Linshang Chemical
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5-Chloro-2-Nitrobenzenemethanol
Linshang Chemical
|
HS Code |
942885 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Solid |
| Color | Yellow |
| Melting Point | 116 - 118 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Purity | Typically high - purity for research use |
| Hazard Class | Irritant (may cause eye, skin and respiratory irritation) |
As an accredited 5-Chloro-2-Nitrobenzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 5 - chloro - 2 - nitrobenzenemethanol packaged in a sealed plastic bottle. |
| Storage | 5 - Chloro - 2 - nitrobenzenemethanol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent moisture absorption and vapor leakage. Store it separately from oxidizing agents and reducing agents to avoid potential chemical reactions. Also, ensure proper labeling for easy identification and safety compliance. |
| Shipping | 5 - chloro - 2 - nitrobenzenemethanol should be shipped in tightly - sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, with proper labeling indicating its nature to ensure safe transportation. |
Competitive 5-Chloro-2-Nitrobenzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 5-Chloro-2-Nitrobenzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 5-chloro-2-nitrobenzenemethanol?
5-Chloro-2-nitrobenzyl alcohol is one of the organic compounds. It has specific chemical properties, let me tell you in detail.
In this compound, the presence of chlorine atoms and nitro groups greatly affects its chemical behavior. The nitro group is a strong electron-absorbing group, and the chlorine atom also has a certain electron-absorbing effect, resulting in a decrease in the electron cloud density of the benzene ring. This characteristic makes it less active than benzene in the electrophilic substitution reaction, and the substitution position is also affected by the localization effect of nitro and chlorine atoms.
In the nucleophilic substitution reaction, compared with benzyl alcohol, due to the decrease in the electron cloud density of the benzene ring, the carbon atoms attached to the hydroxyl group are more susceptible to the attack of the nucleophilic reagents, resulting in
The hydroxyl group of 5-chloro-2-nitrobenzyl alcohol can participate in many reactions. When encountering an acid, the hydroxyl group or protonation occurs, and then the substitution or elimination reaction occurs. When it encounters an acyl halide or an acid anhydride, an esterification reaction can occur to form a corresponding ester compound.
From a redox perspective, it can be oxidized by a suitable oxidant, and the hydroxyl group may be oxidized to an aldehyde group, a carboxyl group, etc. When encountering a strong reducing agent, the nitro group may be reduced to an amino group, and more compounds can be derived.
Furthermore, due to its chlorine-containing atom, under appropriate conditions, the chlorine atom can undergo a substitution reaction and be replaced by other groups, which greatly enriches the deriv Due to the interaction of functional groups, 5-chloro-2-nitrobenzyl alcohol exhibits unique chemical properties and has important applications in the field of organic synthesis. It can be used as a key intermediate to create a variety of complex organic compounds.
In this compound, the presence of chlorine atoms and nitro groups greatly affects its chemical behavior. The nitro group is a strong electron-absorbing group, and the chlorine atom also has a certain electron-absorbing effect, resulting in a decrease in the electron cloud density of the benzene ring. This characteristic makes it less active than benzene in the electrophilic substitution reaction, and the substitution position is also affected by the localization effect of nitro and chlorine atoms.
In the nucleophilic substitution reaction, compared with benzyl alcohol, due to the decrease in the electron cloud density of the benzene ring, the carbon atoms attached to the hydroxyl group are more susceptible to the attack of the nucleophilic reagents, resulting in
The hydroxyl group of 5-chloro-2-nitrobenzyl alcohol can participate in many reactions. When encountering an acid, the hydroxyl group or protonation occurs, and then the substitution or elimination reaction occurs. When it encounters an acyl halide or an acid anhydride, an esterification reaction can occur to form a corresponding ester compound.
From a redox perspective, it can be oxidized by a suitable oxidant, and the hydroxyl group may be oxidized to an aldehyde group, a carboxyl group, etc. When encountering a strong reducing agent, the nitro group may be reduced to an amino group, and more compounds can be derived.
Furthermore, due to its chlorine-containing atom, under appropriate conditions, the chlorine atom can undergo a substitution reaction and be replaced by other groups, which greatly enriches the deriv Due to the interaction of functional groups, 5-chloro-2-nitrobenzyl alcohol exhibits unique chemical properties and has important applications in the field of organic synthesis. It can be used as a key intermediate to create a variety of complex organic compounds.
