Linshang Chemical
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5-Chloro-2-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
323939 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow to light brown solid |
| Boiling Point | 226 - 227 °C |
| Melting Point | 25 - 28 °C |
| Density | 1.484 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 103 °C |
| Vapor Pressure | Low |
| Refractive Index | 1.553 (20 °C) |
As an accredited 5-Chloro-2-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - chloro - 2 - fluoronitrobenzene: Packed in 25 - kg drums for chemical storage and transport. |
| Storage | 5 - Chloro - 2 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and substances reactive to it to avoid potential chemical reactions. |
| Shipping | 5 - Chloro - 2 - fluoronitrobenzene is shipped in tightly - sealed, corrosion - resistant containers. It's handled as a hazardous chemical, following strict regulations, ensuring safe transportation to prevent spills and environmental or health risks. |
Competitive 5-Chloro-2-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the physical properties of 5-chloro-2-fluoronitrobenzene?
5-Chloro-2-fluoronitrobenzene is also an organic compound. Its physical properties are quite specific and are described in detail today.
First, its appearance, at room temperature, 5-chloro-2-fluoronitrobenzene is often a light yellow to brown crystalline solid. This color state can be used to identify this substance.
Second, its melting point. Its melting point is about 32-34 ° C. The melting point is not high, and it is easy to melt into a liquid state when heated. As for the boiling point, it is about 230-232 ° C. A higher boiling point indicates that more heat is required to vaporize it. This boiling point characteristic is crucial when separating, purifying and applying this substance.
Furthermore, the density of 5-chloro-2-fluoronitrobenzene is about 1.57 g/cm ³. This density data is helpful for understanding the floating and sinking conditions when mixed with other substances, and is indispensable in the composition of chemical production materials and the construction of reaction systems.
Solubility is also an important physical property. It is insoluble in water, but soluble in organic solvents such as ethanol, ether, and acetone. This difference in solubility is an important guide for extraction, separation, and selection of reaction media for organic synthesis.
In addition, 5-chloro-2-fluoronitrobenzene has a certain volatility. Although the volatility is not strong, it may also escape into the air in a poorly ventilated environment. Therefore, ventilation measures are essential when handling this compound.
The physical properties of this compound are the basis for its chemical application, production control and safety protection, and are of great significance in various fields of chemical industry.
First, its appearance, at room temperature, 5-chloro-2-fluoronitrobenzene is often a light yellow to brown crystalline solid. This color state can be used to identify this substance.
Second, its melting point. Its melting point is about 32-34 ° C. The melting point is not high, and it is easy to melt into a liquid state when heated. As for the boiling point, it is about 230-232 ° C. A higher boiling point indicates that more heat is required to vaporize it. This boiling point characteristic is crucial when separating, purifying and applying this substance.
Furthermore, the density of 5-chloro-2-fluoronitrobenzene is about 1.57 g/cm ³. This density data is helpful for understanding the floating and sinking conditions when mixed with other substances, and is indispensable in the composition of chemical production materials and the construction of reaction systems.
Solubility is also an important physical property. It is insoluble in water, but soluble in organic solvents such as ethanol, ether, and acetone. This difference in solubility is an important guide for extraction, separation, and selection of reaction media for organic synthesis.
In addition, 5-chloro-2-fluoronitrobenzene has a certain volatility. Although the volatility is not strong, it may also escape into the air in a poorly ventilated environment. Therefore, ventilation measures are essential when handling this compound.
The physical properties of this compound are the basis for its chemical application, production control and safety protection, and are of great significance in various fields of chemical industry.
What are the chemical properties of 5-chloro-2-fluoronitrobenzene?
5-Chloro-2-fluoronitrobenzene, this is an organic compound with many unique chemical properties.
