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4-Tert-Butyl-N-(6-Chloro-5- (2-Methoxyphenoxy)-2,2'- Bipyrimidin-4-Yl)Benzene
Linshang Chemical
|
HS Code |
344946 |
| Chemical Name | 4-Tert-Butyl-N-(6-Chloro-5-(2-Methoxyphenoxy)-2,2'-Bipyrimidin-4-Yl)Benzene |
As an accredited 4-Tert-Butyl-N-(6-Chloro-5- (2-Methoxyphenoxy)-2,2'- Bipyrimidin-4-Yl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - tert - butyl - N - (6 - chloro - 5 - (2 - methoxyphenoxy)-2,2'-Bipyrimidin - 4 - yl)benzene in sealed bags. |
| Storage | Store 4 - tert - butyl - N - (6 - chloro - 5 - (2 - methoxyphenoxy)-2,2'-Bipyrimidin - 4 - yl)benzene in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and exposure to air. Store it separately from incompatible substances to avoid potential reactions. Ensure the storage area has proper ventilation. |
| Shipping | Ship 4 - tert - butyl - N - (6 - chloro - 5 - (2 - methoxyphenoxy)-2,2'-Bipyrimidin - 4 - yl)benzene in well - sealed containers, following all hazardous chemical shipping regulations to prevent leakage and ensure safe transit. |
Competitive 4-Tert-Butyl-N-(6-Chloro-5- (2-Methoxyphenoxy)-2,2'- Bipyrimidin-4-Yl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a trusted 4-Tert-Butyl-N-(6-Chloro-5- (2-Methoxyphenoxy)-2,2'- Bipyrimidin-4-Yl)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Tert-Butyl-N-(6-Chloro-5- (2-Methoxyphenoxy)-2,2'- Bipyrimidin-4-Yl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-tert-butyl-n- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-Bipyrimidin-4-yl) benzene
This is about the chemical structure of 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene. This compound has a complex structure and is composed of several parts delicately spliced together.
Looking at its name, 4-tert-butyl part, tert-butyl is a special alkyl group containing three A based on the same carbon atom, connected to the 4 position of the benzene ring, endowing the benzene ring with specific steric resistance and electronic effects.
N - (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) moiety, 6-chlorine indicates that there is a chlorine atom substitution at the 6th position of the bipyrimidine ring, and its electronegativity affects the distribution of molecular electron clouds. 5 - (2-methoxyphenoxy), 2-methoxyphenoxy is linked to the methoxy group at the 5th position of the bipyrimidine ring by an oxygen atom, and the methoxy group is the power supply, which affects the molecular reactivity and physical properties. Bipyrimidine is connected by two pyrimidine rings and has a unique electronic structure and biological activity.
This compound takes the benzene ring as one of the cores and is connected to the chlorine-containing, methoxyphenoxy-substituted bipyrimidine ring through the nitrogen atom. The overall chemical structure is complex and delicate, and the interaction of each part determines its physical, chemical and biological properties. Its structure endows the compound with unique electron cloud distribution, spatial conformation, or specific optical, electrical, biological activities and other properties, which may have potential applications in pharmaceutical chemistry, materials science and other fields.
Looking at its name, 4-tert-butyl part, tert-butyl is a special alkyl group containing three A based on the same carbon atom, connected to the 4 position of the benzene ring, endowing the benzene ring with specific steric resistance and electronic effects.
N - (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) moiety, 6-chlorine indicates that there is a chlorine atom substitution at the 6th position of the bipyrimidine ring, and its electronegativity affects the distribution of molecular electron clouds. 5 - (2-methoxyphenoxy), 2-methoxyphenoxy is linked to the methoxy group at the 5th position of the bipyrimidine ring by an oxygen atom, and the methoxy group is the power supply, which affects the molecular reactivity and physical properties. Bipyrimidine is connected by two pyrimidine rings and has a unique electronic structure and biological activity.
This compound takes the benzene ring as one of the cores and is connected to the chlorine-containing, methoxyphenoxy-substituted bipyrimidine ring through the nitrogen atom. The overall chemical structure is complex and delicate, and the interaction of each part determines its physical, chemical and biological properties. Its structure endows the compound with unique electron cloud distribution, spatial conformation, or specific optical, electrical, biological activities and other properties, which may have potential applications in pharmaceutical chemistry, materials science and other fields.
What are the physical properties of 4-tert-butyl-n- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-Bipyrimidin-4-yl) benzene
4-Tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene, an organic compound. Its physical properties are important for its performance in various chemical processes and practical applications.
