Linshang Chemical
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5-(Chloromethyl)-1,2,3-Trifluorobenzene
Linshang Chemical
|
HS Code |
236822 |
| Chemical Formula | C7H4ClF3 |
| Molecular Weight | 182.55 |
| Appearance | Liquid (usually) |
| Boiling Point | Approx. 155 - 157 °C |
| Density | Around 1.3 - 1.4 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Relatively low, flammable liquid |
| Vapor Pressure | Varies with temperature, but generally has some vapor pressure in ambient conditions |
As an accredited 5-(Chloromethyl)-1,2,3-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 5-(chloromethyl)-1,2,3 - trifluorobenzene. |
| Storage | Store 5-(chloromethyl)-1,2,3 -trifluorobenzene in a cool, dry, well - ventilated area, away from heat sources, open flames, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. Label the storage clearly to avoid misidentification. This helps prevent potential chemical reactions and ensure safety. |
| Shipping | 5-(Chloromethyl)-1,2,3 -trifluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations to ensure safety during transit. |
Competitive 5-(Chloromethyl)-1,2,3-Trifluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 5-(Chloromethyl)-1,2,3-Trifluorobenzene in China?
As a trusted 5-(Chloromethyl)-1,2,3-Trifluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 5-(Chloromethyl)-1,2,3-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 5- (chloromethyl) -1,2,3-trifluorobenzene?
5- (chloromethyl) - 1,2,3 -trifluorobenzene, also an organic compound. It has a wide range of uses and is important in the field of organic synthesis.
First of all, it can be used as a raw material for pharmaceutical synthesis. The way of medicine is related to people's health. Based on this, through many delicate chemical reactions, a variety of special and good medicines can be prepared. For example, for a certain type of disease, using it as a starting material, after several steps of reaction, molecules with specific pharmacological activities can be obtained, which are powerful tools for treating diseases and treating diseases.
Second, it is also very useful in the creation of pesticides. In today's agriculture, pesticides are indispensable in order to ensure a bumper crop and avoid the disturbance of pests and diseases. 5- (chloromethyl) -1,2,3-trifluorobenzene can be used as a key intermediate to participate in the synthesis of high-efficiency, low-toxicity and environmentally friendly pesticides. Such pesticides can not only effectively eliminate pests and weeds, but also have little harm to the ecological environment, which is required by modern agriculture.
Furthermore, in the field of materials science, it has also emerged. With the advance of science and technology, the demand for new materials is increasing. With this compound as raw material, materials with special properties can be developed, such as some high-performance polymer materials, which have potential applications in high-end fields such as electronics and aerospace.
In summary, 5- (chloromethyl) -1,2,3-trifluorobenzene, with its unique chemical structure, is an important basic raw material in many fields such as medicine, pesticides and materials, and has contributed greatly to the development of various fields.
First of all, it can be used as a raw material for pharmaceutical synthesis. The way of medicine is related to people's health. Based on this, through many delicate chemical reactions, a variety of special and good medicines can be prepared. For example, for a certain type of disease, using it as a starting material, after several steps of reaction, molecules with specific pharmacological activities can be obtained, which are powerful tools for treating diseases and treating diseases.
Second, it is also very useful in the creation of pesticides. In today's agriculture, pesticides are indispensable in order to ensure a bumper crop and avoid the disturbance of pests and diseases. 5- (chloromethyl) -1,2,3-trifluorobenzene can be used as a key intermediate to participate in the synthesis of high-efficiency, low-toxicity and environmentally friendly pesticides. Such pesticides can not only effectively eliminate pests and weeds, but also have little harm to the ecological environment, which is required by modern agriculture.
Furthermore, in the field of materials science, it has also emerged. With the advance of science and technology, the demand for new materials is increasing. With this compound as raw material, materials with special properties can be developed, such as some high-performance polymer materials, which have potential applications in high-end fields such as electronics and aerospace.
In summary, 5- (chloromethyl) -1,2,3-trifluorobenzene, with its unique chemical structure, is an important basic raw material in many fields such as medicine, pesticides and materials, and has contributed greatly to the development of various fields.
What are the physical properties of 5- (chloromethyl) -1,2,3-trifluorobenzene
5- (chloromethyl) -1,2,3 -trifluorobenzene is one of the organic compounds. Its physical properties are quite important and are related to the application in various fields of chemical industry.
