Linshang Chemical
PRODUCTS
Benzene,1-Chloro-2,4-Difluoro-
Linshang Chemical
|
HS Code |
144903 |
| Chemical Formula | C6H3ClF2 |
| Appearance | Colorless liquid (predicted) |
| Boiling Point | 117 - 118 °C |
| Melting Point | -50 °C (predicted) |
| Density | 1.336 g/cm³ (predicted) |
| Vapor Pressure | 3.66 mmHg at 25 °C (predicted) |
| Logp | 3.07 (predicted) |
| Solubility In Water | Insoluble |
| Flash Point | 27 °C |
As an accredited Benzene,1-Chloro-2,4-Difluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - chloro - 2,4 - difluoro - benzene packaged in 5 - liter containers. |
| Storage | Store "Benzene, 1 - chloro - 2,4 - difluoro -" in a cool, well - ventilated area, away from heat, sparks, and open flames as it is likely flammable. Keep it in a tightly closed container, preferably made of corrosion - resistant materials to prevent leakage. Segregate from oxidizing agents and reactive chemicals to avoid dangerous reactions. |
| Shipping | 1 - Chloro - 2,4 - difluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under proper regulatory guidelines, ensuring secure handling to prevent any leakage due to its potentially hazardous nature. |
Competitive Benzene,1-Chloro-2,4-Difluoro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading Benzene,1-Chloro-2,4-Difluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-chloro-2,4-difluoro-benzene?
1-Chloro-2,4-difluorobenzene is one of the organic compounds. Its physical properties, at room temperature, are mostly colorless to light yellow liquids with a special odor. The physical properties of this substance, such as boiling point and melting point, also have their own unique characteristics. The boiling point is about a certain temperature range, and the melting point is also a specific value, both of which are closely related to the force between molecules.
In terms of its chemical properties, the first thing to consider is the characteristics of halogenated aromatics. The chlorine atom and the fluorine atom are above the benzene ring, because the electronegativity of the halogen atom is greater than that of the carbon, resulting in the change of the electron cloud density distribution of the benzene ring. This change makes the reactivity of the benzene ring very different from that of benzene.
Nucleophilic substitution reaction is one of its important chemical properties. Because the halogen atom can be used as a leaving group, when encountering the nucleophilic reagent, the nucleophilic reagent can attack the carbon atom attached to the halogen atom on the benzene ring, and then the nucleophilic substitution reaction occurs. For example, when encountering nucleophilic reagents such as hydroxyl anions, halogen atoms can be replaced by hydroxyl groups to form corresponding phenolic compounds.
And because of its fluorine-containing atoms, the special properties of fluorine atoms make the compound have certain stability and unique reactivity. The existence of fluorine atoms can affect the polarity and fat solubility of molecules. This property has attracted much attention in the fields of medicinal chemistry and materials science.
In addition, in the aromatic electrophilic substitution reaction, the halogen atom is an ortho and para-localization group. Although the electron cloud density of the benzene ring is reduced and the reactivity is slightly reduced, aromatic electrophilic substitution reactions such as nitrification and sulfonation can still occur under appropriate conditions, and mainly form ortho and para-substitution products.
In summary, 1-chloro-2,4-difluorobenzene has rich and diverse chemical properties and has important application value in many fields such as organic synthesis.
In terms of its chemical properties, the first thing to consider is the characteristics of halogenated aromatics. The chlorine atom and the fluorine atom are above the benzene ring, because the electronegativity of the halogen atom is greater than that of the carbon, resulting in the change of the electron cloud density distribution of the benzene ring. This change makes the reactivity of the benzene ring very different from that of benzene.
Nucleophilic substitution reaction is one of its important chemical properties. Because the halogen atom can be used as a leaving group, when encountering the nucleophilic reagent, the nucleophilic reagent can attack the carbon atom attached to the halogen atom on the benzene ring, and then the nucleophilic substitution reaction occurs. For example, when encountering nucleophilic reagents such as hydroxyl anions, halogen atoms can be replaced by hydroxyl groups to form corresponding phenolic compounds.
And because of its fluorine-containing atoms, the special properties of fluorine atoms make the compound have certain stability and unique reactivity. The existence of fluorine atoms can affect the polarity and fat solubility of molecules. This property has attracted much attention in the fields of medicinal chemistry and materials science.
