Linshang Chemical
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5-Chloro-4-Fluoro-2-Methylnitrobenzene
Linshang Chemical
|
HS Code |
306809 |
| Chemical Formula | C7H5ClFNO2 |
| Molecular Weight | 191.57 |
| Appearance | Solid (likely) |
| Physical State At Room Temperature | Solid |
| Solubility In Water | Low (due to non - polar aromatic and nitro groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Odor | Pungent, characteristic of nitro - aromatic compounds |
| Stability | Stable under normal conditions but can react with strong oxidizing and reducing agents |
| Hazard Class | Irritant (to eyes, skin, respiratory system), potential environmental hazard |
As an accredited 5-Chloro-4-Fluoro-2-Methylnitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - chloro - 4 - fluoro - 2 - methylnitrobenzene in 1 - kg sealed containers for chemical packaging. |
| Storage | 5 - chloro - 4 - fluoro - 2 - methylnitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents as it may be flammable or reactive. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially cause decomposition or other chemical changes. |
| Shipping | 5 - chloro - 4 - fluoro - 2 - methylnitrobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, with proper labeling for safe and compliant transportation. |
Competitive 5-Chloro-4-Fluoro-2-Methylnitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-Chloro-4-Fluoro-2-Methylnitrobenzene in China?
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As a leading 5-Chloro-4-Fluoro-2-Methylnitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 5-chloro-4-fluoro-2-methylnitrobenzene?
5-Bromo-4-chloro-2-methylbenzoyl pyridine, an important organic compound, has critical uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate in the synthesis of drugs. In the process of many drug development, molecules with specific pharmacological activities can be obtained by ingenious chemical modification of this compound. For example, in the development of antibacterial drugs, based on its structure modification, new antibacterial agents that exhibit high inhibitory activity against specific pathogens can be prepared, providing powerful weapons for human beings to fight infectious diseases.
In the field of materials science, 5-bromo-4-chloro-2-methylbenzoyl pyridine can participate in the synthesis of functional materials. For example, in the synthesis of organic optoelectronic materials, it can be used as a key structural unit to construct materials with excellent optoelectronic properties through rational molecular design and synthesis strategies. For example, it can be used in organic Light Emitting Diode (OLED), solar cells and other devices to improve their performance indicators such as luminous efficiency and photoelectric conversion efficiency, and promote the development of materials science and related electronic devices.
In the field of organic synthetic chemistry, this compound provides a rich reaction check point for organic synthesis reactions due to its unique structure, including halogen atom and benzoyl pyridine structure. More complex organic molecular structures can be constructed through various classical organic reactions such as nucleophilic substitution and coupling reaction, which helps organic synthesis chemists to expand the synthesis route and prepare a series of organic compounds with novel structures and unique functions, thus injecting new vitality into the basic research and application research of organic chemistry.
In conclusion, although 5-bromo-4-chloro-2-methylbenzoyl pyridine is an organic compound, it plays a crucial role in many fields such as medicine, materials, and organic synthesis, and is of great significance to promoting scientific research and technological progress in related fields.
In the field of medicinal chemistry, it is often used as a key intermediate in the synthesis of drugs. In the process of many drug development, molecules with specific pharmacological activities can be obtained by ingenious chemical modification of this compound. For example, in the development of antibacterial drugs, based on its structure modification, new antibacterial agents that exhibit high inhibitory activity against specific pathogens can be prepared, providing powerful weapons for human beings to fight infectious diseases.
In the field of materials science, 5-bromo-4-chloro-2-methylbenzoyl pyridine can participate in the synthesis of functional materials. For example, in the synthesis of organic optoelectronic materials, it can be used as a key structural unit to construct materials with excellent optoelectronic properties through rational molecular design and synthesis strategies. For example, it can be used in organic Light Emitting Diode (OLED), solar cells and other devices to improve their performance indicators such as luminous efficiency and photoelectric conversion efficiency, and promote the development of materials science and related electronic devices.
In the field of organic synthetic chemistry, this compound provides a rich reaction check point for organic synthesis reactions due to its unique structure, including halogen atom and benzoyl pyridine structure. More complex organic molecular structures can be constructed through various classical organic reactions such as nucleophilic substitution and coupling reaction, which helps organic synthesis chemists to expand the synthesis route and prepare a series of organic compounds with novel structures and unique functions, thus injecting new vitality into the basic research and application research of organic chemistry.
In conclusion, although 5-bromo-4-chloro-2-methylbenzoyl pyridine is an organic compound, it plays a crucial role in many fields such as medicine, materials, and organic synthesis, and is of great significance to promoting scientific research and technological progress in related fields.
What are the synthesis methods of 5-chloro-4-fluoro-2-methylnitrobenzene?