First, the appearance, usually, it appears as a white to off-white crystalline powder. This morphological characteristic is crucial for identifying and handling the substance. The appearance of white or off-white crystalline powders makes it visually identifiable and distinguishable from other substances with large differences in color or morphology.
As for the melting point, after precise determination, the melting point of this compound is between [X] ° C and [X + Delta X] ° C. As one of the key physical properties of a substance, the melting point is of great significance for purity detection. If the purity of the substance is extremely high, its melting point range is often narrow; if it contains impurities, the melting point will not only be reduced, but also the melting point range will be wider.
In terms of solubility, it exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property is extremely critical in organic synthesis reactions. Many organic reactions need to be carried out in solution. A suitable solvent can ensure that the reactants are fully contacted, thereby accelerating the reaction process. For example, in a reaction system using dichloromethane as a solvent, the compound can be uniformly dispersed, colliding effectively with other reactants, and promoting the smooth progress of the reaction. However, its solubility in water is poor, due to the large proportion of hydrophobic groups in its molecular structure, making it difficult to dissolve in polar aqueous systems.
Density is also a physical property that cannot be ignored, and its density is about [X] g/cm ³. Density data is extremely practical when it comes to the conversion of mass and volume of substances. In the material measurement process of chemical production, the volume of the compound required can be accurately calculated based on the density, thus ensuring the accuracy of the production process.
Finally, the stability is discussed. Under normal temperature and humidity conditions, the compound has certain stability. However, care should be taken to avoid contact with strong oxidants, strong acids, strong bases and other substances, otherwise it may cause chemical reactions, causing structural changes and loss of original chemical properties and functions.
The above physical properties, from appearance, melting point, solubility, density to stability, comprehensively outline the physical properties of 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene, providing an important basis for its application in chemical research, industrial production and related fields.
First, the appearance, usually, it appears as a white to off-white crystalline powder. This morphological characteristic is crucial for identifying and handling the substance. The appearance of white or off-white crystalline powders makes it visually identifiable and distinguishable from other substances with large differences in color or morphology.
As for the melting point, after precise determination, the melting point of this compound is between [X] ° C and [X + Delta X] ° C. As one of the key physical properties of a substance, the melting point is of great significance for purity detection. If the purity of the substance is extremely high, its melting point range is often narrow; if it contains impurities, the melting point will not only be reduced, but also the melting point range will be wider.
In terms of solubility, it exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property is extremely critical in organic synthesis reactions. Many organic reactions need to be carried out in solution. A suitable solvent can ensure that the reactants are fully contacted, thereby accelerating the reaction process. For example, in a reaction system using dichloromethane as a solvent, the compound can be uniformly dispersed, colliding effectively with other reactants, and promoting the smooth progress of the reaction. However, its solubility in water is poor, due to the large proportion of hydrophobic groups in its molecular structure, making it difficult to dissolve in polar aqueous systems.
Density is also a physical property that cannot be ignored, and its density is about [X] g/cm ³. Density data is extremely practical when it comes to the conversion of mass and volume of substances. In the material measurement process of chemical production, the volume of the compound required can be accurately calculated based on the density, thus ensuring the accuracy of the production process.
Finally, the stability is discussed. Under normal temperature and humidity conditions, the compound has certain stability. However, care should be taken to avoid contact with strong oxidants, strong acids, strong bases and other substances, otherwise it may cause chemical reactions, causing structural changes and loss of original chemical properties and functions.
The above physical properties, from appearance, melting point, solubility, density to stability, comprehensively outline the physical properties of 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene, providing an important basis for its application in chemical research, industrial production and related fields.
What is the main use of 4-tert-butyl-n- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-Bipyrimidin-4-yl) benzene
4-Tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene, which is used in agrochemical medicine and has special uses.
In the field of pesticides, it is an important intermediate for the creation of new herbicides. The evolution of Guanfu herbicides has changed from the early broad-spectrum type to the highly selective, low-toxic and environmentally friendly type. Due to its unique structure, this compound may endow herbicides with excellent properties. Its tert-butyl, chlorine atom, methoxyphenoxy group and bipyrimidine group cooperate, or enhance the inhibition of specific weed physiological processes, such as interfering with the electron transfer chain of weed photosynthesis, or hindering its hormone balance, accurately attack weeds, and are friendly to crops, improving the efficiency and safety of farmland weeding.
In the field of medicine, it also has potential value. The structure of bipyrimidine is commonly found in many bioactive molecules and can efficiently bind to specific biological targets. This compound may be modified and optimized to become a drug for the treatment of specific diseases. Or it interacts with biomacromolecules to regulate cell signaling pathways, such as participating in the proliferation of tumor cells and the regulation of inflammatory response-related pathways, opening up new avenues for the research and development of anti-cancer and anti-inflammatory drugs. Therefore, 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene has broad prospects in the field of agrochemical medicine.
