Linshang Chemical
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5-Chloro-2,3-Dibromo-1-Fluorobenzene
Linshang Chemical
|
HS Code |
433003 |
| Chemical Formula | C6H2Br2ClF |
| Molecular Weight | 287.34 |
| Appearance | Typically a colorless to pale - yellow liquid or solid (depending on conditions) |
| Boiling Point | Data may vary, but generally in the range related to its molecular structure and intermolecular forces |
| Melting Point | Specific value related to its crystal structure and intermolecular forces |
| Density | Appropriate density value based on its molecular packing |
| Solubility In Water | Low solubility, being an organic halogen - containing compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform etc. |
| Vapor Pressure | Corresponding vapor pressure value at a given temperature |
| Flash Point | Value indicating flammability potential |
As an accredited 5-Chloro-2,3-Dibromo-1-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - chloro - 2,3 - dibromo - 1 - fluorobenzene: 100g in sealed, chemical - resistant glass bottle. |
| Storage | 5 - Chloro - 2,3 - dibromo - 1 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and incompatible substances. Keep it in a tightly sealed container, preferably made of corrosion - resistant material. Avoid storing it near strong oxidizing agents or reactive chemicals to prevent potential reactions. |
| Shipping | 5 - chloro - 2,3 - dibromo - 1 - fluorobenzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. It follows strict hazardous chemical shipping regulations to ensure safe transit. |
Competitive 5-Chloro-2,3-Dibromo-1-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the chemical properties of 5-chloro-2, 3-dibromo-1-fluorobenzene
5-Chloro-2,3-dibromo-1-fluorobenzene is one of the organohalogenated aromatic hydrocarbons. Its chemical properties are fascinating and are related to many reaction characteristics.
First of all, its electrophilic substitution reaction. On the benzene ring of this compound, the halogen atoms all have electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring, so the electrophilic substitution reaction activity is lower than that of benzene. Among them, the localization effects of chlorine, bromine and fluorine atoms are different. Although fluorine and chlorine are ortho-para-sites, they generally passivate the benzene ring due to their strong electron-absorbing induction effect; bromine is also an ortho-site site. When it is an electrophilic substitution reaction, the new substituent is mostly in the adjacent para-position of the halogen atom, and the reaction conditions are more severe than that of benzene.
Let's talk about the reaction of its halogen atom. Chlorine, bromine and fluorine atoms can all participate in the nucleophilic substitution reaction. Under suitable nucleophilic reagents and reaction conditions, halogen atoms can be replaced by nucleophilic reagents. However, due to the high C-F bond energy of fluorine atoms, the substitution reaction is relatively difficult to occur; while the carbon connected to bromine and chlorine atoms is affected by the conjugation effect of benzene ring, and some of its positive charges can be dispersed, so the nucleophilic substitution activity of bromine and chlorine atoms is lower than
Talking about the reduction reaction, under specific reduction conditions, the benzene ring can be reduced, or the halogen atom can be reduced and removed. For example, by catalytic hydrogenation, the benzene ring can be hydrogenated to form the corresponding alicyclic compound; if a specific metal reagent, such as metal magnesium and halogenated aromatics, is formed in the process of Grignard reagent, or some halogen atoms may be reduced and removed.
In terms of hydrolysis reaction, under conditions such as strong bases, halogen atoms may undergo hydrolysis and be replaced by hydroxyl groups. However, due to the conjugation of the benzene ring, the stability of the C-X bond (X is halogen) is increased, and the hydrolysis reaction usually requires more severe conditions. With its unique chemical structure, 5-chloro-2,3-dibromo-1-fluorobenzene exhibits diverse and characteristic chemical properties, and has its unique application and research value in organic synthesis and other fields.
First of all, its electrophilic substitution reaction. On the benzene ring of this compound, the halogen atoms all have electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring, so the electrophilic substitution reaction activity is lower than that of benzene. Among them, the localization effects of chlorine, bromine and fluorine atoms are different. Although fluorine and chlorine are ortho-para-sites, they generally passivate the benzene ring due to their strong electron-absorbing induction effect; bromine is also an ortho-site site. When it is an electrophilic substitution reaction, the new substituent is mostly in the adjacent para-position of the halogen atom, and the reaction conditions are more severe than that of benzene.
