participate in the formation of chromophore, making the dye rich in color, and imparting good light resistance and washable properties. After chemical modification, dyes suitable for dyeing of different fiber materials can be prepared. In conclusion, 4-nitro-2- (trifluoromethyl) chlorobenzene, with its unique structure, plays an indispensable role in many important chemical industries, promoting the innovation and development of products in various industries.
In the field of medicine, it is often used as a key intermediate. The nitro group, trifluoromethyl group and chlorine atoms attached to the benzene ring endow the molecule with unique physical and chemical properties and biological activities. By means of organic synthesis, its structure can be modified and modified to prepare various specific drugs. For example, in the synthesis of some antibacterial and anti-inflammatory drugs, it is often used as a starting material. After multi-step reactions, specific functional groups are introduced to obtain the final product with the required pharmacological activity.
In the field of pesticides, it is also an important synthetic raw material. Due to its structural properties, compounds with high insecticidal, bactericidal or herbicidal properties can be derived. Such pesticides often have high selectivity and activity for specific target organisms, and have low residues in the environment, which meets the development requirements of modern green pesticides.
In the dye industry, 4-nitro-2- (trifluoromethyl) chlorobenzene can be used to construct the conjugate system of dye molecules. The phenyl ring and its substituents can participate in the formation of chromophore, making the dye rich in color, and imparting good light resistance and washable properties. After chemical modification, dyes suitable for dyeing of different fiber materials can be prepared. In conclusion, 4-nitro-2- (trifluoromethyl) chlorobenzene, with its unique structure, plays an indispensable role in many important chemical industries, promoting the innovation and development of products in various industries.
What are the synthesis methods of 4-nitro-2- (trifluoromethyl) chlorobenzene?
4-Nitro-2 - (trifluoromethyl) chlorobenzene is an important intermediate in organic synthesis. The methods of its synthesis are common and have several ends.
One is the method of initiating the halogenation reaction. First, take the benzene derivative containing the appropriate substituent, and use a halogenating agent, such as chlorine gas, under specific conditions to introduce chlorine atoms into the benzene ring. After the nitration step, the nitro group is introduced into the benzene ring with a mixed acid system of nitric acid and sulfuric acid under the control of appropriate temperature and time. Finally, through the trifluoromethylation reaction, with suitable trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., to achieve the access of trifluoromethyl, so as to obtain the target product 4-nitro-2- (trifluoromethyl) chlorobenzene.
The second is initiated by nitrogenation. With benzene or related derivatives, the nitrobenzene compound is first nitrified. Then halogenated, chlorine atoms are introduced. Finally, the introduction of trifluoromethyl is achieved by special trifluoromethylation methods to obtain 4-nitro-2- (trifluoromethyl) chlorobenzene. In this process, the conditions of each step of the reaction need to be carefully controlled, and the temperature, reaction time, and reagent dosage are all related to the success or failure of the reaction and the purity of the product.
Third, there are also benzene derivatives containing trifluoromethyl as the starting material. First, halogenation, the introduction of chlorine atoms, and then nitration to prepare 4-nitro-2- (trifluoromethyl) chlorobenzene. In this approach, the selection of raw materials and the optimization of reaction conditions are also key. Different starting materials and reaction sequences have their own advantages and disadvantages. They need to be selected according to the actual situation, so as to achieve the purpose of high-efficiency and high-purity synthesis of 4-nitro-2- (trifluoromethyl) chlorobenzene.
One is the method of initiating the halogenation reaction. First, take the benzene derivative containing the appropriate substituent, and use a halogenating agent, such as chlorine gas, under specific conditions to introduce chlorine atoms into the benzene ring. After the nitration step, the nitro group is introduced into the benzene ring with a mixed acid system of nitric acid and sulfuric acid under the control of appropriate temperature and time. Finally, through the trifluoromethylation reaction, with suitable trifluoromethylation reagents, such as trifluoromethyl magnesium halide, etc., to achieve the access of trifluoromethyl, so as to obtain the target product 4-nitro-2- (trifluoromethyl) chlorobenzene.
The second is initiated by nitrogenation. With benzene or related derivatives, the nitrobenzene compound is first nitrified. Then halogenated, chlorine atoms are introduced. Finally, the introduction of trifluoromethyl is achieved by special trifluoromethylation methods to obtain 4-nitro-2- (trifluoromethyl) chlorobenzene. In this process, the conditions of each step of the reaction need to be carefully controlled, and the temperature, reaction time, and reagent dosage are all related to the success or failure of the reaction and the purity of the product.
Third, there are also benzene derivatives containing trifluoromethyl as the starting material. First, halogenation, the introduction of chlorine atoms, and then nitration to prepare 4-nitro-2- (trifluoromethyl) chlorobenzene. In this approach, the selection of raw materials and the optimization of reaction conditions are also key. Different starting materials and reaction sequences have their own advantages and disadvantages. They need to be selected according to the actual situation, so as to achieve the purpose of high-efficiency and high-purity synthesis of 4-nitro-2- (trifluoromethyl) chlorobenzene.