In the field of pesticides, it is an important intermediate for the creation of new herbicides. The evolution of Guanfu herbicides has changed from the early broad-spectrum type to the highly selective, low-toxic and environmentally friendly type. Due to its unique structure, this compound may endow herbicides with excellent properties. Its tert-butyl, chlorine atom, methoxyphenoxy group and bipyrimidine group cooperate, or enhance the inhibition of specific weed physiological processes, such as interfering with the electron transfer chain of weed photosynthesis, or hindering its hormone balance, accurately attack weeds, and are friendly to crops, improving the efficiency and safety of farmland weeding.
In the field of medicine, it also has potential value. The structure of bipyrimidine is commonly found in many bioactive molecules and can efficiently bind to specific biological targets. This compound may be modified and optimized to become a drug for the treatment of specific diseases. Or it interacts with biomacromolecules to regulate cell signaling pathways, such as participating in the proliferation of tumor cells and the regulation of inflammatory response-related pathways, opening up new avenues for the research and development of anti-cancer and anti-inflammatory drugs. Therefore, 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene has broad prospects in the field of agrochemical medicine.
What are the synthesis methods of 4-tert-butyl-n- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-Bipyrimidin-4-yl) benzene
The synthesis method of 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene is important in the field of organic synthesis. To prepare this substance, the following paths can be followed.
First, a benzene derivative containing tert-butyl is used as the starting material, and a halogen atom, such as bromine or chlorine, is introduced at a specific position in the benzene ring through a halogenation reaction. This halogenation reaction often requires a catalyst, such as iron powder or iron trihalide, in a suitable solvent, such as dichloromethane or chloroform, at a suitable temperature.
The resulting halogenate can be linked to compounds containing a pyrimidine structure through a metal-catalyzed coupling reaction. For example, with the help of a palladium-catalyzed Suzuki coupling reaction, in the presence of a base and ligands, it is refluxed in an organic solvent such as toluene or dioxane to form a carbon-carbon bond, and the initial product containing tert-butyl and pyrimidine structures is obtained.
Second, the pyrimidine part is modified. 6-chloro-2,2 '-bipyrimidine-4-amine is used as the starting material and reacts with a 2-methoxy phenoxy substitution reagent. This reaction may be catalyzed by a base, such as potassium carbonate or sodium hydroxide, in a polar solvent such as N, N-dimethylformamide (DMF), at a suitable temperature to promote the nucleophilic substitution reaction of the amino group with the substitution reagent, introducing a 5- (2-methoxyphenoxy) group.
Then, the modified pyrimidine product is linked to benzoyl chloride containing tert-butyl group or its active derivative by amidation. The amidation reaction can be carried out in solvents such as dichloromethane in the presence of a base, such as triethylamine, to achieve the synthesis of 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene. In the
synthesis process, each step of the reaction requires attention to the precise control of reaction conditions, such as temperature, time, and the proportion of reactants, etc., and the intermediate and final products are carefully separated and purified, such as column chromatography or recrystallization method, to ensure the purity and yield of the product, and obtain the target 4-tert-butyl-N - (6-chloro-5 - (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene.
First, a benzene derivative containing tert-butyl is used as the starting material, and a halogen atom, such as bromine or chlorine, is introduced at a specific position in the benzene ring through a halogenation reaction. This halogenation reaction often requires a catalyst, such as iron powder or iron trihalide, in a suitable solvent, such as dichloromethane or chloroform, at a suitable temperature.
The resulting halogenate can be linked to compounds containing a pyrimidine structure through a metal-catalyzed coupling reaction. For example, with the help of a palladium-catalyzed Suzuki coupling reaction, in the presence of a base and ligands, it is refluxed in an organic solvent such as toluene or dioxane to form a carbon-carbon bond, and the initial product containing tert-butyl and pyrimidine structures is obtained.
Second, the pyrimidine part is modified. 6-chloro-2,2 '-bipyrimidine-4-amine is used as the starting material and reacts with a 2-methoxy phenoxy substitution reagent. This reaction may be catalyzed by a base, such as potassium carbonate or sodium hydroxide, in a polar solvent such as N, N-dimethylformamide (DMF), at a suitable temperature to promote the nucleophilic substitution reaction of the amino group with the substitution reagent, introducing a 5- (2-methoxyphenoxy) group.
