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5-Chloro-2-Fluorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
802141 |
| Chemical Formula | C6H5BClFO2 |
| Molecular Weight | 175.37 |
| Appearance | White to off - white solid |
| Purity | Typically high - purity (e.g., 95%+) |
| Solubility | Soluble in some organic solvents like dichloromethane, less soluble in water |
| Melting Point | 110 - 114 °C |
| Stability | Stable under normal conditions, but moisture - sensitive |
| Reactivity | Reacts with organohalides in Suzuki - Miyaura coupling reactions |
As an accredited 5-Chloro-2-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - chloro - 2 - fluorobenzeneboronic Acid: 100g in sealed, labeled chemical - resistant bottle. |
| Storage | 5 - Chloro - 2 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially degrade the chemical. Store it separately from incompatible substances like strong oxidizing agents or bases to avoid unwanted reactions. |
| Shipping | 5 - chloro - 2 - fluorobenzeneboronic acid, a chemical, is typically shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical transportation regulations, ensuring safety during transit to prevent leakage and potential hazards. |
Competitive 5-Chloro-2-Fluorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-Chloro-2-Fluorobenzeneboronic Acid in China?
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As a leading 5-Chloro-2-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 5-chloro-2-fluorophenylboronic acid?
5-Alkane-2-enheptyl oxalic acid is an organic compound, and its chemical properties are very complicated. Although this specific compound is not detailed in Tiangong Kaiwu, its properties can be inferred by the method of traditional Chinese chemical cognition.
This compound has functional groups such as carbon-carbon double bonds and carboxyl groups. The existence of carbon-carbon double bonds makes it capable of addition reaction. In case of bromine water, it can be added, and the color of bromine water fades. Due to the high electron cloud density of the double bond, it is vulnerable to attack by electrophilic reagents. When adding hydrogen to hydrogen halide, according to the Markov rule, hydrogen atoms are mostly added to double-bonded carbon atoms containing more hydrogen.
Its carboxyl group can be developed acidity-related reactions. It can neutralize and react with bases to form corresponding salts and water. Taking sodium hydroxide as an example, the two react to produce sodium 5-alkane-2-enheptyl oxalate and water. This carboxyl group can also be esterified with alcohols under the condition of catalysis and heating of concentrated sulfuric acid to produce esters and water. This reaction is reversible.
In addition, since it is an organic compound, it is usually flammable and burns in sufficient oxygen to generate carbon dioxide and water. And the molecule may have good solubility in organic solvents due to its long carbon chain or certain fat solubility. Its specific chemical properties may vary due to the interaction of other atoms or groups in the molecule, but the general properties of functional groups can provide a basic understanding and speculation of its chemical behavior.
This compound has functional groups such as carbon-carbon double bonds and carboxyl groups. The existence of carbon-carbon double bonds makes it capable of addition reaction. In case of bromine water, it can be added, and the color of bromine water fades. Due to the high electron cloud density of the double bond, it is vulnerable to attack by electrophilic reagents. When adding hydrogen to hydrogen halide, according to the Markov rule, hydrogen atoms are mostly added to double-bonded carbon atoms containing more hydrogen.
Its carboxyl group can be developed acidity-related reactions. It can neutralize and react with bases to form corresponding salts and water. Taking sodium hydroxide as an example, the two react to produce sodium 5-alkane-2-enheptyl oxalate and water. This carboxyl group can also be esterified with alcohols under the condition of catalysis and heating of concentrated sulfuric acid to produce esters and water. This reaction is reversible.
In addition, since it is an organic compound, it is usually flammable and burns in sufficient oxygen to generate carbon dioxide and water. And the molecule may have good solubility in organic solvents due to its long carbon chain or certain fat solubility. Its specific chemical properties may vary due to the interaction of other atoms or groups in the molecule, but the general properties of functional groups can provide a basic understanding and speculation of its chemical behavior.
What are the common uses of 5-chloro-2-fluorophenylboronic acid?
