Linshang Chemical
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5-Chloro-2-Methoxybenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
207400 |
| Chemical Formula | C7H6Cl2O3S |
| Molar Mass | 241.09 g/mol |
| Appearance | Solid (usually white or off - white) |
| Physical State At Room Temperature | Solid |
| Melting Point | Data may vary, needs experimental determination |
| Boiling Point | Data may vary, needs experimental determination |
| Solubility In Water | Insoluble (sulfonyl chlorides react with water) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data may vary, needs experimental determination |
| Flash Point | Data may vary, needs experimental determination |
| Hazard Class | Corrosive (due to sulfonyl chloride group) |
| Odor | Pungent |
As an accredited 5-Chloro-2-Methoxybenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 5 - chloro - 2 - methoxybenzenesulfonyl chloride in sealed, corrosion - resistant container. |
| Storage | 5 - Chloro - 2 - methoxybenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent moisture ingress, as it may react with water. Store it separately from incompatible substances like bases, amines, and reducing agents to avoid potential chemical reactions. |
| Shipping | 5 - Chloro - 2 - methoxybenzenesulfonyl chloride, a hazardous chemical, is shipped in tightly sealed, corrosion - resistant containers. Special handling protocols are followed to ensure safe transport, in compliance with all relevant regulations. |
Competitive 5-Chloro-2-Methoxybenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-Chloro-2-Methoxybenzenesulfonyl Chloride in China?
As a trusted 5-Chloro-2-Methoxybenzenesulfonyl Chloride manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 5-Chloro-2-Methoxybenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 5-chloro-2-methoxybenzenesulfonyl chloride?
5-Bromo-2-methoxybenzaldehyde is a crucial intermediate in organic synthesis and is widely used in medicine, pesticides, fragrances and other fields.
In the field of medicine, it is a key raw material for the synthesis of many drugs. For example, in the preparation of some anti-tumor drugs, 5-bromo-2-methoxybenzaldehyde can undergo a series of chemical reactions to build a specific chemical structure, giving the drug the ability to combine with tumor cell targets, and then exert the effect of inhibiting tumor cell growth and proliferation. In the development and synthesis of antidepressant drugs, this compound is one of the starting materials. Through the modification and transformation of its functional groups, it can synthesize active ingredients that regulate neurotransmitter functions and help improve patients' depression symptoms.
In the field of pesticides, 5-bromo-2-methoxybenzaldehyde can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. For example, the synthesis of new pesticides, with their unique chemical structure, interferes with the nervous system or physiological and metabolic processes of specific pests, achieving the purpose of efficient insecticides, while reducing the negative impact on non-target organisms and the environment, which meets the development needs of modern green pesticides.
In the field of fragrances, it can be used as an important intermediate for the synthesis of unique aroma fragrances. By reacting with other compounds, fragrance products with special fragrances can be prepared, which can be used in perfumes, food additives, cosmetics and other industries to give products unique aroma, improve product quality and market competitiveness.
To sum up, 5-bromo-2-methoxybenzaldehyde plays an indispensable role in many fields due to its diverse chemical reactivity and is of key significance to promote the development of related industries.
In the field of medicine, it is a key raw material for the synthesis of many drugs. For example, in the preparation of some anti-tumor drugs, 5-bromo-2-methoxybenzaldehyde can undergo a series of chemical reactions to build a specific chemical structure, giving the drug the ability to combine with tumor cell targets, and then exert the effect of inhibiting tumor cell growth and proliferation. In the development and synthesis of antidepressant drugs, this compound is one of the starting materials. Through the modification and transformation of its functional groups, it can synthesize active ingredients that regulate neurotransmitter functions and help improve patients' depression symptoms.
In the field of pesticides, 5-bromo-2-methoxybenzaldehyde can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. For example, the synthesis of new pesticides, with their unique chemical structure, interferes with the nervous system or physiological and metabolic processes of specific pests, achieving the purpose of efficient insecticides, while reducing the negative impact on non-target organisms and the environment, which meets the development needs of modern green pesticides.
In the field of fragrances, it can be used as an important intermediate for the synthesis of unique aroma fragrances. By reacting with other compounds, fragrance products with special fragrances can be prepared, which can be used in perfumes, food additives, cosmetics and other industries to give products unique aroma, improve product quality and market competitiveness.
