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5-(Tert-Butyl)-1,2-Dichloro-3-Iodobenzene
Linshang Chemical
|
HS Code |
500466 |
| Chemical Formula | C10H11Cl2I |
| Molecular Weight | 347.905 g/mol |
| Appearance | Solid (likely) |
| Boiling Point | Estimated based on similar compounds |
| Solubility In Water | Low (organic compound with non - polar groups) |
| Solubility In Organic Solvents | Good in non - polar and some polar organic solvents |
| Vapor Pressure | Low, as it's a solid (estimated) |
As an accredited 5-(Tert-Butyl)-1,2-Dichloro-3-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 5-(tert - butyl)-1,2 - dichloro - 3 - iodobenzene in sealed, labeled chemical - grade container. |
| Storage | Store 5-(tert -butyl)-1,2 -dichloro-3 -iodobenzene in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials like glass or certain plastics. Avoid exposure to light as the compound may be photosensitive. This storage method helps maintain its chemical integrity and minimizes risks. |
| Shipping | 5-(tert - butyl)-1,2 - dichloro - 3 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to comply with hazardous chemical shipping regulations, ensuring safe transport to the destination. |
Competitive 5-(Tert-Butyl)-1,2-Dichloro-3-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 5- (tert - butyl) -1,2 - dichloro - 3 - iodobenzene?
5- (tert-butyl) -1,2-dichloro-3-iodobenzene is an organic compound with unique chemical properties, which is worth studying.
In this compound, tert-butyl has a large steric barrier, which has a significant impact on the spatial structure and chemical activity of the molecule as a whole. Due to its steric barrier effect, it can hinder the occurrence of chemical reactions at specific locations to a certain extent, and can also change the interactions between molecules, such as affecting their solubility and crystallinity in solution.
The chlorine atom and the iodine atom act as halogen atoms, giving the compound a variety of reactivity. Both chlorine and iodine atoms have certain electronegativity, which can change the electron cloud density distribution of the benzene ring and cause changes in the electrophilic substitution of the benzene ring Usually, halogen atoms are ortho-para-sites, which makes subsequent electrophilic substitution reactions tend to occur in their ortho and para-sites.
Iodine atoms are prone to substitution reactions under certain conditions due to their large atomic radius and relatively small C-I bond energy. For example, in nucleophilic substitution reactions, iodine atoms are easily replaced by nucleophiles to form new carbon-nucleophilic bonds. Although chlorine atoms have higher C-Cl bond energy, they can also participate in substitution reactions under appropriate conditions, such as high temperature and the presence of strong nucleophiles.
In addition, the conjugate system of the benzene ring in this compound gives it certain stability, and also provides the possibility for various reactions based on the benzene ring, such as coupling reactions with metal catalysts to construct more complex organic molecular structures.
The chemical properties of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene are determined by its functional groups and spatial structure, showing many potential applications in the field of organic synthesis.
In this compound, tert-butyl has a large steric barrier, which has a significant impact on the spatial structure and chemical activity of the molecule as a whole. Due to its steric barrier effect, it can hinder the occurrence of chemical reactions at specific locations to a certain extent, and can also change the interactions between molecules, such as affecting their solubility and crystallinity in solution.
The chlorine atom and the iodine atom act as halogen atoms, giving the compound a variety of reactivity. Both chlorine and iodine atoms have certain electronegativity, which can change the electron cloud density distribution of the benzene ring and cause changes in the electrophilic substitution of the benzene ring Usually, halogen atoms are ortho-para-sites, which makes subsequent electrophilic substitution reactions tend to occur in their ortho and para-sites.
Iodine atoms are prone to substitution reactions under certain conditions due to their large atomic radius and relatively small C-I bond energy. For example, in nucleophilic substitution reactions, iodine atoms are easily replaced by nucleophiles to form new carbon-nucleophilic bonds. Although chlorine atoms have higher C-Cl bond energy, they can also participate in substitution reactions under appropriate conditions, such as high temperature and the presence of strong nucleophiles.
In addition, the conjugate system of the benzene ring in this compound gives it certain stability, and also provides the possibility for various reactions based on the benzene ring, such as coupling reactions with metal catalysts to construct more complex organic molecular structures.
The chemical properties of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene are determined by its functional groups and spatial structure, showing many potential applications in the field of organic synthesis.
What are the common synthesis methods for 5- (tert-butyl) -1,2 -dichloro-3 -iodobenzene?
5- (tert-butyl) -1,2-dichloro-3-iodobenzene is also an important compound in the field of organic synthesis. There are about three common synthesis methods.
First, the halogenation reaction method. Take benzene compounds containing tert-butyl first, and under suitable reaction conditions, use chlorine reagents, such as chlorine gas or thionyl chloride, to chlorinate and react to obtain dichlorobenzene derivatives containing tert-butyl. Then, this product is used as the substrate, and a suitable iodization reagent is selected, such as iodine elemental substance combined with an appropriate catalyst, and iodine atoms are introduced through electrophilic substitution reaction to obtain 5- (tert-butyl) -1,2-dichloro-3-iodobenzene. In this way, during the chlorination reaction, the reaction temperature, reagent ratio and other factors have a great influence on the selectivity of the product; for the iodization reaction, attention should be paid to the activity and dosage of the catalyst to promote the efficient progress of the reaction and ensure the purity of the product.
