Linshang Chemical
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5-Amino-2-Chloro-N-(2',4'-Dimethylphenyl)Benzenesulphonamide
Linshang Chemical
|
HS Code |
367840 |
| Chemical Formula | C14H15ClN2O2S |
| Molar Mass | 310.8 g/mol |
| Appearance | Solid |
| Color | White to off - white |
| Odor | Odorless (usually) |
| Solubility In Water | Poorly soluble |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
| Melting Point | 158 - 162 °C |
| Boiling Point | Decomposes before boiling |
| Pka | The sulfonamide group has a pKa around 10 - 11 |
As an accredited 5-Amino-2-Chloro-N-(2',4'-Dimethylphenyl)Benzenesulphonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - amino - 2 - chloro - N - (2',4'-dimethylphenyl)benzenesulphonamide, 100g in sealed, labeled chemical - grade bags. |
| Storage | Store 5 - amino - 2 - chloro - N - (2',4'-dimethylphenyl)benzenesulphonamide in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances. Store in a tightly sealed container to prevent moisture absorption and potential degradation. Avoid storing near oxidizing agents or strong acids and bases. |
| Shipping | 5 - amino - 2 - chloro - N - (2',4'-dimethylphenyl)benzenesulphonamide is a chemical. Shipping should follow strict hazardous materials regulations. It must be properly packaged to prevent leakage, with clear labeling indicating its nature for safe transportation. |
Competitive 5-Amino-2-Chloro-N-(2',4'-Dimethylphenyl)Benzenesulphonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 5-amino-2-chloro-N - (2 ', 4' -dimethylphenyl) benzenesulfonamide?
5-Hydroxy-2-mercapto-N - (2 ', 4' -dimethylphenyl) benzothiazole, this is a unique organic compound with multiple chemical properties, which is quite eye-catching.
It is acidic to a certain extent, because the hydrogen atoms in the hydroxyl group can be partially ionized, and in a suitable solvent or reaction environment, it can exhibit acidic properties, and can react with alkali substances to form corresponding salts. For example, when it encounters sodium hydroxide, hydroxyl hydrogen will combine with hydroxide ions to form water molecules, while the rest of the compound will form a sodium salt with sodium ions.
From a nucleophilic perspective, mercapto is a highly active nucleophilic group. Because sulfur atoms are rich in lone pair electrons, they are quite attractive to electrophilic reagents. In many organic reactions, sulfhydryl groups can attack the electrophilic center by virtue of their nucleophilicity, and then form new chemical bonds. For example, in nucleophilic substitution reactions, they can replace the leaving group on a suitable substrate to achieve a structural transformation of the compound.
Furthermore, the conjugated structure of the compound gives it unique optical properties. The benzothiazole ring forms a conjugated system with the attached phenyl group, which enables it to absorb and emit light of a specific wavelength. In the photophysical process, when excited by light, electrons transition in the conjugated system, thus presenting a fluorescence emission phenomenon, which may have potential applications in the field of fluorescent materials.
In addition, the presence of 2 ', 4' -dimethylphenyl has an impact on the electron cloud distribution of the whole molecule due to the electron-giving effect of methyl. This may not only change the reactivity of the compound, but also affect its physical properties such as melting point and boiling point. The steric hindrance effect of methyl is also significant, which may affect the intermolecular interaction and the selectivity of chemical reactions. In some reactions, due to the steric hindrance, the reactivity of a specific reaction check point may be inhibited, so that the reaction is more inclined to a specific direction.
It is acidic to a certain extent, because the hydrogen atoms in the hydroxyl group can be partially ionized, and in a suitable solvent or reaction environment, it can exhibit acidic properties, and can react with alkali substances to form corresponding salts. For example, when it encounters sodium hydroxide, hydroxyl hydrogen will combine with hydroxide ions to form water molecules, while the rest of the compound will form a sodium salt with sodium ions.
From a nucleophilic perspective, mercapto is a highly active nucleophilic group. Because sulfur atoms are rich in lone pair electrons, they are quite attractive to electrophilic reagents. In many organic reactions, sulfhydryl groups can attack the electrophilic center by virtue of their nucleophilicity, and then form new chemical bonds. For example, in nucleophilic substitution reactions, they can replace the leaving group on a suitable substrate to achieve a structural transformation of the compound.
