Linshang Chemical
PRODUCTS
Benzene, 1-Chloro-2-Fluoro-4-Methoxy-
Linshang Chemical
|
HS Code |
365733 |
| Chemical Formula | C7H6ClFO |
| Molecular Weight | 160.573 g/mol |
As an accredited Benzene, 1-Chloro-2-Fluoro-4-Methoxy- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 1 - chloro - 2 - fluoro - 4 - methoxy - benzene for chemical use. |
| Storage | Store “Benzene, 1 - chloro - 2 - fluoro - 4 - methoxy -” in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent reactions. Ensure proper labeling for easy identification and follow safety regulations. |
| Shipping | The chemical "Benzene, 1 - chloro - 2 - fluoro - 4 - methoxy -" must be shipped in accordance with hazardous material regulations. Use appropriate, leak - proof containers. Ensure proper labeling indicating its nature and safety precautions during transit. |
Competitive Benzene, 1-Chloro-2-Fluoro-4-Methoxy- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy Benzene, 1-Chloro-2-Fluoro-4-Methoxy- in China?
As a trusted Benzene, 1-Chloro-2-Fluoro-4-Methoxy- manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading Benzene, 1-Chloro-2-Fluoro-4-Methoxy- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of this product 1-chloro-2-fluoro-4-methoxybenzene
The chemical properties of this substance, namely 1-bromo-2-chloro-4-methoxybenzene, are as follows:
In this compound, bromine (Br) and chlorine (Cl) are used as halogen atoms, giving them certain reactivity. Halogen atoms can undergo nucleophilic substitution reactions, for example, in the presence of appropriate nucleophilic reagents, halogen atoms can be replaced by other groups. If there is a nucleophilic reagent such as sodium alcohol (RONa), halogen atoms will be replaced by alkoxy groups (RO -) to generate corresponding ether compounds.
Methoxy (-OCH
) is a power supply group. Through its electron-giving conjugation effect, it can increase the electron cloud density on the benzene ring, especially the ortho and para-sites. This makes the benzene ring more prone to electrophilic substitution, which is more reactive with electrophilic reagents than benzene. For example, during nitrification, the ortho and para-sites of the methoxy group are more likely to introduce nitro (-NO ²).
Due to the different spatial positions of bromine, chlorine and methoxy groups, it also affects the physical properties of the molecule. Substituents at different positions will affect the intermolecular forces, which in turn affect their melting point and solubility. From the perspective of solubility, the substance contains halogen atoms and methoxy groups, and should have good solubility in some organic solvents such as dichloromethane and chloroform, because these organic solvents can form certain intermolecular forces with the compound.
Its chemical properties not only reflect the characteristics of halogenated aromatics, but also vary due to the presence of methoxy groups. It can be used as an important intermediate in the field of organic synthesis, participating in a variety of organic reactions to construct more complex organic compounds.
In this compound, bromine (Br) and chlorine (Cl) are used as halogen atoms, giving them certain reactivity. Halogen atoms can undergo nucleophilic substitution reactions, for example, in the presence of appropriate nucleophilic reagents, halogen atoms can be replaced by other groups. If there is a nucleophilic reagent such as sodium alcohol (RONa), halogen atoms will be replaced by alkoxy groups (RO -) to generate corresponding ether compounds.
Methoxy (-OCH
) is a power supply group. Through its electron-giving conjugation effect, it can increase the electron cloud density on the benzene ring, especially the ortho and para-sites. This makes the benzene ring more prone to electrophilic substitution, which is more reactive with electrophilic reagents than benzene. For example, during nitrification, the ortho and para-sites of the methoxy group are more likely to introduce nitro (-NO ²).
Due to the different spatial positions of bromine, chlorine and methoxy groups, it also affects the physical properties of the molecule. Substituents at different positions will affect the intermolecular forces, which in turn affect their melting point and solubility. From the perspective of solubility, the substance contains halogen atoms and methoxy groups, and should have good solubility in some organic solvents such as dichloromethane and chloroform, because these organic solvents can form certain intermolecular forces with the compound.
Its chemical properties not only reflect the characteristics of halogenated aromatics, but also vary due to the presence of methoxy groups. It can be used as an important intermediate in the field of organic synthesis, participating in a variety of organic reactions to construct more complex organic compounds.
What are the main uses of 1-chloro-2-fluoro-4-methoxybenzene?
The main uses of 1 + -deuterium-2 + -tritium-4 + -methoxyphenyl are not directly inked in Tiangong Kaiwu, but combined with the relevant chemical knowledge and application of later generations, there are probably the following numbers.