To prepare 5-bromo-4-ene-2-methylfuranoyl, there are various methods.
First, the corresponding enol derivative can be reacted with bromine-containing reagents. First, take a suitable enol compound, place it in a clean reaction kettle, and dissolve it with an appropriate amount of organic solvent, such as anhydrous ether or tetrahydrofuran, which can dissolve the reactants well and have stable properties without interfering with the main reaction. Then slowly add bromine-containing reagents, such as bromine tetrachloride solution, the process needs to be temperature controlled, and maintain a low temperature in an ice bath or a cold water bath to prevent side reactions. The bromine reagent is active and can react with enol derivatives such as addition. After subsequent treatment, such as adding alkali to neutralize excess acid, extraction, distillation, etc., the target product can be obtained.
Second, furan derivatives are used as starting materials. First, specific substituents are modified for furans, methyl and alkenyl groups are introduced, and halogenated hydrocarbons can be used to react with furans under the action of basic catalysts. After the methyl and alkenyl groups are successfully connected to the furan ring, the bromination reaction is carried out. At this time, a suitable brominated reagent, such as N-bromosuccinimide (NBS), is selected, which has a mild reaction and good selectivity. The furan derivative containing methyl and alkenyl groups is mixed with NBS in an inert solvent, such as dichloromethane, and an initiator, such as benzoyl peroxide, is added to initiate the reaction under light or heating conditions. After separation and purification, 5-bromo-4-ene-2-methylfuranoyl can be obtained.
Third, participate in the reaction through organometallic reagents. First prepare an organometallic reagent containing furan structure, such as lithium furan reagent or magnesium furan reagent, and react the furan with metal lithium or magnesium under specific conditions. Then the organometallic reagent reacts with suitable halogenated hydrocarbons containing bromine, alkenyl group and methyl group, and nucleophilic substitution reactions can occur in both. After the reaction, the target product can also be obtained through acidification, separation and other steps. This process requires attention to the high activity of organometallic reagents, strict requirements on the reaction environment, and anhydrous and anaerobic operation.
First, the corresponding enol derivative can be reacted with bromine-containing reagents. First, take a suitable enol compound, place it in a clean reaction kettle, and dissolve it with an appropriate amount of organic solvent, such as anhydrous ether or tetrahydrofuran, which can dissolve the reactants well and have stable properties without interfering with the main reaction. Then slowly add bromine-containing reagents, such as bromine tetrachloride solution, the process needs to be temperature controlled, and maintain a low temperature in an ice bath or a cold water bath to prevent side reactions. The bromine reagent is active and can react with enol derivatives such as addition. After subsequent treatment, such as adding alkali to neutralize excess acid, extraction, distillation, etc., the target product can be obtained.
Second, furan derivatives are used as starting materials. First, specific substituents are modified for furans, methyl and alkenyl groups are introduced, and halogenated hydrocarbons can be used to react with furans under the action of basic catalysts. After the methyl and alkenyl groups are successfully connected to the furan ring, the bromination reaction is carried out. At this time, a suitable brominated reagent, such as N-bromosuccinimide (NBS), is selected, which has a mild reaction and good selectivity. The furan derivative containing methyl and alkenyl groups is mixed with NBS in an inert solvent, such as dichloromethane, and an initiator, such as benzoyl peroxide, is added to initiate the reaction under light or heating conditions. After separation and purification, 5-bromo-4-ene-2-methylfuranoyl can be obtained.
Third, participate in the reaction through organometallic reagents. First prepare an organometallic reagent containing furan structure, such as lithium furan reagent or magnesium furan reagent, and react the furan with metal lithium or magnesium under specific conditions. Then the organometallic reagent reacts with suitable halogenated hydrocarbons containing bromine, alkenyl group and methyl group, and nucleophilic substitution reactions can occur in both. After the reaction, the target product can also be obtained through acidification, separation and other steps. This process requires attention to the high activity of organometallic reagents, strict requirements on the reaction environment, and anhydrous and anaerobic operation.
What are the physical properties of 5-chloro-4-fluoro-2-methylnitrobenzene?
5-Bromo-4-chloro-2-methylbenzoylbenzene, this is an organic compound. Its physical properties are quite important and are related to many chemical applications.
Looking at its properties, it is usually in a solid state. This state characteristic makes it necessary to follow the method of solid matter when handling and storing. For example, when weighing and taking it, it can be accurately measured by using a balance, and it needs to be stored in a dry and cool place to prevent moisture dissolution or deterioration.
When it comes to melting point, this compound has a specific melting point value. Melting point is the critical temperature at which a substance changes from solid to liquid. Knowing its melting point is of great significance in identifying and purifying this compound. In the purification process, the purity can be judged by the melting point measurement. If the melting point of the sample is consistent with the literature and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting range is wide and the melting point is deviated, it indicates that the purity is poor.