Furthermore, the conjugated structure of the compound gives it unique optical properties. The benzothiazole ring forms a conjugated system with the attached phenyl group, which enables it to absorb and emit light of a specific wavelength. In the photophysical process, when excited by light, electrons transition in the conjugated system, thus presenting a fluorescence emission phenomenon, which may have potential applications in the field of fluorescent materials.
In addition, the presence of 2 ', 4' -dimethylphenyl has an impact on the electron cloud distribution of the whole molecule due to the electron-giving effect of methyl. This may not only change the reactivity of the compound, but also affect its physical properties such as melting point and boiling point. The steric hindrance effect of methyl is also significant, which may affect the intermolecular interaction and the selectivity of chemical reactions. In some reactions, due to the steric hindrance, the reactivity of a specific reaction check point may be inhibited, so that the reaction is more inclined to a specific direction.
What are the main uses of 5-amino-2-chloro-N - (2 ', 4' -dimethylphenyl) benzenesulfonamide?
5-Amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide is a class of organic compounds. Its main uses are as follows:
In the field of medicinal chemistry, such compounds are often important active components or lead compounds. Many drug developers have conducted in-depth research and modification on its structure, aiming to find new drugs with specific biological activities and pharmacological properties. Due to the specific chemical structure of the compound, it can bind to specific targets in organisms or interfere with key biochemical reaction processes, thus demonstrating potential therapeutic effects, such as anti-tumor, anti-inflammatory, and antibacterial effects.
In the field of organic synthetic chemistry, it exists as a key intermediate. With the help of various organic chemical reactions, it can be used as a starting material to further construct more complex organic molecular structures. Based on this, organic synthetic chemists can flexibly use different reaction strategies and methods to transform and expand their functional groups, and synthesize a series of derivatives with diverse structures, providing a key material basis for the development of organic synthetic chemistry and the creation of new materials and fine chemicals.
In the field of materials science, some materials derived from such compounds may have unique physical and chemical properties, such as specific optical and electrical properties. This makes them potentially valuable in applications such as photoelectric materials and sensor materials, providing novel ideas and options for the development of new functional materials.
In the field of medicinal chemistry, such compounds are often important active components or lead compounds. Many drug developers have conducted in-depth research and modification on its structure, aiming to find new drugs with specific biological activities and pharmacological properties. Due to the specific chemical structure of the compound, it can bind to specific targets in organisms or interfere with key biochemical reaction processes, thus demonstrating potential therapeutic effects, such as anti-tumor, anti-inflammatory, and antibacterial effects.
In the field of organic synthetic chemistry, it exists as a key intermediate. With the help of various organic chemical reactions, it can be used as a starting material to further construct more complex organic molecular structures. Based on this, organic synthetic chemists can flexibly use different reaction strategies and methods to transform and expand their functional groups, and synthesize a series of derivatives with diverse structures, providing a key material basis for the development of organic synthetic chemistry and the creation of new materials and fine chemicals.
In the field of materials science, some materials derived from such compounds may have unique physical and chemical properties, such as specific optical and electrical properties. This makes them potentially valuable in applications such as photoelectric materials and sensor materials, providing novel ideas and options for the development of new functional materials.
What is the synthesis method of 5-amino-2-chloro-N - (2 ', 4' -dimethylphenyl) benzenesulfonamide?
To prepare 5-hydroxy-2-bromo-N- (2 ', 4' -dimethylbenzyl) benzamide, the following ancient method can be used.
The starting material is selected from a suitable benzoyl halide and a nitrogen-containing compound. This nitrogen-containing compound needs to have the structure of 2 ', 4' -dimethylbenzyl. When the two meet, in a suitable solvent, with a specific base, it is nucleophilic substituted to form N- (2 ', 4' -dimethylbenzyl) benzamide. Among them, the choice of solvent is related to the smooth reaction, the amount and activity of the base, and also affects the process of the reaction.