In the field of pharmaceutical chemistry, methoxyphenyl is often a key group in drug synthesis. Taking many drugs for the treatment of cardiovascular diseases as an example, their molecular structure contains methoxyphenyl. This structure can adjust the spatial configuration and electron cloud distribution of drug molecules, enhance the affinity and specificity of drugs and targets, and then improve drug efficacy. Deuterium and tritium, as isotopes of hydrogen, play an important role in drug development. Deuterium, because its mass is greater than that of hydrogen, forms a more stable C-D bond than a C-H bond. Introducing deuterium into drug molecules can change the metabolic pathway of drugs, prolong the action time of drugs in the body, and reduce toxic and side effects. For example, deuterated tetrabenazine uses the properties of deuterium to optimize the therapeutic effect. Tritium is radioactive and is often used in drug metabolism research. By tracking the traces of tritium-labeled drugs in the body, the absorption, distribution, metabolism and excretion process of drugs can be clarified, providing key data for the development of new drugs.
In the field of materials science, compounds containing methoxyphenyl can be used to prepare special polymer materials. Methoxyphenyl imparts special physical and chemical properties to materials, such as improving their solubility, thermal stability and optical properties. Some polymers containing methoxyphenyl can be used as photoresists for semiconductor lithography. Deuterium and tritium are also used in materials research. For example, in nuclear fusion research, deuterium and tritium are important fuels, and the fusion of the two can release huge energy and become the hope of future clean energy. In addition, deuterium-containing materials have unique advantages in the field of neutron detection. Because of their different scattering cross sections for neutrons and hydrogen-containing materials, they can be used to make sensitive components of neutron detectors.
In organic synthetic chemistry, methoxyphenyl is often used as a positioning group and a protecting group. Its electron characteristics can guide the position of electrophilic substitution reaction, providing convenience for the synthesis of organic compounds with specific structures. In the synthesis of complex organic molecules, methoxy groups can protect active groups such as hydroxyl groups, and then remove the protective groups after the reaction is completed to ensure the selectivity and efficiency of the reaction. Deuterium and tritium are often introduced into organic molecules as labeled atoms to study the reaction mechanism. By tracking the transfer and change of deuterium and tritium labeled atoms during the reaction process, the formation of reaction paths and intermediates can be gained, which promotes the development of organic synthesis chemistry theory.
In the field of pharmaceutical chemistry, methoxyphenyl is often a key group in drug synthesis. Taking many drugs for the treatment of cardiovascular diseases as an example, their molecular structure contains methoxyphenyl. This structure can adjust the spatial configuration and electron cloud distribution of drug molecules, enhance the affinity and specificity of drugs and targets, and then improve drug efficacy. Deuterium and tritium, as isotopes of hydrogen, play an important role in drug development. Deuterium, because its mass is greater than that of hydrogen, forms a more stable C-D bond than a C-H bond. Introducing deuterium into drug molecules can change the metabolic pathway of drugs, prolong the action time of drugs in the body, and reduce toxic and side effects. For example, deuterated tetrabenazine uses the properties of deuterium to optimize the therapeutic effect. Tritium is radioactive and is often used in drug metabolism research. By tracking the traces of tritium-labeled drugs in the body, the absorption, distribution, metabolism and excretion process of drugs can be clarified, providing key data for the development of new drugs.
In the field of materials science, compounds containing methoxyphenyl can be used to prepare special polymer materials. Methoxyphenyl imparts special physical and chemical properties to materials, such as improving their solubility, thermal stability and optical properties. Some polymers containing methoxyphenyl can be used as photoresists for semiconductor lithography. Deuterium and tritium are also used in materials research. For example, in nuclear fusion research, deuterium and tritium are important fuels, and the fusion of the two can release huge energy and become the hope of future clean energy. In addition, deuterium-containing materials have unique advantages in the field of neutron detection. Because of their different scattering cross sections for neutrons and hydrogen-containing materials, they can be used to make sensitive components of neutron detectors.
In organic synthetic chemistry, methoxyphenyl is often used as a positioning group and a protecting group. Its electron characteristics can guide the position of electrophilic substitution reaction, providing convenience for the synthesis of organic compounds with specific structures. In the synthesis of complex organic molecules, methoxy groups can protect active groups such as hydroxyl groups, and then remove the protective groups after the reaction is completed to ensure the selectivity and efficiency of the reaction. Deuterium and tritium are often introduced into organic molecules as labeled atoms to study the reaction mechanism. By tracking the transfer and change of deuterium and tritium labeled atoms during the reaction process, the formation of reaction paths and intermediates can be gained, which promotes the development of organic synthesis chemistry theory.
