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6-Chloro-2-Fluoro-3-Methoxybenzenecarboxylicacid
Linshang Chemical
|
HS Code |
939290 |
| Name | 6-Chloro-2-Fluoro-3-Methoxybenzenecarboxylic acid |
| Chemical Formula | C8H6ClFO3 |
| Molar Mass | 204.582 g/mol |
| Appearance | Solid (likely white or off - white powder, assumed based on similar compounds) |
| Physical State At Room Temperature | Solid |
| Solubility In Water | Low (aromatic carboxylic acids with halogen and methoxy groups are typically sparingly soluble in water) |
| Melting Point | No specific data provided, but similar aromatic carboxylic acids usually have melting points in the range of 100 - 200 °C |
| Pka | Typical pKa values for aromatic carboxylic acids are around 3 - 5, so this compound may have a pKa in this range |
As an accredited 6-Chloro-2-Fluoro-3-Methoxybenzenecarboxylicacid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 6 - chloro - 2 - fluoro - 3 - methoxybenzenecarboxylic acid in sealed chemical - grade bag. |
| Storage | 6 - Chloro - 2 - fluoro - 3 - methoxybenzenecarboxylic acid should be stored in a cool, dry place. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could potentially degrade the chemical. Store away from heat sources, open flames, and incompatible substances like strong oxidizing agents or bases to ensure safety and maintain its chemical integrity. |
| Shipping | 6 - chloro - 2 - fluoro - 3 - methoxybenzenecarboxylic acid is shipped in well - sealed, corrosion - resistant containers. Special care is taken to prevent leakage during transit, following all relevant chemical shipping regulations. |
Competitive 6-Chloro-2-Fluoro-3-Methoxybenzenecarboxylicacid prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 6-chloro-2-fluoro-3-methoxybenzenecarboxylic acid?
6-Chloro-2-fluoro-3-methoxybenzoic acid, this is an organic compound. Looking at its structure, it contains carboxyl groups, chlorine atoms, fluorine atoms and methoxy groups, and various functional groups endow it with unique chemical properties.
First, the carboxyl group is acidic and can be neutralized with bases to form corresponding carboxylic salts and water. In case of alcohols, under suitable catalysts and conditions, esterification can occur to generate ester compounds and water. This reaction is often used in organic synthesis to prepare ester products.
Although the chlorine atom is relatively stable, it can be replaced under the action of specific nucleophiles. For example, when reacting with a more nucleophilic reagent, the chlorine atom can leave and be replaced by other groups, thereby achieving molecular structure modification and functional expansion.
Fluorine atoms have large electronegativity, which changes the distribution of molecular electron clouds and enhances molecular stability and lipid solubility. In the field of medicinal chemistry, the introduction of fluorine atoms can often adjust drug activity, metabolic stability and bioavailability.
Methoxy group as a power supply group can affect the electron cloud density of the benzene ring, so that the electron cloud density of the benzene ring is relatively increased, making the benzene ring more prone to electrophilic substitution, and has an impact on the reaction check point and activity. With the interaction of these functional groups, 6-chloro-2-fluoro-3-methoxybenzoic acid exhibits diverse chemical properties and has potential applications in many fields such as organic synthesis and drug discovery.
First, the carboxyl group is acidic and can be neutralized with bases to form corresponding carboxylic salts and water. In case of alcohols, under suitable catalysts and conditions, esterification can occur to generate ester compounds and water. This reaction is often used in organic synthesis to prepare ester products.
Although the chlorine atom is relatively stable, it can be replaced under the action of specific nucleophiles. For example, when reacting with a more nucleophilic reagent, the chlorine atom can leave and be replaced by other groups, thereby achieving molecular structure modification and functional expansion.
Fluorine atoms have large electronegativity, which changes the distribution of molecular electron clouds and enhances molecular stability and lipid solubility. In the field of medicinal chemistry, the introduction of fluorine atoms can often adjust drug activity, metabolic stability and bioavailability.
Methoxy group as a power supply group can affect the electron cloud density of the benzene ring, so that the electron cloud density of the benzene ring is relatively increased, making the benzene ring more prone to electrophilic substitution, and has an impact on the reaction check point and activity. With the interaction of these functional groups, 6-chloro-2-fluoro-3-methoxybenzoic acid exhibits diverse chemical properties and has potential applications in many fields such as organic synthesis and drug discovery.
What are the common synthesis methods of 6-chloro-2-fluoro-3-methoxybenzenecarboxylic acid?
There are many common methods for the synthesis of 6-chloro-2-fluoro-3-methoxybenzoic acid.
