Linshang Chemical
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5-Chloro-3-Fluorobenzene-1,2-Diol
Linshang Chemical
|
HS Code |
711460 |
| Chemical Formula | C6H4ClFO2 |
| Molar Mass | 162.546 g/mol |
| Physical State At Room Temp | Solid (assumed) |
| Reactivity | Can react with bases due to -OH groups, reactivity with other substances depends on reaction conditions |
As an accredited 5-Chloro-3-Fluorobenzene-1,2-Diol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - chloro - 3 - fluorobenzene - 1,2 - diol in 100g sealed bottles for chemical packaging. |
| Storage | Store 5 - chloro - 3 - fluorobenzene - 1,2 - diol in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Use tightly - sealed containers made of materials compatible with the chemical, like glass or certain plastics. Store it separately from incompatible substances to prevent reactions. This ensures the chemical's stability and safety during storage. |
| Shipping | 5 - Chloro - 3 - fluorobenzene - 1,2 - diol should be shipped in well - sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, with proper labeling indicating its nature and handling precautions. |
Competitive 5-Chloro-3-Fluorobenzene-1,2-Diol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-Chloro-3-Fluorobenzene-1,2-Diol in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 5-Chloro-3-Fluorobenzene-1,2-Diol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enyl-1,2-diol, this compound has important uses in many fields.
In the field of medicinal chemistry, due to its unique chemical structure, it can be used as a key intermediate for the synthesis of a variety of drugs. The hydroxyl group and carbon-carbon double bond it contains can participate in a variety of chemical reactions, and through specific reaction steps, complex drug molecular structures can be constructed. For example, in the development of some antibacterial drugs, its active group is used to combine with other specific chemical fragments to synthesize new antibacterial drugs with high inhibitory effect on specific bacteria.
In the field of materials science, it can be used as a modifier to improve material properties. Its carbon-carbon double bond can participate in the polymerization reaction and be introduced into the main chain or side chain of polymer materials to change the physical and chemical properties of the material. For example, when adding this substance in the preparation of high-performance plastics, the polymerization reaction makes the plastic have better flexibility and mechanical strength, and expands its application in packaging, automotive parts and other fields.
In the field of organic synthesis, it is an extremely important synthetic block. With its two active hydroxyl groups and unsaturated double bonds, by selecting suitable reaction conditions and reagents, various carbon-carbon bonds and carbon-hetero bonds can be constructed to synthesize organic compounds with complex structures and special functions. For example, complex organic molecules with optical or biological activity are synthesized through a series of reactions such as oxidation, reduction, and esterification, providing rich structural units and synthesis ideas for the development of organic synthetic chemistry.
In short, 5-alkane-3-enyl-1,2-diol plays an indispensable role in many fields such as medicine, materials, and organic synthesis due to its unique structure and active reactivity, and promotes technological innovation and product upgrading in various fields.
In the field of medicinal chemistry, due to its unique chemical structure, it can be used as a key intermediate for the synthesis of a variety of drugs. The hydroxyl group and carbon-carbon double bond it contains can participate in a variety of chemical reactions, and through specific reaction steps, complex drug molecular structures can be constructed. For example, in the development of some antibacterial drugs, its active group is used to combine with other specific chemical fragments to synthesize new antibacterial drugs with high inhibitory effect on specific bacteria.
In the field of materials science, it can be used as a modifier to improve material properties. Its carbon-carbon double bond can participate in the polymerization reaction and be introduced into the main chain or side chain of polymer materials to change the physical and chemical properties of the material. For example, when adding this substance in the preparation of high-performance plastics, the polymerization reaction makes the plastic have better flexibility and mechanical strength, and expands its application in packaging, automotive parts and other fields.
In the field of organic synthesis, it is an extremely important synthetic block. With its two active hydroxyl groups and unsaturated double bonds, by selecting suitable reaction conditions and reagents, various carbon-carbon bonds and carbon-hetero bonds can be constructed to synthesize organic compounds with complex structures and special functions. For example, complex organic molecules with optical or biological activity are synthesized through a series of reactions such as oxidation, reduction, and esterification, providing rich structural units and synthesis ideas for the development of organic synthetic chemistry.
