Linshang Chemical
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5-Bromo-2-(Chloromethyl)-1,3-Difluorobenzene
Linshang Chemical
|
HS Code |
942278 |
| Chemical Formula | C7H4BrClF2 |
| Molecular Weight | 241.46 |
| Appearance | Typically a colorless to light - colored liquid |
| Boiling Point | Data may vary, around a certain temperature range depending on purity |
| Melting Point | Specific value depending on purity and other factors |
| Density | Characteristic value, in g/cm³ |
| Solubility | Solubility in common organic solvents like dichloromethane, toluene etc. varies |
| Flash Point | A specific temperature indicating flammability risk |
| Vapor Pressure | Value related to its volatility |
| Refractive Index | A value representing how light is bent when passing through it |
As an accredited 5-Bromo-2-(Chloromethyl)-1,3-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - bromo - 2 - (chloromethyl)-1,3 - difluorobenzene in 1 kg bottles for packaging. |
| Storage | 5 - bromo - 2 - (chloromethyl)-1,3 - difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. |
| Shipping | 5 - bromo - 2 - (chloromethyl)-1,3 - difluorobenzene is shipped in specialized, well - sealed containers. These are designed to prevent leakage, safeguarding its hazardous chemical nature during transit to ensure safety. |
Competitive 5-Bromo-2-(Chloromethyl)-1,3-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-Bromo-2-(Chloromethyl)-1,3-Difluorobenzene in China?
As a trusted 5-Bromo-2-(Chloromethyl)-1,3-Difluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 5-Bromo-2-(Chloromethyl)-1,3-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 5-bromo-2- (chloromethyl) -1,3-difluorobenzene?
5-Bromo-2- (methoxymethyl) -1,3-dioxane is an important intermediate in organic synthesis and has important uses in many fields, as follows:
1. ** Drug synthesis field **: It can be used as a key intermediate to prepare a variety of drugs. Because the molecule contains specific functional groups, it can participate in various chemical reactions, and the active structure of the drug can be constructed by chemical modification. For example, in the synthesis of some antiviral drugs, 5-bromo-2- (methoxymethyl) -1,3-dioxacyclopentane can be used as a starting material, and through a series of reactions, other key groups can be introduced, and finally compounds with antiviral activity are obtained. Such antiviral drugs are of great significance for resisting viral infections and treating diseases caused by viruses. Or in the development and synthesis path of some anti-tumor drugs, it may also serve as an important intermediate to help build drug molecular structures that can target tumor cells and inhibit tumor growth and spread.
2. ** Materials Science **: In the preparation of special functional materials, 5-bromo-2 - (methoxymethyl) -1,3-dioxane can play a unique role. When preparing organic materials with special optical or electrical properties, it can be introduced into the polymer system as a structural unit. By carefully designing and regulating the reaction conditions, it can polymerize with other monomers to form polymeric materials with specific microstructure and macroscopic properties. Such materials can be used in optoelectronic devices, such as organic Light Emitting Diode (OLED), which gives devices better luminous efficiency, stability and color performance with its special structure; or used to prepare materials with special electrical conductivity, finding applications in the field of electronic devices.
3. ** Organic Synthetic Chemistry Research **: As an important intermediate, 5-bromo-2 - (methoxymethyl) -1,3-dioxane provides organic synthetic chemists with rich reaction possibilities. Its diverse functional groups can participate in a variety of organic reactions such as nucleophilic substitution, electrophilic addition, and redox, providing convenience for the synthesis of organic compounds with complex structures and special functions. Chemists can use it as a starting point and use different reaction strategies and conditions to explore the synthesis of novel organic molecules, enrich the types and structures of organic compounds, promote the development of organic synthetic chemistry, and lay the foundation for downstream fields such as new material research and development and drug creation.
