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(Alphar)-Alpha-Methyl-N-Tosyl-2-Hydroxy-5-Chlorobenzenemethaneamine
Linshang Chemical
|
HS Code |
230643 |
| Chemical Formula | C15H16ClNO3S |
| Molecular Weight | 325.81 |
| Appearance | Solid (usually) |
| Melting Point | N/A (depends on purity, specific data needed) |
| Boiling Point | N/A (depends on purity, specific data needed) |
| Solubility In Water | Low (organic compound, likely sparingly soluble) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Pka | N/A (no obvious acidic/basic functional groups for easy pKa determination without data) |
| Logp | Positive (hydrophobic due to aromatic and alkyl groups) |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited (Alphar)-Alpha-Methyl-N-Tosyl-2-Hydroxy-5-Chlorobenzenemethaneamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram pack of (α)-α - methyl - N - tosyl - 2 - hydroxy - 5 - chlorobenzenemethaneamine in sealed container. |
| Storage | (αR)-α -methyl -N -tosyl -2 -hydroxy -5 -chlorobenzenemethaneamine should be stored in a cool, dry place, away from direct sunlight. Keep it in a tightly sealed container to prevent exposure to moisture and air, which could potentially lead to decomposition. Store it separately from incompatible substances, following safety guidelines to avoid any chemical reactions. |
| Shipping | The chemical (α)-α -methyl -N -tosyl -2 -hydroxy -5 -chlorobenzenemethaneamine is shipped in accordance with strict chemical transportation regulations. It's packaged securely to prevent leakage, and transported by carriers trained in handling such substances. |
Competitive (Alphar)-Alpha-Methyl-N-Tosyl-2-Hydroxy-5-Chlorobenzenemethaneamine prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of -alpha-methyl-n-tosyl-2-hydroxy-5-chlorobenzenemethaneamine?
(α r ） -α - methyl-N-p-toluenesulfonyl-2-hydroxy-5-chlorobenzamine, which is an organic compound. To clarify its chemical structure, it is necessary to analyze the structural information contained in its name.
" (α r) " refers to the specific stereochemical configuration of the compound, indicating that its chiral central stereochemistry is the R configuration. "α-methyl" means that the α position (the carbon atom directly connected to the functional group) is connected with a methyl group. "N-p-toluenesulfonyl" means that the nitrogen atom (N) is connected to the p-toluenesulfonyl group. The p-toluenesulfonyl group structure is -SO ² -phenyl-CH ², in which the phenyl group has a methyl group in the para-position. "2-Hydroxy-5-chlorobenzamine" shows that there is a hydroxyl group (-OH) at 2 positions on the benzene ring, a chlorine atom (-Cl) at 5 positions, and the benzene ring is connected to a methylamine group (-CH ³ - NH ³).
In summary, the core of this compound is a benzene ring, with a hydroxyl group at 2 positions on the ring and a chlorine atom at 5 positions on the ring. One side of the benzene ring is connected to -CH -2 - NH - SO -2 - phenyl - CH , and the other Its structure is composed of benzene ring, hydroxyl group, chlorine atom, methyl group, methylamino group and p-toluenesulfonyl group in a specific order and spatial arrangement, and each part affects each other to determine the chemical properties and reactivity of the compound.
" (α r) " refers to the specific stereochemical configuration of the compound, indicating that its chiral central stereochemistry is the R configuration. "α-methyl" means that the α position (the carbon atom directly connected to the functional group) is connected with a methyl group. "N-p-toluenesulfonyl" means that the nitrogen atom (N) is connected to the p-toluenesulfonyl group. The p-toluenesulfonyl group structure is -SO ² -phenyl-CH ², in which the phenyl group has a methyl group in the para-position. "2-Hydroxy-5-chlorobenzamine" shows that there is a hydroxyl group (-OH) at 2 positions on the benzene ring, a chlorine atom (-Cl) at 5 positions, and the benzene ring is connected to a methylamine group (-CH ³ - NH ³).
In summary, the core of this compound is a benzene ring, with a hydroxyl group at 2 positions on the ring and a chlorine atom at 5 positions on the ring. One side of the benzene ring is connected to -CH -2 - NH - SO -2 - phenyl - CH , and the other Its structure is composed of benzene ring, hydroxyl group, chlorine atom, methyl group, methylamino group and p-toluenesulfonyl group in a specific order and spatial arrangement, and each part affects each other to determine the chemical properties and reactivity of the compound.
What are the main uses of (alphar) -alpha-methyl-n-tosyl-2-hydroxy-5-chlorobenzenemethaneamine?
(α R ） -α - methyl-N-p-toluenesulfonyl-2-hydroxy-5-chlorobenzamine, an organic compound. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry. Due to its specific chemical structure, it can participate in many reactions to construct complex molecular structures with biological activity or to assist in the synthesis of drug molecules with specific targets.
It also plays an important role in the field of organic synthesis. With its unique functional groups, such as hydroxyl, amine and p-toluenesulfonyl, it can undergo a variety of organic reactions, such as nucleophilic substitution, redox, etc., and then prepare various organic compounds with novel structures, enriching the variety of organic synthesis substances.