What is the synthesis method of 1-chloro-2-fluoro-4-methoxybenzene?
To prepare 1-bromo-2-ene-4-acetoxybenzene, the following method can be used.
First, an appropriate amount of benzene is taken as the starting material, and iron bromide is used as the catalyst to undergo an electrophilic substitution reaction with bromine. Under suitable reaction conditions, bromine atoms will selectively replace hydrogen atoms on the benzene ring to obtain bromobenzene. This step requires attention to control the reaction temperature and amount of bromine to prevent the formation of polybrominates.
The obtained bromobenzene, after appropriate treatment, reacts with vinyl Grignard reagent in a suitable solvent such as anhydrous ether. In an anhydrous and oxygen-free environment, Grignard's reagent undergoes nucleophilic substitution with bromobenzene to form vinyl-containing benzene derivatives. In this process, the anhydrous and oxygen-free conditions of the reaction system are strictly required to avoid the failure of Grignard's reagent.
Then, the vinyl-containing benzene derivative is reacted with acetic anhydride under the action of an appropriate amount of catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid. This reaction can acetylate the specific positions of the vinyl benzene derivatives, thereby introducing acetoxy groups at the corresponding positions of the benzene ring.
Finally, a series of separation and purification operations are carried out on the product. The target product can be separated from the reaction mixture system by extraction with a suitable organic solvent. The high purity 1-bromo-2-ene-4-acetoxybenzene can be obtained by column chromatography or recrystallization.
The whole synthesis process needs to carefully control the reaction conditions of each step, such as temperature, reactant ratio, catalyst dosage, etc., and the requirements of the reaction environment are also quite strict, so as to effectively improve the yield and purity of the product.
First, an appropriate amount of benzene is taken as the starting material, and iron bromide is used as the catalyst to undergo an electrophilic substitution reaction with bromine. Under suitable reaction conditions, bromine atoms will selectively replace hydrogen atoms on the benzene ring to obtain bromobenzene. This step requires attention to control the reaction temperature and amount of bromine to prevent the formation of polybrominates.
The obtained bromobenzene, after appropriate treatment, reacts with vinyl Grignard reagent in a suitable solvent such as anhydrous ether. In an anhydrous and oxygen-free environment, Grignard's reagent undergoes nucleophilic substitution with bromobenzene to form vinyl-containing benzene derivatives. In this process, the anhydrous and oxygen-free conditions of the reaction system are strictly required to avoid the failure of Grignard's reagent.
Then, the vinyl-containing benzene derivative is reacted with acetic anhydride under the action of an appropriate amount of catalyst, such as concentrated sulfuric acid or p-toluenesulfonic acid. This reaction can acetylate the specific positions of the vinyl benzene derivatives, thereby introducing acetoxy groups at the corresponding positions of the benzene ring.
Finally, a series of separation and purification operations are carried out on the product. The target product can be separated from the reaction mixture system by extraction with a suitable organic solvent. The high purity 1-bromo-2-ene-4-acetoxybenzene can be obtained by column chromatography or recrystallization.
The whole synthesis process needs to carefully control the reaction conditions of each step, such as temperature, reactant ratio, catalyst dosage, etc., and the requirements of the reaction environment are also quite strict, so as to effectively improve the yield and purity of the product.
What are the precautions for storing and transporting 1-chloro-2-fluoro-4-methoxybenzene?
1 + -Alkane-2 + -ene-4 + -methoxybenzyl should pay attention to many matters during storage and transportation. Many of these substances have their own characteristics and should not be careless.
First, when storing, choose a cool, dry and well-ventilated place. Because of this type of substance, it may be afraid of moisture and heat. If it is in a warm and humid place, it may cause qualitative change and damage its quality. And it must be kept away from fire and heat sources to prevent fires. Such substances may be flammable, and if they are not careful, they will cause fire and endanger the surroundings.
Second, the storage place should be isolated from oxidants, acids, bases, etc. Because of its chemical activity, the cover is easy to react and cause accidents when it encounters various chemicals. When placing it, it should be arranged in order to facilitate point checking and access, and to prevent confusion.
Third, when transporting, it is necessary to strictly select packaging materials in accordance with relevant regulations. Ensure that the packaging is tight, sealed, and there is no risk of leakage. To prevent during transportation, due to bumps and collisions causing material spillage, defacement of the environment, and endangering humans and animals. And transportation vehicles should be equipped with fire extinguishing and leakage emergency treatment equipment to avoid danger.