5-Alkane-2-enheptanoic acid is an organic compound, which is widely used in chemical synthesis, medical preparation and other fields. Its common preparation methods are as follows:
1. ** Reaction method of halogenated hydrocarbons and metal reagents **: The Grignard reagent is made from halogenated alkanes and metals such as magnesium, and then reacts with halogenated compounds containing enheptanoic acid structure. For example, ethyl magnesium bromide is made from bromoethane and magnesium, and then reacts with ethyl 5-bromo-2-enheptanoic acid to obtain the target product after hydrolysis. The reaction formula is:
-\ (C_ {2} H_ {5} Br + Mg\ xrightarrow {anhydrous ether} C_ {2} H_ {5} MgBr\)
-\ (C_ {2} H_ {5} MgBr + Br (CH_ {2}) _ {3} C (= O) CH = CHCOOC_ {2} H_ {5}\ xrightarrow {reaction} product\ xrightarrow {hydrolysis} 5 - alkane - 2 - enheptanoic acid\)
This method requires an anhydrous and anaerobic environment, and the reaction conditions are relatively harsh, which requires high operation.
2. ** Carbonyl compound condensation method **: The use of carbonyl-containing compounds, such as aldose and ketone, to condensate with allyl reagents. For example, acetone and allyl magnesium bromide are added first, and then obtained through a series of oxidation and acidification steps. The approximate reaction process is:
-\ (CH_ {3} COCH_ {3} + C_ {3} H_ {5} MgBr\ xrightarrow {reaction} Addition product\)
- The addition product is oxidized, the alcohol hydroxyl is oxidized to carbonyl, and then acidified to hydrolyze the ester group, etc., and finally 5-alkane-2-enheptanone acid is obtained. There are many reaction steps in this way, and the yield of each step will affect the yield of the final product.
3. ** Biosynthesis method **: Synthesized by the catalytic action of microorganisms or enzymes. Some enzymes in microorganisms can catalyze specific substrates to generate 5-alkane-2-enheptanoic acid through multi-step reaction. This method is green and environmentally friendly, and the reaction conditions are mild. However, the extraction and purification of microorganisms and enzymes are more complicated and costly.
4. ** Carboxylic acid derivative conversion method **: Converted from the corresponding carboxylic acid esters, acyl chlorides and other derivatives. For example, using 5-alkane-2-enheptanoic acid ethyl ester as raw material, the target acid can be obtained by alkaline hydrolysis and acidification. The reaction formula is:
-\ (5-alkane-2-ethyl enheptanoate + NaOH\ xrightarrow {hydrolysis} 5-alkane-2-sodium enheptanoate + C_ {2} H_ {5} OH\)
-\ (5-alkane-2-sodium enheptanoate + HCl\ xrightarrow {acidification} 5-alkane-2-enheptanoic acid + NaCl\)
This method is relatively simple to operate and the raw materials are easy to obtain. However, the hydrolysis and acidification conditions need to be precisely controlled to avoid affecting the purity and yield of the product.
1. ** Reaction method of halogenated hydrocarbons and metal reagents **: The Grignard reagent is made from halogenated alkanes and metals such as magnesium, and then reacts with halogenated compounds containing enheptanoic acid structure. For example, ethyl magnesium bromide is made from bromoethane and magnesium, and then reacts with ethyl 5-bromo-2-enheptanoic acid to obtain the target product after hydrolysis. The reaction formula is:
-\ (C_ {2} H_ {5} Br + Mg\ xrightarrow {anhydrous ether} C_ {2} H_ {5} MgBr\)
-\ (C_ {2} H_ {5} MgBr + Br (CH_ {2}) _ {3} C (= O) CH = CHCOOC_ {2} H_ {5}\ xrightarrow {reaction} product\ xrightarrow {hydrolysis} 5 - alkane - 2 - enheptanoic acid\)
This method requires an anhydrous and anaerobic environment, and the reaction conditions are relatively harsh, which requires high operation.
2. ** Carbonyl compound condensation method **: The use of carbonyl-containing compounds, such as aldose and ketone, to condensate with allyl reagents. For example, acetone and allyl magnesium bromide are added first, and then obtained through a series of oxidation and acidification steps. The approximate reaction process is:
-\ (CH_ {3} COCH_ {3} + C_ {3} H_ {5} MgBr\ xrightarrow {reaction} Addition product\)
- The addition product is oxidized, the alcohol hydroxyl is oxidized to carbonyl, and then acidified to hydrolyze the ester group, etc., and finally 5-alkane-2-enheptanone acid is obtained. There are many reaction steps in this way, and the yield of each step will affect the yield of the final product.
3. ** Biosynthesis method **: Synthesized by the catalytic action of microorganisms or enzymes. Some enzymes in microorganisms can catalyze specific substrates to generate 5-alkane-2-enheptanoic acid through multi-step reaction. This method is green and environmentally friendly, and the reaction conditions are mild. However, the extraction and purification of microorganisms and enzymes are more complicated and costly.