First of all, its appearance, at room temperature, the compound is mostly colorless to light yellow transparent liquid, clear in appearance, no obvious impurities, moderate luster, under light, or a weak refraction phenomenon.
The second and boiling point are about a specific temperature range, which can transform it from liquid to gas. After accurate determination, its boiling point value can be used as a key basis for material identification and separation and purification. The level of the boiling point is closely related to the intermolecular force. The molecular structure of the compound causes the intermolecular force to reach a certain degree, so it presents a corresponding boiling point.
Melting point is also an important physical property. When the temperature drops to a certain exact value, the substance will solidify from liquid to solid. The determination of the melting point provides a reference for the setting of its storage and transportation conditions. If the storage temperature is improper, or its state is changed, it will affect the quality and use.
Furthermore, the density cannot be ignored. Its density indicates the quality of the substance contained in the unit volume. In chemical operations, material measurement, mixing ratio and other links are involved. Accurate knowledge of the density can ensure the accuracy of the production process.
In terms of solubility, this compound exhibits a certain solubility in specific organic solvents. Whether it is soluble or not and the degree of solubility are of great significance to its dispersion in the chemical reaction system and the regulation of the reaction process. In some organic solvents, it may be well dissolved to form a uniform and stable solution, which is convenient for the reaction to proceed; in other solvents, it may have poor solubility, which affects the reaction efficiency.
In summary, the physical properties of 5- (chloromethyl) -1,2,3-trifluorobenzene, such as appearance, boiling point, melting point, density and solubility, play a key role in many aspects of chemical synthesis, storage, transportation and application, and practitioners cannot ignore it.
First of all, its appearance, at room temperature, the compound is mostly colorless to light yellow transparent liquid, clear in appearance, no obvious impurities, moderate luster, under light, or a weak refraction phenomenon.
The second and boiling point are about a specific temperature range, which can transform it from liquid to gas. After accurate determination, its boiling point value can be used as a key basis for material identification and separation and purification. The level of the boiling point is closely related to the intermolecular force. The molecular structure of the compound causes the intermolecular force to reach a certain degree, so it presents a corresponding boiling point.
Melting point is also an important physical property. When the temperature drops to a certain exact value, the substance will solidify from liquid to solid. The determination of the melting point provides a reference for the setting of its storage and transportation conditions. If the storage temperature is improper, or its state is changed, it will affect the quality and use.
Furthermore, the density cannot be ignored. Its density indicates the quality of the substance contained in the unit volume. In chemical operations, material measurement, mixing ratio and other links are involved. Accurate knowledge of the density can ensure the accuracy of the production process.
In terms of solubility, this compound exhibits a certain solubility in specific organic solvents. Whether it is soluble or not and the degree of solubility are of great significance to its dispersion in the chemical reaction system and the regulation of the reaction process. In some organic solvents, it may be well dissolved to form a uniform and stable solution, which is convenient for the reaction to proceed; in other solvents, it may have poor solubility, which affects the reaction efficiency.
In summary, the physical properties of 5- (chloromethyl) -1,2,3-trifluorobenzene, such as appearance, boiling point, melting point, density and solubility, play a key role in many aspects of chemical synthesis, storage, transportation and application, and practitioners cannot ignore it.
What is the synthesis method of 5- (chloromethyl) -1,2,3-trifluorobenzene
The synthesis of 5- (chloromethyl) -1,2,3-trifluorobenzene is an important issue in the field of organic synthesis. To obtain this compound, there are many common methods.
First, it can be started from fluorobenzene derivatives. First, a halogenated reagent, such as thionyl chloride, phosphorus trichloride, etc., is used to introduce a halogen atom at a specific position on the benzene ring. If the raw material is a suitable fluorobenzoic acid derivative, the carboxyl group can be converted into an acyl chloride first, and then reduced by chlorination. For example, the carboxyl group can be converted into chloromethyl group under suitable reaction conditions by using sulfoxide chloride and an appropriate reducing agent, so that the chloromethyl part of the target product can be obtained. In this process, the reaction temperature, the proportion of reactants and the reaction time need to be carefully regulated. Generally speaking, the reaction temperature should be controlled within a certain range, such as room temperature to moderate heating, between about 40-80 degrees Celsius. The proportion of reactants depends on the specific reaction mechanism and the reagents used. It usually needs to be optimized by many experiments.