In addition, in the aromatic electrophilic substitution reaction, the halogen atom is an ortho and para-localization group. Although the electron cloud density of the benzene ring is reduced and the reactivity is slightly reduced, aromatic electrophilic substitution reactions such as nitrification and sulfonation can still occur under appropriate conditions, and mainly form ortho and para-substitution products.
In summary, 1-chloro-2,4-difluorobenzene has rich and diverse chemical properties and has important application value in many fields such as organic synthesis.
What are the physical properties of 1-chloro-2,4-difluoro-benzene?
1-Chloro-2,4-difluorobenzene is also an organic compound. Its physical properties are many and can be described.
First of all, its appearance, under room temperature and pressure, 1-chloro-2,4-difluorobenzene is often colorless to light yellow transparent liquid, clear in appearance, like the liquid of glaze, it can be seen under light slightly flooded, and the reflection is clear.
When it comes to smell, this substance emits a special aromatic smell. Although it is not a rich fragrance, it also has a unique smell. It slowly diffuses in the air and can be observed by the human nose.
Its boiling point is between 126 and 128 degrees Celsius. When this substance is heated, to the temperature range, 1-chloro-2,4-difluorobenzene gradually changes from liquid to gaseous, turning into a curling vapor rising.
As for the melting point, it is about -33 ° C. When the ambient temperature drops to the value and below, the original flowing liquid gradually solidifies and turns into a solid state, just like water becomes ice, and the shape changes from soft to rigid.
In terms of density, it is about 1.39g/cm ³. Compared with water, its density is greater than that of water. If it is co-placed with water, 1-chloro-2,4-difluorobenzene will sink underwater, just like a stone falling into water, and it is distinct.
Solubility is also its important physical property. 1-chloro-2,4-difluorobenzene is insoluble in water, and the two are like two incompatible types. Although it is stirred and shaken, it is difficult to blend and eventually delaminate. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In such solvents, it can be evenly dispersed and soluble, just like salt entering water, without a trace. 1-Chloro-2,4-difluorobenzene has such physical properties that it is useful in many fields such as organic synthesis. It can be used as raw materials, intermediates, etc., and is indispensable in the chemical industry.
First of all, its appearance, under room temperature and pressure, 1-chloro-2,4-difluorobenzene is often colorless to light yellow transparent liquid, clear in appearance, like the liquid of glaze, it can be seen under light slightly flooded, and the reflection is clear.
When it comes to smell, this substance emits a special aromatic smell. Although it is not a rich fragrance, it also has a unique smell. It slowly diffuses in the air and can be observed by the human nose.
Its boiling point is between 126 and 128 degrees Celsius. When this substance is heated, to the temperature range, 1-chloro-2,4-difluorobenzene gradually changes from liquid to gaseous, turning into a curling vapor rising.
As for the melting point, it is about -33 ° C. When the ambient temperature drops to the value and below, the original flowing liquid gradually solidifies and turns into a solid state, just like water becomes ice, and the shape changes from soft to rigid.
In terms of density, it is about 1.39g/cm ³. Compared with water, its density is greater than that of water. If it is co-placed with water, 1-chloro-2,4-difluorobenzene will sink underwater, just like a stone falling into water, and it is distinct.
Solubility is also its important physical property. 1-chloro-2,4-difluorobenzene is insoluble in water, and the two are like two incompatible types. Although it is stirred and shaken, it is difficult to blend and eventually delaminate. However, it is soluble in many organic solvents, such as ethanol, ether, acetone, etc. In such solvents, it can be evenly dispersed and soluble, just like salt entering water, without a trace. 1-Chloro-2,4-difluorobenzene has such physical properties that it is useful in many fields such as organic synthesis. It can be used as raw materials, intermediates, etc., and is indispensable in the chemical industry.
What are the common uses of 1-chloro-2,4-difluoro-benzene?
1 - chloro - 2,4 - difluoro - benzene, that is, 1 - chloro - 2,4 - difluorobenzene, its common use involves the field of chemical synthesis.
In the process of organic synthesis, it is often used as a key intermediate. Due to the unique activity of chlorine atoms and fluorine atoms on the benzene ring, it can borrow nucleophilic substitution reaction and blend with multiple nucleophilic reagents. In case of reagents containing hydroxyl groups, amino groups and other groups, novel fluorine-containing organic compounds can be generated, and such products have a great position in the creation of medicine and pesticides.