To sum up, 5-bromo-2-methoxybenzaldehyde plays an indispensable role in many fields due to its diverse chemical reactivity and is of key significance to promote the development of related industries.
What are the physical properties of 5-chloro-2-methoxybenzenesulfonyl chloride?
5-Bromo-2-methoxybenzaldehyde, this is an organic compound. Its physical properties are as follows:
In appearance, it usually appears as a light yellow to yellow crystalline powder or liquid state. Looking at its color, it may be light yellow or dark yellow depending on its purity and environment, but generally does not leave the yellow category. As for the form, when the room temperature environment is suitable, it is mostly shown as a crystalline powder; if the external temperature is slightly higher and close to its melting point, it may also transform into a liquid state.
In terms of melting point, it is about 43-45 ° C. When the temperature gradually rises to about 43 ° C, the substance begins to transform from a solid state to a liquid state, and when it reaches 45 ° C, it basically melts into a liquid state. This property is a key reference indicator in the process of separation, purification and identification of substances.
The boiling point is about 152 - 154 ° C. /12mmHg. That is, under the pressure condition of 12mmHg, when the temperature rises to 152 ° C, the substance begins to boil, and when it reaches 154 ° C, the boiling becomes more intense, and a large amount of liquid is converted into a gaseous state. The boiling point is significantly affected by the external pressure. When the pressure changes, the boiling point also changes, so the pressure condition is indispensable when expressing the boiling point.
Solubility, slightly soluble in water. Due to the fact that water is a solvent with strong polarity, while the polarity of 5-bromo-2-methoxybenzaldehyde molecules is relatively weak, according to the principle of "similarity and miscibility", the mutual solubility of the two is poor. However, it has good solubility in organic solvents such as ethanol, ether, chloroform, etc. In ethanol, it can be quickly dissolved to form a uniform solution. This characteristic makes this kind of organic solvent often selected as the reaction medium in organic synthesis reactions, so that 5-bromo-2-methoxybenzaldehyde can better participate in the reaction.
In appearance, it usually appears as a light yellow to yellow crystalline powder or liquid state. Looking at its color, it may be light yellow or dark yellow depending on its purity and environment, but generally does not leave the yellow category. As for the form, when the room temperature environment is suitable, it is mostly shown as a crystalline powder; if the external temperature is slightly higher and close to its melting point, it may also transform into a liquid state.
In terms of melting point, it is about 43-45 ° C. When the temperature gradually rises to about 43 ° C, the substance begins to transform from a solid state to a liquid state, and when it reaches 45 ° C, it basically melts into a liquid state. This property is a key reference indicator in the process of separation, purification and identification of substances.
The boiling point is about 152 - 154 ° C. /12mmHg. That is, under the pressure condition of 12mmHg, when the temperature rises to 152 ° C, the substance begins to boil, and when it reaches 154 ° C, the boiling becomes more intense, and a large amount of liquid is converted into a gaseous state. The boiling point is significantly affected by the external pressure. When the pressure changes, the boiling point also changes, so the pressure condition is indispensable when expressing the boiling point.
Solubility, slightly soluble in water. Due to the fact that water is a solvent with strong polarity, while the polarity of 5-bromo-2-methoxybenzaldehyde molecules is relatively weak, according to the principle of "similarity and miscibility", the mutual solubility of the two is poor. However, it has good solubility in organic solvents such as ethanol, ether, chloroform, etc. In ethanol, it can be quickly dissolved to form a uniform solution. This characteristic makes this kind of organic solvent often selected as the reaction medium in organic synthesis reactions, so that 5-bromo-2-methoxybenzaldehyde can better participate in the reaction.
What is the synthesis method of 5-chloro-2-methoxybenzenesulfonyl chloride?
To prepare 5-bromo-2-methoxybenzaldehyde, you can follow the following ancient method.
First take o-methoxyphenol, which is the starting material. Dissolve it in an appropriate solvent, such as dichloromethane, etc., to make a uniform solution. Then, under low temperature and stirring conditions, slowly add a brominating reagent. The brominating reagent can be selected from the carbon tetrachloride solution of bromine. This needs to be handled with caution because bromine is highly corrosive and volatile. With the drop of the brominating reagent, an electrophilic substitution reaction occurs in the solution, and the bromine atom is substituted at a specific position on the methoxyphenol phenol ring. After this step, 5-bromo-2-methoxyphenol can be obtained.