In short, 5-alkane-3-enyl-1,2-diol plays an indispensable role in many fields such as medicine, materials, and organic synthesis due to its unique structure and active reactivity, and promotes technological innovation and product upgrading in various fields.
What are the physical properties of 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enheptyl-1,2-diol is one of the organic compounds. Its physical properties are quite unique, let me describe them in detail for you.
First of all, its appearance, under normal circumstances, 5-alkane-3-enheptyl-1,2-diol is mostly colorless to light yellow viscous liquid, uniform texture, good light transmission, under light, occasionally a faint luster flickers, just like a faint wave of light.
When it comes to smell, this compound exudes a light and special smell, not pungent, but has a different charm, slightly fresh and slightly sweet mixed smell, although not rich, but under the smell, you can also detect its unique flavor.
In addition, its melting point and boiling point are also important physical properties. The melting point is relatively low, and it can be seen in a suitable low temperature environment. The process of gradual change from liquid to solid state is like freezing into ice on a quiet lake, which is silent. The boiling point is higher, and strong heat energy is required to transform it from liquid to gas state. It seems that after many hardships, it can break through the constraints and sublimate into the invisible.
In terms of solubility, 5-alkane-3-enheptyl-1,2-diol is soluble in many organic solvents, such as ethanol and ether, just like fish entering water and naturally fusing. However, the solubility in water is limited, only slightly soluble. When the two meet, it is like trying each other, and it is difficult to completely blend.
Density is also one of its characteristics. Compared with water, its density is slightly larger. When it drops into water, it is like a stone entering water, slowly sinking, and quietly standing at the bottom of the water, forming a world of its own.
In addition, the viscosity of this compound cannot be ignored. Due to the intermolecular force, the viscosity is high. When flowing, it is as if time slows down, and the liquid flows slowly, showing a dignified state.
In summary, the physical properties of 5-alkane-3-enheptyl-1,2-diol are rich and diverse, and each characteristic is intertwined, which together constitute its unique chemical "identity", which is of special research value in the field of organic chemistry.
First of all, its appearance, under normal circumstances, 5-alkane-3-enheptyl-1,2-diol is mostly colorless to light yellow viscous liquid, uniform texture, good light transmission, under light, occasionally a faint luster flickers, just like a faint wave of light.
When it comes to smell, this compound exudes a light and special smell, not pungent, but has a different charm, slightly fresh and slightly sweet mixed smell, although not rich, but under the smell, you can also detect its unique flavor.
In addition, its melting point and boiling point are also important physical properties. The melting point is relatively low, and it can be seen in a suitable low temperature environment. The process of gradual change from liquid to solid state is like freezing into ice on a quiet lake, which is silent. The boiling point is higher, and strong heat energy is required to transform it from liquid to gas state. It seems that after many hardships, it can break through the constraints and sublimate into the invisible.
In terms of solubility, 5-alkane-3-enheptyl-1,2-diol is soluble in many organic solvents, such as ethanol and ether, just like fish entering water and naturally fusing. However, the solubility in water is limited, only slightly soluble. When the two meet, it is like trying each other, and it is difficult to completely blend.
Density is also one of its characteristics. Compared with water, its density is slightly larger. When it drops into water, it is like a stone entering water, slowly sinking, and quietly standing at the bottom of the water, forming a world of its own.
In addition, the viscosity of this compound cannot be ignored. Due to the intermolecular force, the viscosity is high. When flowing, it is as if time slows down, and the liquid flows slowly, showing a dignified state.
In summary, the physical properties of 5-alkane-3-enheptyl-1,2-diol are rich and diverse, and each characteristic is intertwined, which together constitute its unique chemical "identity", which is of special research value in the field of organic chemistry.
What are the chemical properties of 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enyl-1,2-diol, this is a class of organic compounds. It is rich in chemical properties and plays a key role in many chemical reactions and practical applications.
Let's talk about its physical properties first. Such diols are often liquid or solid, depending on the specific carbon chain length and substituent. Because the molecule contains hydroxyl groups (-OH), it can form hydrogen bonds, resulting in a relatively high boiling point and a certain solubility in water, which is due to the formation of hydrogen bonds between hydroxyl groups and water molecules.
