Linshang Chemical
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Benzene, 1-Chloro-2-Methoxy-4-Nitro-
Linshang Chemical
|
HS Code |
640064 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Solid |
| Solubility In Water | Low, as it is an organic compound with non - polar benzene ring and polar functional groups that don't strongly interact with water |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but nitro group can make it potentially reactive in certain chemical environments |
As an accredited Benzene, 1-Chloro-2-Methoxy-4-Nitro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 1 - chloro - 2 - methoxy - 4 - nitro - benzene, securely sealed. |
| Storage | 1 - Chloro - 2 - methoxy - 4 - nitro - benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Separate it from oxidizing agents, reducing agents, and incompatible substances to prevent chemical reactions. Adhere to local safety regulations for storage. |
| Shipping | Shipping of 1 - chloro - 2 - methoxy - 4 - nitro - benzene requires compliance with hazardous chemical regulations. It should be properly packaged in approved containers, labeled clearly, and transported by carriers licensed for such chemicals. |
Competitive Benzene, 1-Chloro-2-Methoxy-4-Nitro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of this product 1-chloro-2-methoxy-4-nitrobenzene
The substance is called 1-bromo-2-methoxy-4-acetylbenzene, which is an organic compound. Looking at its structure, the bromine atom, methoxy group and acetyl group are each based on the specific position of the benzene ring, so the structure gives it unique chemical properties.
Let's talk about the bromine atom first, which has strong electronegativity, which can change the electron cloud density distribution of the benzene ring. In many chemical reactions, the bromine atom is prone to form a leaving group for nucleophilic substitution reactions. When a nucleophilic reagent is close, the bromine atom carries a pair of electrons away, and the nucleophilic reagent occupies its position in the benzene ring. For example, when reacted with sodium alcohol,
Besides, methoxy, which is the power supply group, will increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution. Electrophilic reagents are prone to attack the high electron cloud density of the benzene ring, and the electron cloud density of the methoxy group is relatively higher. Electrophilic substitution often occurs at these positions.
And acetyl is an electron-withdrawing group, which will reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. In addition, the carbonyl group of the acetyl group is chemically active and can participate in reduction reactions, condensation reactions, etc. Like under the action of reducing agents, carbonyl can be reduced to alcohol hydroxyl groups. Due to the presence of these groups, this compound can participate in a variety of organic synthesis reactions, and may have important uses in medicinal chemistry, materials science, and other fields. It can be used as an intermediate in organic synthesis to build more complex and functional organic molecules through a series of reactions.
Let's talk about the bromine atom first, which has strong electronegativity, which can change the electron cloud density distribution of the benzene ring. In many chemical reactions, the bromine atom is prone to form a leaving group for nucleophilic substitution reactions. When a nucleophilic reagent is close, the bromine atom carries a pair of electrons away, and the nucleophilic reagent occupies its position in the benzene ring. For example, when reacted with sodium alcohol,
Besides, methoxy, which is the power supply group, will increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution. Electrophilic reagents are prone to attack the high electron cloud density of the benzene ring, and the electron cloud density of the methoxy group is relatively higher. Electrophilic substitution often occurs at these positions.
And acetyl is an electron-withdrawing group, which will reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. In addition, the carbonyl group of the acetyl group is chemically active and can participate in reduction reactions, condensation reactions, etc. Like under the action of reducing agents, carbonyl can be reduced to alcohol hydroxyl groups. Due to the presence of these groups, this compound can participate in a variety of organic synthesis reactions, and may have important uses in medicinal chemistry, materials science, and other fields. It can be used as an intermediate in organic synthesis to build more complex and functional organic molecules through a series of reactions.
What are the main uses of 1-chloro-2-methoxy-4-nitrobenzene?
1 + -Deuterium-2-methoxy-4-acetylbenzene is widely used. As a key intermediate in the field of medicine, it plays an indispensable role in the synthesis of many drugs. Due to its specific chemical structure, it can participate in many reactions, helping to construct biologically active molecular structures, laying the foundation for the creation of drugs for the treatment of various diseases.
