Linshang Chemical
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5-Bromo-1,3-Dichloro-2-Fluorobenzene
Linshang Chemical
|
HS Code |
233780 |
| Chemical Formula | C6H2BrCl2F |
| Molar Mass | 245.89 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 200 - 210 °C |
| Density | Approx. 1.8 - 2.0 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
As an accredited 5-Bromo-1,3-Dichloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - bromo - 1,3 - dichloro - 2 - fluorobenzene in 500g sealed glass bottles for chemical packaging. |
| Storage | 5 - Bromo - 1,3 - dichloro - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container made of materials resistant to its corrosive nature, such as glass or certain plastics. Label the storage container clearly to prevent misidentification. |
| Shipping | 5 - bromo - 1,3 - dichloro - 2 - fluorobenzene is shipped in accordance with strict chemical transport regulations. It's packaged in suitable containers to prevent leakage, and transported by carriers experienced in handling hazardous chemicals. |
Competitive 5-Bromo-1,3-Dichloro-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 5-Bromo-1,3-Dichloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 5-bromo-1,3-dichloro-2-fluorobenzene?
5-% hydroxyl-1,3-dichloro-2-propanol is an organic compound. Its physical properties are quite characteristic.
Looking at its morphology, under room temperature, 5-% hydroxyl-1,3-dichloro-2-propanol is often colorless to light yellow liquid, with a slightly viscous texture. Its color and luster are like light light, which catches the eye.
Smell its smell, the smell emitted by this substance is spicy and irritating. If you don't smell it carefully, it can cause nasal and respiratory discomfort, like a pungent needle, tingling.
On solubility, 5-% hydroxyl-1,3-dichloro-2-propanol can be dissolved in water and many organic solvents. In water, it can interact with water molecules, just like a fish merging into the sea, and the two are fused. Organic solvents such as ethanol and ether can also be seen, showing good solubility, just like salt dissolving in water, quietly dispersing.
Looking at its boiling point, it is about a high value, which is caused by the force between molecules. Molecules pull each other, and in order to make it boil and vaporize, a higher energy needs to be applied, just like heavy objects need to be lifted with force. The characteristics of its boiling point make it change its state of matter in a specific temperature environment.
As for the melting point, it is also a specific value. When the temperature drops below the melting point, 5-% hydroxyl-1,3-dichloro-2-propanol will gradually change from a liquid state to a solid state, as if time solidifies and the liquid turns into a solid state.
In terms of density, it is larger than water. Placing it in water is like a stone sinking to the bottom of the water, and it will settle at the bottom of the water, showing its own density characteristics.
The physical properties of this 5-% hydroxyl-1,3-dichloro-2-propanol are of great significance in many fields such as chemical research and industrial applications. It has far-reaching implications for the way it is separated, purified, stored and used.
Looking at its morphology, under room temperature, 5-% hydroxyl-1,3-dichloro-2-propanol is often colorless to light yellow liquid, with a slightly viscous texture. Its color and luster are like light light, which catches the eye.
Smell its smell, the smell emitted by this substance is spicy and irritating. If you don't smell it carefully, it can cause nasal and respiratory discomfort, like a pungent needle, tingling.
On solubility, 5-% hydroxyl-1,3-dichloro-2-propanol can be dissolved in water and many organic solvents. In water, it can interact with water molecules, just like a fish merging into the sea, and the two are fused. Organic solvents such as ethanol and ether can also be seen, showing good solubility, just like salt dissolving in water, quietly dispersing.
Looking at its boiling point, it is about a high value, which is caused by the force between molecules. Molecules pull each other, and in order to make it boil and vaporize, a higher energy needs to be applied, just like heavy objects need to be lifted with force. The characteristics of its boiling point make it change its state of matter in a specific temperature environment.
As for the melting point, it is also a specific value. When the temperature drops below the melting point, 5-% hydroxyl-1,3-dichloro-2-propanol will gradually change from a liquid state to a solid state, as if time solidifies and the liquid turns into a solid state.
In terms of density, it is larger than water. Placing it in water is like a stone sinking to the bottom of the water, and it will settle at the bottom of the water, showing its own density characteristics.