First, it can be started from suitable aromatic hydrocarbons. With the corresponding halogenated aromatic hydrocarbons as raw materials, the halogen atoms can be introduced into methoxy groups through nucleophilic substitution reactions under specific conditions. For example, a halogenated benzene containing chlorine and fluorine is selected, and a nucleophilic agent such as sodium methoxide is selected, and a suitable organic solvent such as N, N-dimethylformamide (DMF) is reacted at a certain temperature and time to introduce methoxy groups. Thereafter, carboxyl groups are introduced through carboxylation reactions. The commonly used carboxylation method is to react halogenated aromatics with metallic magnesium to prepare Grignard reagents, and then react with carbon dioxide to obtain the target benzoic acid after hydrolysis. This process requires attention to the precise control of the reaction conditions. The amount of magnesium, the reaction temperature and time are all related to the success or failure of the reaction and the yield.
Second, it can be started from phenolic compounds. The phenolic hydroxyl group is first methylated to convert to methoxy. Commonly used methylation reagents include dimethyl sulfate, iodomethane, etc. Under basic conditions, such as the presence of potassium carbonate, it is reacted in an organic solvent. After that, the benzene ring is halogenated to introduce chlorine and fluorine atoms. Halogenation reagents are selected according to specific needs, such as chlorine, N-chlorosuccinimide (NCS) for chlorination, and fluorination reagents such as Selectfluor for fluorination. Finally, 6-chloro-2-fluoro-3-methoxybenzoic acid can also be obtained through the carboxylation step.
Third, the reaction involving arylboronic acid or borate esters can also be used. The coupling reaction between arylboric acid and halogenated hydrocarbons under palladium catalysis can construct a substituent structure on the benzene ring. Chlorine, fluorine and methoxy are introduced through the coupling reaction first, and then converted into the target benzoic acid through suitable oxidation or carboxylation steps. This method requires the selection of suitable palladium catalysts and ligands to improve the selectivity and efficiency of the reaction.
Synthesis of this compound requires fine regulation of the reaction conditions at each step. Factors such as the purity of the raw material, reaction temperature, time, and reagent dosage all have a significant impact on the yield and purity of the final product. And the reaction process often requires multiple steps, and the separation and purification after each step is also crucial to ensure the smooth progress of the subsequent reaction and the high quality of the product.
First, it can be started from suitable aromatic hydrocarbons. With the corresponding halogenated aromatic hydrocarbons as raw materials, the halogen atoms can be introduced into methoxy groups through nucleophilic substitution reactions under specific conditions. For example, a halogenated benzene containing chlorine and fluorine is selected, and a nucleophilic agent such as sodium methoxide is selected, and a suitable organic solvent such as N, N-dimethylformamide (DMF) is reacted at a certain temperature and time to introduce methoxy groups. Thereafter, carboxyl groups are introduced through carboxylation reactions. The commonly used carboxylation method is to react halogenated aromatics with metallic magnesium to prepare Grignard reagents, and then react with carbon dioxide to obtain the target benzoic acid after hydrolysis. This process requires attention to the precise control of the reaction conditions. The amount of magnesium, the reaction temperature and time are all related to the success or failure of the reaction and the yield.
Second, it can be started from phenolic compounds. The phenolic hydroxyl group is first methylated to convert to methoxy. Commonly used methylation reagents include dimethyl sulfate, iodomethane, etc. Under basic conditions, such as the presence of potassium carbonate, it is reacted in an organic solvent. After that, the benzene ring is halogenated to introduce chlorine and fluorine atoms. Halogenation reagents are selected according to specific needs, such as chlorine, N-chlorosuccinimide (NCS) for chlorination, and fluorination reagents such as Selectfluor for fluorination. Finally, 6-chloro-2-fluoro-3-methoxybenzoic acid can also be obtained through the carboxylation step.
Third, the reaction involving arylboronic acid or borate esters can also be used. The coupling reaction between arylboric acid and halogenated hydrocarbons under palladium catalysis can construct a substituent structure on the benzene ring. Chlorine, fluorine and methoxy are introduced through the coupling reaction first, and then converted into the target benzoic acid through suitable oxidation or carboxylation steps. This method requires the selection of suitable palladium catalysts and ligands to improve the selectivity and efficiency of the reaction.
Synthesis of this compound requires fine regulation of the reaction conditions at each step. Factors such as the purity of the raw material, reaction temperature, time, and reagent dosage all have a significant impact on the yield and purity of the final product. And the reaction process often requires multiple steps, and the separation and purification after each step is also crucial to ensure the smooth progress of the subsequent reaction and the high quality of the product.