Besides the boiling point, its boiling point is also a key physical property. The boiling point is the temperature at which a substance changes from a liquid state to a gas state under a specific pressure. When separating the compound by distillation, the boiling point becomes an important basis. According to the difference in the boiling points of each component of the mixture, the purpose of separation can be achieved by distillation.
In terms of solubility, 5-bromo-4-chloro-2-methylbenzoyl benzene has different solubility in different solvents. In general, in organic solvents such as dichloromethane and chloroform, the solubility is relatively high, but the solubility in water is very small. This solubility characteristic plays a significant role in the extraction and recrystallization steps of organic synthesis. For example, in the extraction process, an organic solvent with high solubility to the compound and immiscibility with water can be selected, and it can be extracted from the aqueous phase to the organic phase to achieve separation from other impurities; during recrystallization, a suitable solvent is selected to take advantage of the effect of temperature changes on its solubility to achieve purification.
In addition, the density of the compound cannot be ignored. The density is related to its distribution in the solution. In some liquid-liquid reaction systems, understanding the density can help to determine the stratification of the reaction, so as to better control the reaction process and separate the product.
Looking at its properties, it is usually in a solid state. This state characteristic makes it necessary to follow the method of solid matter when handling and storing. For example, when weighing and taking it, it can be accurately measured by using a balance, and it needs to be stored in a dry and cool place to prevent moisture dissolution or deterioration.
When it comes to melting point, this compound has a specific melting point value. Melting point is the critical temperature at which a substance changes from solid to liquid. Knowing its melting point is of great significance in identifying and purifying this compound. In the purification process, the purity can be judged by the melting point measurement. If the melting point of the sample is consistent with the literature and the melting range is narrow, it indicates that the purity is quite high; conversely, if the melting range is wide and the melting point is deviated, it indicates that the purity is poor.
Besides the boiling point, its boiling point is also a key physical property. The boiling point is the temperature at which a substance changes from a liquid state to a gas state under a specific pressure. When separating the compound by distillation, the boiling point becomes an important basis. According to the difference in the boiling points of each component of the mixture, the purpose of separation can be achieved by distillation.
In terms of solubility, 5-bromo-4-chloro-2-methylbenzoyl benzene has different solubility in different solvents. In general, in organic solvents such as dichloromethane and chloroform, the solubility is relatively high, but the solubility in water is very small. This solubility characteristic plays a significant role in the extraction and recrystallization steps of organic synthesis. For example, in the extraction process, an organic solvent with high solubility to the compound and immiscibility with water can be selected, and it can be extracted from the aqueous phase to the organic phase to achieve separation from other impurities; during recrystallization, a suitable solvent is selected to take advantage of the effect of temperature changes on its solubility to achieve purification.
In addition, the density of the compound cannot be ignored. The density is related to its distribution in the solution. In some liquid-liquid reaction systems, understanding the density can help to determine the stratification of the reaction, so as to better control the reaction process and separate the product.
What are the precautions for 5-chloro-4-fluoro-2-methylnitrobenzene during storage and transportation?
During the storage and transportation of 5-bromo-4-chloro-2-methylbenzoyl benzene, the following things should be noted:
First, this is a chemical substance, or it is more active. Store in a dry and cool place. If it is in a humid place, or deteriorated due to water vapor invasion; if the temperature is too high, it may cause chemical reactions, resulting in changes in properties, and even safety risks. Therefore, choose a well-ventilated warehouse with stable temperature, and keep it away from fire and heat sources to prevent accidents.
Second, when transporting, the packaging must be solid and reliable. This substance may be corrosive and irritating to a certain extent. If the packaging is damaged and leaks out, it will not only stain the means of transportation, but also endanger the safety of transportation personnel and may also cause pollution to the surrounding environment. Packaging materials should be able to resist vibration, collision and friction to ensure that they are intact during transportation.
Third, be cautious when mixed with other items and mixed with other items. This compound may react with certain substances, such as strong oxidizing agents, strong alkalis, etc. Once it comes into contact with each other, it may react violently, such as combustion, explosion, etc. Therefore, when storing and transporting, it must not be co-located with objects that are contrary to their nature. It must be stored and transported separately to avoid hidden dangers.
Fourth, whether it is stored or transported, the signs are clear and prominent. On the packaging, clearly mark the key information such as its name, nature, hazard and emergency treatment method. In this way, the staff can know its characteristics at a glance, and in case of a situation, they can also take appropriate emergency measures according to the label to minimize losses and hazards.