The physical properties of this 5-% hydroxyl-1,3-dichloro-2-propanol are of great significance in many fields such as chemical research and industrial applications. It has far-reaching implications for the way it is separated, purified, stored and used.
What are the chemical properties of 5-bromo-1,3-dichloro-2-fluorobenzene?
5-% hydrazine-1,3-dichloro-2-propene is an organic compound with the following chemical properties:
First, the nucleophilic substitution reaction activity is quite good. The chlorine atom in this molecule is easily attacked by nucleophiles due to its high electronegativity and the significant polarity of the C-Cl bond connected to the carbon atom. For example, in an alkaline environment, hydroxyl negative ions (OH) can act as nucleophiles. By virtue of their electron-rich properties, they attack the carbon atoms connected to chlorine. The chlorine atoms leave with a pair of electrons, and then form new compounds containing hydroxyl groups. This is a nucleophilic substitution reaction. Its reaction mechanism is clear and it is often used to introduce new functional groups in organic synthesis.
Second, it has the characteristics of addition reactions. The compound has a carbon-carbon double bond, which is an unsaturated bond, and the electron cloud density is high, which is easy to be favored by electrophilic reagents. For example, hydrogen chloride (HCl) is used as an electrophilic reagent. The hydrogen atom first forms a π complex with the carbon-carbon double bond, and then the π bond is heterocleaved, and the electrons are transferred to the hydrogen atom to form a carbon cation intermediate. The chloride ion is then combined with the carbon cation to complete the addition reaction. The final product is a compound with hydrogen atoms and chlorine atoms connected at the carbon-carbon double bond, respectively. This addition reaction enriches the reaction path of the substance.
Third, the hydrazine group (-NHNH ²) is reductive. The nitrogen atom in the hydrazine group has lone pairs of electrons, and nitrogen is in a relatively low oxidation state, which is prone to lose electrons and presents reduc For example, in a specific redox system, high-valent metal ions can be reduced to low-priced states and oxidized themselves. This reduction can be used as a reagent to provide electrons in organic synthesis and some reactions involved in redox processes to promote the reaction, which is of great significance for the construction of organic compounds with specific structures.
Fourth, there is the possibility of elimination reactions. Under appropriate conditions, such as strong alkaline and heated environments, the chlorine atoms on adjacent carbon atoms in the molecule and the hydrogen atoms on the carbon atoms connected by the hydrazine group may be eliminated in the form of hydrogen chloride and ammonia (or its derivatives), and new unsaturated bonds are formed at the same time. This elimination reaction provides a way for the synthesis of compounds with conjugated structures or specific unsaturated systems, enriching organic synthesis strategies.
First, the nucleophilic substitution reaction activity is quite good. The chlorine atom in this molecule is easily attacked by nucleophiles due to its high electronegativity and the significant polarity of the C-Cl bond connected to the carbon atom. For example, in an alkaline environment, hydroxyl negative ions (OH) can act as nucleophiles. By virtue of their electron-rich properties, they attack the carbon atoms connected to chlorine. The chlorine atoms leave with a pair of electrons, and then form new compounds containing hydroxyl groups. This is a nucleophilic substitution reaction. Its reaction mechanism is clear and it is often used to introduce new functional groups in organic synthesis.
Second, it has the characteristics of addition reactions. The compound has a carbon-carbon double bond, which is an unsaturated bond, and the electron cloud density is high, which is easy to be favored by electrophilic reagents. For example, hydrogen chloride (HCl) is used as an electrophilic reagent. The hydrogen atom first forms a π complex with the carbon-carbon double bond, and then the π bond is heterocleaved, and the electrons are transferred to the hydrogen atom to form a carbon cation intermediate. The chloride ion is then combined with the carbon cation to complete the addition reaction. The final product is a compound with hydrogen atoms and chlorine atoms connected at the carbon-carbon double bond, respectively. This addition reaction enriches the reaction path of the substance.
