Linshang Chemical
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5-Chloro-1,2-Difluoro-3-Nitrobenzene
Linshang Chemical
|
HS Code |
365395 |
| Chemical Formula | C6H2ClF2NO2 |
| Molar Mass | 193.536 g/mol |
| Appearance | Solid (usually) |
| Color | Typically colorless to light - colored |
| Odor | May have a characteristic aromatic odor |
| Density | Data may vary, needs experimental determination |
| Melting Point | Data may vary, requires experimental measurement |
| Boiling Point | Data may vary, needs experimental determination |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene etc. |
| Vapor Pressure | Low vapor pressure |
| Stability | Stable under normal conditions but reactive towards strong reducing agents and bases |
As an accredited 5-Chloro-1,2-Difluoro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - chloro - 1,2 - difluoro - 3 - nitrobenzene in 500g bottles for chemical packaging. |
| Storage | 5 - Chloro - 1,2 - difluoro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contamination. Ensure proper labeling for easy identification and safety. |
| Shipping | 5 - chloro - 1,2 - difluoro - 3 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations to ensure safety during transit, avoiding exposure and potential hazards. |
Competitive 5-Chloro-1,2-Difluoro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 5-Chloro-1,2-Difluoro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 5-chloro-1,2-difluoro-3-nitrobenzene?
5-Bromo-1,2-diethylene-3-furanylbenzene is a component of Western medicine, which is hard to find in the traditional Chinese "Tiangong Kaiwu". When the book "Tiangong Kaiwu" was written, such Western chemical synthesis has not yet appeared in the land of China. However, in terms of current chemical knowledge and medical uses, its outline can be briefly described.
5-bromo-1,2-diethylene-3-furanylbenzene, which is often used as a key intermediate in the field of organic synthesis. Organic synthesis, just like skilled craftsmen building exquisite pavilions, this intermediate is the cornerstone of building complex organic molecular structures. Through various chemical reactions, such as nucleophilic substitution, addition, etc., it can be connected with other organic fragments to construct compounds with unique structures and functions.
In the field of pharmaceutical research and development, such compounds containing bromine and furan groups have potential biological activities. Many studies have shown that organic molecules containing bromine atoms can enhance the interaction between compounds and biological targets due to the special electronic and spatial effects of bromine atoms. Furan groups are also important pharmacoactive groups, which can affect the solubility, permeability and binding ability of drugs to receptors. Therefore, based on this, through modification and optimization, drugs for specific diseases may be developed, such as anti-cancer, antibacterial and other drugs.
Although this item is not contained in "Tiangong Kaiwu", today, science is prosperous, and human understanding and utilization of matter have far exceeded the past. The use of this ingredient also highlights the subtlety of modern chemistry and medical science, and is of great significance in promoting human health and the progress of organic synthesis technology.
5-bromo-1,2-diethylene-3-furanylbenzene, which is often used as a key intermediate in the field of organic synthesis. Organic synthesis, just like skilled craftsmen building exquisite pavilions, this intermediate is the cornerstone of building complex organic molecular structures. Through various chemical reactions, such as nucleophilic substitution, addition, etc., it can be connected with other organic fragments to construct compounds with unique structures and functions.
In the field of pharmaceutical research and development, such compounds containing bromine and furan groups have potential biological activities. Many studies have shown that organic molecules containing bromine atoms can enhance the interaction between compounds and biological targets due to the special electronic and spatial effects of bromine atoms. Furan groups are also important pharmacoactive groups, which can affect the solubility, permeability and binding ability of drugs to receptors. Therefore, based on this, through modification and optimization, drugs for specific diseases may be developed, such as anti-cancer, antibacterial and other drugs.
Although this item is not contained in "Tiangong Kaiwu", today, science is prosperous, and human understanding and utilization of matter have far exceeded the past. The use of this ingredient also highlights the subtlety of modern chemistry and medical science, and is of great significance in promoting human health and the progress of organic synthesis technology.
What are the physical properties of 5-chloro-1,2-difluoro-3-nitrobenzene?
5-Bromo-1,2-dichloroethylene-3-fluorophenyl is a relatively complex organic compound with the following physical properties:
Looking at its properties, under normal temperature and pressure, 5-bromo-1,2-dichloroethylene-3-fluorophenyl mostly takes on a colorless to pale yellow liquid form. This form is more common in many organic reactions and chemical processes. The fluidity of the liquid is conducive to its uniform dispersion in the system and participation in various reaction processes.