What are the main applications of 6-chloro-2-fluoro-3-methoxybenzenecarboxylic acid?
6-Chloro-2-fluoro-3-methoxybenzoic acid, this compound has important uses in the fields of medicine, pesticides and materials science.
In the field of medicine, it can be used as a key intermediate for the synthesis of specific drugs. Due to its unique chemical structure, it can interact with specific biological targets. Taking the development of anti-cancer drugs as an example, it can be chemically modified to construct structures that fit with specific proteins or enzymes of cancer cells, providing new opportunities for conquering cancer by inhibiting cancer cell proliferation and inducing cancer cell apoptosis. Or in the research and development of anti-infective drugs, by virtue of their structural characteristics, they interfere with the metabolic process of pathogens or destroy their cell membranes, etc., showing potential antibacterial and antiviral activities, and contributing to the development of new anti-infective drugs.
In the field of pesticides, it can be used as a key raw material for the synthesis of high-efficiency pesticides. In view of its certain biological activity, it can effectively resist the invasion of pests and pathogens. For example, for some common pests of crops, pesticides synthesized based on 6-chloro-2-fluoro-3-methoxybenzoic acid can precisely act on the nervous system or digestive system of pests, interfere with the normal physiological functions of pests, achieve the purpose of efficient insecticidal purposes, and have little impact on the environment, contributing to the green and sustainable development At the same time, it also has an inhibitory effect on crop pathogens, which can reduce the incidence of diseases and ensure crop yield and quality.
In the field of material science, it can be used to prepare special functional materials. Because it contains chlorine, fluorine and other atoms, it gives the material unique physical and chemical properties. For example, the introduction of this compound in the synthesis of polymer materials can improve the thermal stability, corrosion resistance and mechanical properties of the material. The modified materials can be used to make parts in the aerospace field to meet the strict requirements of high performance and high stability in this field; or to make electronic equipment shells to improve the wear resistance and aging resistance of the shells and prolong the service life of electronic equipment.
In the field of medicine, it can be used as a key intermediate for the synthesis of specific drugs. Due to its unique chemical structure, it can interact with specific biological targets. Taking the development of anti-cancer drugs as an example, it can be chemically modified to construct structures that fit with specific proteins or enzymes of cancer cells, providing new opportunities for conquering cancer by inhibiting cancer cell proliferation and inducing cancer cell apoptosis. Or in the research and development of anti-infective drugs, by virtue of their structural characteristics, they interfere with the metabolic process of pathogens or destroy their cell membranes, etc., showing potential antibacterial and antiviral activities, and contributing to the development of new anti-infective drugs.
In the field of pesticides, it can be used as a key raw material for the synthesis of high-efficiency pesticides. In view of its certain biological activity, it can effectively resist the invasion of pests and pathogens. For example, for some common pests of crops, pesticides synthesized based on 6-chloro-2-fluoro-3-methoxybenzoic acid can precisely act on the nervous system or digestive system of pests, interfere with the normal physiological functions of pests, achieve the purpose of efficient insecticidal purposes, and have little impact on the environment, contributing to the green and sustainable development At the same time, it also has an inhibitory effect on crop pathogens, which can reduce the incidence of diseases and ensure crop yield and quality.
In the field of material science, it can be used to prepare special functional materials. Because it contains chlorine, fluorine and other atoms, it gives the material unique physical and chemical properties. For example, the introduction of this compound in the synthesis of polymer materials can improve the thermal stability, corrosion resistance and mechanical properties of the material. The modified materials can be used to make parts in the aerospace field to meet the strict requirements of high performance and high stability in this field; or to make electronic equipment shells to improve the wear resistance and aging resistance of the shells and prolong the service life of electronic equipment.
What are the physical properties of 6-chloro-2-fluoro-3-methoxybenzenecarboxylic acid?
6-Chloro-2-fluoro-3-methoxybenzoic acid, this substance is an organic compound with unique physical properties. Its properties are mostly white to light yellow crystalline powder at room temperature. This form is conducive to storage and transportation. Because it is relatively stable, it is not easy to change the state due to slight external vibration and friction.
Looking at its melting point, it is about a specific range. The melting point is of great significance for its identification and purity judgment. When heated to the melting point, the substance gradually turns from a solid to a liquid state. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the range becomes wider. This characteristic is a key indicator for purity control in chemical production and laboratory research.
