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5-Bromo-2-Chlorofluorobenzene
Linshang Chemical
|
HS Code |
841979 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 225.44 |
| Appearance | Liquid (usually) |
| Color | Colorless to light yellow |
| Odor | Characteristic organic odor |
| Density | Data needed |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Data needed |
| Vapor Pressure | Data needed |
| Stability | Stable under normal conditions |
| Hazard Class | Irritant (potential) |
| Cas Number | Data needed |
As an accredited 5-Bromo-2-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 5 - bromo - 2 - chlorofluorobenzene packaged in a sealed glass bottle. |
| Storage | Store 5 - bromo - 2 - chlorofluorobenzene in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. It should be stored separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential chemical reactions. Follow proper safety protocols when handling its storage. |
| Shipping | 5 - bromo - 2 - chlorofluorobenzene is shipped in well - sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 5-Bromo-2-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-Bromo-2-Chlorofluorobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 5-Bromo-2-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 5-bromo-2-chlorofluorobenzene?
5-Bromo-2-chlorofluorobenzene is a class of organic compounds. Its main uses are widely involved in the field of organic synthesis.
In the synthesis of medicine, it is often a key intermediary. Molecular structures with specific pharmacological activities can be derived through various chemical reactions. For example, by substitution and addition reactions with other organic reagents, novel chemical structures can be constructed, which can be used to create drugs for the treatment of specific diseases. In the development of many new antibacterial and anti-inflammatory drugs, the intermediates derived from 5-bromo-2-chlorofluorobenzene often play an indispensable role.
In the synthesis of pesticides, it also plays an important role. It can be used as a starting material for the synthesis of high-efficiency and low-toxicity pesticides. After carefully designed reaction steps, it can be converted into compounds that have significant killing or inhibitory effects on crop pests. Its unique chemical structure endows the prepared pesticides with good biological activity and environmental compatibility, which helps to improve crop yield and quality, and reduce the negative impact on the environment.
In the field of materials science, 5-bromo-2-chlorofluorobenzene has also emerged. It can be used to prepare polymer materials with special properties. Through clever polymerization, it is introduced into the polymer chain segment, giving the material special properties such as excellent heat resistance, chemical corrosion resistance or optical properties. These materials may be used in high-end fields such as electronic devices, aerospace, etc., to meet the strict requirements of material properties in specific environments.
5-Bromo-2-chlorofluorobenzene has shown extremely important application value in many fields such as medicine, pesticides and materials science due to its unique chemical structure, providing a key material foundation and innovation possibility for technological innovation and Product Research & Development in various fields.
In the synthesis of medicine, it is often a key intermediary. Molecular structures with specific pharmacological activities can be derived through various chemical reactions. For example, by substitution and addition reactions with other organic reagents, novel chemical structures can be constructed, which can be used to create drugs for the treatment of specific diseases. In the development of many new antibacterial and anti-inflammatory drugs, the intermediates derived from 5-bromo-2-chlorofluorobenzene often play an indispensable role.
In the synthesis of pesticides, it also plays an important role. It can be used as a starting material for the synthesis of high-efficiency and low-toxicity pesticides. After carefully designed reaction steps, it can be converted into compounds that have significant killing or inhibitory effects on crop pests. Its unique chemical structure endows the prepared pesticides with good biological activity and environmental compatibility, which helps to improve crop yield and quality, and reduce the negative impact on the environment.
In the field of materials science, 5-bromo-2-chlorofluorobenzene has also emerged. It can be used to prepare polymer materials with special properties. Through clever polymerization, it is introduced into the polymer chain segment, giving the material special properties such as excellent heat resistance, chemical corrosion resistance or optical properties. These materials may be used in high-end fields such as electronic devices, aerospace, etc., to meet the strict requirements of material properties in specific environments.
5-Bromo-2-chlorofluorobenzene has shown extremely important application value in many fields such as medicine, pesticides and materials science due to its unique chemical structure, providing a key material foundation and innovation possibility for technological innovation and Product Research & Development in various fields.
What are the physical properties of 5-bromo-2-chlorofluorobenzene?
5-Bromo-2-chlorofluorobenzene is one of the organic compounds. Its physical properties are particularly important, related to its application and reaction characteristics.
First of all, under normal temperature and pressure, 5-bromo-2-chlorofluorobenzene is often colorless to light yellow liquid. The appearance is clear and has a special smell. Although this smell is not strong and pungent, it is still recognizable to a certain extent.
