Linshang Chemical
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Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)-
Linshang Chemical
|
HS Code |
668793 |
| Chemical Formula | C8H6ClF3O |
| Molecular Weight | 210.58 |
| Appearance | Typically a colorless to light - colored liquid |
| Odor | Characteristic organic odor |
| Boiling Point | Varies depending on purity, but generally in a certain range related to its molecular structure |
| Melting Point | Specific value determined by its crystal lattice energy |
| Density | A value indicating mass per unit volume |
| Solubility | Solubility in organic solvents like ethanol, acetone; limited in water |
| Vapor Pressure | Pressure exerted by its vapor at a given temperature |
| Flash Point | Temperature at which it can form an ignitable vapor - air mixture |
As an accredited Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(chloromethyl)-3-(trifluoromethoxy)benzene in sealed chemical - grade containers. |
| Storage | Store "Benzene, 1-(chloromethyl)-3-(trifluoromethoxy)-" in a cool, dry, well - ventilated area, away from heat, ignition sources, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Since it is likely a hazardous chemical, ensure storage is in accordance with local safety regulations and in a designated chemical storage area. |
| Shipping | Shipment of "Benzene, 1-(chloromethyl)-3-(trifluoromethoxy)-" requires strict compliance with hazardous chemical shipping regulations. It must be properly packaged, labeled, and transported by carriers licensed for such chemicals. |
Competitive Benzene, 1-(Chloromethyl)-3-(Trifluoromethoxy)- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
(Monomethyl) -3- (trifluoromethoxy) benzene, its physical properties are as follows:
This substance is mostly liquid at room temperature, and it looks clear and transparent, like smart water, without suspended impurities, pure and homogeneous. Its smell is unique. Although it is not pungent or intolerable, it is volatile to a certain extent. It diffuses in the air and smells close to it. It can sense a special aromatic smell, but it is exposed to it for a long time, or has a slight irritation to the nasal mucosa.
The boiling point is in a specific range, about [X] ° C. This boiling point characteristic makes it change from liquid to gas state smoothly under the heating environment at the corresponding temperature, and the phase change occurs. And during the boiling process, the temperature remains relatively constant until it is completely vaporized.
The melting point is also an important physical property, about [X] ° C. When the external temperature drops below the melting point, it gradually solidifies, changing from a flowing liquid to a solid state, and the molecular arrangement changes from disorder to order, and the morphology becomes more stable.
Compared with water, its density has its own characteristics. If it is placed in the same container as water, it will assume different states due to density differences, either floating on water or submerged underwater, depending on the comparison of its exact density value with the density of water (1g/cm ³). In terms of solubility, in organic solvents such as ethanol and ether, there is a certain solubility, which can be mixed with them to form a uniform solution system. However, in water, the solubility is poor, and when the two are mixed, they are prone to stratification, reflecting their hydrophobicity. This solubility characteristic is closely related to the properties of groups in the molecular structure. The existence of methyl and trifluoromethoxy groups affects the interaction between molecules and different solvent molecules.
This substance is mostly liquid at room temperature, and it looks clear and transparent, like smart water, without suspended impurities, pure and homogeneous. Its smell is unique. Although it is not pungent or intolerable, it is volatile to a certain extent. It diffuses in the air and smells close to it. It can sense a special aromatic smell, but it is exposed to it for a long time, or has a slight irritation to the nasal mucosa.
The boiling point is in a specific range, about [X] ° C. This boiling point characteristic makes it change from liquid to gas state smoothly under the heating environment at the corresponding temperature, and the phase change occurs. And during the boiling process, the temperature remains relatively constant until it is completely vaporized.
The melting point is also an important physical property, about [X] ° C. When the external temperature drops below the melting point, it gradually solidifies, changing from a flowing liquid to a solid state, and the molecular arrangement changes from disorder to order, and the morphology becomes more stable.
Compared with water, its density has its own characteristics. If it is placed in the same container as water, it will assume different states due to density differences, either floating on water or submerged underwater, depending on the comparison of its exact density value with the density of water (1g/cm ³). In terms of solubility, in organic solvents such as ethanol and ether, there is a certain solubility, which can be mixed with them to form a uniform solution system. However, in water, the solubility is poor, and when the two are mixed, they are prone to stratification, reflecting their hydrophobicity. This solubility characteristic is closely related to the properties of groups in the molecular structure. The existence of methyl and trifluoromethoxy groups affects the interaction between molecules and different solvent molecules.
What are the chemical properties of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
1 - (cyanomethyl) - 3 - (trifluoromethoxy) benzene is one of the organic compounds. Its chemical properties are quite unique, let me explain in detail for you.
Among this compound, the cyanomethyl functional group adds its unique reactivity. The presence of cyanyl groups makes it possible to involve many reactions. First, cyanyl groups can undergo hydrolysis and can be converted into carboxyl groups under appropriate conditions. This carboxyl group is an important intermediate in many organic synthesis reactions. It can be esterified with alcohols to form ester compounds. This reaction is widely used in the field of organic synthesis of fragrances, drugs and other fields.
Furthermore, the cyanyl group can be converted into an amino group through reduction reaction. Amino groups play a key role in the construction of nitrogen-containing organic compounds, and the synthesis of many drugs and dyes depends on this process.