Second, a nucleophilic substitution reaction strategy can also be used. Using fluorohalogenated benzene as the substrate, select a suitable nucleophilic reagent, such as a nucleophilic reagent containing chloromethyl, and react in a suitable solvent in the presence of a phase transfer catalyst. Commonly used solvents include N, N-dimethylformamide (DMF), acetonitrile, etc. Phase transfer catalysts such as tetrabutylammonium bromide can effectively promote the reaction. The reaction conditions also need to be carefully selected, the temperature is mostly between 60 and 100 degrees Celsius, and the reaction time depends on the monitoring of the reaction process. It is often necessary to track the reaction by means of thin-layer chromatography (TLC).
Furthermore, from the perspective of constructing the benzene ring structure, if a suitable small molecule containing fluorine and chloromethyl is used as the raw material, it can also be prepared by cyclization reaction. For example, when using a multi-step reaction to construct a benzene ring skeleton, chloromethyl and fluorine atoms are introduced at a suitable stage. This method requires extremely precise control of the reaction steps and intermediates, and strict requirements for the reaction conditions of each step to ensure that the target 5- (chloromethyl) -1,2,3-trifluorobenzene can be generated in the end, and the purity and yield of the product can reach a satisfactory level.
First, it can be started from fluorobenzene derivatives. First, a halogenated reagent, such as thionyl chloride, phosphorus trichloride, etc., is used to introduce a halogen atom at a specific position on the benzene ring. If the raw material is a suitable fluorobenzoic acid derivative, the carboxyl group can be converted into an acyl chloride first, and then reduced by chlorination. For example, the carboxyl group can be converted into chloromethyl group under suitable reaction conditions by using sulfoxide chloride and an appropriate reducing agent, so that the chloromethyl part of the target product can be obtained. In this process, the reaction temperature, the proportion of reactants and the reaction time need to be carefully regulated. Generally speaking, the reaction temperature should be controlled within a certain range, such as room temperature to moderate heating, between about 40-80 degrees Celsius. The proportion of reactants depends on the specific reaction mechanism and the reagents used. It usually needs to be optimized by many experiments.
Second, a nucleophilic substitution reaction strategy can also be used. Using fluorohalogenated benzene as the substrate, select a suitable nucleophilic reagent, such as a nucleophilic reagent containing chloromethyl, and react in a suitable solvent in the presence of a phase transfer catalyst. Commonly used solvents include N, N-dimethylformamide (DMF), acetonitrile, etc. Phase transfer catalysts such as tetrabutylammonium bromide can effectively promote the reaction. The reaction conditions also need to be carefully selected, the temperature is mostly between 60 and 100 degrees Celsius, and the reaction time depends on the monitoring of the reaction process. It is often necessary to track the reaction by means of thin-layer chromatography (TLC).
Furthermore, from the perspective of constructing the benzene ring structure, if a suitable small molecule containing fluorine and chloromethyl is used as the raw material, it can also be prepared by cyclization reaction. For example, when using a multi-step reaction to construct a benzene ring skeleton, chloromethyl and fluorine atoms are introduced at a suitable stage. This method requires extremely precise control of the reaction steps and intermediates, and strict requirements for the reaction conditions of each step to ensure that the target 5- (chloromethyl) -1,2,3-trifluorobenzene can be generated in the end, and the purity and yield of the product can reach a satisfactory level.
What are the precautions for 5- (chloromethyl) -1,2,3-trifluorobenzene in storage and transportation?
5 - (chloromethyl) - 1,2,3 -trifluorobenzene is an important compound in organic chemistry. During storage and transportation, many precautions should not be ignored.
First words storage, this compound must be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, it is easy to cause reactions and risk deterioration when heated, so it is important to avoid heat. And moisture can also affect its stability, or react with groups such as chloromethyl, which is indispensable in a dry environment. In addition, it should be separated from oxidants, strong bases and other substances. Edge oxidants are prone to oxidation reactions with the compound, and strong bases may promote reactions such as hydrolysis of chloromethyl, endangering storage safety. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or specific plastic materials, should be used to prevent the interaction between the container and the compound.
As for transportation, be sure to ensure that the packaging is tight. Use professional packaging materials to prevent packaging damage due to bumps and collisions during transportation and leakage of compounds. Transportation vehicles need to be equipped with corresponding fire and emergency treatment equipment to deal with emergencies. Transport personnel should also be familiar with the characteristics of the compound and emergency disposal methods. And the transportation process should avoid high temperature periods and high temperature areas to prevent danger caused by excessive ambient temperature. In addition, transportation documents must be complete, including detailed compound information, emergency treatment measures, etc., so that all parties can know how to deal with it. Therefore, it is necessary to ensure the safety of 5- (chloromethyl) -1,2,3-trifluorobenzene during storage and transportation.