All the way to pharmaceutical research and development, fluorinated organic compounds often have excellent biological activity and metabolic stability. 1-Chloro-2,4-difluorobenzene can be converted through a series of reactions to produce drug intermediates with specific structures, which lays the foundation for innovative drug molecular design and synthesis, and may be able to breed new drugs with excellent efficacy and minimal side effects.
In the field of pesticides, the synthesis of fluorinated pesticides through it is also an important direction. Fluorinated pesticides usually show the characteristics of high efficiency, low toxicity, and environmental friendliness, which can effectively prevent and control pests and diseases, and improve crop yield and quality. 1-Chloro-2,4-difluorobenzene participates in the synthesis of pesticides, which are quite competitive in the market.
The path of materials science, 1-chloro-2,4-difluorobenzene can also contribute. By appropriate reaction, it can be introduced into the polymer material structure, endowing the material with special properties such as chemical resistance and thermal stability, and expanding the application scope of polymer materials in special environments.
In general, although 1-chloro-2,4-difluorobenzene is a small molecule of organic compounds, it plays a crucial role in many fields such as chemical industry, medicine, pesticides, and materials, and occupies a key position in the development of modern chemical industry.
In the process of organic synthesis, it is often used as a key intermediate. Due to the unique activity of chlorine atoms and fluorine atoms on the benzene ring, it can borrow nucleophilic substitution reaction and blend with multiple nucleophilic reagents. In case of reagents containing hydroxyl groups, amino groups and other groups, novel fluorine-containing organic compounds can be generated, and such products have a great position in the creation of medicine and pesticides.
All the way to pharmaceutical research and development, fluorinated organic compounds often have excellent biological activity and metabolic stability. 1-Chloro-2,4-difluorobenzene can be converted through a series of reactions to produce drug intermediates with specific structures, which lays the foundation for innovative drug molecular design and synthesis, and may be able to breed new drugs with excellent efficacy and minimal side effects.
In the field of pesticides, the synthesis of fluorinated pesticides through it is also an important direction. Fluorinated pesticides usually show the characteristics of high efficiency, low toxicity, and environmental friendliness, which can effectively prevent and control pests and diseases, and improve crop yield and quality. 1-Chloro-2,4-difluorobenzene participates in the synthesis of pesticides, which are quite competitive in the market.
The path of materials science, 1-chloro-2,4-difluorobenzene can also contribute. By appropriate reaction, it can be introduced into the polymer material structure, endowing the material with special properties such as chemical resistance and thermal stability, and expanding the application scope of polymer materials in special environments.
In general, although 1-chloro-2,4-difluorobenzene is a small molecule of organic compounds, it plays a crucial role in many fields such as chemical industry, medicine, pesticides, and materials, and occupies a key position in the development of modern chemical industry.
What are the preparation methods of 1-chloro-2,4-difluoro-benzene?
1-Chloro-2,4-difluorobenzene is also an organic compound. There are several methods for its preparation, which are described in detail as follows:
First, 2,4-difluoroaniline is used as the starting material, and can be obtained through the steps of diazotization and chlorination. First, 2,4-difluoroaniline is prepared into a diazonium salt solution with hydrochloric acid and sodium nitrite at low temperature. This process requires careful temperature control to prevent the decomposition of diazonium salts. After adding the hydrochloric acid solution of cuprous chloride, the diazonium group is then replaced by chlorine atoms to produce 1-chloro-2,4-difluorobenzene. This route is easy to find raw materials, but the diazotization reaction is dangerous and requires strict operation.
Second, 2,4-difluorophenol is used as the starting material and is prepared by halogenation reaction. 2,4-difluorophenol reacts with chlorinated reagents, such as phosphorus oxychloride and phosphorus pentachloride. During the reaction, the phenolic hydroxyl group is replaced by chlorine atoms, and the final product is obtained. The reaction conditions of this method are relatively mild, but the chlorinated reagents used are mostly corrosive, which requires high equipment, and the product separation and purification may be cumbersome.
Third, 1,3-difluorobenzene is used as the raw material and is prepared by chlorination reaction. 1,3-difluorobenzene reacts with chlorine gas in the presence of catalysts such as ferric chloride or iron powder. In the reaction, chlorine selectively replaces hydrogen atoms at specific positions on the benzene ring to generate 1-chloro-2,4-difluorobenzene. This path is relatively simple to operate, but chlorine is highly toxic, and strict safety protection measures are required, and the reaction selectivity may need to be optimized to improve the yield of the product.