When it comes to the boiling point, it is about 190-200 ° C. The boiling point is the temperature limit at which a substance changes from liquid to gas. This boiling point indicates that in order to gasify it, it needs to be added to the corresponding high temperature. Such a boiling point can be used as a reference for temperature control in many organic synthesis reactions, so that the reaction can be carried out under suitable conditions, or used to separate and purify this compound.
In terms of melting point, it is about -30 ° C. The melting point is the temperature at which a substance melts from a solid state to a liquid state. The lower melting point allows it to maintain a liquid state in a common low temperature environment. In actual operation, it is easy to access and participate in the reaction.
The density of 5-bromo-2-chlorofluorobenzene is about 1.8-1.9 g/cm ³. The density value reflects the mass per unit volume. This density is greater than that of water, so if placed in water, it will sink to the bottom. This property can be used in some operations involving liquid-liquid separation.
Solubility is also an important physical property. It is slightly soluble in water, but it has good solubility in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is of great significance in the fields of organic synthesis and analysis and testing. In organic synthesis, a suitable organic solvent can be selected to fully dissolve it and come into full contact with other reactants to facilitate the smooth progress of the reaction; in analysis and testing, an appropriate solvent can be selected according to its solubility for sample preparation and processing.
In summary, the physical properties of 5-bromo-2-chlorofluorobenzene, such as their properties, boiling point, melting point, density, and solubility, are interrelated and together determine their application and operation in the chemical field.
First of all, under normal temperature and pressure, 5-bromo-2-chlorofluorobenzene is often colorless to light yellow liquid. The appearance is clear and has a special smell. Although this smell is not strong and pungent, it is still recognizable to a certain extent.
When it comes to the boiling point, it is about 190-200 ° C. The boiling point is the temperature limit at which a substance changes from liquid to gas. This boiling point indicates that in order to gasify it, it needs to be added to the corresponding high temperature. Such a boiling point can be used as a reference for temperature control in many organic synthesis reactions, so that the reaction can be carried out under suitable conditions, or used to separate and purify this compound.
In terms of melting point, it is about -30 ° C. The melting point is the temperature at which a substance melts from a solid state to a liquid state. The lower melting point allows it to maintain a liquid state in a common low temperature environment. In actual operation, it is easy to access and participate in the reaction.
The density of 5-bromo-2-chlorofluorobenzene is about 1.8-1.9 g/cm ³. The density value reflects the mass per unit volume. This density is greater than that of water, so if placed in water, it will sink to the bottom. This property can be used in some operations involving liquid-liquid separation.
Solubility is also an important physical property. It is slightly soluble in water, but it has good solubility in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic is of great significance in the fields of organic synthesis and analysis and testing. In organic synthesis, a suitable organic solvent can be selected to fully dissolve it and come into full contact with other reactants to facilitate the smooth progress of the reaction; in analysis and testing, an appropriate solvent can be selected according to its solubility for sample preparation and processing.
In summary, the physical properties of 5-bromo-2-chlorofluorobenzene, such as their properties, boiling point, melting point, density, and solubility, are interrelated and together determine their application and operation in the chemical field.
What are the chemical properties of 5-bromo-2-chlorofluorobenzene?
5-Bromo-2-chlorofluorobenzene is one of the organic compounds. It has the characteristics of halogenated aromatics, and its chemical properties are very interesting.
First of all, its reactivity, due to the presence of bromine, chlorine and fluorine halogen atoms on the benzene ring, causes it to have a tendency to nucleophilic substitution reaction. Compared with chlorine and fluorine, bromine is relatively easy to leave. Under appropriate nucleophilic reagents and reaction conditions, nucleophilic reagents can attack the benzene ring and replace bromine atoms. For example, in case of alcohol salt nucleophilic reagents, corresponding ether compounds may be formed; in case of amine nucleophilic reagents, nitrogen-containing substitutes may be formed.
Furthermore, it also has a unique performance in the aromatic electrophilic substitution reaction. Although the halogen atom on the benzene ring is an blunt group, such a reaction can still occur under certain conditions. Due to the positioning effect of halogen atoms, the newly introduced electrophilic groups will mostly enter the adjacent and para-sites of halogen atoms. For example, during nitrification, the nitro group may mainly enter the ortho-site of the fluorine atom and the para-site of the bromine atom, which is caused by the effect of halogen atoms on the electron cloud density distribution of the benzene ring.