1. ** Drug synthesis field **: It can be used as a key intermediate to prepare a variety of drugs. Because the molecule contains specific functional groups, it can participate in various chemical reactions, and the active structure of the drug can be constructed by chemical modification. For example, in the synthesis of some antiviral drugs, 5-bromo-2- (methoxymethyl) -1,3-dioxacyclopentane can be used as a starting material, and through a series of reactions, other key groups can be introduced, and finally compounds with antiviral activity are obtained. Such antiviral drugs are of great significance for resisting viral infections and treating diseases caused by viruses. Or in the development and synthesis path of some anti-tumor drugs, it may also serve as an important intermediate to help build drug molecular structures that can target tumor cells and inhibit tumor growth and spread.
2. ** Materials Science **: In the preparation of special functional materials, 5-bromo-2 - (methoxymethyl) -1,3-dioxane can play a unique role. When preparing organic materials with special optical or electrical properties, it can be introduced into the polymer system as a structural unit. By carefully designing and regulating the reaction conditions, it can polymerize with other monomers to form polymeric materials with specific microstructure and macroscopic properties. Such materials can be used in optoelectronic devices, such as organic Light Emitting Diode (OLED), which gives devices better luminous efficiency, stability and color performance with its special structure; or used to prepare materials with special electrical conductivity, finding applications in the field of electronic devices.
3. ** Organic Synthetic Chemistry Research **: As an important intermediate, 5-bromo-2 - (methoxymethyl) -1,3-dioxane provides organic synthetic chemists with rich reaction possibilities. Its diverse functional groups can participate in a variety of organic reactions such as nucleophilic substitution, electrophilic addition, and redox, providing convenience for the synthesis of organic compounds with complex structures and special functions. Chemists can use it as a starting point and use different reaction strategies and conditions to explore the synthesis of novel organic molecules, enrich the types and structures of organic compounds, promote the development of organic synthetic chemistry, and lay the foundation for downstream fields such as new material research and development and drug creation.
What are the physical properties of 5-bromo-2- (chloromethyl) -1,3-difluorobenzene
5-Bromo-2- (methoxymethyl) -1,3-dialkane is an organic compound with unique physical properties. It is usually liquid at room temperature, which is determined by intermolecular forces and structural characteristics.
Looking at its solubility, 5-bromo-2- (methoxymethyl) -1,3-dialkane can be dissolved in some organic solvents, such as common ether, dichloromethane, etc. This is because the molecular structure of the compound has a similar polarity to these organic solvents, and according to the principle of "similar miscibility", it can be miscible with each other. However, in water, its solubility is not good, because although there are some oxygenated compounds in the molecule, the overall polarity is not enough to form a good interaction with water.
When it comes to the boiling point, the boiling point of 5-bromo-2- (methoxymethyl) -1,3-dioxane is quite high. Due to the existence of various forces within the molecule, such as van der Waals forces, dipole-dipole interactions, etc., in order to transform it from a liquid state to a gaseous state, more energy is required to overcome these forces, resulting in an increase in the boiling point. Specifically, the presence of bromine atoms in the molecule increases the asymmetry of the mass of the molecule and the distribution of electron clouds, enhances the intermolecular forces, and further increases the boiling point.
The density of 5-bromo-2- (methoxymethyl) -1,3-dioxane also has its own characteristics, which may be different from that of water. This is related to the mass of the molecule and the way the molecule is deposited. The molecular structure makes the mass contained in the unit volume different from water, showing a specific density value.
In addition, the volatility of 5-bromo-2- (methoxymethyl) -1,3-dialkane is relatively moderate. Although it is not a highly volatile substance, under suitable conditions, some molecules can still overcome intermolecular forces and enter the gas phase. This is not only related to the boiling point, but also related to environmental temperature, pressure and other factors. At room temperature and pressure, its volatilization rate is relatively stable, neither too fast volatilization nor completely non-volatilization.
Looking at its solubility, 5-bromo-2- (methoxymethyl) -1,3-dialkane can be dissolved in some organic solvents, such as common ether, dichloromethane, etc. This is because the molecular structure of the compound has a similar polarity to these organic solvents, and according to the principle of "similar miscibility", it can be miscible with each other. However, in water, its solubility is not good, because although there are some oxygenated compounds in the molecule, the overall polarity is not enough to form a good interaction with water.