All methods for preparing 1-chloro-2,4-difluorobenzene have advantages and disadvantages. In practical application, it is necessary to carefully weigh and select the optimal preparation scheme according to many factors such as raw material availability, cost, safety and product purity.
First, 2,4-difluoroaniline is used as the starting material, and can be obtained through the steps of diazotization and chlorination. First, 2,4-difluoroaniline is prepared into a diazonium salt solution with hydrochloric acid and sodium nitrite at low temperature. This process requires careful temperature control to prevent the decomposition of diazonium salts. After adding the hydrochloric acid solution of cuprous chloride, the diazonium group is then replaced by chlorine atoms to produce 1-chloro-2,4-difluorobenzene. This route is easy to find raw materials, but the diazotization reaction is dangerous and requires strict operation.
Second, 2,4-difluorophenol is used as the starting material and is prepared by halogenation reaction. 2,4-difluorophenol reacts with chlorinated reagents, such as phosphorus oxychloride and phosphorus pentachloride. During the reaction, the phenolic hydroxyl group is replaced by chlorine atoms, and the final product is obtained. The reaction conditions of this method are relatively mild, but the chlorinated reagents used are mostly corrosive, which requires high equipment, and the product separation and purification may be cumbersome.
Third, 1,3-difluorobenzene is used as the raw material and is prepared by chlorination reaction. 1,3-difluorobenzene reacts with chlorine gas in the presence of catalysts such as ferric chloride or iron powder. In the reaction, chlorine selectively replaces hydrogen atoms at specific positions on the benzene ring to generate 1-chloro-2,4-difluorobenzene. This path is relatively simple to operate, but chlorine is highly toxic, and strict safety protection measures are required, and the reaction selectivity may need to be optimized to improve the yield of the product.
All methods for preparing 1-chloro-2,4-difluorobenzene have advantages and disadvantages. In practical application, it is necessary to carefully weigh and select the optimal preparation scheme according to many factors such as raw material availability, cost, safety and product purity.
What are the precautions for 1-chloro-2,4-difluoro-benzene in storage and transportation?
1-Chloro-2,4-difluorobenzene is an organic compound. When storing and transporting, there are several important things to pay attention to.
First, it concerns the storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat, high temperature can easily cause chemical reactions, or even cause danger, so it should be kept away from fire and heat sources and should not be exposed to the sun. Furthermore, it should be stored in a sealed container to prevent contact with air and moisture. Due to reactions such as moisture or hydrolysis, oxygen and other ingredients in the air may also react with it and cause it to deteriorate.
Second, about packaging. Packaging must be strong and tight to prevent leakage. Commonly used packaging materials may be glass bottles, metal drums, etc. However, the packaging materials must be compatible with 1-chloro-2,4-difluorobenzene and do not chemically react with it. And the packaging should be clearly marked with its name, nature, hazard warning and other information for identification and disposal.
Furthermore, when it comes to transportation safety. During transportation, relevant hazardous chemical transportation regulations must be followed. Transportation vehicles should be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And this compound should not be mixed with oxidants, acids, alkalis and other substances, because these substances meet with it, or cause violent chemical reactions, endangering transportation safety. At the same time, transportation personnel also need to undergo professional training to be familiar with their characteristics and emergency handling methods. During transportation, they should pay close attention to the status of the goods to ensure safe transportation.
First, it concerns the storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat, high temperature can easily cause chemical reactions, or even cause danger, so it should be kept away from fire and heat sources and should not be exposed to the sun. Furthermore, it should be stored in a sealed container to prevent contact with air and moisture. Due to reactions such as moisture or hydrolysis, oxygen and other ingredients in the air may also react with it and cause it to deteriorate.
Second, about packaging. Packaging must be strong and tight to prevent leakage. Commonly used packaging materials may be glass bottles, metal drums, etc. However, the packaging materials must be compatible with 1-chloro-2,4-difluorobenzene and do not chemically react with it. And the packaging should be clearly marked with its name, nature, hazard warning and other information for identification and disposal.
Furthermore, when it comes to transportation safety. During transportation, relevant hazardous chemical transportation regulations must be followed. Transportation vehicles should be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And this compound should not be mixed with oxidants, acids, alkalis and other substances, because these substances meet with it, or cause violent chemical reactions, endangering transportation safety. At the same time, transportation personnel also need to undergo professional training to be familiar with their characteristics and emergency handling methods. During transportation, they should pay close attention to the status of the goods to ensure safe transportation.
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