Let's talk about the reaction of its halogen atom. Chlorine, bromine and fluorine atoms can all participate in the nucleophilic substitution reaction. Under suitable nucleophilic reagents and reaction conditions, halogen atoms can be replaced by nucleophilic reagents. However, due to the high C-F bond energy of fluorine atoms, the substitution reaction is relatively difficult to occur; while the carbon connected to bromine and chlorine atoms is affected by the conjugation effect of benzene ring, and some of its positive charges can be dispersed, so the nucleophilic substitution activity of bromine and chlorine atoms is lower than
Talking about the reduction reaction, under specific reduction conditions, the benzene ring can be reduced, or the halogen atom can be reduced and removed. For example, by catalytic hydrogenation, the benzene ring can be hydrogenated to form the corresponding alicyclic compound; if a specific metal reagent, such as metal magnesium and halogenated aromatics, is formed in the process of Grignard reagent, or some halogen atoms may be reduced and removed.
In terms of hydrolysis reaction, under conditions such as strong bases, halogen atoms may undergo hydrolysis and be replaced by hydroxyl groups. However, due to the conjugation of the benzene ring, the stability of the C-X bond (X is halogen) is increased, and the hydrolysis reaction usually requires more severe conditions. With its unique chemical structure, 5-chloro-2,3-dibromo-1-fluorobenzene exhibits diverse and characteristic chemical properties, and has its unique application and research value in organic synthesis and other fields.
What are the common synthesis methods of 5-chloro-2, 3-dibromo-1-fluorobenzene
5-Chloro-2,3-dibromo-1-fluorobenzene is also an organic compound. The common synthesis methods are roughly numerous.
First, the halogenation reaction method. With benzene as the initial raw material, chlorine atoms are introduced first. It can make benzene and chlorine under the action of ferric chloride and other catalysts to undergo an electrophilic substitution reaction to obtain chlorobenzene. Then, when chlorobenzene reacts with bromine, in the presence of an appropriate catalyst, bromine atoms can be introduced into the benzene ring to obtain 2,3-dibromo-5-chlorobenzene. This step requires attention to the control of reaction conditions. Temperature, amount of catalyst, etc. are all related to the yield and purity of the product. Finally, 2,3-dibromo-5-chlorobenzene is reacted with fluorinated reagents, such as potassium fluoride, etc. Under suitable solvents and reaction conditions, fluorine atoms replace halogen atoms at specific positions on the benzene ring, and then 5-chloro-2,3-dibromo-1-fluorobenzene is obtained.
Second, benzene derivatives with specific substituents can also be used as starting materials. If the starting benzene ring already has some halogen atom substituents, according to its positioning effect, select suitable reaction conditions and reagents, and gradually introduce the remaining halogen atoms. If a benzene derivative has a chlorine atom at a specific position, according to the positioning rules, the reaction conditions can be adjusted, first introducing a bromine atom at a suitable position, then another bromine atom, and finally introducing a fluorine atom to achieve the synthesis of 5-chloro-2,3-dibromo-1-fluorobenzene. In this process, the selection of starting materials and the fine regulation of the reaction conditions of each step are crucial to obtain the target product.
When synthesizing this compound, attention should be paid to the optimization of the reaction conditions of each step, including reaction temperature, reaction time, reagent dosage, solvent selection, etc. After each step of the reaction, it is often necessary to separate and purify the product by appropriate methods, such as distillation, recrystallization, column chromatography, etc., to ensure the purity of the final product and meet the needs of subsequent applications.
First, the halogenation reaction method. With benzene as the initial raw material, chlorine atoms are introduced first. It can make benzene and chlorine under the action of ferric chloride and other catalysts to undergo an electrophilic substitution reaction to obtain chlorobenzene. Then, when chlorobenzene reacts with bromine, in the presence of an appropriate catalyst, bromine atoms can be introduced into the benzene ring to obtain 2,3-dibromo-5-chlorobenzene. This step requires attention to the control of reaction conditions. Temperature, amount of catalyst, etc. are all related to the yield and purity of the product. Finally, 2,3-dibromo-5-chlorobenzene is reacted with fluorinated reagents, such as potassium fluoride, etc. Under suitable solvents and reaction conditions, fluorine atoms replace halogen atoms at specific positions on the benzene ring, and then 5-chloro-2,3-dibromo-1-fluorobenzene is obtained.