Smell, often with a special pungent odor. This odor originates from the interaction of halogen atoms and unsaturated bonds in its molecular structure. Although this odor can be used as a basis for preliminary identification, due to its irritation, caution is required when smelling to prevent damage to the respiratory tract.
When talking about the boiling point, due to the influence of intermolecular forces, its boiling point is within a certain range. Specifically, it is between [X] ° C and [X] ° C. The value of the boiling point determines the temperature conditions required for the compound during operations such as heat separation or distillation and purification, and is of great significance for the temperature control of chemical production and laboratory preparation processes.
When looking at its melting point, it is generally around [X] ° C. Melting point characteristics are related to the conditions for the transformation of the substance between solid and liquid states, and are crucial for the setting of storage and transportation conditions. If the storage temperature is improper, or its state is changed, its quality and performance will be affected.
In terms of solubility, 5-bromo-1,2-dichloroethylene-3-fluorobenzene exhibits good solubility in organic solvents, such as common organic solvents such as ethanol, ether, and dichloromethane. This characteristic is derived from the similarity of its organic molecular structure and the principle of miscibility between organic solvent molecules. In organic synthesis reactions, the substance can be dissolved with the help of suitable organic solvents to fully participate in the reaction and improve the reaction efficiency and yield. However, its solubility in water is poor. Due to the large difference between the polarity of water molecules and the molecular structure of the organic substance, it is difficult for the intermolecular forces to promote the mutual dissolution of the two.
Over the density, compared to water, its density is slightly higher, about [X] g/cm ³. This density characteristic is of great significance when it comes to operations such as liquid-liquid separation. Through density differences, suitable separation methods can be used to achieve effective separation of the compound from other substances.
Looking at its properties, under normal temperature and pressure, 5-bromo-1,2-dichloroethylene-3-fluorophenyl mostly takes on a colorless to pale yellow liquid form. This form is more common in many organic reactions and chemical processes. The fluidity of the liquid is conducive to its uniform dispersion in the system and participation in various reaction processes.
Smell, often with a special pungent odor. This odor originates from the interaction of halogen atoms and unsaturated bonds in its molecular structure. Although this odor can be used as a basis for preliminary identification, due to its irritation, caution is required when smelling to prevent damage to the respiratory tract.
When talking about the boiling point, due to the influence of intermolecular forces, its boiling point is within a certain range. Specifically, it is between [X] ° C and [X] ° C. The value of the boiling point determines the temperature conditions required for the compound during operations such as heat separation or distillation and purification, and is of great significance for the temperature control of chemical production and laboratory preparation processes.
When looking at its melting point, it is generally around [X] ° C. Melting point characteristics are related to the conditions for the transformation of the substance between solid and liquid states, and are crucial for the setting of storage and transportation conditions. If the storage temperature is improper, or its state is changed, its quality and performance will be affected.
In terms of solubility, 5-bromo-1,2-dichloroethylene-3-fluorobenzene exhibits good solubility in organic solvents, such as common organic solvents such as ethanol, ether, and dichloromethane. This characteristic is derived from the similarity of its organic molecular structure and the principle of miscibility between organic solvent molecules. In organic synthesis reactions, the substance can be dissolved with the help of suitable organic solvents to fully participate in the reaction and improve the reaction efficiency and yield. However, its solubility in water is poor. Due to the large difference between the polarity of water molecules and the molecular structure of the organic substance, it is difficult for the intermolecular forces to promote the mutual dissolution of the two.
Over the density, compared to water, its density is slightly higher, about [X] g/cm ³. This density characteristic is of great significance when it comes to operations such as liquid-liquid separation. Through density differences, suitable separation methods can be used to achieve effective separation of the compound from other substances.
What are the chemical properties of 5-chloro-1,2-difluoro-3-nitrobenzene?
5-Bromo-1,2-diethylene-3-thiazolylbenzene, this substance is an organic compound. Its chemical properties are rich, let me explain them one by one.
First of all, the bromine atom imparts its reactivity. Bromine is often a good leaving group in organic reactions, and nucleophilic substitution reactions can occur. For example, if nucleophilic reagents such as sodium alcohol and amines are attacked, the bromine atom can be replaced to generate new compounds. This reaction is like a knight replacing waist accessories to generate a different "rivers and lakes product".
Furthermore, the 1,2-diethylene structure is unsaturated, rich in π electron clouds, and prone to addition reactions. If added to hydrogen, the double bond can be turned into a single bond, which is like "covering it with saturation"; in case of bromine, addition can also occur to make the reddish-brown of bromine fade away. This is a common means to identify such unsaturated structures, just like giving them a special "mark".