The obtained 5-bromo-2-methoxyphenol is then formylated to introduce formyl groups. The commonly used method of formylation can be Vilsmeier-Haack reaction. First take an appropriate amount of N, N-dimethylformamide (DMF), add an appropriate amount of phosphorus oxychloride (POCl), and mix the two at low temperature to form an active Vilsmeier reagent. Then, add the solution of 5-bromo-2-methoxyphenol slowly to this mixture, warm to an appropriate temperature and maintain it for a period of time. In this process, Vilsmeier reagent reacts with 5-bromo-2-methoxyphenol to successfully introduce formyl groups on the benzene ring, resulting in 5-bromo-2-methoxybenzaldehyde.
After the reaction is completed, a post-treatment process is required. First neutralize the excess acid in the reaction system with an appropriate alkali solution such as sodium carbonate solution, and then extract the product with an organic solvent, such as multiple extractions with ethyl acetate. Combine the organic phases, remove water with a desiccant such as anhydrous sodium sulfate, filter, remove the organic solvent by vacuum distillation, and then further purify it by column chromatography. Pure 5-bromo-2-methoxybenzaldehyde can be obtained. Throughout the process, each step requires careful operation and attention to the control of reaction conditions in order to achieve satisfactory yield and purity.
First take o-methoxyphenol, which is the starting material. Dissolve it in an appropriate solvent, such as dichloromethane, etc., to make a uniform solution. Then, under low temperature and stirring conditions, slowly add a brominating reagent. The brominating reagent can be selected from the carbon tetrachloride solution of bromine. This needs to be handled with caution because bromine is highly corrosive and volatile. With the drop of the brominating reagent, an electrophilic substitution reaction occurs in the solution, and the bromine atom is substituted at a specific position on the methoxyphenol phenol ring. After this step, 5-bromo-2-methoxyphenol can be obtained.
The obtained 5-bromo-2-methoxyphenol is then formylated to introduce formyl groups. The commonly used method of formylation can be Vilsmeier-Haack reaction. First take an appropriate amount of N, N-dimethylformamide (DMF), add an appropriate amount of phosphorus oxychloride (POCl), and mix the two at low temperature to form an active Vilsmeier reagent. Then, add the solution of 5-bromo-2-methoxyphenol slowly to this mixture, warm to an appropriate temperature and maintain it for a period of time. In this process, Vilsmeier reagent reacts with 5-bromo-2-methoxyphenol to successfully introduce formyl groups on the benzene ring, resulting in 5-bromo-2-methoxybenzaldehyde.
After the reaction is completed, a post-treatment process is required. First neutralize the excess acid in the reaction system with an appropriate alkali solution such as sodium carbonate solution, and then extract the product with an organic solvent, such as multiple extractions with ethyl acetate. Combine the organic phases, remove water with a desiccant such as anhydrous sodium sulfate, filter, remove the organic solvent by vacuum distillation, and then further purify it by column chromatography. Pure 5-bromo-2-methoxybenzaldehyde can be obtained. Throughout the process, each step requires careful operation and attention to the control of reaction conditions in order to achieve satisfactory yield and purity.
What are the precautions for storing and transporting 5-chloro-2-methoxybenzenesulfonyl chloride?
When storing and transporting 5-bromo-2-methoxybenzaldehyde bromide, many things need to be paid attention to.
Its properties are certain to be lively. When storing, the first environment should be selected. It should be placed in a cool and dry place to avoid sun and heat. Because heat and light can promote its chemical reaction and cause it to deteriorate. If it is placed in a high temperature environment, or causes decomposition, it will reduce its purity and damage its quality.
Furthermore, it is necessary to seal it. It must be stored in a tight container to prevent moisture and air from invading. Moisture can cause hydrolysis, and air or promote its oxidation are not conducive to its storage. The material of the container used is also critical. It is advisable to choose a chemically stable material, such as glass or a specific plastic material, to prevent reactions with the object.
When transporting, shock and collision prevention are essential. This compound may be damaged by vibration and impact, causing the package to break and leakage to cause danger. The transport equipment must be properly fixed and equipped with buffer materials to ensure its stability during the journey.
It also needs to be done in accordance with relevant regulations and standards. When transporting such chemicals, safety procedures must be followed, and the dangerous nature must be clearly marked, so that the transporter knows what to take precautions against. The transportation documents must also be complete, detailing the characteristics, quantity and emergency response methods of the object, in case.