Third, the hydrazine group (-NHNH ²) is reductive. The nitrogen atom in the hydrazine group has lone pairs of electrons, and nitrogen is in a relatively low oxidation state, which is prone to lose electrons and presents reduc For example, in a specific redox system, high-valent metal ions can be reduced to low-priced states and oxidized themselves. This reduction can be used as a reagent to provide electrons in organic synthesis and some reactions involved in redox processes to promote the reaction, which is of great significance for the construction of organic compounds with specific structures.
Fourth, there is the possibility of elimination reactions. Under appropriate conditions, such as strong alkaline and heated environments, the chlorine atoms on adjacent carbon atoms in the molecule and the hydrogen atoms on the carbon atoms connected by the hydrazine group may be eliminated in the form of hydrogen chloride and ammonia (or its derivatives), and new unsaturated bonds are formed at the same time. This elimination reaction provides a way for the synthesis of compounds with conjugated structures or specific unsaturated systems, enriching organic synthesis strategies.
What are the main uses of 5-bromo-1,3-dichloro-2-fluorobenzene?
5-Hydroxy-1,3-dichloro-2-propanol, which is an organic compound with a wide range of main uses.
In the industrial field, it is often used as an intermediate in organic synthesis. Because of its specific chemical structure and activity, it can participate in many chemical reactions and assist in the synthesis of other complex organic compounds. For example, in the preparation of some fine chemicals, 5-hydroxy-1,3-dichloro-2-propanol can be used as a key starting material, going through a series of reaction steps to eventually generate the desired product.
In the field of pharmaceutical chemistry, it also has its uses. In some drug development processes, the compound may be used to construct specific structural fragments of drug molecules due to its unique chemical properties, laying the foundation for the development of drugs with specific pharmacological activities.
However, it should be noted that 5-hydroxyl-1,3-dichloro-2-propanol may be potentially harmful to human health. If inadvertently exposed or ingested, it may have adverse effects on the body. Therefore, when dealing with the operation and use of this substance, it is necessary to follow strict safety regulations and operating procedures to ensure the safety of personnel and the environment from pollution. In industrial production and application, attention should also be paid to waste disposal to avoid its harm to the environment.
In the industrial field, it is often used as an intermediate in organic synthesis. Because of its specific chemical structure and activity, it can participate in many chemical reactions and assist in the synthesis of other complex organic compounds. For example, in the preparation of some fine chemicals, 5-hydroxy-1,3-dichloro-2-propanol can be used as a key starting material, going through a series of reaction steps to eventually generate the desired product.
In the field of pharmaceutical chemistry, it also has its uses. In some drug development processes, the compound may be used to construct specific structural fragments of drug molecules due to its unique chemical properties, laying the foundation for the development of drugs with specific pharmacological activities.
However, it should be noted that 5-hydroxyl-1,3-dichloro-2-propanol may be potentially harmful to human health. If inadvertently exposed or ingested, it may have adverse effects on the body. Therefore, when dealing with the operation and use of this substance, it is necessary to follow strict safety regulations and operating procedures to ensure the safety of personnel and the environment from pollution. In industrial production and application, attention should also be paid to waste disposal to avoid its harm to the environment.
What are the synthesis methods of 5-bromo-1,3-dichloro-2-fluorobenzene?
The synthesis method of 5-bromo-1,3-difluoro-2-chlorobenzene is as follows:
Using o-dichlorobenzene as the starting material
1. ** Nitration reaction **: Take o-dichlorobenzene, add mixed acid (concentrated sulfuric acid and concentrated nitric acid in a certain proportion) in an appropriate reaction vessel, and carry out nitration reaction within a specific temperature range (about 30-50 ° C). This step aims to introduce nitro groups into the benzene ring to generate 2,3-dichloro-1-nitrobenzene. The reaction principle is based on the electrophilic substitution reaction of the benzene ring, and the nitro positive ion attacks the benzene ring as an electrophilic reagent.
2. ** Fluorination reaction **: The obtained 2,3-dichloro-1-nitrobenzene is reacted with fluorine sources such as potassium fluoride in a suitable organic solvent (such as N, N-dimethylformamide, etc.) at a higher temperature (about 150-200 ° C) to achieve the replacement of chlorine atoms by fluorine atoms to obtain 2-fluoro-3-chloro-1-nitrobenzene. This reaction depends on the difference in the activity of halogen atoms and the mechanism of nucleophilic substitution.