And the thiazolylbenzene part, the thiazole ring has a certain fragrance. Because it meets the Shock rule, it has a closed conjugate system, making it relatively stable. However, the nitrogen and sulfur atoms on the thiazole ring give it a certain alkalinity and coordination ability, and can form complexes with metal ions, just like "hand in hand" with metal ions, which may have wonderful uses in catalysis, materials and other fields.
The multiple chemical properties of this compound make it potentially valuable in many fields such as organic synthesis and drug research and development. It is like a piece of unpolished jade with infinite possibilities, waiting for skilled craftsmen to explore and utilize it.
First of all, the bromine atom imparts its reactivity. Bromine is often a good leaving group in organic reactions, and nucleophilic substitution reactions can occur. For example, if nucleophilic reagents such as sodium alcohol and amines are attacked, the bromine atom can be replaced to generate new compounds. This reaction is like a knight replacing waist accessories to generate a different "rivers and lakes product".
Furthermore, the 1,2-diethylene structure is unsaturated, rich in π electron clouds, and prone to addition reactions. If added to hydrogen, the double bond can be turned into a single bond, which is like "covering it with saturation"; in case of bromine, addition can also occur to make the reddish-brown of bromine fade away. This is a common means to identify such unsaturated structures, just like giving them a special "mark".
And the thiazolylbenzene part, the thiazole ring has a certain fragrance. Because it meets the Shock rule, it has a closed conjugate system, making it relatively stable. However, the nitrogen and sulfur atoms on the thiazole ring give it a certain alkalinity and coordination ability, and can form complexes with metal ions, just like "hand in hand" with metal ions, which may have wonderful uses in catalysis, materials and other fields.
The multiple chemical properties of this compound make it potentially valuable in many fields such as organic synthesis and drug research and development. It is like a piece of unpolished jade with infinite possibilities, waiting for skilled craftsmen to explore and utilize it.
What are the preparation methods of 5-chloro-1,2-difluoro-3-nitrobenzene?
To prepare 5-% deuterium-1,2-dibromo-3-fluorobenzyl, the method is as follows:
Take an appropriate amount of starting material first, which needs to be pure and free of impurities before laying the foundation for subsequent reactions. Compounds containing benzyl groups can be found, and their structure should be similar to the target product for modification.
Then perform a halogenation reaction and introduce bromine atoms. Choose a suitable brominating reagent, such as liquid bromine or N-bromosuccinimide (NBS). If liquid bromine is used, pay attention to its corrosiveness and volatility, and operate in a well-ventilated and well-protected environment. With NBS, it is relatively mild and the reaction is easy to control. During the reaction, adjust the temperature, solvent, or start at a low temperature, and gradually rise to a suitable degree for the reaction. Solvents such as carbon tetrachloride or dichloromethane can be selected to homogenize the reaction.
After the introduction of bromine atoms, proceed to introduce deuterium atoms. This step can be used with deuterated reagents, such as deuterated water (D 2O O) or other deuterium sources. After an appropriate reaction path, such as nucleophilic substitution or addition, deuterium atoms can be replaced at the desired position of hydrogen atoms. The key to this process is to precisely control the reaction check point, which can be guided by catalysts or specific reaction conditions. Catalysts or metal salts are selected to adjust their dosage and activity to ensure that deuterium atoms are in place according to the plan.
As for the introduction of fluorine atoms, nucleophilic substitution is often selected. Take a fluorine-containing nucleophilic reagent and react The strength and dosage of the base must be just right, and the polarity of the solvent also affects it. Appropriate polarity can promote the activity of nucleophiles.
After each step of the reaction, fine separation and purification are required. Column chromatography, recrystallization and other methods can be used. Column chromatography selects the appropriate fixed phase and mobile phase, and separates the product according to the polarity difference between the product and the impurity. Recrystallization seeks a suitable solvent, so that the solubility of the product changes significantly with temperature, so as to obtain a high-purity product. Rigorous operation of each step and attention to details can obtain a high-purity 5-% deuterium-1,2-dibromo-3-fluorobenzyl.
Take an appropriate amount of starting material first, which needs to be pure and free of impurities before laying the foundation for subsequent reactions. Compounds containing benzyl groups can be found, and their structure should be similar to the target product for modification.
Then perform a halogenation reaction and introduce bromine atoms. Choose a suitable brominating reagent, such as liquid bromine or N-bromosuccinimide (NBS). If liquid bromine is used, pay attention to its corrosiveness and volatility, and operate in a well-ventilated and well-protected environment. With NBS, it is relatively mild and the reaction is easy to control. During the reaction, adjust the temperature, solvent, or start at a low temperature, and gradually rise to a suitable degree for the reaction. Solvents such as carbon tetrachloride or dichloromethane can be selected to homogenize the reaction.
