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Benzene, 1-Bromo-4-Chloro-2-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
159722 |
| Chemical Formula | C7H3BrClF3 |
| Molar Mass | 261.45 g/mol |
| Appearance | Solid (likely) |
| Solubility In Water | Insoluble (expected due to non - polar nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low (due to relatively high molar mass) |
| Stability | Stable under normal conditions, but reactive towards strong nucleophiles and bases |
As an accredited Benzene, 1-Bromo-4-Chloro-2-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 1 - bromo - 4 - chloro - 2 - (trifluoromethyl) benzene, well - sealed. |
| Storage | **1 - bromo - 4 - chloro - 2 - (trifluoromethyl) benzene** should be stored in a cool, well - ventilated area, away from heat and ignition sources as it is likely flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Ensure proper labeling for easy identification and handling in case of emergency. |
| Shipping | Benzene, 1 - bromo - 4 - chloro - 2 - (trifluoromethyl)- is a chemical. Shipments must comply with hazardous material regulations. It should be properly packaged, labeled, and transported by carriers authorized for such chemicals. |
Competitive Benzene, 1-Bromo-4-Chloro-2-(Trifluoromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of Benzene, 1-bromo-4-chloro-2- (trifluoromethyl) -?
1-Bromo-4-chloro-2- (trifluoromethyl) benzene, its chemical properties are particularly important and have many applications in the field of organic chemistry. In this compound, the benzene ring is a stable structure, but the existence of its side chain and halogen atom endows it with unique properties.
Its halogen atom, bromine and chlorine, is very active. In case of nucleophilic reagents, a nucleophilic substitution reaction can occur. If it encounters sodium alcohol, the halogen atom can be replaced by an alkoxy group to obtain the corresponding ether. This is because the halogen atom has considerable electronegativity, causing the carbon connected to it to be partially positively charged, which is easy to be attacked by nucleophilic reagents.
Furthermore, trifluoromethyl is a strong electron-absorbing group, which can reduce the electron cloud density of benzene rings. This makes benzene rings less active than benzene in electrophilic substitution reactions. And the existence of trifluoromethyl can affect the polarity and physical properties of molecules, such as boiling point, solubility, etc.
And due to the action of halogen atoms and trifluoromethyl, the compound can participate in the coupling reaction. Under appropriate catalysts and reaction conditions, it can be connected with other organic halides or organometallic reagents to construct more complex organic molecular structures. This is of great significance in the fields of drug synthesis, materials science, etc.
In addition, its chemical properties are also influenced by reaction conditions. Temperature, solvent, type and amount of catalyst can change the rate and selectivity of the reaction. Therefore, in order to make good use of this compound, various reaction conditions must be studied in detail to achieve the expected reaction effect.
Its halogen atom, bromine and chlorine, is very active. In case of nucleophilic reagents, a nucleophilic substitution reaction can occur. If it encounters sodium alcohol, the halogen atom can be replaced by an alkoxy group to obtain the corresponding ether. This is because the halogen atom has considerable electronegativity, causing the carbon connected to it to be partially positively charged, which is easy to be attacked by nucleophilic reagents.
Furthermore, trifluoromethyl is a strong electron-absorbing group, which can reduce the electron cloud density of benzene rings. This makes benzene rings less active than benzene in electrophilic substitution reactions. And the existence of trifluoromethyl can affect the polarity and physical properties of molecules, such as boiling point, solubility, etc.
And due to the action of halogen atoms and trifluoromethyl, the compound can participate in the coupling reaction. Under appropriate catalysts and reaction conditions, it can be connected with other organic halides or organometallic reagents to construct more complex organic molecular structures. This is of great significance in the fields of drug synthesis, materials science, etc.
In addition, its chemical properties are also influenced by reaction conditions. Temperature, solvent, type and amount of catalyst can change the rate and selectivity of the reaction. Therefore, in order to make good use of this compound, various reaction conditions must be studied in detail to achieve the expected reaction effect.
Benzene, 1-bromo-4-chloro-2- (trifluoromethyl) - In which chemical reactions is it commonly used?
1-Bromo-4-chloro-2- (trifluoromethyl) benzene is often used in various chemical reactions. For example, in the field of organic synthesis, it can be used as a key raw material to participate in the construction of complex organic molecules.