Fourth, those engaged in storage and transportation must undergo professional training, understand the nature of this object, and be familiar with emergency response methods. In case of emergencies, they can properly respond and reduce the harm.
All of these are important for storage and transportation of 1 + -alkane-2 + -ene-4 + -methoxybenzyl, and must not be ignored to ensure safety.
First, when storing, choose a cool, dry and well-ventilated place. Because of this type of substance, it may be afraid of moisture and heat. If it is in a warm and humid place, it may cause qualitative change and damage its quality. And it must be kept away from fire and heat sources to prevent fires. Such substances may be flammable, and if they are not careful, they will cause fire and endanger the surroundings.
Second, the storage place should be isolated from oxidants, acids, bases, etc. Because of its chemical activity, the cover is easy to react and cause accidents when it encounters various chemicals. When placing it, it should be arranged in order to facilitate point checking and access, and to prevent confusion.
Third, when transporting, it is necessary to strictly select packaging materials in accordance with relevant regulations. Ensure that the packaging is tight, sealed, and there is no risk of leakage. To prevent during transportation, due to bumps and collisions causing material spillage, defacement of the environment, and endangering humans and animals. And transportation vehicles should be equipped with fire extinguishing and leakage emergency treatment equipment to avoid danger.
Fourth, those engaged in storage and transportation must undergo professional training, understand the nature of this object, and be familiar with emergency response methods. In case of emergencies, they can properly respond and reduce the harm.
All of these are important for storage and transportation of 1 + -alkane-2 + -ene-4 + -methoxybenzyl, and must not be ignored to ensure safety.
What are the effects of 1-chloro-2-fluoro-4-methoxybenzene on the environment and human health?
Elements such as oil, oxygen, and carbon are affected by the environment and human health.
The first word. Water is the basic element of matter. Water, that is, the compound of oxygen, is the most important to life. Many physiological activities of human beings are caused by water, such as water, replacement and excretion. If it is missing, the basic activities of life are not enough. And in the environment, it is also necessary for human respiration. Human beings perform aerobic respiration to generate energy and maintain life. If the oxygen content in the environment is low, it will make people feel sleepy, dizzy, and life-threatening. In addition, the oxidation effect of oxygen in nature, the substances follow the shadow, rot, burn, etc., all of which are aerobic.
Furthermore, carbon. Carbohydrates, fats, proteins, etc., are all important substances that people need, and they all contain carbon. However, carbon emissions also cause many environmental problems. For example, carbon dioxide emissions are high, causing global warming, melting glaciers, and sea level rise. And the incomplete combustion of carbon-containing compounds generates more harmful substances, such as carbon monoxide, which affects the blood protein and oxygen, causing the organs to lack oxygen, which is harmful to health.
And formaldehyde, which is often harmful. It has an irritating taste and is often newly repaired. Formaldehyde can enter the respiratory tract and skin, harming the respiratory system, immune system, etc. Exposure to formaldehyde during the period is easy to cause respiratory diseases, allergies, and even carcinogens.
As a result, oxygen, carbon and formaldehyde, etc., are closely related to the environment and human health. Make good use of it, which is beneficial to the environment of life; if it is not controlled, it will cause serious problems, so be careful.
The first word. Water is the basic element of matter. Water, that is, the compound of oxygen, is the most important to life. Many physiological activities of human beings are caused by water, such as water, replacement and excretion. If it is missing, the basic activities of life are not enough. And in the environment, it is also necessary for human respiration. Human beings perform aerobic respiration to generate energy and maintain life. If the oxygen content in the environment is low, it will make people feel sleepy, dizzy, and life-threatening. In addition, the oxidation effect of oxygen in nature, the substances follow the shadow, rot, burn, etc., all of which are aerobic.
Furthermore, carbon. Carbohydrates, fats, proteins, etc., are all important substances that people need, and they all contain carbon. However, carbon emissions also cause many environmental problems. For example, carbon dioxide emissions are high, causing global warming, melting glaciers, and sea level rise. And the incomplete combustion of carbon-containing compounds generates more harmful substances, such as carbon monoxide, which affects the blood protein and oxygen, causing the organs to lack oxygen, which is harmful to health.
And formaldehyde, which is often harmful. It has an irritating taste and is often newly repaired. Formaldehyde can enter the respiratory tract and skin, harming the respiratory system, immune system, etc. Exposure to formaldehyde during the period is easy to cause respiratory diseases, allergies, and even carcinogens.
As a result, oxygen, carbon and formaldehyde, etc., are closely related to the environment and human health. Make good use of it, which is beneficial to the environment of life; if it is not controlled, it will cause serious problems, so be careful.
Scan to WhatsApp