In addition, the physical properties of 5-bromo-2-chlorofluorobenzene are also related to its chemical properties. It is a halogenated aromatic hydrocarbon with a relatively large molecular weight and strong intermolecular force, so the melting boiling point may be higher than that of ordinary benzene derivatives. And due to the difference in electronegativity of halogen atoms in the molecule, the molecule has a certain polarity and should have good solubility in organic solvents.
In short, the structural combination of 5-bromo-2-chlorofluorobenzene benzene ring and halogen atom exhibits diverse chemical properties and may have important uses in organic synthesis and other fields. It can also be used as a key intermediate in the synthesis of complex organic compounds.
First of all, its reactivity, due to the presence of bromine, chlorine and fluorine halogen atoms on the benzene ring, causes it to have a tendency to nucleophilic substitution reaction. Compared with chlorine and fluorine, bromine is relatively easy to leave. Under appropriate nucleophilic reagents and reaction conditions, nucleophilic reagents can attack the benzene ring and replace bromine atoms. For example, in case of alcohol salt nucleophilic reagents, corresponding ether compounds may be formed; in case of amine nucleophilic reagents, nitrogen-containing substitutes may be formed.
Furthermore, it also has a unique performance in the aromatic electrophilic substitution reaction. Although the halogen atom on the benzene ring is an blunt group, such a reaction can still occur under certain conditions. Due to the positioning effect of halogen atoms, the newly introduced electrophilic groups will mostly enter the adjacent and para-sites of halogen atoms. For example, during nitrification, the nitro group may mainly enter the ortho-site of the fluorine atom and the para-site of the bromine atom, which is caused by the effect of halogen atoms on the electron cloud density distribution of the benzene ring.
In addition, the physical properties of 5-bromo-2-chlorofluorobenzene are also related to its chemical properties. It is a halogenated aromatic hydrocarbon with a relatively large molecular weight and strong intermolecular force, so the melting boiling point may be higher than that of ordinary benzene derivatives. And due to the difference in electronegativity of halogen atoms in the molecule, the molecule has a certain polarity and should have good solubility in organic solvents.
In short, the structural combination of 5-bromo-2-chlorofluorobenzene benzene ring and halogen atom exhibits diverse chemical properties and may have important uses in organic synthesis and other fields. It can also be used as a key intermediate in the synthesis of complex organic compounds.
What are 5-bromo-2-chlorofluorobenzene synthesis methods?
5-Bromo-2-chlorofluorobenzene is also an important intermediate in organic synthesis. The synthesis method depends on various reactions in organic chemistry. The following are the common ones.
First, it is based on the nucleophilic substitution reaction of halogenated aromatics. You can first take suitable halogenated benzene, such as 2-chloro-5-nitrofluorobenzene, and nitrate it into an amino group through a reduction system such as iron powder and hydrochloric acid to obtain 2-chloro-5-aminofluorobenzene. Then, with cuprous bromide, hydrogen bromide and sodium nitrite, the diazotization-bromine reaction can be carried out, and bromine atoms can be introduced to obtain 5-bromo-2-chlorofluorobenzene. This path step is slightly complicated, but each step is more controllable and the yield can be guaranteed.
Second, the Fourier-gram reaction is used as the starting point. Using fluorobenzene as the substrate, under the catalysis of Lewis acid such as aluminum trichloride, the Fourier-gram acylation reaction is carried out with bromoacetyl chloride to obtain the para-brominated acylation product. Then by Clemson reduction and other methods, the carbonyl group is reduced to methylene, and then under suitable conditions, chlorine atoms are introduced, which can be reacted by chlorinated reagents such as N-chlorosuccinimide (NCS) in the presence of light or initiator to obtain the target product. The key to this method lies in the localization selectivity of the Fu-gram reaction, and the reaction conditions must be carefully controlled.
Third, use the Grignard reagent method. First, 2-chlorofluorobenzene and magnesium chips are prepared in anhydrous ether and other solvents to make Grignard reagent, and then react with brominated reagents, such as copper bromide, which can directly introduce bromine atoms to obtain 5-bromo-2-chlorofluorobenzene. This approach is simple, but Grignard's reagent has strict requirements on the reaction environment, and must be anhydrous and oxygen-free. If the operation is not careful, the yield will be affected.
All synthesis methods have advantages and disadvantages. In practical applications, the optimal method is selected to synthesize according to the availability of raw materials, the ease of control of reaction conditions, and the purity and yield of the target product.