Then, for the N - (2 ', 4' -dimethylbenzyl) benzamide obtained, hydroxyl and bromine atoms are introduced. The introduction of hydroxyl groups can be achieved by hydrolysis of halogenated hydrocarbons or substitution of phenolic compounds. If hydrolysis of halogenated hydrocarbons is selected, a suitable halogenated benzamide is selected, and it is treated with an aqueous solution of alkali to control the temperature and time, so that the halogen atoms leave and the hydroxyl groups settle in.
As for the introduction of bromine atoms, brominating reagents can be used, such as liquid bromine, N-bromosuccinimide (NBS), etc. If NBS is used, in the presence of suitable initiators, the reaction in an inert solvent can precisely place the bromine atoms in the target position. During the reaction, temperature, light and other conditions need to be carefully regulated to avoid side reactions.
Or bromine atoms are introduced first, followed by hydroxyl groups. The change in this order also depends on the characteristics of the substrate and the reaction conditions. Between operations, each step of the reaction product needs to be separated and purified, such as recrystallization, column chromatography, etc., to ensure the purity of the product before it can be used for the next reaction. In this way, after several steps of delicate reaction, 5-hydroxy-2-bromo-N - (2 ', 4' -dimethylbenzyl) benzamide can be prepared.
The starting material is selected from a suitable benzoyl halide and a nitrogen-containing compound. This nitrogen-containing compound needs to have the structure of 2 ', 4' -dimethylbenzyl. When the two meet, in a suitable solvent, with a specific base, it is nucleophilic substituted to form N- (2 ', 4' -dimethylbenzyl) benzamide. Among them, the choice of solvent is related to the smooth reaction, the amount and activity of the base, and also affects the process of the reaction.
Then, for the N - (2 ', 4' -dimethylbenzyl) benzamide obtained, hydroxyl and bromine atoms are introduced. The introduction of hydroxyl groups can be achieved by hydrolysis of halogenated hydrocarbons or substitution of phenolic compounds. If hydrolysis of halogenated hydrocarbons is selected, a suitable halogenated benzamide is selected, and it is treated with an aqueous solution of alkali to control the temperature and time, so that the halogen atoms leave and the hydroxyl groups settle in.
As for the introduction of bromine atoms, brominating reagents can be used, such as liquid bromine, N-bromosuccinimide (NBS), etc. If NBS is used, in the presence of suitable initiators, the reaction in an inert solvent can precisely place the bromine atoms in the target position. During the reaction, temperature, light and other conditions need to be carefully regulated to avoid side reactions.
Or bromine atoms are introduced first, followed by hydroxyl groups. The change in this order also depends on the characteristics of the substrate and the reaction conditions. Between operations, each step of the reaction product needs to be separated and purified, such as recrystallization, column chromatography, etc., to ensure the purity of the product before it can be used for the next reaction. In this way, after several steps of delicate reaction, 5-hydroxy-2-bromo-N - (2 ', 4' -dimethylbenzyl) benzamide can be prepared.
5-Amino-2-chloro-N - (2 ', 4' -dimethylphenyl) benzenesulfonamide What are the precautions in storage and transportation?
Fu 5-amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide has several points to pay attention to during storage and transportation.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Cover it or be sensitive to moisture, heat and light. If it is in a high temperature environment, its chemical properties may change or even decompose. Moisture can also cause reactions such as hydrolysis, which can damage its purity and quality. Therefore, be sure to choose a dry place and store it in a sealed container to prevent moisture from invading. And because of its sensitivity to light, it should be stored in a dark place or in an opaque container.
As for transportation, it is subject to relevant laws and regulations. Because it may be a special chemical, it must be packaged firmly during transportation. Packaging materials should be able to resist vibration, collision, and prevent leakage. During transportation, it should also control its environmental conditions, such as temperature and humidity. It must not be exposed to extreme conditions. Transport personnel also need to be familiar with the characteristics of this chemical. In case of emergencies, such as leakage, it should be properly disposed of according to the established emergency plan. And transportation documents should be complete, detailing the nature, hazards and emergency measures of this substance, so that all parties can know and deal with it. In this way, 5-amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide can be guaranteed to be safe during storage and transportation.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Cover it or be sensitive to moisture, heat and light. If it is in a high temperature environment, its chemical properties may change or even decompose. Moisture can also cause reactions such as hydrolysis, which can damage its purity and quality. Therefore, be sure to choose a dry place and store it in a sealed container to prevent moisture from invading. And because of its sensitivity to light, it should be stored in a dark place or in an opaque container.