In terms of chemical properties, hydroxyl groups endow the compound with significant nucleophilicity. First, esterification can occur. When it meets carboxylic acid or acid chloride, under suitable catalyst and reaction conditions, the hydrogen atom in the hydroxyl group will be replaced by the acyl group to form the corresponding ester compound. This reaction is extremely important in organic synthesis and is widely used in the preparation of materials such as fragrances, drugs and plastics. For example, acetic acid reacts with 5-alkane-3-enyl-1,2-diol and is heated under the catalysis of concentrated sulfuric acid to form acetate esters. In the process, concentrated sulfuric acid not only acts as a catalyst, but also has the effect of water absorption, which prompts the reaction to move in the direction of ester formation.
Second, oxidation reactions are also important chemical properties. Hydroxyl groups can be oxidized when subjected to oxidants. Under moderate oxidation conditions, one of the hydroxyl groups can be oxidized to an aldehyde group or a ketone group; if the oxidation conditions are severe, both hydroxyl groups may be oxidized to a carboxyl group. For example, treatment with mild oxidizing agents such as pyridine-sulfur trioxide complexes can oxidize one hydroxyl group to an aldehyde group to form an aldehyde-containing alkenal compound.
Third, dehydration reaction. In the presence of acidic catalysts such as sulfuric acid or phosphoric acid, when heated, the hydroxyl groups in the 5-alkane-3-alkenyl-1,2-diol molecule can dehydrate with hydrogen atoms on adjacent carbon atoms to form epoxy compounds or olefins. If the appropriate reaction conditions are controlled, different products can be selectively generated, which is of great significance for the construction of carbon-carbon double bonds and cyclic structures in organic synthesis.
Fourth, react with active metals. Hydroxyhydrogen of 5-alkane-3-enyl-1,2-diol has a certain acidity and can react with active metals such as sodium and potassium to replace hydrogen and generate corresponding alkoxides. This reaction can be used to prepare specific organometallic reagents, which play a unique role in organic synthesis.
Let's talk about its physical properties first. Such diols are often liquid or solid, depending on the specific carbon chain length and substituent. Because the molecule contains hydroxyl groups (-OH), it can form hydrogen bonds, resulting in a relatively high boiling point and a certain solubility in water, which is due to the formation of hydrogen bonds between hydroxyl groups and water molecules.
In terms of chemical properties, hydroxyl groups endow the compound with significant nucleophilicity. First, esterification can occur. When it meets carboxylic acid or acid chloride, under suitable catalyst and reaction conditions, the hydrogen atom in the hydroxyl group will be replaced by the acyl group to form the corresponding ester compound. This reaction is extremely important in organic synthesis and is widely used in the preparation of materials such as fragrances, drugs and plastics. For example, acetic acid reacts with 5-alkane-3-enyl-1,2-diol and is heated under the catalysis of concentrated sulfuric acid to form acetate esters. In the process, concentrated sulfuric acid not only acts as a catalyst, but also has the effect of water absorption, which prompts the reaction to move in the direction of ester formation.
Second, oxidation reactions are also important chemical properties. Hydroxyl groups can be oxidized when subjected to oxidants. Under moderate oxidation conditions, one of the hydroxyl groups can be oxidized to an aldehyde group or a ketone group; if the oxidation conditions are severe, both hydroxyl groups may be oxidized to a carboxyl group. For example, treatment with mild oxidizing agents such as pyridine-sulfur trioxide complexes can oxidize one hydroxyl group to an aldehyde group to form an aldehyde-containing alkenal compound.
Third, dehydration reaction. In the presence of acidic catalysts such as sulfuric acid or phosphoric acid, when heated, the hydroxyl groups in the 5-alkane-3-alkenyl-1,2-diol molecule can dehydrate with hydrogen atoms on adjacent carbon atoms to form epoxy compounds or olefins. If the appropriate reaction conditions are controlled, different products can be selectively generated, which is of great significance for the construction of carbon-carbon double bonds and cyclic structures in organic synthesis.