First, it is based on the nucleophilic substitution reaction of halogenated aromatics. You can first take suitable halogenated benzene, such as 2-chloro-5-nitrofluorobenzene, and nitrate it into an amino group through a reduction system such as iron powder and hydrochloric acid to obtain 2-chloro-5-aminofluorobenzene. Then, with cuprous bromide, hydrogen bromide and sodium nitrite, the diazotization-bromine reaction can be carried out, and bromine atoms can be introduced to obtain 5-bromo-2-chlorofluorobenzene. This path step is slightly complicated, but each step is more controllable and the yield can be guaranteed.
Second, the Fourier-gram reaction is used as the starting point. Using fluorobenzene as the substrate, under the catalysis of Lewis acid such as aluminum trichloride, the Fourier-gram acylation reaction is carried out with bromoacetyl chloride to obtain the para-brominated acylation product. Then by Clemson reduction and other methods, the carbonyl group is reduced to methylene, and then under suitable conditions, chlorine atoms are introduced, which can be reacted by chlorinated reagents such as N-chlorosuccinimide (NCS) in the presence of light or initiator to obtain the target product. The key to this method lies in the localization selectivity of the Fu-gram reaction, and the reaction conditions must be carefully controlled.
Third, use the Grignard reagent method. First, 2-chlorofluorobenzene and magnesium chips are prepared in anhydrous ether and other solvents to make Grignard reagent, and then react with brominated reagents, such as copper bromide, which can directly introduce bromine atoms to obtain 5-bromo-2-chlorofluorobenzene. This approach is simple, but Grignard's reagent has strict requirements on the reaction environment, and must be anhydrous and oxygen-free. If the operation is not careful, the yield will be affected.
All synthesis methods have advantages and disadvantages. In practical applications, the optimal method is selected to synthesize according to the availability of raw materials, the ease of control of reaction conditions, and the purity and yield of the target product.
5-bromo-2-chlorofluorobenzene What are the precautions during storage and transportation?
5-Bromo-2-chlorofluorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
When storing, choose the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because it has certain chemical activity, high temperature or open flame is prone to danger. The temperature of the warehouse should be controlled within an appropriate range. Generally speaking, it is safer at room temperature, but it should not be in contact with overheated or overcooled environments.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored in mixed storage. The chemical properties of 5-bromo-2-chlorofluorobenzene determine that it interacts with other chemicals or causes violent reactions, such as encounters with oxidants, or the risk of combustion or explosion.
Packaging is also crucial. Appropriate packaging materials must be used to ensure good sealing to prevent leakage. Common packaging may be glass bottles, reinforced with wooden boxes or plastic drums to resist external impact and protect their integrity.
When transporting, comply with relevant regulations and standards. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, drivers should be cautious and avoid violent actions such as sudden braking and sharp turns to prevent damage to the packaging.
During transportation, also pay attention to weather changes. In case of hot weather, it is advisable to take necessary cooling measures; in rainy and wet weather, it is necessary to ensure that the packaging is not damp and protected from flooding.
Escort personnel are also indispensable. They need to pay attention to the status of the goods at all times. If there is any abnormality, they should be disposed of immediately. In short, the storage and transportation of 5-bromo-2-chlorofluorobenzene is related to safety and quality. All links should not be ignored. It must be operated in strict accordance with regulations to keep it safe.
When storing, choose the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because it has certain chemical activity, high temperature or open flame is prone to danger. The temperature of the warehouse should be controlled within an appropriate range. Generally speaking, it is safer at room temperature, but it should not be in contact with overheated or overcooled environments.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be stored in mixed storage. The chemical properties of 5-bromo-2-chlorofluorobenzene determine that it interacts with other chemicals or causes violent reactions, such as encounters with oxidants, or the risk of combustion or explosion.
Packaging is also crucial. Appropriate packaging materials must be used to ensure good sealing to prevent leakage. Common packaging may be glass bottles, reinforced with wooden boxes or plastic drums to resist external impact and protect their integrity.
When transporting, comply with relevant regulations and standards. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, drivers should be cautious and avoid violent actions such as sudden braking and sharp turns to prevent damage to the packaging.
During transportation, also pay attention to weather changes. In case of hot weather, it is advisable to take necessary cooling measures; in rainy and wet weather, it is necessary to ensure that the packaging is not damp and protected from flooding.
Escort personnel are also indispensable. They need to pay attention to the status of the goods at all times. If there is any abnormality, they should be disposed of immediately. In short, the storage and transportation of 5-bromo-2-chlorofluorobenzene is related to safety and quality. All links should not be ignored. It must be operated in strict accordance with regulations to keep it safe.
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