3. ** Reduction reaction **: 2-fluoro-3-chloro-1-nitrobenzene is reduced by iron powder, hydrochloric acid and other reducing agent systems, and the nitro group is converted into an amino group to generate 2-fluoro-3-chloroaniline.
4. ** Diazotization and bromination reaction **: 2-fluoro-3-chloroaniline is reacted with sodium nitrite at low temperature (0-5 ° C) in hydrochloric acid solution to perform diazotization to generate diazonium salts. Subsequently, bromine sources such as potassium bromide are added, heated, and the diazo group is replaced by bromine atoms to obtain 5-bromo-1-fluoro-2-chloro-3-aminobenzene.
5. ** Deamination Reaction **: 5-bromo-1-fluoro-2-chloro-3-aminobenzene is reacted with reagents such as hypophosphoric acid, so that the amino group is replaced by hydrogen atoms, and finally 5-bromo-1,3-difluoro-2-chlorobenzene is obtained.
With 1,2,3-trichlorobenzene as the starting material
1. ** Fluorination reaction **: 1,2,3-trichlorobenzene and potassium fluoride undergo fluorination reaction under specific conditions (such as suitable catalysts, high temperatures, etc.), and some chlorine atoms are replaced by fluorine atoms to generate 1,3-difluoro-2-chlorobenzene.
2. ** Bromination reaction **: 1, 3-difluoro-2-chlorobenzene is reacted with brominating reagents (such as N-bromosuccinimide, liquid bromine, etc.) in a suitable organic solvent (such as carbon tetrachloride) in the presence of light or initiators (such as benzoyl peroxide), so that bromine atoms replace hydrogen atoms at specific positions on the benzene ring to obtain 5-bromo-1, 3-difluoro-2-chlorobenzene. This reaction is based on a free radical substitution mechanism.
Using o-dichlorobenzene as the starting material
1. ** Nitration reaction **: Take o-dichlorobenzene, add mixed acid (concentrated sulfuric acid and concentrated nitric acid in a certain proportion) in an appropriate reaction vessel, and carry out nitration reaction within a specific temperature range (about 30-50 ° C). This step aims to introduce nitro groups into the benzene ring to generate 2,3-dichloro-1-nitrobenzene. The reaction principle is based on the electrophilic substitution reaction of the benzene ring, and the nitro positive ion attacks the benzene ring as an electrophilic reagent.
2. ** Fluorination reaction **: The obtained 2,3-dichloro-1-nitrobenzene is reacted with fluorine sources such as potassium fluoride in a suitable organic solvent (such as N, N-dimethylformamide, etc.) at a higher temperature (about 150-200 ° C) to achieve the replacement of chlorine atoms by fluorine atoms to obtain 2-fluoro-3-chloro-1-nitrobenzene. This reaction depends on the difference in the activity of halogen atoms and the mechanism of nucleophilic substitution.
3. ** Reduction reaction **: 2-fluoro-3-chloro-1-nitrobenzene is reduced by iron powder, hydrochloric acid and other reducing agent systems, and the nitro group is converted into an amino group to generate 2-fluoro-3-chloroaniline.
4. ** Diazotization and bromination reaction **: 2-fluoro-3-chloroaniline is reacted with sodium nitrite at low temperature (0-5 ° C) in hydrochloric acid solution to perform diazotization to generate diazonium salts. Subsequently, bromine sources such as potassium bromide are added, heated, and the diazo group is replaced by bromine atoms to obtain 5-bromo-1-fluoro-2-chloro-3-aminobenzene.
5. ** Deamination Reaction **: 5-bromo-1-fluoro-2-chloro-3-aminobenzene is reacted with reagents such as hypophosphoric acid, so that the amino group is replaced by hydrogen atoms, and finally 5-bromo-1,3-difluoro-2-chlorobenzene is obtained.
With 1,2,3-trichlorobenzene as the starting material
1. ** Fluorination reaction **: 1,2,3-trichlorobenzene and potassium fluoride undergo fluorination reaction under specific conditions (such as suitable catalysts, high temperatures, etc.), and some chlorine atoms are replaced by fluorine atoms to generate 1,3-difluoro-2-chlorobenzene.