Fourth, react with active metals. Hydroxyhydrogen of 5-alkane-3-enyl-1,2-diol has a certain acidity and can react with active metals such as sodium and potassium to replace hydrogen and generate corresponding alkoxides. This reaction can be used to prepare specific organometallic reagents, which play a unique role in organic synthesis.
What are the synthesis methods of 5-chloro-3-fluorobenzene-1,2-diol?
To prepare 5-bromo-3-allyl-1,2-dione, the following method can be used.
First, an allyl compound is reacted with a reagent containing bromine and carbonyl groups. First, an allyl halide, such as allyl bromide, is taken with an active methylene compound such as ethyl acetoacetate, and under the catalysis of a base, a nucleophilic substitution reaction occurs. Sodium alcohol, such as sodium ethyl alcohol, can be used for the base. In a suitable organic solvent such as ethanol, the allyl moiety of allyl bromide replaces the methylene hydrogen in ethyl acetoacetate. Then, the obtained product is hydrolyzed and decarboxylated to obtain an allyl-containing ketone compound. Then brominating reagents, such as bromine tetrachloride solution, are used to brominate the ketone compound. Under suitable conditions, bromine atoms can be introduced at specific positions to obtain the target product. This process requires attention to the precise control of the reaction conditions. The amount of base, reaction temperature and time all affect the yield and purity of the product.
Second, carbonyl-containing compounds are used as starting materials and are converted in multiple steps. First, simple ketones such as acetone are used to undergo hydroxyaldehyde condensation reaction with formaldehyde under basic conditions, which can grow the carbon chain and introduce the precursor of allyl structure fragments. The base used for the reaction can be a dilute solution of sodium hydroxide, and the reaction conditions are controlled to generate an intermediate product with suitable activity. Then the intermediate product is brominated, and a suitable brominating agent, such as N-bromosuccinimide (NBS), is selected to achieve specific bromination in the presence of light or initiator. Finally, after an appropriate oxidation step, part of the functional groups are converted into carbonyl groups to achieve the synthesis of 5-bromo-3-allyl-1,2-dione. In this path, the selectivity and conversion of each step of the reaction need to be paid attention to, and the condition selection of the oxidation step is particularly critical to avoid excessive oxidation or side reactions.
Third, with the help of organometallic reagents. Allyl Grignard reagent can be prepared first, which is obtained by reacting allyl halogen with magnesium in anhydrous ether and other solvents. Subsequently, the allyl Grignard reagent is reacted with compounds containing carbonyl and bromine atoms, such as bromoyl halogen. In a low temperature and anhydrous and anaerobic environment, the allyl Grignard reagent performs nucleophilic addition to bromoyl halogen, and the target product can be obtained after subsequent treatment such as hydrolysis. This method requires strict reaction environment, and anhydrous and anaerobic operation requires fine operation to ensure the activity of Grignard reagent and the smooth progress of the reaction. At the same time, attention should be paid to controlling the reaction process to avoid side reactions interfering with the main reaction.
First, an allyl compound is reacted with a reagent containing bromine and carbonyl groups. First, an allyl halide, such as allyl bromide, is taken with an active methylene compound such as ethyl acetoacetate, and under the catalysis of a base, a nucleophilic substitution reaction occurs. Sodium alcohol, such as sodium ethyl alcohol, can be used for the base. In a suitable organic solvent such as ethanol, the allyl moiety of allyl bromide replaces the methylene hydrogen in ethyl acetoacetate. Then, the obtained product is hydrolyzed and decarboxylated to obtain an allyl-containing ketone compound. Then brominating reagents, such as bromine tetrachloride solution, are used to brominate the ketone compound. Under suitable conditions, bromine atoms can be introduced at specific positions to obtain the target product. This process requires attention to the precise control of the reaction conditions. The amount of base, reaction temperature and time all affect the yield and purity of the product.