Cover because of its unique molecular structure, bromine, chlorine and trifluoromethyl have their own chemical activities and characteristics. Bromine atoms have high activity and are easily replaced by nucleophiles in nucleophilic substitution reactions, which allows molecules to introduce other functional groups. For example, when reacted with sodium alcohol, bromine can be replaced by alkoxy groups to generate corresponding ether compounds. This reaction is like embroidering new patterns on the brocade of organic molecules, enriching the structure and function of molecules.
Chlorine atoms are not idle, and can participate in many reactions under specific conditions. For example, in metal-catalyzed coupling reactions, chlorine atoms can be combined with other organic halides or organometallic reagents to achieve the construction of carbon-carbon bonds, which is like building a new skeleton for organic molecules. The existence of trifluoromethyl groups greatly affects the physical and chemical properties of molecules. Due to its strong electron absorption, it can change the electron cloud density of the benzene ring, which in turn affects the reactivity of other substituents on the benzene ring, so that the whole molecule exhibits a unique chemical behavior in the reaction.
In the field of medicinal chemistry, 1-bromo-4-chloro-2- (trifluoromethyl) benzene can be used as a structural fragment of lead compounds. By chemically modifying it and adjusting the types and positions of substituents, the activity, selectivity and pharmacokinetic properties of the compounds can be changed, laying the foundation for the creation of new drugs. In materials science, it may participate in the preparation of organic materials with special properties, such as fluorine-containing functional materials, which may have excellent weather resistance, chemical stability and other characteristics, and are very useful in aerospace, electronics and other fields.
Cover because of its unique molecular structure, bromine, chlorine and trifluoromethyl have their own chemical activities and characteristics. Bromine atoms have high activity and are easily replaced by nucleophiles in nucleophilic substitution reactions, which allows molecules to introduce other functional groups. For example, when reacted with sodium alcohol, bromine can be replaced by alkoxy groups to generate corresponding ether compounds. This reaction is like embroidering new patterns on the brocade of organic molecules, enriching the structure and function of molecules.
Chlorine atoms are not idle, and can participate in many reactions under specific conditions. For example, in metal-catalyzed coupling reactions, chlorine atoms can be combined with other organic halides or organometallic reagents to achieve the construction of carbon-carbon bonds, which is like building a new skeleton for organic molecules. The existence of trifluoromethyl groups greatly affects the physical and chemical properties of molecules. Due to its strong electron absorption, it can change the electron cloud density of the benzene ring, which in turn affects the reactivity of other substituents on the benzene ring, so that the whole molecule exhibits a unique chemical behavior in the reaction.
In the field of medicinal chemistry, 1-bromo-4-chloro-2- (trifluoromethyl) benzene can be used as a structural fragment of lead compounds. By chemically modifying it and adjusting the types and positions of substituents, the activity, selectivity and pharmacokinetic properties of the compounds can be changed, laying the foundation for the creation of new drugs. In materials science, it may participate in the preparation of organic materials with special properties, such as fluorine-containing functional materials, which may have excellent weather resistance, chemical stability and other characteristics, and are very useful in aerospace, electronics and other fields.
What are the physical properties of Benzene, 1-bromo-4-chloro-2- (trifluoromethyl) -?
1-Bromo-4-chloro-2 - (trifluoromethyl) benzene, this is an organic compound. According to its physical properties, it is mostly in a liquid state at room temperature and pressure. Its color is colorless or slightly yellow, and it has a special smell. This smell may be due to the halogen atom and trifluoromethyl in the structure.
Its boiling point varies depending on the intermolecular force. The presence of halogen atoms and trifluoromethyl in the molecule enhances the intermolecular force, so the boiling point is higher than that of benzene. The specific value may vary slightly due to the precise measurement conditions, but it is roughly within a certain temperature range.
The melting point is also affected by the molecular structure. The regularity of the structure and the intermolecular force jointly determine the melting point. The structure of this compound has certain particularities, resulting in a specific melting point range.
In terms of solubility, because it is an organic compound, it follows the principle of similar phase dissolution, and should have good solubility in common organic solvents, such as ethanol, ether, chloroform, etc. However, in water, because water is a polar solvent, and the polarity of the compound is relatively weak, the solubility is not good.