First words storage, this compound must be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, it is easy to cause reactions and risk deterioration when heated, so it is important to avoid heat. And moisture can also affect its stability, or react with groups such as chloromethyl, which is indispensable in a dry environment. In addition, it should be separated from oxidants, strong bases and other substances. Edge oxidants are prone to oxidation reactions with the compound, and strong bases may promote reactions such as hydrolysis of chloromethyl, endangering storage safety. Storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or specific plastic materials, should be used to prevent the interaction between the container and the compound.
As for transportation, be sure to ensure that the packaging is tight. Use professional packaging materials to prevent packaging damage due to bumps and collisions during transportation and leakage of compounds. Transportation vehicles need to be equipped with corresponding fire and emergency treatment equipment to deal with emergencies. Transport personnel should also be familiar with the characteristics of the compound and emergency disposal methods. And the transportation process should avoid high temperature periods and high temperature areas to prevent danger caused by excessive ambient temperature. In addition, transportation documents must be complete, including detailed compound information, emergency treatment measures, etc., so that all parties can know how to deal with it. Therefore, it is necessary to ensure the safety of 5- (chloromethyl) -1,2,3-trifluorobenzene during storage and transportation.
What are the environmental effects of 5- (chloromethyl) -1,2,3-trifluorobenzene?
5- (chloromethyl) -1,2,3-trifluorobenzene is one of the organic compounds. Its impact on the environment is quite complex and needs to be examined in detail.
This substance has a certain volatility. If it escapes in the atmosphere or participates in photochemical reactions. In the atmosphere, it may interact with active substances such as free radicals to generate secondary pollutants, which have adverse effects on air quality. And because of its halogenated atoms, under specific conditions, halogenated radicals may be formed, which further affects the process of atmospheric chemistry.
If 5- (chloromethyl) -1,2,3-trifluorobenzene enters the water body, it will settle to the bottom sediment due to hydrophobicity or adsorption to suspended particles. This substance is difficult to degrade in water or poses a threat to aquatic organisms. It may be transmitted and enriched through the food chain, accumulating in organisms such as plankton to fish, endangering the balance of aquatic ecosystems.
In soil, the mobility or limitation of 5- (chloromethyl) -1,2,3-trifluorobenzene can be slowly metabolized by soil microorganisms. If it exists in large quantities in soil for a long time, or changes the structure and function of soil microbial communities, it will affect soil fertility and ecological processes.
Humans may also come into contact with this substance on a daily basis, such as through respiration, skin contact or dietary intake. Because of its potential toxicity, or harmful to human health, it can cause adverse effects such as nervous system, reproductive system, etc.
5- (chloromethyl) -1,2,3-trifluorobenzene has many effects on the environment. When it is produced, used and disposed of, it should be done with caution and appropriate prevention and control measures should be taken to reduce its harm to the environment and humans.
This substance has a certain volatility. If it escapes in the atmosphere or participates in photochemical reactions. In the atmosphere, it may interact with active substances such as free radicals to generate secondary pollutants, which have adverse effects on air quality. And because of its halogenated atoms, under specific conditions, halogenated radicals may be formed, which further affects the process of atmospheric chemistry.
If 5- (chloromethyl) -1,2,3-trifluorobenzene enters the water body, it will settle to the bottom sediment due to hydrophobicity or adsorption to suspended particles. This substance is difficult to degrade in water or poses a threat to aquatic organisms. It may be transmitted and enriched through the food chain, accumulating in organisms such as plankton to fish, endangering the balance of aquatic ecosystems.
In soil, the mobility or limitation of 5- (chloromethyl) -1,2,3-trifluorobenzene can be slowly metabolized by soil microorganisms. If it exists in large quantities in soil for a long time, or changes the structure and function of soil microbial communities, it will affect soil fertility and ecological processes.
Humans may also come into contact with this substance on a daily basis, such as through respiration, skin contact or dietary intake. Because of its potential toxicity, or harmful to human health, it can cause adverse effects such as nervous system, reproductive system, etc.
5- (chloromethyl) -1,2,3-trifluorobenzene has many effects on the environment. When it is produced, used and disposed of, it should be done with caution and appropriate prevention and control measures should be taken to reduce its harm to the environment and humans.
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