When it comes to the boiling point, the boiling point of 5-bromo-2- (methoxymethyl) -1,3-dioxane is quite high. Due to the existence of various forces within the molecule, such as van der Waals forces, dipole-dipole interactions, etc., in order to transform it from a liquid state to a gaseous state, more energy is required to overcome these forces, resulting in an increase in the boiling point. Specifically, the presence of bromine atoms in the molecule increases the asymmetry of the mass of the molecule and the distribution of electron clouds, enhances the intermolecular forces, and further increases the boiling point.
The density of 5-bromo-2- (methoxymethyl) -1,3-dioxane also has its own characteristics, which may be different from that of water. This is related to the mass of the molecule and the way the molecule is deposited. The molecular structure makes the mass contained in the unit volume different from water, showing a specific density value.
In addition, the volatility of 5-bromo-2- (methoxymethyl) -1,3-dialkane is relatively moderate. Although it is not a highly volatile substance, under suitable conditions, some molecules can still overcome intermolecular forces and enter the gas phase. This is not only related to the boiling point, but also related to environmental temperature, pressure and other factors. At room temperature and pressure, its volatilization rate is relatively stable, neither too fast volatilization nor completely non-volatilization.
What are the synthesis methods of 5-bromo-2- (chloromethyl) -1,3-difluorobenzene?
There are various methods for preparing 5-bromo-2- (methoxymethyl) -1,3-dialkane. Common ones include the following:
First, a compound containing the corresponding functional group is used as the starting material and bromine atoms are introduced through a halogenation reaction. You can first take a 1,3-dialkane derivative with a suitable substituent, which, under specific conditions, interacts with brominating reagents such as hydrogen bromide, N-bromosuccinimide (NBS), etc. If hydrogen bromide is used, it is heated or illuminated in a suitable solvent such as dichloromethane and carbon tetrachloride to promote an electrophilic substitution reaction, so that bromine atoms replace hydrogen atoms at the target position, and then the product is obtained.
Second, it can be done by the strategy of constructing 1,3-dialkane ring. Appropriate alcohol and aldehyde or ketone can be selected, and under the catalysis of acidic catalysts such as p-toluenesulfonic acid, condensation forms 1,3-dialkane ring. At the same time, if the starting material already contains bromine atoms and methoxy methyl-related substituents, or after cyclization, it can be precisely introduced through subsequent reactions, and the functional groups can be adjusted through a series of reactions, and finally 5-bromo-2- (methoxy methyl) -1,3-dialkane can be obtained.
Third, the reaction is participated by organometallic reagents. For example, a bromine-containing organometallic reagent, such as Grignard reagent or organolithium reagent, is reacted with a compound containing methoxy methyl and suitable carbonyl groups, and the structure of the target product is constructed through steps such as addition and cyclization. The reaction needs to be carried out in an anhydrous and oxygen-free inert gas protective atmosphere to ensure the activity and smooth reaction of organometallic reagents.
The above methods have advantages and disadvantages. In actual synthesis, the optimal route should be selected according to factors such as the availability of raw materials, the difficulty of reaction conditions, the yield and the number of side reactions. To efficiently prepare 5-bromo-2 - (methoxy methyl) -1,3-dialkane.
First, a compound containing the corresponding functional group is used as the starting material and bromine atoms are introduced through a halogenation reaction. You can first take a 1,3-dialkane derivative with a suitable substituent, which, under specific conditions, interacts with brominating reagents such as hydrogen bromide, N-bromosuccinimide (NBS), etc. If hydrogen bromide is used, it is heated or illuminated in a suitable solvent such as dichloromethane and carbon tetrachloride to promote an electrophilic substitution reaction, so that bromine atoms replace hydrogen atoms at the target position, and then the product is obtained.
