Linshang Chemical
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5-Bromo-3-Chloro-2-Fluoro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
398650 |
| Chemical Formula | C6H2BrClFNO2 |
| Molecular Weight | 257.44 |
| Appearance | Solid (predicted) |
| Boiling Point | 258.7 °C at 760 mmHg (predicted) |
| Melting Point | 64 - 66 °C |
| Density | 1.919 g/cm³ (predicted) |
| Vapor Pressure | 0.0145 mmHg at 25 °C (predicted) |
| Logp | 3.49 (predicted) |
| Solubility | Insoluble in water (predicted) |
| Flash Point | 110.2 °C (predicted) |
As an accredited 5-Bromo-3-Chloro-2-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 5 - bromo - 3 - chloro - 2 - fluoro - 1 - nitrobenzene in a sealed chemical - grade bottle. |
| Storage | 5 - bromo - 3 - chloro - 2 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air or moisture, which could potentially cause decomposition or reactions. |
| Shipping | 5 - bromo - 3 - chloro - 2 - fluoro - 1 - nitrobenzene, a hazardous chemical, is shipped in sealed, corrosion - resistant containers. Special handling procedures are followed to ensure compliance with safety regulations during transport. |
Competitive 5-Bromo-3-Chloro-2-Fluoro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 5-Bromo-3-Chloro-2-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 5-bromo-3-chloro-2-fluoro-1-nitrobenzene?
The physical properties of 5-hydroxyl-3-amine-2-ene-1-carbonyl indole are particularly important. At room temperature, this substance is mostly in a solid state, with a fine texture and a specific crystal shape. It may appear white to light yellow powder or crystalline. It has a soft luster, just like the essence of precipitation over time.
Its melting point is quite unique, about a specific temperature range. The value of this melting point is the key to identify this substance. When heated near the melting point, the substance gradually melts from solid to liquid. This phase transition process is like ice and snow meeting the spring sun, quietly changing the shape.
Furthermore, the solubility of this substance also has characteristics. The degree of solubility in water is limited, and it is difficult to completely blend with water. However, in organic solvents, such as ethanol and ether, it can show good solubility, just like a wanderer returning home and finding a suitable place. This difference in solubility is a factor that needs to be carefully considered when separating, purifying, and preparing related preparations.
Its density is also an important physical property. Although the specific value varies depending on the precise measurement conditions, it is roughly within a given range. This density property plays an indispensable role in the storage, transportation, and participation of various chemical reactions in the process of substances.
In addition, the stability of this substance to light and heat is also worthy of attention. In places with sufficient light or long-term heating environment, its structure may change, and this stability is like its inherent nature, which determines its existence form and chemical activity in different environments.
All these physical properties are intertwined, and together outline the unique "portrait" of 5-hydroxyl-3-amine-2-ene-1-carbonyl indole, which has laid a solid foundation for its research and application in many fields.
Its melting point is quite unique, about a specific temperature range. The value of this melting point is the key to identify this substance. When heated near the melting point, the substance gradually melts from solid to liquid. This phase transition process is like ice and snow meeting the spring sun, quietly changing the shape.
Furthermore, the solubility of this substance also has characteristics. The degree of solubility in water is limited, and it is difficult to completely blend with water. However, in organic solvents, such as ethanol and ether, it can show good solubility, just like a wanderer returning home and finding a suitable place. This difference in solubility is a factor that needs to be carefully considered when separating, purifying, and preparing related preparations.
Its density is also an important physical property. Although the specific value varies depending on the precise measurement conditions, it is roughly within a given range. This density property plays an indispensable role in the storage, transportation, and participation of various chemical reactions in the process of substances.
In addition, the stability of this substance to light and heat is also worthy of attention. In places with sufficient light or long-term heating environment, its structure may change, and this stability is like its inherent nature, which determines its existence form and chemical activity in different environments.
All these physical properties are intertwined, and together outline the unique "portrait" of 5-hydroxyl-3-amine-2-ene-1-carbonyl indole, which has laid a solid foundation for its research and application in many fields.
What are the chemical properties of 5-bromo-3-chloro-2-fluoro-1-nitrobenzene?
5-Hydroxy-3-mercapto-2-ene-1-carbonylbenzene is an organic compound with rich and diverse chemical properties.
This substance is acidic because it contains hydroxyl groups. The oxygen atoms in the hydroxyl groups are highly electronegative, and the hydrogen-oxygen bond electron pairs are biased towards oxygen, making hydrogen easy to dissociate in the form of protons, so it can neutralize with bases. For example, it reacts with sodium hydroxide to generate the corresponding sodium salt and water.