The density is higher than that of water, or due to the heavier atom of halogen atoms and trifluoromethyl atoms, the density is higher than that of water. When mixed with water, it should sink to the bottom of the water.
In terms of volatility, although it is not a highly volatile substance, it is still volatile under appropriate temperature and environment because it is an organic liquid.
The physical properties of 1-bromo-4-chloro-2 - (trifluoromethyl) benzene are determined by its unique molecular structure and are of great significance in chemical research and industrial applications.
Its boiling point varies depending on the intermolecular force. The presence of halogen atoms and trifluoromethyl in the molecule enhances the intermolecular force, so the boiling point is higher than that of benzene. The specific value may vary slightly due to the precise measurement conditions, but it is roughly within a certain temperature range.
The melting point is also affected by the molecular structure. The regularity of the structure and the intermolecular force jointly determine the melting point. The structure of this compound has certain particularities, resulting in a specific melting point range.
In terms of solubility, because it is an organic compound, it follows the principle of similar phase dissolution, and should have good solubility in common organic solvents, such as ethanol, ether, chloroform, etc. However, in water, because water is a polar solvent, and the polarity of the compound is relatively weak, the solubility is not good.
The density is higher than that of water, or due to the heavier atom of halogen atoms and trifluoromethyl atoms, the density is higher than that of water. When mixed with water, it should sink to the bottom of the water.
In terms of volatility, although it is not a highly volatile substance, it is still volatile under appropriate temperature and environment because it is an organic liquid.
The physical properties of 1-bromo-4-chloro-2 - (trifluoromethyl) benzene are determined by its unique molecular structure and are of great significance in chemical research and industrial applications.
What are the methods for preparing Benzene, 1-bromo-4-chloro-2- (trifluoromethyl) -?
There are several ways to prepare 1-bromo-4-chloro-2- (trifluoromethyl) benzene.
First, it can be started from a suitable aromatic hydrocarbon. Using p-chlorotrifluorotoluene as a raw material, bromine atoms are introduced under specific reaction conditions. A bromination reaction can be used to select a suitable brominating reagent, such as liquid bromine, with a catalyst such as iron or iron salts. At appropriate temperatures and reaction environments, liquid bromine undergoes a substitution reaction with p-chlorotrifluorotoluene, and bromine atoms replace hydrogen atoms at specific positions on the benzene ring. After controlling the reaction conditions, it mainly generates 1-bromo-4-chloro-2 - (trifluoromethyl) benzene. This process requires attention to the regulation of the reaction temperature. If the temperature is too high or the byproducts of polybromide are formed, if it is too low, the reaction rate will be delayed.
Second, benzene derivatives containing halogenated methyl can also be started. First prepare benzyl derivatives containing suitable chlorine and bromine substituents, and then convert methyl to trifluoromethyl. For example, using 1-bromo-4-chloro-2-methylbenzene as raw material, methyl is halogenated first by haloform reaction, and then reacted with trifluorinated reagents to achieve the conversion of methyl to trifluoromethyl, and then obtain 1-bromo-4-chloro-2 - (trifluoromethyl) benzene. This path requires precise control of the reaction conditions of each step. The halogenation step requires attention to the degree of halogenation, and the conversion of trifluoromethyl requires the selection of appropriate trifluorinated reagents and reaction environments.
Third, the Grignard reagent method can also be used. The Grignard reagent is made from halogenated aromatics containing chlorine and bromine, and then reacts with reagents containing trifluoromethyl. If the Grignard reagent is first made from 1-bromo-4-chlorobenzene, and then reacts with suitable trifluoromethyl halides or other reagents that can provide trifluoromethyl under suitable conditions such as anhydrous and anaerobic conditions, the target product 1-bromo-4-chloro-2 - (trifluoromethyl) benzene can This process has strict requirements on the reaction environment. If the anhydrous and anaerobic conditions are not properly controlled, it is easy to cause the Grignard reagent to fail, making it difficult for the reaction to proceed smoothly.