Second, benzene derivatives with specific substituents can also be used as starting materials. If the starting benzene ring already has some halogen atom substituents, according to its positioning effect, select suitable reaction conditions and reagents, and gradually introduce the remaining halogen atoms. If a benzene derivative has a chlorine atom at a specific position, according to the positioning rules, the reaction conditions can be adjusted, first introducing a bromine atom at a suitable position, then another bromine atom, and finally introducing a fluorine atom to achieve the synthesis of 5-chloro-2,3-dibromo-1-fluorobenzene. In this process, the selection of starting materials and the fine regulation of the reaction conditions of each step are crucial to obtain the target product.
When synthesizing this compound, attention should be paid to the optimization of the reaction conditions of each step, including reaction temperature, reaction time, reagent dosage, solvent selection, etc. After each step of the reaction, it is often necessary to separate and purify the product by appropriate methods, such as distillation, recrystallization, column chromatography, etc., to ensure the purity of the final product and meet the needs of subsequent applications.
5-Chloro-2, 3-dibromo-1-fluorobenzene in which areas
5-Chloro-2,3-dibromo-1-fluorobenzene is one of the organic compounds. It is useful in many fields.
In the field of medicinal chemistry, this compound is often the key raw material for the creation of new drugs. Due to the introduction of halogen atoms, the physical and chemical properties of the compound can be changed, such as lipophilicity and stability, which in turn affect its biological activity. With this as a starting material, chemists can use various chemical reactions to construct complex molecular structures to find compounds with specific pharmacological activities, or for antibacterial, antiviral, or for the development of new anti-cancer drugs.
In the field of materials science, 5-chloro-2,3-dibromo-1-fluorobenzene also has important uses. It can be used as a monomer for the synthesis of special polymer materials. Due to the unique electronic effect of halogen atoms, the synthesized polymer materials may have excellent heat resistance and chemical corrosion resistance. For example, in electronic devices, such materials can be used to make high-performance insulating materials to ensure the stable operation of electronic devices.
Furthermore, in the field of organic synthesis chemistry, this compound is an extremely important intermediate. Chemists can use the activity of halogen atoms to introduce different functional groups through nucleophilic substitution, coupling and other reactions to achieve the construction of complex organic molecules. Whether it is the total synthesis of natural products or the creation of new functional materials, it is often used as the basis for multi-step reactions to achieve the synthesis of target molecules.
In short, 5-chloro-2,3-dibromo-1-fluorobenzene plays an indispensable role in many fields such as medicine, materials, and organic synthesis, promoting the development and progress of various fields.
In the field of medicinal chemistry, this compound is often the key raw material for the creation of new drugs. Due to the introduction of halogen atoms, the physical and chemical properties of the compound can be changed, such as lipophilicity and stability, which in turn affect its biological activity. With this as a starting material, chemists can use various chemical reactions to construct complex molecular structures to find compounds with specific pharmacological activities, or for antibacterial, antiviral, or for the development of new anti-cancer drugs.
In the field of materials science, 5-chloro-2,3-dibromo-1-fluorobenzene also has important uses. It can be used as a monomer for the synthesis of special polymer materials. Due to the unique electronic effect of halogen atoms, the synthesized polymer materials may have excellent heat resistance and chemical corrosion resistance. For example, in electronic devices, such materials can be used to make high-performance insulating materials to ensure the stable operation of electronic devices.
Furthermore, in the field of organic synthesis chemistry, this compound is an extremely important intermediate. Chemists can use the activity of halogen atoms to introduce different functional groups through nucleophilic substitution, coupling and other reactions to achieve the construction of complex organic molecules. Whether it is the total synthesis of natural products or the creation of new functional materials, it is often used as the basis for multi-step reactions to achieve the synthesis of target molecules.