Second, carbonyl-containing compounds are used as starting materials and are converted in multiple steps. First, simple ketones such as acetone are used to undergo hydroxyaldehyde condensation reaction with formaldehyde under basic conditions, which can grow the carbon chain and introduce the precursor of allyl structure fragments. The base used for the reaction can be a dilute solution of sodium hydroxide, and the reaction conditions are controlled to generate an intermediate product with suitable activity. Then the intermediate product is brominated, and a suitable brominating agent, such as N-bromosuccinimide (NBS), is selected to achieve specific bromination in the presence of light or initiator. Finally, after an appropriate oxidation step, part of the functional groups are converted into carbonyl groups to achieve the synthesis of 5-bromo-3-allyl-1,2-dione. In this path, the selectivity and conversion of each step of the reaction need to be paid attention to, and the condition selection of the oxidation step is particularly critical to avoid excessive oxidation or side reactions.
Third, with the help of organometallic reagents. Allyl Grignard reagent can be prepared first, which is obtained by reacting allyl halogen with magnesium in anhydrous ether and other solvents. Subsequently, the allyl Grignard reagent is reacted with compounds containing carbonyl and bromine atoms, such as bromoyl halogen. In a low temperature and anhydrous and anaerobic environment, the allyl Grignard reagent performs nucleophilic addition to bromoyl halogen, and the target product can be obtained after subsequent treatment such as hydrolysis. This method requires strict reaction environment, and anhydrous and anaerobic operation requires fine operation to ensure the activity of Grignard reagent and the smooth progress of the reaction. At the same time, attention should be paid to controlling the reaction process to avoid side reactions interfering with the main reaction.
What are the precautions for storing and transporting 5-chloro-3-fluorobenzene-1,2-diol?
5-Bromo-3-allyl-1,2-diol, its preservation and transportation must not be ignored. This material is lively and easy to react with surrounding objects, so when storing, it should be placed in a low temperature, dry and dark place. If exposed to light and heat, the structure may become easy and the performance will be damaged.
The choice of container is very important. It must be made with good corrosion resistance and sealing properties to prevent it from changing in contact with the material of the container, and to avoid external moisture, air, etc. If using glassware, check its texture, do not have defects, so as not to damage and cause material leakage.
During transportation, stability is essential. Shock absorption and protection measures are essential to prevent the container from breaking due to bumps and collisions. And the transportation environment also needs to be controlled. The temperature and humidity should be constant. According to its materialization, choose the right temperature and transport. If the temperature is high, it may evaporate or decompose; if it is wet, it is easy to deliquescence and deterioration.
Furthermore, when handling, the operator should be cautious and wear protective equipment, such as gloves, goggles, etc. This substance may be irritating and corrosive, and if it is accidentally touched, it will hurt the skin and eyes. And the handling place should be well ventilated to avoid the accumulation of its volatile gas and accidents.
It should also be noted that 5-bromo-3-allyl-1,2-diol is often used in chemical and scientific research, but it may have an impact on the environment. When storing and transporting, we should also consider the responsibility of environmental protection. If there is a leak, we should take appropriate measures to clean it up quickly, so as not to pollute the soil, water sources, etc., and ensure the safety of the environment.
The choice of container is very important. It must be made with good corrosion resistance and sealing properties to prevent it from changing in contact with the material of the container, and to avoid external moisture, air, etc. If using glassware, check its texture, do not have defects, so as not to damage and cause material leakage.
During transportation, stability is essential. Shock absorption and protection measures are essential to prevent the container from breaking due to bumps and collisions. And the transportation environment also needs to be controlled. The temperature and humidity should be constant. According to its materialization, choose the right temperature and transport. If the temperature is high, it may evaporate or decompose; if it is wet, it is easy to deliquescence and deterioration.
Furthermore, when handling, the operator should be cautious and wear protective equipment, such as gloves, goggles, etc. This substance may be irritating and corrosive, and if it is accidentally touched, it will hurt the skin and eyes. And the handling place should be well ventilated to avoid the accumulation of its volatile gas and accidents.
It should also be noted that 5-bromo-3-allyl-1,2-diol is often used in chemical and scientific research, but it may have an impact on the environment. When storing and transporting, we should also consider the responsibility of environmental protection. If there is a leak, we should take appropriate measures to clean it up quickly, so as not to pollute the soil, water sources, etc., and ensure the safety of the environment.
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