What are the physical properties of 5-chloro-2-nitrobenzenemethanol?
5-Chloro-2-nitrobenzyl alcohol is one of the organic compounds. Its physical properties are quite well researched.
Looking at its morphology, under room temperature and pressure, it is mostly in a solid state. Due to the intermolecular forces, the molecules are arranged in an orderly manner, so they condense into a solid state. Its color is usually white to light yellow, like the first yellowish color of autumn wood leaves. The formation of color is related to the distribution and transition of electron clouds of each atom in the molecular structure.
The melting point is about [X] ° C. The value of the melting point is actually determined by the interaction between molecules, such as van der Waals force, hydrogen bond, etc. When the external temperature rises to the melting point, the energy obtained by the molecule is sufficient to overcome some intermolecular forces, causing it to gradually melt from solid to liquid. The boiling point also exists due to intermolecular forces, and its specific value is about [X] ° C. At that time, the molecule has sufficient energy to break free from the liquid phase and escape into the gas phase.
In terms of solubility, this compound can have certain solubility in organic solvents such as ethanol and ether. The molecular structure of organic solvents such as ethanol and ether is similar to that of 5-chloro-2-nitrobenzyl alcohol. According to the principle of "similarity and compatibility", the two can be mixed with each other. However, in water, its solubility is poor, because water is a highly polar solvent, and although 5-chloro-2-nitrobenzyl alcohol contains polar groups, the overall polarity is not enough to match with water, so it is difficult to dissolve in water.
The density is related to the mass per unit volume of the substance. The density of 5-chloro-2-nitrobenzyl alcohol is about [X] g/cm ³, which is also closely related to the molecular structure. The mass and spatial arrangement of atoms or groups such as chlorine and nitro in the molecule all affect the density.
In addition, its odor is weak, but it is also a unique smell. This smell is produced by the evaporation of molecules into the air and the interaction with olfactory receptors. The various physical properties are the cornerstones for exploring its chemical properties and practical applications.
Looking at its morphology, under room temperature and pressure, it is mostly in a solid state. Due to the intermolecular forces, the molecules are arranged in an orderly manner, so they condense into a solid state. Its color is usually white to light yellow, like the first yellowish color of autumn wood leaves. The formation of color is related to the distribution and transition of electron clouds of each atom in the molecular structure.
The melting point is about [X] ° C. The value of the melting point is actually determined by the interaction between molecules, such as van der Waals force, hydrogen bond, etc. When the external temperature rises to the melting point, the energy obtained by the molecule is sufficient to overcome some intermolecular forces, causing it to gradually melt from solid to liquid. The boiling point also exists due to intermolecular forces, and its specific value is about [X] ° C. At that time, the molecule has sufficient energy to break free from the liquid phase and escape into the gas phase.
In terms of solubility, this compound can have certain solubility in organic solvents such as ethanol and ether. The molecular structure of organic solvents such as ethanol and ether is similar to that of 5-chloro-2-nitrobenzyl alcohol. According to the principle of "similarity and compatibility", the two can be mixed with each other. However, in water, its solubility is poor, because water is a highly polar solvent, and although 5-chloro-2-nitrobenzyl alcohol contains polar groups, the overall polarity is not enough to match with water, so it is difficult to dissolve in water.
The density is related to the mass per unit volume of the substance. The density of 5-chloro-2-nitrobenzyl alcohol is about [X] g/cm ³, which is also closely related to the molecular structure. The mass and spatial arrangement of atoms or groups such as chlorine and nitro in the molecule all affect the density.
In addition, its odor is weak, but it is also a unique smell. This smell is produced by the evaporation of molecules into the air and the interaction with olfactory receptors. The various physical properties are the cornerstones for exploring its chemical properties and practical applications.
What are the common synthetic methods of 5-chloro-2-nitrobenzenemethanol?
5-Chloro-2-nitrobenzyl alcohol is also an organic compound. There are about three ways to synthesize it.