Fifth, there are also requirements for storage and transportation personnel. Relevant personnel must be professionally trained to be familiar with the characteristics, operating procedures and emergency treatment methods of this substance. In this way, they can operate normally in their daily work, and in case of emergencies, they can respond calmly to avoid serious consequences due to ignorance.
First, this is a chemical substance, or it is more active. Store in a dry and cool place. If it is in a humid place, or deteriorated due to water vapor invasion; if the temperature is too high, it may cause chemical reactions, resulting in changes in properties, and even safety risks. Therefore, choose a well-ventilated warehouse with stable temperature, and keep it away from fire and heat sources to prevent accidents.
Second, when transporting, the packaging must be solid and reliable. This substance may be corrosive and irritating to a certain extent. If the packaging is damaged and leaks out, it will not only stain the means of transportation, but also endanger the safety of transportation personnel and may also cause pollution to the surrounding environment. Packaging materials should be able to resist vibration, collision and friction to ensure that they are intact during transportation.
Third, be cautious when mixed with other items and mixed with other items. This compound may react with certain substances, such as strong oxidizing agents, strong alkalis, etc. Once it comes into contact with each other, it may react violently, such as combustion, explosion, etc. Therefore, when storing and transporting, it must not be co-located with objects that are contrary to their nature. It must be stored and transported separately to avoid hidden dangers.
Fourth, whether it is stored or transported, the signs are clear and prominent. On the packaging, clearly mark the key information such as its name, nature, hazard and emergency treatment method. In this way, the staff can know its characteristics at a glance, and in case of a situation, they can also take appropriate emergency measures according to the label to minimize losses and hazards.
Fifth, there are also requirements for storage and transportation personnel. Relevant personnel must be professionally trained to be familiar with the characteristics, operating procedures and emergency treatment methods of this substance. In this way, they can operate normally in their daily work, and in case of emergencies, they can respond calmly to avoid serious consequences due to ignorance.
What are the effects of 5-chloro-4-fluoro-2-methylnitrobenzene on the environment and human health?
5-Bromo-4-chloro-2-methylbenzoyl pyridine, an intermediate in organic synthesis, is commonly used in the field of chemical production. However, its potential impact on the environment and human health cannot be ignored.
At the environmental level, if this substance flows into nature without proper treatment, it is difficult to be rapidly degraded by microorganisms due to its stable structure, or to accumulate in the environment. If the soil is polluted by it, or changes the physical and chemical properties of the soil, it will affect the structure and function of the soil microbial community, which will have negative effects on plant growth and development, such as inhibiting seed germination and hindering root growth. Its flow into the water body will harm aquatic organisms, affect the balance of aquatic ecosystems, and reduce the self-purification capacity of the water body.
As for human health, if the human body comes into contact with this substance through breathing, skin contact or accidental ingestion, it may pose a health risk. It may be irritating, and contact with the skin and eyes can cause skin redness, itching, eye tingling, tears and other uncomfortable symptoms. Long-term exposure to it, according to relevant studies, may interfere with the human endocrine system, affect hormone balance, and have adverse effects on reproductive, immune and other systems. Some similar structural substances have been confirmed to have mutagenic and carcinogenic potential. Although there is no conclusive evidence that 5-bromo-4-chloro-2-methylbenzoyl pyridine must be the case, it should not be taken lightly due to structural similarities. Therefore, during the production and use of this substance, environmental protection and safety regulations should be strictly followed, effective protective measures should be taken to reduce its potential threats to the environment and human health, and production activities should be harmonious with ecological and personal safety.
At the environmental level, if this substance flows into nature without proper treatment, it is difficult to be rapidly degraded by microorganisms due to its stable structure, or to accumulate in the environment. If the soil is polluted by it, or changes the physical and chemical properties of the soil, it will affect the structure and function of the soil microbial community, which will have negative effects on plant growth and development, such as inhibiting seed germination and hindering root growth. Its flow into the water body will harm aquatic organisms, affect the balance of aquatic ecosystems, and reduce the self-purification capacity of the water body.
As for human health, if the human body comes into contact with this substance through breathing, skin contact or accidental ingestion, it may pose a health risk. It may be irritating, and contact with the skin and eyes can cause skin redness, itching, eye tingling, tears and other uncomfortable symptoms. Long-term exposure to it, according to relevant studies, may interfere with the human endocrine system, affect hormone balance, and have adverse effects on reproductive, immune and other systems. Some similar structural substances have been confirmed to have mutagenic and carcinogenic potential. Although there is no conclusive evidence that 5-bromo-4-chloro-2-methylbenzoyl pyridine must be the case, it should not be taken lightly due to structural similarities. Therefore, during the production and use of this substance, environmental protection and safety regulations should be strictly followed, effective protective measures should be taken to reduce its potential threats to the environment and human health, and production activities should be harmonious with ecological and personal safety.
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