4. ** Carboxylic acid derivative conversion method **: Converted from the corresponding carboxylic acid esters, acyl chlorides and other derivatives. For example, using 5-alkane-2-enheptanoic acid ethyl ester as raw material, the target acid can be obtained by alkaline hydrolysis and acidification. The reaction formula is:
-\ (5-alkane-2-ethyl enheptanoate + NaOH\ xrightarrow {hydrolysis} 5-alkane-2-sodium enheptanoate + C_ {2} H_ {5} OH\)
-\ (5-alkane-2-sodium enheptanoate + HCl\ xrightarrow {acidification} 5-alkane-2-enheptanoic acid + NaCl\)
This method is relatively simple to operate and the raw materials are easy to obtain. However, the hydrolysis and acidification conditions need to be precisely controlled to avoid affecting the purity and yield of the product.
What is the synthesis method of 5-chloro-2-fluorophenylboronic acid?
To make 5-bromo-2-pentenyl benzoic acid, you can follow the following ancient method.
First take an appropriate amount of pentene, place it in a clean kettle, and slowly add liquid bromine at a low temperature. This step requires extreme caution, because bromine is highly corrosive and volatile. Bromine and pentene can be obtained by addition reaction. During the reaction, pay close attention to the temperature and reaction process to avoid excessive reaction.
After obtaining bromopentene, place it in the reaction vessel with the derivative of benzoic acid, and add an appropriate amount of catalyst. The choice of this catalyst is crucial and needs to be carefully selected according to the reaction characteristics and conditions. Then, under a specific temperature and pressure, the substitution reaction between the two is promoted. During the reaction, stirring is continued to make the reactants fully contact and improve the reaction efficiency.
After the reaction is completed, the resulting mixed products are separated and purified by distillation, extraction, etc. During distillation, according to the boiling point of each component, they are separated one by one. Extraction selects an appropriate extractant to enrich the target product. After several separation operations, pure 5-bromo-2-pentenylbenzoic acid is finally obtained.
The whole preparation process requires strict control of the reaction conditions, from temperature, pressure to the proportion of reactants, all of which need to be accurate. And each step must follow the specifications to ensure safety and product purity and yield.
First take an appropriate amount of pentene, place it in a clean kettle, and slowly add liquid bromine at a low temperature. This step requires extreme caution, because bromine is highly corrosive and volatile. Bromine and pentene can be obtained by addition reaction. During the reaction, pay close attention to the temperature and reaction process to avoid excessive reaction.
After obtaining bromopentene, place it in the reaction vessel with the derivative of benzoic acid, and add an appropriate amount of catalyst. The choice of this catalyst is crucial and needs to be carefully selected according to the reaction characteristics and conditions. Then, under a specific temperature and pressure, the substitution reaction between the two is promoted. During the reaction, stirring is continued to make the reactants fully contact and improve the reaction efficiency.
After the reaction is completed, the resulting mixed products are separated and purified by distillation, extraction, etc. During distillation, according to the boiling point of each component, they are separated one by one. Extraction selects an appropriate extractant to enrich the target product. After several separation operations, pure 5-bromo-2-pentenylbenzoic acid is finally obtained.
The whole preparation process requires strict control of the reaction conditions, from temperature, pressure to the proportion of reactants, all of which need to be accurate. And each step must follow the specifications to ensure safety and product purity and yield.
What are the precautions for storing and transporting 5-chloro-2-fluorophenylboronic acid?
5-Bromo-2-pentenoic acid is one of the organic compounds. During storage and transportation, many matters must be paid attention to to to ensure its quality and safety.
As far as storage is concerned, first, it should be placed in a cool, dry and well-ventilated place. The cover is chemically active. If the environment is too warm and humid, it may cause deterioration, and even pose a safety risk. If it is in a humid place, it is easily eroded by water vapor, triggering reactions such as hydrolysis; under high temperature, it may accelerate its decomposition process. Second, it needs to be stored separately from oxidants, alkalis and other substances. 5-Bromo-2-pentenoic acid has a certain acidity, and when it encounters alkalis, it is easy to neutralize; while the oxidant has strong oxidation, coexists with it, or triggers a violent oxidation reaction, causing dangerous situations such as combustion and explosion. Third, the storage container should also be carefully selected. Corrosion-resistant materials, such as glass, specific plastics, etc., should be used to prevent the container from being corroded and leaking, causing material loss and environmental hazards.