First, 5-chloro-2-nitrobenzoic acid is used as the starting material, and the carboxyl group can be converted into an alcohol hydroxyl group by the reduction method. This reduction method often uses lithium aluminum hydride (LiAlH) as a reducing agent and reacts in anhydrous ether and other organic solvents. Lithium aluminum hydride is also a strong reducing agent, which can effectively reduce carboxyl groups to alcohol hydroxyl groups. However, this agent has high activity. The reaction needs to be carefully operated in a low temperature and anhydrous environment to prevent accidents. After the reaction is completed, pure 5-chloro-2-nitrobenzyl alcohol can be obtained by post-processing steps such as extraction, washing, drying, distillation, etc.
Second, 5-chloro-2-nitrobenzaldehyde is used as raw material for reduction reaction. Sodium borohydride (NaBH) can be selected as a reducing agent, which can gently reduce aldehyde groups to alcohol hydroxyl groups in alcoholic solvents such as methanol and ethanol. Compared with lithium aluminum hydride, sodium borohydride is slightly less active, and the reaction conditions are relatively mild and easy to control. After the reaction is completed, appropriate post-processing steps are also required to obtain the target product.
Third, the halogenated aromatics are used as the starting materials, and the nitro group is introduced through the nucleophilic substitution reaction, and then the hydroxymethyl group is introduced through other steps. For example, the chlorobenzene is nitrified first to obtain 2-nitrochlorobenzene, and then the nucleophilic substitution reaction is carried out under appropriate conditions with suitable nucleophilic reagents, such as hydroxymethyl-containing reagents, to obtain 5-chloro-2-nitrobenzyl alcohol. However, this approach is a little more complicated, and each step requires fine regulation of the reaction conditions to ensure the smooth progress of the reaction and the purity of the product.
First, 5-chloro-2-nitrobenzoic acid is used as the starting material, and the carboxyl group can be converted into an alcohol hydroxyl group by the reduction method. This reduction method often uses lithium aluminum hydride (LiAlH) as a reducing agent and reacts in anhydrous ether and other organic solvents. Lithium aluminum hydride is also a strong reducing agent, which can effectively reduce carboxyl groups to alcohol hydroxyl groups. However, this agent has high activity. The reaction needs to be carefully operated in a low temperature and anhydrous environment to prevent accidents. After the reaction is completed, pure 5-chloro-2-nitrobenzyl alcohol can be obtained by post-processing steps such as extraction, washing, drying, distillation, etc.
Second, 5-chloro-2-nitrobenzaldehyde is used as raw material for reduction reaction. Sodium borohydride (NaBH) can be selected as a reducing agent, which can gently reduce aldehyde groups to alcohol hydroxyl groups in alcoholic solvents such as methanol and ethanol. Compared with lithium aluminum hydride, sodium borohydride is slightly less active, and the reaction conditions are relatively mild and easy to control. After the reaction is completed, appropriate post-processing steps are also required to obtain the target product.
Third, the halogenated aromatics are used as the starting materials, and the nitro group is introduced through the nucleophilic substitution reaction, and then the hydroxymethyl group is introduced through other steps. For example, the chlorobenzene is nitrified first to obtain 2-nitrochlorobenzene, and then the nucleophilic substitution reaction is carried out under appropriate conditions with suitable nucleophilic reagents, such as hydroxymethyl-containing reagents, to obtain 5-chloro-2-nitrobenzyl alcohol. However, this approach is a little more complicated, and each step requires fine regulation of the reaction conditions to ensure the smooth progress of the reaction and the purity of the product.
5-chloro-2-nitrobenzenemethanol in what areas?
5-Chloro-2-nitrobenzyl alcohol is widely used in the field of chemical pharmaceuticals.
In the field of pharmaceuticals, it can be an important raw material for traditional Chinese medicine. Due to its unique chemical structure, it can be prepared through various chemical reactions. For example, by organic synthesis and reaction with specific reagents, suitable functional groups can be introduced to form compounds with specific pharmacological activities. Or it can be used to develop antibacterial drugs, with its structure and activity, inhibit the growth and reproduction of bacteria.
In the context of materials science, it is also useful. It can be chemically modified to introduce it into the structure of polymer materials to give new properties to the materials. Such as improving the stability and solubility of materials to meet special needs.