In short, 5-chloro-2,3-dibromo-1-fluorobenzene plays an indispensable role in many fields such as medicine, materials, and organic synthesis, promoting the development and progress of various fields.
What are the physical properties of 5-chloro-2, 3-dibromo-1-fluorobenzene
5-Chloro-2,3-dibromo-1-fluorobenzene is one of the organic compounds. Its physical properties are quite unique.
Looking at its shape, under room temperature and pressure, it usually takes the form of a colorless to light yellow liquid, with a clear appearance and a certain fluidity. It is like a clear spring in the mountains, which is smart and does not lose its shape.
The smell of the smell often emits a special aromatic smell, but this fragrance is not pleasant and slightly irritating. If it is smelled by mistake into a strange forest, the smell is unique and warning.
When it comes to melting point, this compound has a low melting point, like thin ice in spring, which melts when warm. It can maintain a solid state in a specific low temperature environment. If the temperature rises slightly, it will quickly turn into a liquid state.
The boiling point is also a key physical property. Its boiling point is moderate. When the temperature rises to a certain extent, the intermolecular force cannot be sustained, and then it changes from a liquid state to a gaseous state, such as cloud evaporation, out of the liquid state.
In terms of solubility, 5-chloro-2,3-dibromo-1-fluorobenzene is insoluble in water, just like the incompatibility of oil and water. The two meet and the boundaries are clear. However, in organic solvents, such as alcohols, ethers, aromatics, etc., it can be well dissolved, just like a wanderer returning home and integrating into it.
The density is heavier than water. If it is placed in a container with water, it will quietly sink to the bottom of the water, like a treasure hidden in the deep sea, silently living below.
The physical properties of this compound are of great significance in the fields of organic synthesis and chemical production. Due to its unique morphology, solubility and other properties, it can act as a solvent, reactant or intermediate in many chemical reactions, just like an important role in the stage of chemical reactions, participating in and promoting the interpretation of various chemical processes.
Looking at its shape, under room temperature and pressure, it usually takes the form of a colorless to light yellow liquid, with a clear appearance and a certain fluidity. It is like a clear spring in the mountains, which is smart and does not lose its shape.
The smell of the smell often emits a special aromatic smell, but this fragrance is not pleasant and slightly irritating. If it is smelled by mistake into a strange forest, the smell is unique and warning.
When it comes to melting point, this compound has a low melting point, like thin ice in spring, which melts when warm. It can maintain a solid state in a specific low temperature environment. If the temperature rises slightly, it will quickly turn into a liquid state.
The boiling point is also a key physical property. Its boiling point is moderate. When the temperature rises to a certain extent, the intermolecular force cannot be sustained, and then it changes from a liquid state to a gaseous state, such as cloud evaporation, out of the liquid state.
In terms of solubility, 5-chloro-2,3-dibromo-1-fluorobenzene is insoluble in water, just like the incompatibility of oil and water. The two meet and the boundaries are clear. However, in organic solvents, such as alcohols, ethers, aromatics, etc., it can be well dissolved, just like a wanderer returning home and integrating into it.
The density is heavier than water. If it is placed in a container with water, it will quietly sink to the bottom of the water, like a treasure hidden in the deep sea, silently living below.
The physical properties of this compound are of great significance in the fields of organic synthesis and chemical production. Due to its unique morphology, solubility and other properties, it can act as a solvent, reactant or intermediate in many chemical reactions, just like an important role in the stage of chemical reactions, participating in and promoting the interpretation of various chemical processes.
What are the precautions in the preparation of 5-chloro-2,3-dibromo-1-fluorobenzene
When preparing 5-chloro-2,3-dibromo-1-fluorobenzene, many matters need to be paid attention to. When selecting and refining the first raw materials, the purity of the raw materials such as chlorobenzene, bromine, and fluorination reagents used must be excellent. If there are many impurities, not only will the reaction yield be damaged, but the purity of the product will also be difficult to guarantee. For example, bromine, if it contains moisture or other impurities, reacts with chlorobenzene, or causes side reactions that affect the formation of the target product.