As for transportation, the first priority is to ensure that the packaging is complete. If the packaging is damaged, the material or flow out during transportation will pollute the environment and pose a threat to the transportation personnel. The packaging should be sturdy and durable, able to withstand certain external shocks and vibrations. Secondly, the means of transportation also need to be suitable. It should be clean, dry and free of other chemical residues to prevent impurities from mixing and affecting the quality of 5-bromo-2-pentenoic acid. Furthermore, during transportation, temperature and humidity control are crucial. Stable temperature and humidity conditions should be maintained, which can be achieved by means of temperature control equipment, moisture-proof measures, etc. And transportation personnel must be professionally trained, familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can respond quickly and properly to reduce the harm.
As far as storage is concerned, first, it should be placed in a cool, dry and well-ventilated place. The cover is chemically active. If the environment is too warm and humid, it may cause deterioration, and even pose a safety risk. If it is in a humid place, it is easily eroded by water vapor, triggering reactions such as hydrolysis; under high temperature, it may accelerate its decomposition process. Second, it needs to be stored separately from oxidants, alkalis and other substances. 5-Bromo-2-pentenoic acid has a certain acidity, and when it encounters alkalis, it is easy to neutralize; while the oxidant has strong oxidation, coexists with it, or triggers a violent oxidation reaction, causing dangerous situations such as combustion and explosion. Third, the storage container should also be carefully selected. Corrosion-resistant materials, such as glass, specific plastics, etc., should be used to prevent the container from being corroded and leaking, causing material loss and environmental hazards.
As for transportation, the first priority is to ensure that the packaging is complete. If the packaging is damaged, the material or flow out during transportation will pollute the environment and pose a threat to the transportation personnel. The packaging should be sturdy and durable, able to withstand certain external shocks and vibrations. Secondly, the means of transportation also need to be suitable. It should be clean, dry and free of other chemical residues to prevent impurities from mixing and affecting the quality of 5-bromo-2-pentenoic acid. Furthermore, during transportation, temperature and humidity control are crucial. Stable temperature and humidity conditions should be maintained, which can be achieved by means of temperature control equipment, moisture-proof measures, etc. And transportation personnel must be professionally trained, familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can respond quickly and properly to reduce the harm.
What is the market price of 5-chloro-2-fluorophenylboronic acid?
The market value of 5-% -2-alkylthiobenzoic acid varies depending on the general reasons. This compound is often used in the chemical industry and the chemical industry, and its level depends on the quality of the product, supply and demand, and ease of use.
On the one end of the product, those with high quality must be high due to the complexity and high cost of extraction. If it is used for high-quality research, the quality requirements are stringent, and the cost may be hundreds or even thousands of yuan per gram. If the quality is slightly low, it can be slightly reduced for general chemical synthesis, or 10 to 100 yuan per gram.
The supply and demand situation also affects its cost. Those who are seeking in the market are low, and the quantity is limited, and the cost must be high. If there is a surge in demand for this compound in a certain research area, then the supply of this compound will increase rapidly, or increase significantly. On the contrary, if the supply is limited to demand, there will be a decline.
It is easy, and it is also the main reason for the situation. If its synthesis requires rare raw materials, special anti-waste parts or complex steps, the cost is high and the cost is also high. On the contrary, if the method is easy, the cost is controllable, and the cost is easy.
Generally speaking, the market price of 5-% -2-alkylthiobenzoic acid, according to the above-mentioned general price, or from 10 yuan to 1,000 yuan per gram, has a value of 10 yuan to 1,000 yuan.
On the one end of the product, those with high quality must be high due to the complexity and high cost of extraction. If it is used for high-quality research, the quality requirements are stringent, and the cost may be hundreds or even thousands of yuan per gram. If the quality is slightly low, it can be slightly reduced for general chemical synthesis, or 10 to 100 yuan per gram.
The supply and demand situation also affects its cost. Those who are seeking in the market are low, and the quantity is limited, and the cost must be high. If there is a surge in demand for this compound in a certain research area, then the supply of this compound will increase rapidly, or increase significantly. On the contrary, if the supply is limited to demand, there will be a decline.
It is easy, and it is also the main reason for the situation. If its synthesis requires rare raw materials, special anti-waste parts or complex steps, the cost is high and the cost is also high. On the contrary, if the method is easy, the cost is controllable, and the cost is easy.
Generally speaking, the market price of 5-% -2-alkylthiobenzoic acid, according to the above-mentioned general price, or from 10 yuan to 1,000 yuan per gram, has a value of 10 yuan to 1,000 yuan.
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