Second, it can be done by the strategy of constructing 1,3-dialkane ring. Appropriate alcohol and aldehyde or ketone can be selected, and under the catalysis of acidic catalysts such as p-toluenesulfonic acid, condensation forms 1,3-dialkane ring. At the same time, if the starting material already contains bromine atoms and methoxy methyl-related substituents, or after cyclization, it can be precisely introduced through subsequent reactions, and the functional groups can be adjusted through a series of reactions, and finally 5-bromo-2- (methoxy methyl) -1,3-dialkane can be obtained.
Third, the reaction is participated by organometallic reagents. For example, a bromine-containing organometallic reagent, such as Grignard reagent or organolithium reagent, is reacted with a compound containing methoxy methyl and suitable carbonyl groups, and the structure of the target product is constructed through steps such as addition and cyclization. The reaction needs to be carried out in an anhydrous and oxygen-free inert gas protective atmosphere to ensure the activity and smooth reaction of organometallic reagents.
The above methods have advantages and disadvantages. In actual synthesis, the optimal route should be selected according to factors such as the availability of raw materials, the difficulty of reaction conditions, the yield and the number of side reactions. To efficiently prepare 5-bromo-2 - (methoxy methyl) -1,3-dialkane.
What are the precautions for storing and transporting 5-bromo-2- (chloromethyl) -1,3-difluorobenzene?
5-Bromo-2- (methoxymethyl) -1,3-dioxane must pay attention to the following things when storing and transporting:
First, it is related to packaging. The packaging of this substance must be tight to prevent leakage. It is advisable to choose packaging materials that meet relevant standards, such as glass bottles, plastic drums with good sealing, etc., and the name, characteristics, warning labels and other information of the substance should be clearly marked on the outside of the package, so that users and transporters can see at a glance and take precautions in advance.
Second, the control of temperature and humidity. The substance is quite sensitive to temperature and humidity, and should be stored in a cool and dry place. High temperature can easily cause its volatilization to accelerate, and even cause chemical reactions; if the humidity is too high, it may cause the substance to deteriorate under moisture, affecting its quality and performance. Therefore, in the warehouse, when installing temperature and humidity control equipment to maintain the temperature within a suitable range, the humidity also needs to be strictly controlled.
Third, avoid contact with contraindicated substances. 5-Bromo-2- (methoxy methyl) -1,3-dialkane should not coexist with strong oxidants, strong bases and other substances. Because of its active chemical nature, strong oxidants are prone to violent oxidation reactions, or cause danger such as combustion and explosion; strong alkalis may also cause chemical reactions, causing the substance to deteriorate and even produce harmful products. When the warehouse is stored, it must be stored in partitions and set up obvious isolation signs.
Fourth, the transportation process is stable. During transportation, the vehicle should run smoothly to avoid severe bumps and vibrations to prevent packaging damage. At the same time, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment, such as fire extinguishers, leakage emergency treatment tools, etc. If a leak occurs unfortunately, the driver and passenger can properly handle it in time to reduce the harm.
Fifth, personnel protection. Those involved in storage and transportation must wear appropriate protective equipment, such as protective gloves, protective glasses, protective clothing, etc., to prevent substances from contacting the skin and eyes and causing damage. And the staff should be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, and able to respond calmly in case of emergencies.
First, it is related to packaging. The packaging of this substance must be tight to prevent leakage. It is advisable to choose packaging materials that meet relevant standards, such as glass bottles, plastic drums with good sealing, etc., and the name, characteristics, warning labels and other information of the substance should be clearly marked on the outside of the package, so that users and transporters can see at a glance and take precautions in advance.
Second, the control of temperature and humidity. The substance is quite sensitive to temperature and humidity, and should be stored in a cool and dry place. High temperature can easily cause its volatilization to accelerate, and even cause chemical reactions; if the humidity is too high, it may cause the substance to deteriorate under moisture, affecting its quality and performance. Therefore, in the warehouse, when installing temperature and humidity control equipment to maintain the temperature within a suitable range, the humidity also needs to be strictly controlled.