In the field of materials science, it is also of great value. With its unique chemical properties, it can be used to synthesize materials with special properties, such as some functional polymer materials. The new substances formed by its participation in the reaction may have good electrical conductivity and optical properties, which contribute to the development of materials science.
In the field of organic synthesis chemistry, it is a commonly used raw material. Chemists use its structural characteristics to construct complex organic molecules through various organic reactions, such as substitution reactions, addition reactions, etc. With this as a starting material, many organic compounds with different structures and functions can be derived, greatly enriching the variety of organic compounds and promoting the progress of organic synthesis chemistry. In short, 1 + -deuterium-2-methoxy-4-acetylbenzene plays an important role in many fields and has a profound impact on the development of related fields.
In the field of materials science, it is also of great value. With its unique chemical properties, it can be used to synthesize materials with special properties, such as some functional polymer materials. The new substances formed by its participation in the reaction may have good electrical conductivity and optical properties, which contribute to the development of materials science.
In the field of organic synthesis chemistry, it is a commonly used raw material. Chemists use its structural characteristics to construct complex organic molecules through various organic reactions, such as substitution reactions, addition reactions, etc. With this as a starting material, many organic compounds with different structures and functions can be derived, greatly enriching the variety of organic compounds and promoting the progress of organic synthesis chemistry. In short, 1 + -deuterium-2-methoxy-4-acetylbenzene plays an important role in many fields and has a profound impact on the development of related fields.
What is the production method of 1-chloro-2-methoxy-4-nitrobenzene?
1. ** Preparation of raw materials **:
- To prepare 1-bromo-2-methoxy-4-acetylbenzene, it is necessary to prepare corresponding starting materials. Usually p-methoxyacetophenone is used as the starting point, which is due to the positioning effect of methoxy and acetyl groups on the benzene ring, which is conducive to the subsequent bromination reaction to occur at a specific position.
- Another bromine is required as a bromination reagent, and suitable solvents should also be prepared, such as halogenated hydrocarbon solvents such as dichloromethane, which have good solubility to the reaction substrate and bromine, and are relatively stable in nature and do not interfere with the main reaction.
2. ** Bromide reaction process **:
- In a reaction vessel equipped with a stirrer, thermometer and reflux condensing device, add p-methoxyacetophenone and an appropriate amount of dichloromethane first, stir to dissolve to form a uniform solution.
- Under low temperature and stirring conditions, slowly add bromine dropwise. Due to the exothermic bromide reaction, it is extremely critical to control the dropwise addition speed and reaction temperature. Generally, it is maintained at 0-10 ° C to prevent the reaction from being too violent and causing the formation of polybrominated by-products.
- Add dropwise and keep it at low temperature for a period of time to allow the reaction to proceed fully. The reaction process can be monitored by thin layer chromatography (TLC) to determine the reaction endpoint.
3. ** Post-reaction treatment **:
- At the end of the reaction, pour the reaction solution into an appropriate amount of ice water and stir well. At this time, the unreacted bromine reacts with water to form hydrobromic acid and hypobromic acid, which can reduce the bromine content in the system.
- Multiple extractions with an organic solvent such as dichloromethane and the organic phases are combined. The organic phase is successively washed with a saturated sodium bicarbonate solution to remove residual acid; then washed with water to neutral to reduce salt impurities in the organic phase.
- The organic phase is dried with a desiccant such as anhydrous sodium sulfate. After filtering to remove the desiccant, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
4. ** Product purification **:
- The crude product was purified by column chromatography. Silica gel was selected as the stationary phase, and petroleum ether and ethyl acetate were mixed in a certain proportion as the mobile phase. By adjusting the ratio of the mobile phase, the target product and impurities were effectively separated. The fractions containing the target product were collected and the solvent was removed by vacuum distillation to obtain pure 1-bromo-2-methoxy-4-acetylbenzene.