Its ethylenically bond properties are active and can be added to the reaction. Taking bromine water as an example, the double bond on the ethylenically bond is broken, and the bromine atoms are added to the carbon atoms at both ends of the double bond to fade the bromine water. This is a common method for testing the carbon-carbon double bond. At the same time, under appropriate catalysts and conditions, it can also undergo an addition reaction with hydrogen, and the ethylenically bond is converted into a single bond to form a saturated compound.
The thiol group has strong reductivity and is easy to be oxidized. In case of strong oxidants such as potassium permanganate, the thiol group will be oxidized to higher valence sulfur-containing groups such as sulfonic acid groups. In addition, the thiol group can form stable complexes with some metal ions, such as combining with mercury ions to form insoluble precipitation, which can be used to detect and remove mercury ions in the environment.
Carbonyl group acts as an electron-withdrawing group, making the carbon atoms connected to it partially positively charged, vulnerable to nucleophilic attack, and nucleophilic addition reaction occurs. For example, under acid catalysis with alcohols, oxygen atoms in alcohols attack carbonyl carbon atoms as nucleophiles to form hemiacetal or acetal structures.
In summary, 5-hydroxyl-3-mercapto-2-ene-1-carbonylphenyl contains a variety of functional groups, exhibiting rich chemical properties such as acidic, addition, redox, and nucleophilic addition, which have potential applications in many fields such as organic synthesis, pharmaceutical chemistry, and materials science.
This substance is acidic because it contains hydroxyl groups. The oxygen atoms in the hydroxyl groups are highly electronegative, and the hydrogen-oxygen bond electron pairs are biased towards oxygen, making hydrogen easy to dissociate in the form of protons, so it can neutralize with bases. For example, it reacts with sodium hydroxide to generate the corresponding sodium salt and water.
Its ethylenically bond properties are active and can be added to the reaction. Taking bromine water as an example, the double bond on the ethylenically bond is broken, and the bromine atoms are added to the carbon atoms at both ends of the double bond to fade the bromine water. This is a common method for testing the carbon-carbon double bond. At the same time, under appropriate catalysts and conditions, it can also undergo an addition reaction with hydrogen, and the ethylenically bond is converted into a single bond to form a saturated compound.
The thiol group has strong reductivity and is easy to be oxidized. In case of strong oxidants such as potassium permanganate, the thiol group will be oxidized to higher valence sulfur-containing groups such as sulfonic acid groups. In addition, the thiol group can form stable complexes with some metal ions, such as combining with mercury ions to form insoluble precipitation, which can be used to detect and remove mercury ions in the environment.
Carbonyl group acts as an electron-withdrawing group, making the carbon atoms connected to it partially positively charged, vulnerable to nucleophilic attack, and nucleophilic addition reaction occurs. For example, under acid catalysis with alcohols, oxygen atoms in alcohols attack carbonyl carbon atoms as nucleophiles to form hemiacetal or acetal structures.
In summary, 5-hydroxyl-3-mercapto-2-ene-1-carbonylphenyl contains a variety of functional groups, exhibiting rich chemical properties such as acidic, addition, redox, and nucleophilic addition, which have potential applications in many fields such as organic synthesis, pharmaceutical chemistry, and materials science.
What are the common methods for synthesizing 5-bromo-3-chloro-2-fluoro-1-nitrobenzene?
The common synthesis methods of 5-hydroxyl-3-amine-2-ene-1-carbonyl indoles are very important in the field of chemical synthesis. The common synthesis paths follow the principles and methods of organic chemistry.
First, the desired structure can be constructed by a specific indole derivative through clever substitution reaction. For example, using an indole containing an appropriate substituent as the starting material, under specific reaction conditions, the nucleophilic substitution reaction is used to introduce a suitable substituent group to gradually build the structure of the target molecule. This process requires precise control of reaction conditions, such as temperature, solvent, catalyst, etc., to ensure that the reaction proceeds in the desired direction. If the temperature is too high or too low, the reaction rate may be abnormal or unnecessary by-products may be formed. The appropriate solvent not only affects the solubility of the reactants, but also has a significant impact on the reaction mechanism and selectivity.
Second, it is also a common strategy to construct the key indole ring structure through cyclization. The chain compound with the appropriate functional group is used as the starting material, and the intramolecular cyclization reaction occurs under the induction of specific reagents and conditions. This cyclization reaction often involves the rearrangement and formation of chemical bonds, and requires a deep understanding of the reaction mechanism. For example, some Lewis acids or bases are used as catalysts to promote nucleophilic attack and electron rearrangement in molecules, so as to efficiently generate indole rings, and then subsequent modifications are carried out on this basis to achieve the synthesis of 5-hydroxyl-3-amine-2-ene-1-carbonyl indoles.