2. ** Bromination reaction **: 1, 3-difluoro-2-chlorobenzene is reacted with brominating reagents (such as N-bromosuccinimide, liquid bromine, etc.) in a suitable organic solvent (such as carbon tetrachloride) in the presence of light or initiators (such as benzoyl peroxide), so that bromine atoms replace hydrogen atoms at specific positions on the benzene ring to obtain 5-bromo-1, 3-difluoro-2-chlorobenzene. This reaction is based on a free radical substitution mechanism.
What are the precautions for storing and transporting 5-bromo-1,3-dichloro-2-fluorobenzene?
In storage and transportation of 5-% hydrazine-1,3-dichloro-2-propene, many key matters need to be paid attention to.
When storing, the first environment should be selected. It should be placed in a cool and ventilated warehouse, away from fire and heat sources, because the substance can easily cause combustion and explosion when exposed to open flames and hot topics. The temperature of the warehouse should be controlled within a reasonable range to prevent its properties from being unstable due to excessive temperature. At the same time, it is necessary to ensure that the humidity of the warehouse is suitable. Too humid environment may cause chemical reactions of substances, which will affect their quality and safety.
Furthermore, it needs to be strictly classified and stored. 5-% hydrazine-1,3-dichloro-2-propene should not be mixed with oxidants, acids, alkalis, etc., because contact with these substances may cause severe reactions and increase safety risks. Clear warning signs should be set up at the storage place to remind personnel to pay attention to its danger.
In addition, storage equipment should not be ignored. It should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Regularly check the storage container to see if there is any damage or leakage. If so, it needs to be dealt with in time to avoid causing greater harm.
During transportation, the packaging must be tight. Use packaging materials that meet safety standards to ensure that substances will not leak during transportation bumps. Transport vehicles should have the appropriate qualifications, drivers and escorts need to be professionally trained, familiar with the dangerous characteristics of the substance and emergency treatment methods.
The route selection should also be cautious to avoid passing through sensitive areas such as densely populated areas and water sources. During transportation, the status of the goods should be checked regularly. If any abnormalities are found, such as damaged packaging and peculiar smell, etc., immediate measures should be taken. After transportation, the vehicles should be thoroughly cleaned and cleaned to prevent residual substances from affecting subsequent transportation. In this way, the safety of 5-% hydrazine-1,3-dichloro-2-propene during storage and transportation can be ensured.
When storing, the first environment should be selected. It should be placed in a cool and ventilated warehouse, away from fire and heat sources, because the substance can easily cause combustion and explosion when exposed to open flames and hot topics. The temperature of the warehouse should be controlled within a reasonable range to prevent its properties from being unstable due to excessive temperature. At the same time, it is necessary to ensure that the humidity of the warehouse is suitable. Too humid environment may cause chemical reactions of substances, which will affect their quality and safety.
Furthermore, it needs to be strictly classified and stored. 5-% hydrazine-1,3-dichloro-2-propene should not be mixed with oxidants, acids, alkalis, etc., because contact with these substances may cause severe reactions and increase safety risks. Clear warning signs should be set up at the storage place to remind personnel to pay attention to its danger.
In addition, storage equipment should not be ignored. It should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Regularly check the storage container to see if there is any damage or leakage. If so, it needs to be dealt with in time to avoid causing greater harm.
During transportation, the packaging must be tight. Use packaging materials that meet safety standards to ensure that substances will not leak during transportation bumps. Transport vehicles should have the appropriate qualifications, drivers and escorts need to be professionally trained, familiar with the dangerous characteristics of the substance and emergency treatment methods.
The route selection should also be cautious to avoid passing through sensitive areas such as densely populated areas and water sources. During transportation, the status of the goods should be checked regularly. If any abnormalities are found, such as damaged packaging and peculiar smell, etc., immediate measures should be taken. After transportation, the vehicles should be thoroughly cleaned and cleaned to prevent residual substances from affecting subsequent transportation. In this way, the safety of 5-% hydrazine-1,3-dichloro-2-propene during storage and transportation can be ensured.
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