- To prepare 1-bromo-2-methoxy-4-acetylbenzene, it is necessary to prepare corresponding starting materials. Usually p-methoxyacetophenone is used as the starting point, which is due to the positioning effect of methoxy and acetyl groups on the benzene ring, which is conducive to the subsequent bromination reaction to occur at a specific position.
- Another bromine is required as a bromination reagent, and suitable solvents should also be prepared, such as halogenated hydrocarbon solvents such as dichloromethane, which have good solubility to the reaction substrate and bromine, and are relatively stable in nature and do not interfere with the main reaction.
2. ** Bromide reaction process **:
- In a reaction vessel equipped with a stirrer, thermometer and reflux condensing device, add p-methoxyacetophenone and an appropriate amount of dichloromethane first, stir to dissolve to form a uniform solution.
- Under low temperature and stirring conditions, slowly add bromine dropwise. Due to the exothermic bromide reaction, it is extremely critical to control the dropwise addition speed and reaction temperature. Generally, it is maintained at 0-10 ° C to prevent the reaction from being too violent and causing the formation of polybrominated by-products.
- Add dropwise and keep it at low temperature for a period of time to allow the reaction to proceed fully. The reaction process can be monitored by thin layer chromatography (TLC) to determine the reaction endpoint.
3. ** Post-reaction treatment **:
- At the end of the reaction, pour the reaction solution into an appropriate amount of ice water and stir well. At this time, the unreacted bromine reacts with water to form hydrobromic acid and hypobromic acid, which can reduce the bromine content in the system.
- Multiple extractions with an organic solvent such as dichloromethane and the organic phases are combined. The organic phase is successively washed with a saturated sodium bicarbonate solution to remove residual acid; then washed with water to neutral to reduce salt impurities in the organic phase.
- The organic phase is dried with a desiccant such as anhydrous sodium sulfate. After filtering to remove the desiccant, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
4. ** Product purification **:
- The crude product was purified by column chromatography. Silica gel was selected as the stationary phase, and petroleum ether and ethyl acetate were mixed in a certain proportion as the mobile phase. By adjusting the ratio of the mobile phase, the target product and impurities were effectively separated. The fractions containing the target product were collected and the solvent was removed by vacuum distillation to obtain pure 1-bromo-2-methoxy-4-acetylbenzene.
What are the precautions for 1-chloro-2-methoxy-4-nitrobenzene during storage and transportation?
For 1-bromo-2-methoxy-4-benzylbenzene, many things should be paid attention to during storage and transportation.
The first to bear the brunt, this material has a certain chemical activity and is easy to react with other substances, so when storing, it is necessary to keep its environment dry and cool. Due to humidity and high temperature, it is very easy to induce chemical reactions, resulting in material deterioration. For example, in contact with water, the original structure may be damaged by hydrolysis, affecting its quality and utility.
Furthermore, during transportation, you must also beware of vibration and collision. This material structure may be damaged due to violent vibration, causing unpredictable risks. Just like porcelain, it will break if you are not careful. Similarly, if the structure of this compound is damaged by external force, or the chemical properties are changed, it will even be dangerous.
And because it may have certain toxicity and irritation, there must be complete protection measures for storage and transportation. When people come into contact with it, they must wear suitable protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from coming into contact with the skin and eyes and causing physical damage. If you accidentally touch it, rinse it with plenty of water quickly and seek medical treatment.
Repeat, the storage place should be separated from oxidants, acids and other substances. Due to its chemical properties, it may coexist with it, or cause violent chemical reactions, and even risk burning and explosion. If this ice and fire are incompatible, the combination of two types of different chemical properties will lead to disaster.
Finally, whether it is the storage site or the means of transportation, it should be clearly marked, clearly indicating that it contains 1-bromo-2-methoxy-4-benzyl benzene, so that relevant personnel know, alert to the latent risk, so as to properly deal with it, to ensure the smooth storage and transportation process.