Second, the method of metal catalytic coupling reaction. First, halogenated benzene containing tert-butyl (such as bromo or chloro), and borate or halide containing iodine are prepared Subsequently, under the action of metal catalysts, such as palladium catalysts, the coupling reaction is carried out in a base and an appropriate solvent environment. For example, the classic Suzuki coupling reaction or the Stille coupling reaction. The key to this synthesis strategy lies in the selection of metal catalysts and the optimization of ligands to improve the activity and selectivity of the reaction. At the same time, the anhydrous and oxygen-free conditions of the reaction system are also crucial, otherwise it is easy to cause the catalyst to deactivate and affect the reaction process.
Third, the method of multi-step functional group conversion. Starting from benzene containing tert-butyl, the functional groups that are easy to convert are first introduced, such as nitro groups. After a series of reactions such as reduction and diazotization, the functional groups are gradually converted into chlorine atoms and iodine atoms. Although there are many steps in this process, it can be flexibly adjusted according to different substrates and reaction conditions to achieve the purpose of synthesizing the target product. Each step requires precise control of the reaction conditions to ensure the yield and selectivity of each step in order to efficiently synthesize 5- (tert-butyl) -1,2-dichloro-3-iodobenzene.
First, the halogenation reaction method. Take benzene compounds containing tert-butyl first, and under suitable reaction conditions, use chlorine reagents, such as chlorine gas or thionyl chloride, to chlorinate and react to obtain dichlorobenzene derivatives containing tert-butyl. Then, this product is used as the substrate, and a suitable iodization reagent is selected, such as iodine elemental substance combined with an appropriate catalyst, and iodine atoms are introduced through electrophilic substitution reaction to obtain 5- (tert-butyl) -1,2-dichloro-3-iodobenzene. In this way, during the chlorination reaction, the reaction temperature, reagent ratio and other factors have a great influence on the selectivity of the product; for the iodization reaction, attention should be paid to the activity and dosage of the catalyst to promote the efficient progress of the reaction and ensure the purity of the product.
Second, the method of metal catalytic coupling reaction. First, halogenated benzene containing tert-butyl (such as bromo or chloro), and borate or halide containing iodine are prepared Subsequently, under the action of metal catalysts, such as palladium catalysts, the coupling reaction is carried out in a base and an appropriate solvent environment. For example, the classic Suzuki coupling reaction or the Stille coupling reaction. The key to this synthesis strategy lies in the selection of metal catalysts and the optimization of ligands to improve the activity and selectivity of the reaction. At the same time, the anhydrous and oxygen-free conditions of the reaction system are also crucial, otherwise it is easy to cause the catalyst to deactivate and affect the reaction process.
Third, the method of multi-step functional group conversion. Starting from benzene containing tert-butyl, the functional groups that are easy to convert are first introduced, such as nitro groups. After a series of reactions such as reduction and diazotization, the functional groups are gradually converted into chlorine atoms and iodine atoms. Although there are many steps in this process, it can be flexibly adjusted according to different substrates and reaction conditions to achieve the purpose of synthesizing the target product. Each step requires precise control of the reaction conditions to ensure the yield and selectivity of each step in order to efficiently synthesize 5- (tert-butyl) -1,2-dichloro-3-iodobenzene.
In what fields is 5- (tert - butyl) -1,2 - dichloro - 3 - iodobenzene used?
5- (tert-butyl) -1,2-dichloro-3-iodobenzene is one of the organic compounds. It has applications in many fields.
In the field of organic synthesis, this compound can be used as a key intermediate. Due to its unique structure, it contains tert-butyl, chlorine and iodine atoms, and each atom has specific reactivity. Tert-butyl can affect the spatial structure and electron cloud distribution of molecules, and chlorine and iodine atoms are excellent leaving groups for nucleophilic substitution and other reactions. With this compound as a starting material, chemists can use nucleophilic substitution, coupling reactions and other organic reactions to construct complex organic molecular structures, laying the foundation for drug synthesis and material preparation.
In the field of medicinal chemistry, such organic compounds may have potential biological activities. Scientists can modify and optimize their structures to explore their interactions with biological targets. For example, by changing the type, position and number of substituents, the lipid-soluble, water-soluble and spatial configuration of molecules can be adjusted to improve their affinity and selectivity to specific disease-related targets, and then new drugs can be developed.
In the field of materials science, 5- (tert-butyl) -1,2-dichloro-3-iodobenzene is also useful. Because its atoms can participate in polymerization reactions or other material construction reactions, materials with special properties can be prepared. Or can be used to prepare photoelectric materials, using their molecular structure and electronic properties to achieve the regulation of optical and electrical properties, and applied to organic Light Emitting Diodes, solar cells and other devices.