The control of the reaction conditions is crucial. Temperature is a matter of precise regulation. This reaction can only proceed smoothly within a specific temperature range. If the temperature is too high, the bromination and chlorination reactions may be out of control, resulting in an increase in polybromination and polychlorination by-products. If the temperature is too low, the reaction rate will be slow, time-consuming, and production costs will also increase. Taking the bromination reaction as an example, it is generally necessary to start at a suitable low temperature, and then increase the temperature moderately according to the reaction process.
Furthermore, the choice of reaction solvent cannot be ignored. The selected solvent needs to have good solubility to the reactants and no adverse reactions with the reactants and products. Halogenated hydrocarbon solvents such as dichloromethane and carbon tetrachloride are often selected for their good solubility and stability to halogenation reactions, but their boiling point, toxicity and other factors should be considered when using them to ensure safe operation and convenient subsequent separation.
During the reaction process, the stirring rate should also be appropriate. Good stirring can promote the full contact of the reactants, make the reaction proceed uniformly, and prevent the local concentration from being too high or too low to cause side reactions. If the stirring is too slow, the reactants such as bromine may accumulate locally, resulting in excessive bromination; if the stirring is too fast, it may lead to increased equipment loss and affect the stability of the reaction system.
In the stage of product separation and purification, in view of the complex reaction system and many by-products, the separation method needs to be fine. It is commonly used to combine distillation, extraction, column chromatography and other methods. During distillation, the temperature and pressure should be precisely controlled according to the difference in boiling point of each component to achieve effective separation; the extractant used in extraction should have good selectivity for the target product; column chromatography needs to select the appropriate fixed phase and mobile phase to obtain high-purity products.
In addition, safety protection must not be forgotten. Bromine and other reagents are highly corrosive and irritating. When operating, protective clothing, goggles, gloves and other protective equipment should be worn, and the reaction should be carried out in a well-ventilated environment, such as a fume hood, to prevent harmful gases from endangering human health. Exhaust gas and waste liquid should also be properly handled, follow environmental protection requirements, and should not be discharged at will to avoid polluting the environment.
The control of the reaction conditions is crucial. Temperature is a matter of precise regulation. This reaction can only proceed smoothly within a specific temperature range. If the temperature is too high, the bromination and chlorination reactions may be out of control, resulting in an increase in polybromination and polychlorination by-products. If the temperature is too low, the reaction rate will be slow, time-consuming, and production costs will also increase. Taking the bromination reaction as an example, it is generally necessary to start at a suitable low temperature, and then increase the temperature moderately according to the reaction process.
Furthermore, the choice of reaction solvent cannot be ignored. The selected solvent needs to have good solubility to the reactants and no adverse reactions with the reactants and products. Halogenated hydrocarbon solvents such as dichloromethane and carbon tetrachloride are often selected for their good solubility and stability to halogenation reactions, but their boiling point, toxicity and other factors should be considered when using them to ensure safe operation and convenient subsequent separation.
During the reaction process, the stirring rate should also be appropriate. Good stirring can promote the full contact of the reactants, make the reaction proceed uniformly, and prevent the local concentration from being too high or too low to cause side reactions. If the stirring is too slow, the reactants such as bromine may accumulate locally, resulting in excessive bromination; if the stirring is too fast, it may lead to increased equipment loss and affect the stability of the reaction system.
In the stage of product separation and purification, in view of the complex reaction system and many by-products, the separation method needs to be fine. It is commonly used to combine distillation, extraction, column chromatography and other methods. During distillation, the temperature and pressure should be precisely controlled according to the difference in boiling point of each component to achieve effective separation; the extractant used in extraction should have good selectivity for the target product; column chromatography needs to select the appropriate fixed phase and mobile phase to obtain high-purity products.
In addition, safety protection must not be forgotten. Bromine and other reagents are highly corrosive and irritating. When operating, protective clothing, goggles, gloves and other protective equipment should be worn, and the reaction should be carried out in a well-ventilated environment, such as a fume hood, to prevent harmful gases from endangering human health. Exhaust gas and waste liquid should also be properly handled, follow environmental protection requirements, and should not be discharged at will to avoid polluting the environment.
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