In addition, in materials science related research, it may also show certain value. Or it can be chemically modified and modified to give materials specific properties, such as improving the solubility and stability of materials, providing new paths and options for material development and optimization.
It also plays an important role in the field of organic synthesis. With its unique functional groups, such as hydroxyl, amine and p-toluenesulfonyl, it can undergo a variety of organic reactions, such as nucleophilic substitution, redox, etc., and then prepare various organic compounds with novel structures, enriching the variety of organic synthesis substances.
In addition, in materials science related research, it may also show certain value. Or it can be chemically modified and modified to give materials specific properties, such as improving the solubility and stability of materials, providing new paths and options for material development and optimization.
What are the physical properties of -alpha-methyl-n-tosyl-2-hydroxy-5-chlorobenzenemethaneamine?
(α R ） -α - methyl-N-p-toluenesulfonyl-2-hydroxy-5-chlorobenzamine, is an organic compound. Looking at its physical properties, at room temperature, it is mostly in a solid state, because of its strong intermolecular forces, resulting in orderly molecular arrangement.
When it comes to the melting point, because its structure contains polar groups, such as hydroxyl groups, it can form intermolecular hydrogen bonds, causing the melting point to rise. However, the specific value needs to be determined by accurate experiments. Its solubility is due to the non-polar parts such as polar groups and benzene rings. In polar organic solvents such as methanol and ethanol, it should have a certain solubility. It can form hydrogen bonds or other intermolecular forces with solvent molecules. In non-polar solvents such as n-hexane, the solubility is relatively low, and the non-polar part has a weak interaction with non-polar solvents.
The color state of this compound is usually pure or white to off-white. If it contains impurities, the color may vary. Its density is determined by its molecular composition and accumulation method. It probably has a specific value due to factors such as the compactness of the molecular structure and atomic weight. However, accurate determination depends on experimental methods.
In addition, its volatility is very low, due to the strong intermolecular force, it is not easy to escape from the liquid or solid state to the gas phase. And it has a certain stability. When encountering strong acids, strong bases or specific strong oxidants, the functional groups in the structure may react, causing its properties to change.
When it comes to the melting point, because its structure contains polar groups, such as hydroxyl groups, it can form intermolecular hydrogen bonds, causing the melting point to rise. However, the specific value needs to be determined by accurate experiments. Its solubility is due to the non-polar parts such as polar groups and benzene rings. In polar organic solvents such as methanol and ethanol, it should have a certain solubility. It can form hydrogen bonds or other intermolecular forces with solvent molecules. In non-polar solvents such as n-hexane, the solubility is relatively low, and the non-polar part has a weak interaction with non-polar solvents.
The color state of this compound is usually pure or white to off-white. If it contains impurities, the color may vary. Its density is determined by its molecular composition and accumulation method. It probably has a specific value due to factors such as the compactness of the molecular structure and atomic weight. However, accurate determination depends on experimental methods.
In addition, its volatility is very low, due to the strong intermolecular force, it is not easy to escape from the liquid or solid state to the gas phase. And it has a certain stability. When encountering strong acids, strong bases or specific strong oxidants, the functional groups in the structure may react, causing its properties to change.
What are the synthesis methods of (alphar) -alpha-methyl-n-tosyl-2-hydroxy-5-chlorobenzenemethaneamine?
To obtain (α R ） -α - methyl-N-p-toluenesulfonyl-2-hydroxy-5-chlorobenzamine, there are various methods for its synthesis.
First, it can be achieved by multi-step reaction from suitable starting materials. First select the chlorine-containing benzaldehyde derivative, react it with a specific methylating agent, and introduce methyl. This step requires attention to the precise control of the reaction conditions to ensure the accuracy of the methylation position and stereochemistry. Next, the condensation reaction between the product and p-toluenesulfonamide occurs under suitable basic conditions to form a key carbon-nitrogen bond, thereby constructing the structure of N-p-toluenesulfonyl group. Subsequently, the aldehyde group is reduced by a suitable reducing agent and converted to a hydroxyl group. In this series of reactions, chiral aids or asymmetric catalysis are used to ensure the (α R) configuration of the product.
Second, another strategy can also be used. Using 5-chloro-2-hydroxybenzoic acid as the starting material, the carboxyl group is first converted into a suitable active intermediate, such as acid chloride, and then reacted with methylamine to form an amide. After that, the amide is specifically reduced to obtain the corresponding amine. At the same time, the hydroxyl group on the benzene ring is properly protected and deprotected to prevent it from interfering with the process in subsequent reactions. After the amine group is formed, it reacts with p-toluenesulfonyl chloride to introduce p-toluenesulfonyl group. Finally, through the regulation of reaction conditions of stereoselectivity, the construction of the (α R) configuration is achieved.
In addition, it can also be synthesized from chiral sources. If the raw material with suitable chiral center can be obtained, the reaction route can be designed according to its structural characteristics. Through the transformation and modification of functional groups, the required functional groups such as methyl, p-toluenesulfonyl, hydroxyl and chlorine atoms are gradually introduced, and the reaction sequence and conditions of each step are carefully planned to achieve efficient synthesis of the target product.