First, it can be started from a suitable aromatic hydrocarbon. Using p-chlorotrifluorotoluene as a raw material, bromine atoms are introduced under specific reaction conditions. A bromination reaction can be used to select a suitable brominating reagent, such as liquid bromine, with a catalyst such as iron or iron salts. At appropriate temperatures and reaction environments, liquid bromine undergoes a substitution reaction with p-chlorotrifluorotoluene, and bromine atoms replace hydrogen atoms at specific positions on the benzene ring. After controlling the reaction conditions, it mainly generates 1-bromo-4-chloro-2 - (trifluoromethyl) benzene. This process requires attention to the regulation of the reaction temperature. If the temperature is too high or the byproducts of polybromide are formed, if it is too low, the reaction rate will be delayed.
Second, benzene derivatives containing halogenated methyl can also be started. First prepare benzyl derivatives containing suitable chlorine and bromine substituents, and then convert methyl to trifluoromethyl. For example, using 1-bromo-4-chloro-2-methylbenzene as raw material, methyl is halogenated first by haloform reaction, and then reacted with trifluorinated reagents to achieve the conversion of methyl to trifluoromethyl, and then obtain 1-bromo-4-chloro-2 - (trifluoromethyl) benzene. This path requires precise control of the reaction conditions of each step. The halogenation step requires attention to the degree of halogenation, and the conversion of trifluoromethyl requires the selection of appropriate trifluorinated reagents and reaction environments.
Third, the Grignard reagent method can also be used. The Grignard reagent is made from halogenated aromatics containing chlorine and bromine, and then reacts with reagents containing trifluoromethyl. If the Grignard reagent is first made from 1-bromo-4-chlorobenzene, and then reacts with suitable trifluoromethyl halides or other reagents that can provide trifluoromethyl under suitable conditions such as anhydrous and anaerobic conditions, the target product 1-bromo-4-chloro-2 - (trifluoromethyl) benzene can This process has strict requirements on the reaction environment. If the anhydrous and anaerobic conditions are not properly controlled, it is easy to cause the Grignard reagent to fail, making it difficult for the reaction to proceed smoothly.
Benzene, 1-bromo-4-chloro-2- (trifluoromethyl) - What are the main uses?
1-Bromo-4-chloro-2- (trifluoromethyl) benzene, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it can be used as a key intermediate. For example, when preparing specific targeted anti-cancer drugs, its unique structure can introduce special functional groups into drug molecules, which can help to precisely act on cancer cell targets, enhance drug efficacy, and reduce damage to normal cells.
In terms of materials science, it can be used to synthesize new organic optoelectronic materials. Because it contains trifluoromethyl, it can endow materials with unique electrical and optical properties. It is used to manufacture high-performance organic Light Emitting Diodes (OLEDs), improve luminous efficiency and stability, and make the picture of display devices clearer and brighter.
In the field of pesticide creation, it can be used as a lead compound for structural modification and optimization. The presence of trifluoromethyl can enhance the biological activity, stability and fat solubility of pesticides, making it easier for pesticides to penetrate the body surface of pests, kill pests efficiently, and are not easy to decompose in the environment, prolonging the shelf life.
In addition, in the field of fine chemicals, it can be used to synthesize special fragrances or additives. Its special structure can give products a unique aroma or improve product performance. For example, it is used in fragrance blending of high-end cosmetics to add a unique flavor; it is used as a plastic additive to enhance the weather resistance and chemical stability of plastic products.
In terms of materials science, it can be used to synthesize new organic optoelectronic materials. Because it contains trifluoromethyl, it can endow materials with unique electrical and optical properties. It is used to manufacture high-performance organic Light Emitting Diodes (OLEDs), improve luminous efficiency and stability, and make the picture of display devices clearer and brighter.
In the field of pesticide creation, it can be used as a lead compound for structural modification and optimization. The presence of trifluoromethyl can enhance the biological activity, stability and fat solubility of pesticides, making it easier for pesticides to penetrate the body surface of pests, kill pests efficiently, and are not easy to decompose in the environment, prolonging the shelf life.
In addition, in the field of fine chemicals, it can be used to synthesize special fragrances or additives. Its special structure can give products a unique aroma or improve product performance. For example, it is used in fragrance blending of high-end cosmetics to add a unique flavor; it is used as a plastic additive to enhance the weather resistance and chemical stability of plastic products.
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