Furthermore, the coupling reaction catalyzed by transition metals is also a powerful means. Transition metal catalysts such as palladium and copper can effectively promote the coupling between different organic fragments. Select the appropriate halogenated indole derivatives and nucleophiles containing specific functional groups, and under the catalysis of transition metals, the formation of carbon-carbon or carbon-heteroatomic bonds can be achieved, and then the complex structure of the target compound can be gradually constructed. The advantages of this method are that the reaction selectivity is high and the conditions are relatively mild, but the selection and dosage of catalysts are strict, and the cost of catalysts also needs to be considered.
The above several common synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected according to the specific situation, such as the availability of raw materials, cost considerations, and the purity requirements of the target product.
First, the desired structure can be constructed by a specific indole derivative through clever substitution reaction. For example, using an indole containing an appropriate substituent as the starting material, under specific reaction conditions, the nucleophilic substitution reaction is used to introduce a suitable substituent group to gradually build the structure of the target molecule. This process requires precise control of reaction conditions, such as temperature, solvent, catalyst, etc., to ensure that the reaction proceeds in the desired direction. If the temperature is too high or too low, the reaction rate may be abnormal or unnecessary by-products may be formed. The appropriate solvent not only affects the solubility of the reactants, but also has a significant impact on the reaction mechanism and selectivity.
Second, it is also a common strategy to construct the key indole ring structure through cyclization. The chain compound with the appropriate functional group is used as the starting material, and the intramolecular cyclization reaction occurs under the induction of specific reagents and conditions. This cyclization reaction often involves the rearrangement and formation of chemical bonds, and requires a deep understanding of the reaction mechanism. For example, some Lewis acids or bases are used as catalysts to promote nucleophilic attack and electron rearrangement in molecules, so as to efficiently generate indole rings, and then subsequent modifications are carried out on this basis to achieve the synthesis of 5-hydroxyl-3-amine-2-ene-1-carbonyl indoles.
Furthermore, the coupling reaction catalyzed by transition metals is also a powerful means. Transition metal catalysts such as palladium and copper can effectively promote the coupling between different organic fragments. Select the appropriate halogenated indole derivatives and nucleophiles containing specific functional groups, and under the catalysis of transition metals, the formation of carbon-carbon or carbon-heteroatomic bonds can be achieved, and then the complex structure of the target compound can be gradually constructed. The advantages of this method are that the reaction selectivity is high and the conditions are relatively mild, but the selection and dosage of catalysts are strict, and the cost of catalysts also needs to be considered.
The above several common synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be selected according to the specific situation, such as the availability of raw materials, cost considerations, and the purity requirements of the target product.
What are the main uses of 5-bromo-3-chloro-2-fluoro-1-nitrobenzene?
5-Bromo-3-chloro-2-fluoro-1-benzoylbenzene, which has important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to its unique chemical structure, it can participate in many organic reactions and help synthesize drug molecules with specific structures. For example, it can combine with heteroatom reagents such as nitrogen and oxygen through nucleophilic substitution, addition, etc., to construct bioactive pharmacophore for the development of antibacterial, anti-tumor, neurological disease treatment drugs, etc.
In the field of materials science, 5-bromo-3-chloro-2-fluoro-1-benzoylbenzene can be used to prepare functional polymer materials. By introducing different substituents into the benzene ring, the electronic properties, solubility and thermal stability of the material can be adjusted. For example, by polymerizing it with a specific monomer, a polymer with photoelectric properties can be prepared, which can be used in organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices to improve device performance and efficiency.
In the field of pesticide chemistry, this compound also has a place. With its halogen atom and benzoyl group structure, it can endow pesticides with specific biological activities. It can be used as a lead compound to develop high-efficiency, low-toxicity and environmentally friendly new pesticides for pest control and ensure crop yield and quality through structural modification and optimization.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to its unique chemical structure, it can participate in many organic reactions and help synthesize drug molecules with specific structures. For example, it can combine with heteroatom reagents such as nitrogen and oxygen through nucleophilic substitution, addition, etc., to construct bioactive pharmacophore for the development of antibacterial, anti-tumor, neurological disease treatment drugs, etc.