What are the precautions for 4-nitro-2- (trifluoromethyl) chlorobenzene during storage and transportation?
4-Nitro-2 - (trifluoromethyl) chlorobenzene is an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage. This substance has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. Avoid open flames, hot topics, and are prone to chemical reactions or hazards due to heat. It needs to be stored separately from oxidizing agents, alkalis, etc., and must not be mixed with them. It may react violently with them. The storage area should be equipped with suitable materials to contain leaks to prevent inadvertent leakage and cause greater harm.
Next talk about transportation. Make sure the packaging is complete and sealed before transportation. When handling, it should be lightly loaded and unloaded. Do not collide or fall to prevent material leakage caused by damaged packaging. During transportation, transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. The driving route should avoid densely populated areas and traffic arteries, and drive according to the specified route. Summer transportation should be carried out in the morning and evening to avoid high temperature periods, due to high temperature or increase its danger.
Furthermore, whether it is storage or transportation, it is necessary to strictly follow relevant laws and regulations and operating procedures. Operators should be professionally trained and familiar with the nature of the substance and emergency treatment methods. In this way, the safety of storage and transportation should be guaranteed, and accidents should be avoided. The safety of personnel and the environment will not be damaged.
First words storage. This substance has a certain chemical activity and should be stored in a cool, dry and well-ventilated place. Avoid open flames, hot topics, and are prone to chemical reactions or hazards due to heat. It needs to be stored separately from oxidizing agents, alkalis, etc., and must not be mixed with them. It may react violently with them. The storage area should be equipped with suitable materials to contain leaks to prevent inadvertent leakage and cause greater harm.
Next talk about transportation. Make sure the packaging is complete and sealed before transportation. When handling, it should be lightly loaded and unloaded. Do not collide or fall to prevent material leakage caused by damaged packaging. During transportation, transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. The driving route should avoid densely populated areas and traffic arteries, and drive according to the specified route. Summer transportation should be carried out in the morning and evening to avoid high temperature periods, due to high temperature or increase its danger.
Furthermore, whether it is storage or transportation, it is necessary to strictly follow relevant laws and regulations and operating procedures. Operators should be professionally trained and familiar with the nature of the substance and emergency treatment methods. In this way, the safety of storage and transportation should be guaranteed, and accidents should be avoided. The safety of personnel and the environment will not be damaged.
What are the environmental effects of 4-nitro-2- (trifluoromethyl) chlorobenzene?
4-Nitro-2- (trifluoromethyl) chlorobenzene is an organic compound, and its impact on the environment is particularly important and cannot be ignored.
This compound has certain toxicity. When it enters the natural environment, or due to the characteristics of nitro and trifluoromethyl in its own structure, it can interfere with the normal physiological process of organisms. In aquatic ecology, it may cause poisoning of aquatic organisms, affecting their growth, reproduction and development. Such as plankton, sensitive to such toxins, or as a result of the sharp decrease in the number of populations, which may disrupt the balance of the food chain.
And 4-nitro-2- (trifluoromethyl) chlorobenzene is highly stable and difficult to degrade in the environment. It can remain in soil and water for a long time and accumulate continuously. If it is enriched by the food chain, its concentration in high nutrient level organisms may increase significantly, threatening the health of the ecosystem.
And because of its low volatility, it is not easy to diffuse in the atmosphere, and mainly remains in soil and water. In the soil, it may affect the activity of soil microorganisms, inhibit material circulation and energy conversion in the soil, cause soil fertility to decline, and damage vegetation growth. In water bodies, it can pollute water sources and pose a hazard to drinking and irrigation water.
In summary, 4-nitro-2- (trifluoromethyl) chlorobenzene has many hazards to the environment. It is urgent to control the production, use and discharge to protect the safety of the ecological environment.
This compound has certain toxicity. When it enters the natural environment, or due to the characteristics of nitro and trifluoromethyl in its own structure, it can interfere with the normal physiological process of organisms. In aquatic ecology, it may cause poisoning of aquatic organisms, affecting their growth, reproduction and development. Such as plankton, sensitive to such toxins, or as a result of the sharp decrease in the number of populations, which may disrupt the balance of the food chain.
And 4-nitro-2- (trifluoromethyl) chlorobenzene is highly stable and difficult to degrade in the environment. It can remain in soil and water for a long time and accumulate continuously. If it is enriched by the food chain, its concentration in high nutrient level organisms may increase significantly, threatening the health of the ecosystem.
And because of its low volatility, it is not easy to diffuse in the atmosphere, and mainly remains in soil and water. In the soil, it may affect the activity of soil microorganisms, inhibit material circulation and energy conversion in the soil, cause soil fertility to decline, and damage vegetation growth. In water bodies, it can pollute water sources and pose a hazard to drinking and irrigation water.
In summary, 4-nitro-2- (trifluoromethyl) chlorobenzene has many hazards to the environment. It is urgent to control the production, use and discharge to protect the safety of the ecological environment.
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