It has the properties of halogenated aromatics. Chlorine and fluorine act as halogen atoms, giving the substance specific reactivity. Halogen atoms can participate in nucleophilic substitution reactions. Under appropriate conditions, hydroxyl, amino and other nucleophilic reagents can attack the benzene ring and replace halogen atoms. For example, when an aqueous solution of sodium hydroxide is used as a reagent, when heated, the chlorine atom can be replaced by a hydroxyl group to form 5-hydroxy-2-fluoronitrobenzene; if it is reacted with an alcohol solution of ammonia, the chlorine atom will be replaced by an amino group to obtain 5-amino-2-fluoronitroben
Furthermore, its nitro properties are remarkable. Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring, but makes the electron cloud density of the ortho and para-position relatively low and the meta-position relatively high. Therefore, during the electrophilic substitution reaction, the new group mainly enters the meta-position. At the same time, the nitro group can be reduced. Under the action of reducing agents such as iron and hydrochloric acid, the nitro group can be gradually reduced to an amino group to generate 5-chloro-2-fluoroaniline.
In addition, 5-chloro-2-fluoronitrobenzene also has certain stability. Due to the influence of halogen atoms and nitro groups on the benzene ring conjugate system, the compound is relatively stable under general conditions, and specific reaction conditions are required to promote its chemical changes.
Its chemical properties are widely used in the field of organic synthesis, and can be used as intermediates to synthesize organic compounds such as drugs, pesticides, dyes, etc., and to construct complex organic molecular structures through various reactions.
It has the properties of halogenated aromatics. Chlorine and fluorine act as halogen atoms, giving the substance specific reactivity. Halogen atoms can participate in nucleophilic substitution reactions. Under appropriate conditions, hydroxyl, amino and other nucleophilic reagents can attack the benzene ring and replace halogen atoms. For example, when an aqueous solution of sodium hydroxide is used as a reagent, when heated, the chlorine atom can be replaced by a hydroxyl group to form 5-hydroxy-2-fluoronitrobenzene; if it is reacted with an alcohol solution of ammonia, the chlorine atom will be replaced by an amino group to obtain 5-amino-2-fluoronitroben
Furthermore, its nitro properties are remarkable. Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution activity of the benzene ring, but makes the electron cloud density of the ortho and para-position relatively low and the meta-position relatively high. Therefore, during the electrophilic substitution reaction, the new group mainly enters the meta-position. At the same time, the nitro group can be reduced. Under the action of reducing agents such as iron and hydrochloric acid, the nitro group can be gradually reduced to an amino group to generate 5-chloro-2-fluoroaniline.
In addition, 5-chloro-2-fluoronitrobenzene also has certain stability. Due to the influence of halogen atoms and nitro groups on the benzene ring conjugate system, the compound is relatively stable under general conditions, and specific reaction conditions are required to promote its chemical changes.
Its chemical properties are widely used in the field of organic synthesis, and can be used as intermediates to synthesize organic compounds such as drugs, pesticides, dyes, etc., and to construct complex organic molecular structures through various reactions.
What are the main uses of 5-chloro-2-fluoronitrobenzene?
5-Chloro-2-fluoronitrobenzene is an important raw material for organic synthesis. It has a wide range of uses and has outstanding performance in the fields of medicine, pesticides, dyes, etc.
In the field of medicine, this compound is often a key intermediate. Because it contains special functional groups such as chlorine, fluorine and nitro, it can participate in various reactions to construct complex drug molecular structures. Through a series of chemical transformations, it can prepare a variety of antibacterial, antiviral and anti-tumor drugs. For example, by introducing specific groups through nucleophilic substitution reactions, compounds with unique biological activities can be obtained, providing an important basis for the development of new drugs.
In the field of pesticides, 5-chloro-2-fluoronitrobenzene also plays an important role. It can be used as a starting material for the synthesis of high-efficiency pesticides. Using its functional group characteristics, it can be modified and transformed to produce pesticide varieties with high selectivity, strong lethality and environmental friendliness to pests. The introduction of fluorine atoms can often improve the stability and biological activity of pesticides, making them play a key role in crop protection.
In the dye industry, 5-chloro-2-fluoronitrobenzene can be used to synthesize characteristic dyes. The nitro and halogen atoms in its structure can participate in reactions such as diazotization and coupling, giving the dyes unique color and properties. It can prepare dyes with bright color, excellent light resistance and washable properties, and is widely used in textile, printing and dyeing industries to meet the dyeing needs of different fabrics.
In summary, 5-chloro-2-fluoronitrophenyl has a unique structure and plays an indispensable role in the pharmaceutical, pesticide, and dye industries, which is of great significance to promoting the development of related industries.