In the field of materials science, 5-bromo-3-chloro-2-fluoro-1-benzoylbenzene can be used to prepare functional polymer materials. By introducing different substituents into the benzene ring, the electronic properties, solubility and thermal stability of the material can be adjusted. For example, by polymerizing it with a specific monomer, a polymer with photoelectric properties can be prepared, which can be used in organic Light Emitting Diode (OLED), solar cells and other optoelectronic devices to improve device performance and efficiency.
In the field of pesticide chemistry, this compound also has a place. With its halogen atom and benzoyl group structure, it can endow pesticides with specific biological activities. It can be used as a lead compound to develop high-efficiency, low-toxicity and environmentally friendly new pesticides for pest control and ensure crop yield and quality through structural modification and optimization.
What are the precautions for storing and transporting 5-bromo-3-chloro-2-fluoro-1-nitrobenzene?
5-Mercury, 3-arsenic, 2-lead, and 1-cyanobenzene must be kept in mind during storage and transportation.
Mercury is highly toxic and can evaporate at room temperature. If its vapor is inhaled into the human body, it can cause serious damage to the nervous system and kidneys. When storing, use a strong and sealed container to prevent leakage. The container material should be made of thick glass or metal, and it must be well sealed. During transportation, it is necessary to strictly follow the transportation specifications of hazardous chemicals, and take measures to prevent heat insulation, shock and leakage to prevent mercury leakage.
Arsenic is also highly toxic, and its compounds are often carcinogenic. When storing, it should be placed in a dry, ventilated and low temperature place, away from fire sources and oxidants, because some arsenides are prone to react when heated or oxidants. During transportation, it is necessary to prevent damage to the packaging and avoid mixing with other items to prevent the spread of pollution.
Although lead is slightly less toxic, long-term exposure will also endanger human health, especially on the nervous system and hematopoietic system. Storage should be in a dry environment to avoid moisture, because it is easy to oxidize when damp, which affects the quality and may generate harmful lead salts. During transportation, good protection should be taken to prevent damage and deformation of lead products, so as to prevent lead dust from escaping.
Cyanobenzene, as an organic poison, is flammable and explosive, and has serious irritation and toxicity to the nervous system and respiratory system of the human body. Storage must be stored in a cool and ventilated special warehouse, away from fire and heat sources, and the storage temperature should not exceed 30 ° C. Store separately from oxidants, acids and alkalis, and do not mix storage. When transporting, use a special tank truck or container to ensure that the container is well grounded to prevent static electricity from causing explosions, and the transportation vehicle must be equipped with corresponding fire equipment and leakage emergency treatment equipment.
During storage and transportation of these poisons, clear warning signs should be posted, and personnel should also be professionally trained and familiar with emergency treatment methods to ensure safe operation, prevent accidents, and protect the environment and personal safety.
Mercury is highly toxic and can evaporate at room temperature. If its vapor is inhaled into the human body, it can cause serious damage to the nervous system and kidneys. When storing, use a strong and sealed container to prevent leakage. The container material should be made of thick glass or metal, and it must be well sealed. During transportation, it is necessary to strictly follow the transportation specifications of hazardous chemicals, and take measures to prevent heat insulation, shock and leakage to prevent mercury leakage.
Arsenic is also highly toxic, and its compounds are often carcinogenic. When storing, it should be placed in a dry, ventilated and low temperature place, away from fire sources and oxidants, because some arsenides are prone to react when heated or oxidants. During transportation, it is necessary to prevent damage to the packaging and avoid mixing with other items to prevent the spread of pollution.
Although lead is slightly less toxic, long-term exposure will also endanger human health, especially on the nervous system and hematopoietic system. Storage should be in a dry environment to avoid moisture, because it is easy to oxidize when damp, which affects the quality and may generate harmful lead salts. During transportation, good protection should be taken to prevent damage and deformation of lead products, so as to prevent lead dust from escaping.
Cyanobenzene, as an organic poison, is flammable and explosive, and has serious irritation and toxicity to the nervous system and respiratory system of the human body. Storage must be stored in a cool and ventilated special warehouse, away from fire and heat sources, and the storage temperature should not exceed 30 ° C. Store separately from oxidants, acids and alkalis, and do not mix storage. When transporting, use a special tank truck or container to ensure that the container is well grounded to prevent static electricity from causing explosions, and the transportation vehicle must be equipped with corresponding fire equipment and leakage emergency treatment equipment.
During storage and transportation of these poisons, clear warning signs should be posted, and personnel should also be professionally trained and familiar with emergency treatment methods to ensure safe operation, prevent accidents, and protect the environment and personal safety.
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