The first to bear the brunt, this material has a certain chemical activity and is easy to react with other substances, so when storing, it is necessary to keep its environment dry and cool. Due to humidity and high temperature, it is very easy to induce chemical reactions, resulting in material deterioration. For example, in contact with water, the original structure may be damaged by hydrolysis, affecting its quality and utility.
Furthermore, during transportation, you must also beware of vibration and collision. This material structure may be damaged due to violent vibration, causing unpredictable risks. Just like porcelain, it will break if you are not careful. Similarly, if the structure of this compound is damaged by external force, or the chemical properties are changed, it will even be dangerous.
And because it may have certain toxicity and irritation, there must be complete protection measures for storage and transportation. When people come into contact with it, they must wear suitable protective equipment, such as gloves, goggles, protective clothing, etc., to prevent it from coming into contact with the skin and eyes and causing physical damage. If you accidentally touch it, rinse it with plenty of water quickly and seek medical treatment.
Repeat, the storage place should be separated from oxidants, acids and other substances. Due to its chemical properties, it may coexist with it, or cause violent chemical reactions, and even risk burning and explosion. If this ice and fire are incompatible, the combination of two types of different chemical properties will lead to disaster.
Finally, whether it is the storage site or the means of transportation, it should be clearly marked, clearly indicating that it contains 1-bromo-2-methoxy-4-benzyl benzene, so that relevant personnel know, alert to the latent risk, so as to properly deal with it, to ensure the smooth storage and transportation process.
What are the effects of 1-chloro-2-methoxy-4-nitrobenzene on the environment and human health?
It is the foundation of matter, the beginning of heaven and earth, and exists in the world. And 2-methoxy-4-propylbenzene, this compound, its environmental impact on people's health, cannot be ignored.
At one end of the environment, 2-methoxy-4-propylbenzene can be used for photochemical reactions. When it arrives in the air, it encounters light and other pollutants, or it can be transformed to form secondary pollutants such as ozone. If the ozone level is high, it will cause great harm to the environment, causing photosynthesis to be blocked, causing vegetation and plant life to be balanced. And if this compound enters the water, or is absorbed and enriched by aquatic organisms. In the past, along the food, endangering the entire aquatic system.
to human health, 2-methoxy-4-propylbenzene respiration, skin contact or food into people. If inhaled, or irritated the respiratory tract, causing cough, respiratory distress and other symptoms. Exposure to the respiratory system, or respiratory system, increase respiratory diseases. If the skin is connected, or cause skin sensitivity, inflammation, broken skin barrier function. In addition, into the, or blood circulation to various organs, affecting the liver, and other organs normal generation, tired toxicity, health.
Therefore, 2-methoxy-4-propylbenzene has many health problems in the environment. It is necessary to be careful to prevent it from being released indiscriminately, so as to ensure the well-being of people in the environment.
At one end of the environment, 2-methoxy-4-propylbenzene can be used for photochemical reactions. When it arrives in the air, it encounters light and other pollutants, or it can be transformed to form secondary pollutants such as ozone. If the ozone level is high, it will cause great harm to the environment, causing photosynthesis to be blocked, causing vegetation and plant life to be balanced. And if this compound enters the water, or is absorbed and enriched by aquatic organisms. In the past, along the food, endangering the entire aquatic system.
to human health, 2-methoxy-4-propylbenzene respiration, skin contact or food into people. If inhaled, or irritated the respiratory tract, causing cough, respiratory distress and other symptoms. Exposure to the respiratory system, or respiratory system, increase respiratory diseases. If the skin is connected, or cause skin sensitivity, inflammation, broken skin barrier function. In addition, into the, or blood circulation to various organs, affecting the liver, and other organs normal generation, tired toxicity, health.
Therefore, 2-methoxy-4-propylbenzene has many health problems in the environment. It is necessary to be careful to prevent it from being released indiscriminately, so as to ensure the well-being of people in the environment.
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