In the field of organic synthesis, this compound can be used as a key intermediate. Due to its unique structure, it contains tert-butyl, chlorine and iodine atoms, and each atom has specific reactivity. Tert-butyl can affect the spatial structure and electron cloud distribution of molecules, and chlorine and iodine atoms are excellent leaving groups for nucleophilic substitution and other reactions. With this compound as a starting material, chemists can use nucleophilic substitution, coupling reactions and other organic reactions to construct complex organic molecular structures, laying the foundation for drug synthesis and material preparation.
In the field of medicinal chemistry, such organic compounds may have potential biological activities. Scientists can modify and optimize their structures to explore their interactions with biological targets. For example, by changing the type, position and number of substituents, the lipid-soluble, water-soluble and spatial configuration of molecules can be adjusted to improve their affinity and selectivity to specific disease-related targets, and then new drugs can be developed.
In the field of materials science, 5- (tert-butyl) -1,2-dichloro-3-iodobenzene is also useful. Because its atoms can participate in polymerization reactions or other material construction reactions, materials with special properties can be prepared. Or can be used to prepare photoelectric materials, using their molecular structure and electronic properties to achieve the regulation of optical and electrical properties, and applied to organic Light Emitting Diodes, solar cells and other devices.
What are the physical properties of 5- (tert - butyl) -1,2 - dichloro - 3 - iodobenzene?
5- (tert-butyl) -1,2-dichloro-3-iodobenzene is one of the organic compounds. Looking at its physical properties, this substance is either solid or liquid at room temperature, but the exact state depends on the intermolecular force and molecular structure. Its melting point and boiling point are also restricted by the attractive force between molecules. The molecular weight is large and the structure is complex, the attractive force between molecules is strong, and the melting point and boiling point are high.
On solubility, because it contains aromatic rings, halogen atoms and tert-butyl groups, it has certain hydrophobicity, and its solubility in water is low. However, organic solvents such as dichloromethane, chloroform, ether, toluene, etc., have good compatibility with them because of their similar miscibility.
The color state of this compound, if there is no conjugate system or chromophore, or it is colorless. If the molecular structure has chromogenic factors, or a specific color is present. Its density depends on the molecular weight and the packing method. The molecular weight is large and the packing is tight, and the density is large.
Furthermore, its volatility is also related to the intermolecular force. The action force is weak, the volatility is strong; the action force is strong, and the volatility is weak. This substance is used in the field of organic synthesis or as a key intermediate to participate in various reactions and synthesize other organic compounds. Its physical properties have a profound impact on the synthesis, separation and purification process, and are related to the choice of reaction conditions and the purity of the product.
On solubility, because it contains aromatic rings, halogen atoms and tert-butyl groups, it has certain hydrophobicity, and its solubility in water is low. However, organic solvents such as dichloromethane, chloroform, ether, toluene, etc., have good compatibility with them because of their similar miscibility.
The color state of this compound, if there is no conjugate system or chromophore, or it is colorless. If the molecular structure has chromogenic factors, or a specific color is present. Its density depends on the molecular weight and the packing method. The molecular weight is large and the packing is tight, and the density is large.
Furthermore, its volatility is also related to the intermolecular force. The action force is weak, the volatility is strong; the action force is strong, and the volatility is weak. This substance is used in the field of organic synthesis or as a key intermediate to participate in various reactions and synthesize other organic compounds. Its physical properties have a profound impact on the synthesis, separation and purification process, and are related to the choice of reaction conditions and the purity of the product.
What is the market price of 5- (tert - butyl) -1,2 - dichloro - 3 - iodobenzene?
What you are inquiring about is the market price of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene. However, the market price of this compound is difficult to sum up, and it is affected by many factors.
First, the manufacturer and the origin have a great influence. Different manufacturers have different prices due to different production processes and cost control. And the distance of the origin is related to transportation costs, which will also lead to price differences.
Second, the market supply and demand situation is the key. If demand is strong and supply is limited, the price will rise; conversely, if supply exceeds demand, the price will fall.
Third, the purity of the product also affects the price. High purity of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene is difficult to prepare and expensive, so the price is often higher than that of ordinary purity.
In addition, the fluctuation of raw material prices and the degree of market competition all affect its price.
In my opinion, if you want to know the exact market price, you can consult chemical product trading platforms, chemical reagent suppliers, or industry insiders. They can often give you more accurate price information based on current market conditions.
First, the manufacturer and the origin have a great influence. Different manufacturers have different prices due to different production processes and cost control. And the distance of the origin is related to transportation costs, which will also lead to price differences.
Second, the market supply and demand situation is the key. If demand is strong and supply is limited, the price will rise; conversely, if supply exceeds demand, the price will fall.
Third, the purity of the product also affects the price. High purity of 5- (tert-butyl) -1,2-dichloro-3-iodobenzene is difficult to prepare and expensive, so the price is often higher than that of ordinary purity.
In addition, the fluctuation of raw material prices and the degree of market competition all affect its price.
In my opinion, if you want to know the exact market price, you can consult chemical product trading platforms, chemical reagent suppliers, or industry insiders. They can often give you more accurate price information based on current market conditions.
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