First, it can be achieved by multi-step reaction from suitable starting materials. First select the chlorine-containing benzaldehyde derivative, react it with a specific methylating agent, and introduce methyl. This step requires attention to the precise control of the reaction conditions to ensure the accuracy of the methylation position and stereochemistry. Next, the condensation reaction between the product and p-toluenesulfonamide occurs under suitable basic conditions to form a key carbon-nitrogen bond, thereby constructing the structure of N-p-toluenesulfonyl group. Subsequently, the aldehyde group is reduced by a suitable reducing agent and converted to a hydroxyl group. In this series of reactions, chiral aids or asymmetric catalysis are used to ensure the (α R) configuration of the product.
Second, another strategy can also be used. Using 5-chloro-2-hydroxybenzoic acid as the starting material, the carboxyl group is first converted into a suitable active intermediate, such as acid chloride, and then reacted with methylamine to form an amide. After that, the amide is specifically reduced to obtain the corresponding amine. At the same time, the hydroxyl group on the benzene ring is properly protected and deprotected to prevent it from interfering with the process in subsequent reactions. After the amine group is formed, it reacts with p-toluenesulfonyl chloride to introduce p-toluenesulfonyl group. Finally, through the regulation of reaction conditions of stereoselectivity, the construction of the (α R) configuration is achieved.
In addition, it can also be synthesized from chiral sources. If the raw material with suitable chiral center can be obtained, the reaction route can be designed according to its structural characteristics. Through the transformation and modification of functional groups, the required functional groups such as methyl, p-toluenesulfonyl, hydroxyl and chlorine atoms are gradually introduced, and the reaction sequence and conditions of each step are carefully planned to achieve efficient synthesis of the target product.
(Alphar) What are the precautions in the use of -alpha-methyl-n-tosyl-2-hydroxy-5-chlorobenzenemethaneamine?
(α R ） -α - methyl-N-p-toluenesulfonyl-2-hydroxy-5-chlorobenzamide. When using this product, many things need to be paid attention to.
First, safety is of paramount importance. The characteristics of this compound may have unknown risks, or be toxic, corrosive, or flammable and explosive. When using and handling, be sure to strictly follow safety procedures. Wear protective clothing, such as lab clothes, gloves, protective glasses, to ensure that the respiratory tract is not damaged, or wear a gas mask to prevent inhalation of harmful vapors and dust.
Second, accurate weighing and access are key. Due to its chemical properties or extremely sensitive to the dosage, a little deviation may lead to false experimental results. When taking it, use precise measuring tools, such as balances, pipettes, etc., and operate in a clean and dry environment. Beware of impurities mixed in, so as not to affect its purity and reaction process.
Third, the method of storage cannot be ignored. According to its characteristics, choose a suitable place. If sensitive to light and heat, it should be stored in a cool and dark place; if it is easy to deliquescent, it must be placed in a dry place or add desiccant. And it should be properly separated from other chemicals to prevent interaction and cause danger.
Fourth, the chemical reaction environment needs to be carefully regulated. Temperature, pH, reaction time and other factors will all affect the reaction effect. If the temperature is too high or too low, the reaction may be too fast, too slow, or even unable to occur; if the pH is not good, the reaction will also be biased towards abnormality. Therefore, before the experiment, check the data carefully to explore the appropriate reaction conditions.
Fifth, waste treatment should not be underestimated. Residues and reaction by-products after use should not be discarded at will. They should be collected in accordance with relevant regulations and disposed of properly to prevent environmental pollution and harm to the ecology.
First, safety is of paramount importance. The characteristics of this compound may have unknown risks, or be toxic, corrosive, or flammable and explosive. When using and handling, be sure to strictly follow safety procedures. Wear protective clothing, such as lab clothes, gloves, protective glasses, to ensure that the respiratory tract is not damaged, or wear a gas mask to prevent inhalation of harmful vapors and dust.
Second, accurate weighing and access are key. Due to its chemical properties or extremely sensitive to the dosage, a little deviation may lead to false experimental results. When taking it, use precise measuring tools, such as balances, pipettes, etc., and operate in a clean and dry environment. Beware of impurities mixed in, so as not to affect its purity and reaction process.
Third, the method of storage cannot be ignored. According to its characteristics, choose a suitable place. If sensitive to light and heat, it should be stored in a cool and dark place; if it is easy to deliquescent, it must be placed in a dry place or add desiccant. And it should be properly separated from other chemicals to prevent interaction and cause danger.
Fourth, the chemical reaction environment needs to be carefully regulated. Temperature, pH, reaction time and other factors will all affect the reaction effect. If the temperature is too high or too low, the reaction may be too fast, too slow, or even unable to occur; if the pH is not good, the reaction will also be biased towards abnormality. Therefore, before the experiment, check the data carefully to explore the appropriate reaction conditions.
Fifth, waste treatment should not be underestimated. Residues and reaction by-products after use should not be discarded at will. They should be collected in accordance with relevant regulations and disposed of properly to prevent environmental pollution and harm to the ecology.
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