After the introduction of bromine atoms, proceed to introduce deuterium atoms. This step can be used with deuterated reagents, such as deuterated water (D 2O O) or other deuterium sources. After an appropriate reaction path, such as nucleophilic substitution or addition, deuterium atoms can be replaced at the desired position of hydrogen atoms. The key to this process is to precisely control the reaction check point, which can be guided by catalysts or specific reaction conditions. Catalysts or metal salts are selected to adjust their dosage and activity to ensure that deuterium atoms are in place according to the plan.
As for the introduction of fluorine atoms, nucleophilic substitution is often selected. Take a fluorine-containing nucleophilic reagent and react The strength and dosage of the base must be just right, and the polarity of the solvent also affects it. Appropriate polarity can promote the activity of nucleophiles.
After each step of the reaction, fine separation and purification are required. Column chromatography, recrystallization and other methods can be used. Column chromatography selects the appropriate fixed phase and mobile phase, and separates the product according to the polarity difference between the product and the impurity. Recrystallization seeks a suitable solvent, so that the solubility of the product changes significantly with temperature, so as to obtain a high-purity product. Rigorous operation of each step and attention to details can obtain a high-purity 5-% deuterium-1,2-dibromo-3-fluorobenzyl.
What are the precautions for storing and transporting 5-chloro-1,2-difluoro-3-nitrobenzene?
5-Bromo-1,2-dichloro-3-fluorobenzene is a kind of organic compound. During storage and transportation, many matters must be paid attention to.
In terms of storage, the first choice of environment. When placed in a cool and ventilated place, away from fire and heat sources. This is because it has certain chemical activity, high temperature or open flame can easily cause danger. The temperature of the warehouse should be controlled within a reasonable range, generally not exceeding 30 ° C. Humidity should not be ignored. It is necessary to prevent moisture. If it is too humid, it may cause it to deteriorate.
In addition, it should be separated from oxidants and edible chemicals, and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., or trigger violent chemical reactions, endangering safety. Storage containers must also be carefully selected to ensure that they are well sealed to prevent leakage. Commonly used glass bottles or plastic drums should be selected according to their specific characteristics, and the material should be able to withstand the corrosion of the compound.
As for transportation, transportation vehicles must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During transportation, it should be protected from sun exposure, rain exposure, and high temperature. Summer transportation should be carried out in the morning and evening to avoid high temperature periods. If transported by rail, it should be strictly assembled in accordance with the dangerous goods assembly table in the "Dangerous Goods Transportation Rules" of the Ministry of Railways.
When loading and unloading, the operator should handle it lightly to prevent damage to the packaging and containers. Do not operate brutally to avoid leakage due to damaged packaging, causing environmental pollution and safety accidents. During transportation, transportation vehicles should follow the specified route and do not stop in residential areas and densely populated areas. All of this is to ensure the safety of 5-bromo-1,2-dichloro-3-fluorobenzene during storage and transportation, and must not be negligent.
In terms of storage, the first choice of environment. When placed in a cool and ventilated place, away from fire and heat sources. This is because it has certain chemical activity, high temperature or open flame can easily cause danger. The temperature of the warehouse should be controlled within a reasonable range, generally not exceeding 30 ° C. Humidity should not be ignored. It is necessary to prevent moisture. If it is too humid, it may cause it to deteriorate.
In addition, it should be separated from oxidants and edible chemicals, and should not be mixed. Due to its active chemical properties, contact with oxidants, etc., or trigger violent chemical reactions, endangering safety. Storage containers must also be carefully selected to ensure that they are well sealed to prevent leakage. Commonly used glass bottles or plastic drums should be selected according to their specific characteristics, and the material should be able to withstand the corrosion of the compound.
As for transportation, transportation vehicles must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During transportation, it should be protected from sun exposure, rain exposure, and high temperature. Summer transportation should be carried out in the morning and evening to avoid high temperature periods. If transported by rail, it should be strictly assembled in accordance with the dangerous goods assembly table in the "Dangerous Goods Transportation Rules" of the Ministry of Railways.
When loading and unloading, the operator should handle it lightly to prevent damage to the packaging and containers. Do not operate brutally to avoid leakage due to damaged packaging, causing environmental pollution and safety accidents. During transportation, transportation vehicles should follow the specified route and do not stop in residential areas and densely populated areas. All of this is to ensure the safety of 5-bromo-1,2-dichloro-3-fluorobenzene during storage and transportation, and must not be negligent.
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