In the field of medicine, this compound is often a key intermediate. Because it contains special functional groups such as chlorine, fluorine and nitro, it can participate in various reactions to construct complex drug molecular structures. Through a series of chemical transformations, it can prepare a variety of antibacterial, antiviral and anti-tumor drugs. For example, by introducing specific groups through nucleophilic substitution reactions, compounds with unique biological activities can be obtained, providing an important basis for the development of new drugs.
In the field of pesticides, 5-chloro-2-fluoronitrobenzene also plays an important role. It can be used as a starting material for the synthesis of high-efficiency pesticides. Using its functional group characteristics, it can be modified and transformed to produce pesticide varieties with high selectivity, strong lethality and environmental friendliness to pests. The introduction of fluorine atoms can often improve the stability and biological activity of pesticides, making them play a key role in crop protection.
In the dye industry, 5-chloro-2-fluoronitrobenzene can be used to synthesize characteristic dyes. The nitro and halogen atoms in its structure can participate in reactions such as diazotization and coupling, giving the dyes unique color and properties. It can prepare dyes with bright color, excellent light resistance and washable properties, and is widely used in textile, printing and dyeing industries to meet the dyeing needs of different fabrics.
In summary, 5-chloro-2-fluoronitrophenyl has a unique structure and plays an indispensable role in the pharmaceutical, pesticide, and dye industries, which is of great significance to promoting the development of related industries.
What are 5-chloro-2-fluoronitrobenzene synthesis methods?
The common methods for the synthesis of 5-chloro-2-fluoronitrobenzene are as follows.
One is the halogenation reaction path. First, take the appropriate nitrobenzene derivative and treat it with a specific halogenating reagent. If the halogenating agent containing chlorine and fluorine is used, the benzene ring is halogenated under suitable reaction conditions. This requires fine regulation of the reaction temperature, time and reagent ratio. If the temperature is too high, it may cause the formation of polyhalogenated by-products; if the temperature is too low, the reaction rate will be delayed. Time control is also critical. If it is too short, the reaction will not be completed, and if it is too long, it will only increase energy consumption and the risk of side reactions. The proportion of reagents is accurate, so that chlorine atoms and fluorine atoms can be introduced into the benzene ring in the desired position and ratio to obtain the target product 5-chloro-2-fluoronitrobenzene.
The second is based on a substitution reaction. Select an appropriate benzene ring substrate, which has a group that can be substituted by chlorine and fluorine on the benzene ring. For example, nitrobenzene with a specific substituent group is used as the starting material, and it is substituted with the chlorine source and fluorine source under the action of the catalyst. The choice of catalyst is of paramount importance, and the activity and selectivity of different catalysts are different. Those who are suitable can efficiently promote the target substitution reaction and inhibit other unnecessary At the same time, the properties of the reaction solvent also affect the reaction process. A solvent with good compatibility with the reactants and catalysts and favorable for the reaction should be selected to create a good reaction environment to facilitate the formation of 5-chloro-2-fluoronitrobenzene.
Third, it can be constructed by multi-step reaction. First, nitro groups are introduced into the benzene ring by conventional methods, and then chlorine atoms and fluorine atoms are introduced in an orderly manner. Each step of this process requires strict control of the reaction conditions, and the intermediate products need to be carefully separated and purified to prevent the accumulation of impurities from affecting the purity and yield of the final product. After each step of the reaction, the structure and purity of the product should be monitored by suitable analytical means, such as chromatography, spectroscopy, etc., to ensure that the reaction proceeds according to the expected path, and the final result is 5-chloro-2-fluoronitrobenzene.
One is the halogenation reaction path. First, take the appropriate nitrobenzene derivative and treat it with a specific halogenating reagent. If the halogenating agent containing chlorine and fluorine is used, the benzene ring is halogenated under suitable reaction conditions. This requires fine regulation of the reaction temperature, time and reagent ratio. If the temperature is too high, it may cause the formation of polyhalogenated by-products; if the temperature is too low, the reaction rate will be delayed. Time control is also critical. If it is too short, the reaction will not be completed, and if it is too long, it will only increase energy consumption and the risk of side reactions. The proportion of reagents is accurate, so that chlorine atoms and fluorine atoms can be introduced into the benzene ring in the desired position and ratio to obtain the target product 5-chloro-2-fluoronitrobenzene.