Furthermore, in organic synthesis chemistry experiments, it is often used as a reagent or intermediate. Scientists use it to explore various reactions, expand the methods and paths of organic synthesis, and lay the foundation for the creation of new compounds. Due to its particularity of structure, it can open up many novel reaction modes and help the development and progress of organic chemistry.
In short, 5-chloro-2-nitrobenzyl alcohol has important application value in many fields such as chemical pharmaceuticals, materials science, and organic synthesis experiments, promoting the continuous progress of related disciplines and industries.
In the field of pharmaceuticals, it can be an important raw material for traditional Chinese medicine. Due to its unique chemical structure, it can be prepared through various chemical reactions. For example, by organic synthesis and reaction with specific reagents, suitable functional groups can be introduced to form compounds with specific pharmacological activities. Or it can be used to develop antibacterial drugs, with its structure and activity, inhibit the growth and reproduction of bacteria.
In the context of materials science, it is also useful. It can be chemically modified to introduce it into the structure of polymer materials to give new properties to the materials. Such as improving the stability and solubility of materials to meet special needs.
Furthermore, in organic synthesis chemistry experiments, it is often used as a reagent or intermediate. Scientists use it to explore various reactions, expand the methods and paths of organic synthesis, and lay the foundation for the creation of new compounds. Due to its particularity of structure, it can open up many novel reaction modes and help the development and progress of organic chemistry.
In short, 5-chloro-2-nitrobenzyl alcohol has important application value in many fields such as chemical pharmaceuticals, materials science, and organic synthesis experiments, promoting the continuous progress of related disciplines and industries.
What are 5-chloro-2-nitrobenzenemethanol safety precautions?
5-Chloro-2-nitrobenzyl alcohol, this material has certain dangers and is related to safety. Everything should be known.
It is active, flammable in case of fire, or causes fire, burning or toxic fumes, such as chlorine, nitrogen oxides, etc., which are harmful to human health and pollute the environment. During operation, avoid fire and heat sources, and use explosion-proof electric lamps and lanterns. And its powder is in the air, or into an explosive mixture, so the operation should be in a well-ventilated place to prevent the powder from spreading.
5-chloro-2-nitrobenzyl alcohol is also toxic. It can harm the body through mouth, inhalation or skin contact. Or irritate the eyes, skin and respiratory tract. When operating, you must wear protective clothing, goggles, gloves, and a gas mask. If you accidentally touch the body, quickly rinse with a lot of water and seek medical treatment.
Furthermore, its chemical properties are lively, do not mix with strong oxidants, strong alkalis, etc., to prevent severe reactions. Storage should be in a cool, dry, and ventilated place, away from contraindications, and sealed to prevent deterioration and leakage.
Handle with care when handling to prevent package damage. In the event of leakage, quickly isolate the scene and restrict access. Emergency personnel wear protective equipment, use suitable materials to contain leaks, and dispose of them according to regulations. Do not discharge at will.
In short, handling 5-chloro-2-nitrobenzyl alcohol requires following safety procedures to ensure safety and avoid accidents.
It is active, flammable in case of fire, or causes fire, burning or toxic fumes, such as chlorine, nitrogen oxides, etc., which are harmful to human health and pollute the environment. During operation, avoid fire and heat sources, and use explosion-proof electric lamps and lanterns. And its powder is in the air, or into an explosive mixture, so the operation should be in a well-ventilated place to prevent the powder from spreading.
5-chloro-2-nitrobenzyl alcohol is also toxic. It can harm the body through mouth, inhalation or skin contact. Or irritate the eyes, skin and respiratory tract. When operating, you must wear protective clothing, goggles, gloves, and a gas mask. If you accidentally touch the body, quickly rinse with a lot of water and seek medical treatment.
Furthermore, its chemical properties are lively, do not mix with strong oxidants, strong alkalis, etc., to prevent severe reactions. Storage should be in a cool, dry, and ventilated place, away from contraindications, and sealed to prevent deterioration and leakage.
Handle with care when handling to prevent package damage. In the event of leakage, quickly isolate the scene and restrict access. Emergency personnel wear protective equipment, use suitable materials to contain leaks, and dispose of them according to regulations. Do not discharge at will.
In short, handling 5-chloro-2-nitrobenzyl alcohol requires following safety procedures to ensure safety and avoid accidents.
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