In terms of solubility, it has a certain solubility in organic solvents such as ethanol and ether, but very little solubility in water. This property makes it very useful in separation, purification and reaction system construction. In organic synthesis reactions, the appropriate solvent can be selected according to the solubility to make the reaction proceed efficiently. For example, when the reaction needs to be carried out in ethanol solution, the substance can be well dissolved, providing a suitable environment for the collision of reacting molecules and accelerating the reaction process.
In addition, its density is also an important physical property. Although the specific value fluctuates slightly according to the experimental conditions, it is relatively fixed. This density characteristic is of great significance in the mixing and separation of substances, such as extraction and centrifugation through density differences.
The physical properties of 6-chloro-2-fluoro-3-methoxybenzoic acid are fundamental and key factors in the fields of organic synthesis, drug development, and materials science, providing important basis and guidance for related research and production practices.
Looking at its melting point, it is about a specific range. The melting point is of great significance for its identification and purity judgment. When heated to the melting point, the substance gradually turns from a solid to a liquid state. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the range becomes wider. This characteristic is a key indicator for purity control in chemical production and laboratory research.
In terms of solubility, it has a certain solubility in organic solvents such as ethanol and ether, but very little solubility in water. This property makes it very useful in separation, purification and reaction system construction. In organic synthesis reactions, the appropriate solvent can be selected according to the solubility to make the reaction proceed efficiently. For example, when the reaction needs to be carried out in ethanol solution, the substance can be well dissolved, providing a suitable environment for the collision of reacting molecules and accelerating the reaction process.
In addition, its density is also an important physical property. Although the specific value fluctuates slightly according to the experimental conditions, it is relatively fixed. This density characteristic is of great significance in the mixing and separation of substances, such as extraction and centrifugation through density differences.
The physical properties of 6-chloro-2-fluoro-3-methoxybenzoic acid are fundamental and key factors in the fields of organic synthesis, drug development, and materials science, providing important basis and guidance for related research and production practices.
What should 6-chloro-2-fluoro-3-methoxybenzenecarboxylic acid pay attention to when storing and transporting?
6-Chloro-2-fluoro-3-methoxybenzoic acid is an organic compound, and many aspects need to be paid attention to when storing and transporting.
The first thing to do is to store it. This compound should be stored in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity, humid environments can easily cause deterioration, which in turn affects its quality and chemical properties. Storage temperatures must also be strictly controlled to avoid too high or too low, to prevent unnecessary chemical reactions. Keep away from fires and heat sources, because organic compounds are flammable, in case of open flames or high temperatures, or there is a risk of combustion or even explosion. It should also be stored separately from oxidizing agents, alkalis, etc. This is because the chemical properties of the compound are active, contact with the above substances, or violent chemical reactions may occur, endangering safety.
As for transportation, the same should not be taken lightly. It is necessary to ensure that the packaging is complete and well sealed to prevent it from leaking due to package damage during transportation. During transportation, care must be taken to avoid collisions and vibrations to prevent damage to the packaging. The means of transportation must also be clean, dry and free of other chemicals to avoid cross-contamination. In addition, transportation personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of an unexpected situation, they can be disposed of quickly and properly to minimize the harm.
In conclusion, 6-chloro-2-fluoro-3-methoxybenzoic acid must be stored and transported with due consideration of environmental conditions, packaging, personnel, and other factors to ensure its safety and stability.
The first thing to do is to store it. This compound should be stored in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity, humid environments can easily cause deterioration, which in turn affects its quality and chemical properties. Storage temperatures must also be strictly controlled to avoid too high or too low, to prevent unnecessary chemical reactions. Keep away from fires and heat sources, because organic compounds are flammable, in case of open flames or high temperatures, or there is a risk of combustion or even explosion. It should also be stored separately from oxidizing agents, alkalis, etc. This is because the chemical properties of the compound are active, contact with the above substances, or violent chemical reactions may occur, endangering safety.
As for transportation, the same should not be taken lightly. It is necessary to ensure that the packaging is complete and well sealed to prevent it from leaking due to package damage during transportation. During transportation, care must be taken to avoid collisions and vibrations to prevent damage to the packaging. The means of transportation must also be clean, dry and free of other chemicals to avoid cross-contamination. In addition, transportation personnel need to be professionally trained and familiar with the characteristics of the compound and emergency treatment methods. In the event of an unexpected situation, they can be disposed of quickly and properly to minimize the harm.
In conclusion, 6-chloro-2-fluoro-3-methoxybenzoic acid must be stored and transported with due consideration of environmental conditions, packaging, personnel, and other factors to ensure its safety and stability.
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