Third, avoid contact with contraindicated substances. 5-Bromo-2- (methoxy methyl) -1,3-dialkane should not coexist with strong oxidants, strong bases and other substances. Because of its active chemical nature, strong oxidants are prone to violent oxidation reactions, or cause danger such as combustion and explosion; strong alkalis may also cause chemical reactions, causing the substance to deteriorate and even produce harmful products. When the warehouse is stored, it must be stored in partitions and set up obvious isolation signs.
Fourth, the transportation process is stable. During transportation, the vehicle should run smoothly to avoid severe bumps and vibrations to prevent packaging damage. At the same time, the transportation vehicle should be equipped with corresponding emergency treatment equipment and protective equipment, such as fire extinguishers, leakage emergency treatment tools, etc. If a leak occurs unfortunately, the driver and passenger can properly handle it in time to reduce the harm.
Fifth, personnel protection. Those involved in storage and transportation must wear appropriate protective equipment, such as protective gloves, protective glasses, protective clothing, etc., to prevent substances from contacting the skin and eyes and causing damage. And the staff should be professionally trained, familiar with the characteristics of the substance and emergency treatment methods, and able to respond calmly in case of emergencies.
What is the market price of 5-bromo-2- (chloromethyl) -1,3-difluorobenzene?
5-% alcohol-2- (chloromethyl) -1,3-diethyl ether. The price of this product varies according to time, place and quality in the market.
When it comes to the factors that affect the price, the cost of the raw material is the first. The price fluctuation of the raw material required for the preparation of this compound has a great impact on the selling price of 5-% alcohol-2- (chloromethyl) -1,3-diethyl ether. If the price of the finished product rises due to the lack of raw materials or the surge in market demand, the price of the finished product will also rise.
Secondly, the production process and cost are also key. Sophisticated and efficient production processes can reduce energy consumption and yield, thereby controlling costs. If the process is complicated or special equipment and conditions are required, the production cost will increase, and the price of the product in the market will also increase accordingly.
Furthermore, the supply and demand relationship in the market determines the price. If the market demand for this product is strong and the supply is limited, if the downstream industry purchases in large quantities, the price will tend to rise; on the contrary, if the supply exceeds the demand, the manufacturer may reduce the price in order to reduce the inventory.
In addition, factors such as regulations and policies, transportation costs cannot be ignored. Stricter environmental protection policies may cause manufacturers to increase environmental protection inputs and push up costs; the distance of transportation and the fluctuation of oil prices will affect transportation costs and indirectly affect the market price of products.
Therefore, in order to know the exact market price of 5-% alcohol-2- (chloromethyl) -1,3-diethyl ether, it is necessary to consider the above factors in real time, and consult the industry merchants, market survey agencies, or refer to the latest quotations of relevant trading platforms in order to obtain more accurate price information.
When it comes to the factors that affect the price, the cost of the raw material is the first. The price fluctuation of the raw material required for the preparation of this compound has a great impact on the selling price of 5-% alcohol-2- (chloromethyl) -1,3-diethyl ether. If the price of the finished product rises due to the lack of raw materials or the surge in market demand, the price of the finished product will also rise.
Secondly, the production process and cost are also key. Sophisticated and efficient production processes can reduce energy consumption and yield, thereby controlling costs. If the process is complicated or special equipment and conditions are required, the production cost will increase, and the price of the product in the market will also increase accordingly.
Furthermore, the supply and demand relationship in the market determines the price. If the market demand for this product is strong and the supply is limited, if the downstream industry purchases in large quantities, the price will tend to rise; on the contrary, if the supply exceeds the demand, the manufacturer may reduce the price in order to reduce the inventory.
In addition, factors such as regulations and policies, transportation costs cannot be ignored. Stricter environmental protection policies may cause manufacturers to increase environmental protection inputs and push up costs; the distance of transportation and the fluctuation of oil prices will affect transportation costs and indirectly affect the market price of products.
Therefore, in order to know the exact market price of 5-% alcohol-2- (chloromethyl) -1,3-diethyl ether, it is necessary to consider the above factors in real time, and consult the industry merchants, market survey agencies, or refer to the latest quotations of relevant trading platforms in order to obtain more accurate price information.
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