The second is based on a substitution reaction. Select an appropriate benzene ring substrate, which has a group that can be substituted by chlorine and fluorine on the benzene ring. For example, nitrobenzene with a specific substituent group is used as the starting material, and it is substituted with the chlorine source and fluorine source under the action of the catalyst. The choice of catalyst is of paramount importance, and the activity and selectivity of different catalysts are different. Those who are suitable can efficiently promote the target substitution reaction and inhibit other unnecessary At the same time, the properties of the reaction solvent also affect the reaction process. A solvent with good compatibility with the reactants and catalysts and favorable for the reaction should be selected to create a good reaction environment to facilitate the formation of 5-chloro-2-fluoronitrobenzene.
Third, it can be constructed by multi-step reaction. First, nitro groups are introduced into the benzene ring by conventional methods, and then chlorine atoms and fluorine atoms are introduced in an orderly manner. Each step of this process requires strict control of the reaction conditions, and the intermediate products need to be carefully separated and purified to prevent the accumulation of impurities from affecting the purity and yield of the final product. After each step of the reaction, the structure and purity of the product should be monitored by suitable analytical means, such as chromatography, spectroscopy, etc., to ensure that the reaction proceeds according to the expected path, and the final result is 5-chloro-2-fluoronitrobenzene.
5-chloro-2-fluoronitrobenzene What are the precautions in storage and transportation?
5-Chloro-2-fluoronitrobenzene is a commonly used raw material in organic synthesis. When storing and transporting, many matters must be paid attention to.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because the substance is heated or exposed to open flames, there is a risk of combustion and explosion. The temperature of the warehouse should be strictly controlled and should not be too high to prevent its chemical properties from being unstable due to temperature.
Furthermore, it should be stored separately from oxidants, reducing agents, acids, bases, etc., and must not be mixed. Because of its active chemical properties, contact with the above various substances can easily cause violent chemical reactions, resulting in dangerous accidents. There are also requirements for storage containers. It is necessary to ensure that it is well sealed to prevent its volatilization and leakage. At the same time, the container should be checked regularly, and if there is any damage, it should be dealt with in time.
When transporting, the packaging must be tight and firm. Appropriate packaging materials are used to ensure that there is no leakage caused by vibration, collision and other factors during transportation. Transportation vehicles must also meet relevant safety standards and be equipped with necessary emergency treatment equipment. During transportation, drivers and escorts must have professional knowledge and be familiar with the dangerous characteristics of the substance and emergency disposal methods. Driving routes should avoid sensitive areas such as densely populated areas and water sources, and transportation time should be arranged during periods with low traffic flow as much as possible to reduce risks.
In short, the storage and transportation of 5-chloro-2-fluoronitrobenzene is related to the overall safety situation, and every link cannot be ignored. It is necessary to strictly follow the relevant regulations and operating guidelines to ensure safety.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because the substance is heated or exposed to open flames, there is a risk of combustion and explosion. The temperature of the warehouse should be strictly controlled and should not be too high to prevent its chemical properties from being unstable due to temperature.
Furthermore, it should be stored separately from oxidants, reducing agents, acids, bases, etc., and must not be mixed. Because of its active chemical properties, contact with the above various substances can easily cause violent chemical reactions, resulting in dangerous accidents. There are also requirements for storage containers. It is necessary to ensure that it is well sealed to prevent its volatilization and leakage. At the same time, the container should be checked regularly, and if there is any damage, it should be dealt with in time.
When transporting, the packaging must be tight and firm. Appropriate packaging materials are used to ensure that there is no leakage caused by vibration, collision and other factors during transportation. Transportation vehicles must also meet relevant safety standards and be equipped with necessary emergency treatment equipment. During transportation, drivers and escorts must have professional knowledge and be familiar with the dangerous characteristics of the substance and emergency disposal methods. Driving routes should avoid sensitive areas such as densely populated areas and water sources, and transportation time should be arranged during periods with low traffic flow as much as possible to reduce risks.
In short, the storage and transportation of 5-chloro-2-fluoronitrobenzene is related to the overall safety situation, and every link cannot be ignored. It is necessary to strictly follow the relevant regulations and operating guidelines to ensure safety.
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