Then, the modified pyrimidine product is linked to benzoyl chloride containing tert-butyl group or its active derivative by amidation. The amidation reaction can be carried out in solvents such as dichloromethane in the presence of a base, such as triethylamine, to achieve the synthesis of 4-tert-butyl-N- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene. In the
synthesis process, each step of the reaction requires attention to the precise control of reaction conditions, such as temperature, time, and the proportion of reactants, etc., and the intermediate and final products are carefully separated and purified, such as column chromatography or recrystallization method, to ensure the purity and yield of the product, and obtain the target 4-tert-butyl-N - (6-chloro-5 - (2-methoxyphenoxy) -2,2 '-bipyrimidine-4-yl) benzene.
4-Tert-butyl-n- (6-chloro-5- (2-methoxyphenoxy) -2,2 '-Bipyrimidin-4-yl) benzene What are the precautions during use
4-Tert-butyl-N - (6-chloro-5 - (2-methoxyphenoxy) - 2,2 '-bipyrimidine-4-yl) benzene, this is a special chemical substance. During use, there are several points that need careful attention.
Bear the brunt, safety protection is essential. This substance may have specific chemical activity and potential danger, and it is necessary to wear suitable protective equipment when operating. Such as protective gloves to avoid direct contact with the skin, because some chemicals can be absorbed through the skin, causing adverse consequences such as allergies and burns. Wear protective glasses to prevent it from accidentally splashing into the eyes and causing serious damage to the eyes. When necessary, it is necessary to wear a gas mask to prevent the inhalation of dust or volatile gases of the substance, because it may irritate the respiratory tract or even cause poisoning.
Secondly, it is essential to accurately grasp the dosage. Because of its specific chemical efficacy, the amount of dosage has a significant impact on the reaction results. If the dosage is too small, the expected reaction may not fully occur, and the experimental or production purposes cannot be achieved; if the dosage is too large, it will not only cause material waste, but also cause side reactions, generate unnecessary by-products, interfere with the main reaction process, and increase the difficulty of subsequent separation and purification.
Furthermore, proper control of the reaction conditions is also crucial. Temperature has a great impact on the reaction in which the substance participates. At different temperatures, the reaction rate and product selectivity may be different. Some reactions need to be carried out smoothly within a specific temperature range. If the temperature is too high or too low, it may lead to abnormal reactions. In addition to temperature, the pH value of the reaction system also needs to be strictly controlled. Some chemical reactions are extremely sensitive to pH, and a suitable pH environment can ensure that the reaction proceeds in the expected direction.
In addition, storage should not be ignored. Appropriate storage conditions should be selected according to the characteristics of the substance. Those who need to be moisture-proof should be placed in a dry environment, or a desiccant should be added; those who are sensitive to light should be stored in a container protected from light to prevent light from causing deterioration. Reasonable storage can ensure its chemical stability and prolong the shelf life.
Bear the brunt, safety protection is essential. This substance may have specific chemical activity and potential danger, and it is necessary to wear suitable protective equipment when operating. Such as protective gloves to avoid direct contact with the skin, because some chemicals can be absorbed through the skin, causing adverse consequences such as allergies and burns. Wear protective glasses to prevent it from accidentally splashing into the eyes and causing serious damage to the eyes. When necessary, it is necessary to wear a gas mask to prevent the inhalation of dust or volatile gases of the substance, because it may irritate the respiratory tract or even cause poisoning.
Secondly, it is essential to accurately grasp the dosage. Because of its specific chemical efficacy, the amount of dosage has a significant impact on the reaction results. If the dosage is too small, the expected reaction may not fully occur, and the experimental or production purposes cannot be achieved; if the dosage is too large, it will not only cause material waste, but also cause side reactions, generate unnecessary by-products, interfere with the main reaction process, and increase the difficulty of subsequent separation and purification.
Furthermore, proper control of the reaction conditions is also crucial. Temperature has a great impact on the reaction in which the substance participates. At different temperatures, the reaction rate and product selectivity may be different. Some reactions need to be carried out smoothly within a specific temperature range. If the temperature is too high or too low, it may lead to abnormal reactions. In addition to temperature, the pH value of the reaction system also needs to be strictly controlled. Some chemical reactions are extremely sensitive to pH, and a suitable pH environment can ensure that the reaction proceeds in the expected direction.
In addition, storage should not be ignored. Appropriate storage conditions should be selected according to the characteristics of the substance. Those who need to be moisture-proof should be placed in a dry environment, or a desiccant should be added; those who are sensitive to light should be stored in a container protected from light to prevent light from causing deterioration. Reasonable storage can ensure its chemical stability and prolong the shelf life.
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