In summary, the storage and transport of 5-bromo-2-methoxybenzaldehyde bromide requires careful attention in terms of environment, packaging, shock resistance and compliance to ensure its quality and safety.
Its properties are certain to be lively. When storing, the first environment should be selected. It should be placed in a cool and dry place to avoid sun and heat. Because heat and light can promote its chemical reaction and cause it to deteriorate. If it is placed in a high temperature environment, or causes decomposition, it will reduce its purity and damage its quality.
Furthermore, it is necessary to seal it. It must be stored in a tight container to prevent moisture and air from invading. Moisture can cause hydrolysis, and air or promote its oxidation are not conducive to its storage. The material of the container used is also critical. It is advisable to choose a chemically stable material, such as glass or a specific plastic material, to prevent reactions with the object.
When transporting, shock and collision prevention are essential. This compound may be damaged by vibration and impact, causing the package to break and leakage to cause danger. The transport equipment must be properly fixed and equipped with buffer materials to ensure its stability during the journey.
It also needs to be done in accordance with relevant regulations and standards. When transporting such chemicals, safety procedures must be followed, and the dangerous nature must be clearly marked, so that the transporter knows what to take precautions against. The transportation documents must also be complete, detailing the characteristics, quantity and emergency response methods of the object, in case.
In summary, the storage and transport of 5-bromo-2-methoxybenzaldehyde bromide requires careful attention in terms of environment, packaging, shock resistance and compliance to ensure its quality and safety.
What are the effects of 5-chloro-2-methoxybenzenesulfonyl chloride on the environment and humans?
5-Bromo-2-methoxybenzaldehyde bromide, which has an impact on both the environment and the human body.
In terms of the environment, it is difficult to degrade in the natural environment. If released in water bodies, it will diffuse through water flow, pollute the water source, contact with aquatic organisms, or cause abnormal physiological functions, affecting their reproduction, growth and survival. If some fish come into contact with water bodies containing this substance, they may exhibit abnormal behavior and developmental deformities. If it enters the soil, it will change soil properties, affect soil microbial activity and soil fertility, and then affect plant growth.
In terms of personal effects, it is irritating. If accidentally exposed to the skin, it can cause allergic symptoms such as redness, swelling, itching, pain, etc. Long-term exposure or damage to the skin barrier function, increasing the risk of skin diseases. If exposed to the eyes, it will irritate the eye tissue, and in severe cases, it may cause vision damage. If inhaled its volatile gases, it will irritate the respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, and long-term inhalation or damage to the respiratory mucosa, increasing the incidence of respiratory diseases such as asthma and bronchitis. In addition, animal experiments have shown that the substance may be potentially toxic. Long-term exposure to exposure may interfere with the human endocrine system, affect hormone balance, and have adverse effects on the reproductive system and immune system. Therefore, when using and treating 5-bromo-2-methoxybenzaldehyde bromide, it is necessary to follow strict safety regulations and take protective measures to prevent it from causing harm to the environment and people.
In terms of the environment, it is difficult to degrade in the natural environment. If released in water bodies, it will diffuse through water flow, pollute the water source, contact with aquatic organisms, or cause abnormal physiological functions, affecting their reproduction, growth and survival. If some fish come into contact with water bodies containing this substance, they may exhibit abnormal behavior and developmental deformities. If it enters the soil, it will change soil properties, affect soil microbial activity and soil fertility, and then affect plant growth.
In terms of personal effects, it is irritating. If accidentally exposed to the skin, it can cause allergic symptoms such as redness, swelling, itching, pain, etc. Long-term exposure or damage to the skin barrier function, increasing the risk of skin diseases. If exposed to the eyes, it will irritate the eye tissue, and in severe cases, it may cause vision damage. If inhaled its volatile gases, it will irritate the respiratory tract, causing symptoms such as cough, asthma, breathing difficulties, and long-term inhalation or damage to the respiratory mucosa, increasing the incidence of respiratory diseases such as asthma and bronchitis. In addition, animal experiments have shown that the substance may be potentially toxic. Long-term exposure to exposure may interfere with the human endocrine system, affect hormone balance, and have adverse effects on the reproductive system and immune system. Therefore, when using and treating 5-bromo-2-methoxybenzaldehyde bromide, it is necessary to follow strict safety regulations and take protective measures to prevent it from causing harm to the environment and people.
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