As for transportation, it is subject to relevant laws and regulations. Because it may be a special chemical, it must be packaged firmly during transportation. Packaging materials should be able to resist vibration, collision, and prevent leakage. During transportation, it should also control its environmental conditions, such as temperature and humidity. It must not be exposed to extreme conditions. Transport personnel also need to be familiar with the characteristics of this chemical. In case of emergencies, such as leakage, it should be properly disposed of according to the established emergency plan. And transportation documents should be complete, detailing the nature, hazards and emergency measures of this substance, so that all parties can know and deal with it. In this way, 5-amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide can be guaranteed to be safe during storage and transportation.
What are the effects of 5-amino-2-chloro-N - (2 ', 4' -dimethylphenyl) benzenesulfonamide on the environment and human health?
Alas! Now I want to discuss the impact of 5-amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide on the environment and human health, which is really important.
This substance, in the environment, has a complex impact. If released in soil, it may affect the balance of soil microbial communities. Soil microorganisms are essential for the maintenance of soil fertility and material circulation. These amides may interfere with the metabolic pathways of microorganisms, causing the growth of beneficial microorganisms to be inhibited, which in turn affects the ecological functions of soil, such as nutrient transformation and conservation.
As for the aquatic environment, if it flows into rivers, lakes and seas, it may pose a threat to aquatic organisms. Aquatic organisms such as fish and shellfish may be damaged by exposure to this substance. Or interfere with their nervous system, causing abnormal movement, decreased ability to forage and escape natural enemies; or affect their reproductive system, reducing their reproductive capacity, and in the long run, or destroying the biodiversity of aquatic ecosystems.
There is also a latent risk to human health. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing uncomfortable symptoms such as cough and asthma. Long-term exposure to this substance environment, or risk of sensitization, causing human immune system disorders. If it comes into contact with the skin or penetrates into the skin, it affects the normal metabolism of skin cells and causes skin inflammation. What's more, through the enrichment of the food chain, this substance may enter the human body and accumulate, accumulate for a long time or affect the function of human organs, such as liver, kidney and other detoxification and excretion organs, and increase the probability of disease.
In short, 5-amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide has an impact on the environment and human health that cannot be ignored. It needs to be treated with caution and studied in detail to ensure the well-being of the environment and people.
This substance, in the environment, has a complex impact. If released in soil, it may affect the balance of soil microbial communities. Soil microorganisms are essential for the maintenance of soil fertility and material circulation. These amides may interfere with the metabolic pathways of microorganisms, causing the growth of beneficial microorganisms to be inhibited, which in turn affects the ecological functions of soil, such as nutrient transformation and conservation.
As for the aquatic environment, if it flows into rivers, lakes and seas, it may pose a threat to aquatic organisms. Aquatic organisms such as fish and shellfish may be damaged by exposure to this substance. Or interfere with their nervous system, causing abnormal movement, decreased ability to forage and escape natural enemies; or affect their reproductive system, reducing their reproductive capacity, and in the long run, or destroying the biodiversity of aquatic ecosystems.
There is also a latent risk to human health. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing uncomfortable symptoms such as cough and asthma. Long-term exposure to this substance environment, or risk of sensitization, causing human immune system disorders. If it comes into contact with the skin or penetrates into the skin, it affects the normal metabolism of skin cells and causes skin inflammation. What's more, through the enrichment of the food chain, this substance may enter the human body and accumulate, accumulate for a long time or affect the function of human organs, such as liver, kidney and other detoxification and excretion organs, and increase the probability of disease.
In short, 5-amino-2-bromo-N - (2 ', 4' -dimethylphenyl) benzamide has an impact on the environment and human health that cannot be ignored. It needs to be treated with caution and studied in detail to ensure the well-being of the environment and people.
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