The introduction of trifluoromethoxy functional groups also has a great impact on its properties. Trifluoromethoxy groups have strong electron absorption and can change the electron cloud density distribution of the benzene ring. This makes the electrophilic substitution reaction on the benzene ring different from that of the ordinary benzene ring, which usually makes the electrophilic substitution reaction more likely to occur in the relatively high electron cloud density. And because of its strong electron-absorbing effect, it can enhance the stability and fat solubility of molecules. In the field of drug development, this property can affect the transmembrane transportation and bioavailability of drugs.
In addition, the overall structure of 1- (cyanomethyl) -3- (trifluoromethoxy) benzene determines that it can be used as an important substrate in organic reactions, participating in reactions such as arylation and alkylation, laying the foundation for the construction of more complex organic molecular structures, and playing a significant role in the research and practice of organic synthetic chemistry.
Among this compound, the cyanomethyl functional group adds its unique reactivity. The presence of cyanyl groups makes it possible to involve many reactions. First, cyanyl groups can undergo hydrolysis and can be converted into carboxyl groups under appropriate conditions. This carboxyl group is an important intermediate in many organic synthesis reactions. It can be esterified with alcohols to form ester compounds. This reaction is widely used in the field of organic synthesis of fragrances, drugs and other fields.
Furthermore, the cyanyl group can be converted into an amino group through reduction reaction. Amino groups play a key role in the construction of nitrogen-containing organic compounds, and the synthesis of many drugs and dyes depends on this process.
The introduction of trifluoromethoxy functional groups also has a great impact on its properties. Trifluoromethoxy groups have strong electron absorption and can change the electron cloud density distribution of the benzene ring. This makes the electrophilic substitution reaction on the benzene ring different from that of the ordinary benzene ring, which usually makes the electrophilic substitution reaction more likely to occur in the relatively high electron cloud density. And because of its strong electron-absorbing effect, it can enhance the stability and fat solubility of molecules. In the field of drug development, this property can affect the transmembrane transportation and bioavailability of drugs.
In addition, the overall structure of 1- (cyanomethyl) -3- (trifluoromethoxy) benzene determines that it can be used as an important substrate in organic reactions, participating in reactions such as arylation and alkylation, laying the foundation for the construction of more complex organic molecular structures, and playing a significant role in the research and practice of organic synthetic chemistry.
What are the main uses of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
(1) This substance is called 1- (cyanomethyl) -3- (trifluoromethoxy) benzene, and it has a wide range of uses.
In the field of pharmaceutical synthesis, its position is crucial. Due to its special chemical structure, it can be used as a key intermediate to assist in the preparation of many specific drugs. For example, some anti-cancer drugs with unique pharmacological activities, in the synthesis process, 1- (cyanomethyl) -3- (trifluoromethoxy) benzene can participate in the construction of the core structure of drug molecules. Through a series of delicate chemical reactions, it gives the drug the excellent ability to precisely target cancer cells and inhibit their proliferation.
In the field of pesticide creation, it is also indispensable. With this raw material, new pesticides with high efficiency and low toxicity can be developed. Such pesticides can show strong control effects on specific pests or diseases, and are environmentally friendly, with low residues, which can effectively maintain ecological balance. For example, for some stubborn crop pests, pesticides based on 1- (cyanomethyl) -3- (trifluoromethoxy) benzene can precisely act on the nervous system or physiological metabolic pathways of pests, so as to achieve the purpose of efficient pest removal.
In the field of materials science, it also has extraordinary performance. It can be used to prepare polymer materials with special properties. After ingenious design and synthesis, it can be introduced into the polymer structure, which can significantly improve the physical and chemical properties of the material, such as improving the heat resistance, chemical corrosion resistance and mechanical properties of the material. Such materials with excellent properties have broad application prospects in high-end fields such as aerospace, electronics and electrical appliances.
In short, 1- (cyanomethyl) -3- (trifluoromethoxy) benzene, with its unique chemical properties, plays a key role in many fields such as medicine, pesticides, and materials, and has made great contributions to promoting technological innovation and development in various fields.
In the field of pharmaceutical synthesis, its position is crucial. Due to its special chemical structure, it can be used as a key intermediate to assist in the preparation of many specific drugs. For example, some anti-cancer drugs with unique pharmacological activities, in the synthesis process, 1- (cyanomethyl) -3- (trifluoromethoxy) benzene can participate in the construction of the core structure of drug molecules. Through a series of delicate chemical reactions, it gives the drug the excellent ability to precisely target cancer cells and inhibit their proliferation.
In the field of pesticide creation, it is also indispensable. With this raw material, new pesticides with high efficiency and low toxicity can be developed. Such pesticides can show strong control effects on specific pests or diseases, and are environmentally friendly, with low residues, which can effectively maintain ecological balance. For example, for some stubborn crop pests, pesticides based on 1- (cyanomethyl) -3- (trifluoromethoxy) benzene can precisely act on the nervous system or physiological metabolic pathways of pests, so as to achieve the purpose of efficient pest removal.
In the field of materials science, it also has extraordinary performance. It can be used to prepare polymer materials with special properties. After ingenious design and synthesis, it can be introduced into the polymer structure, which can significantly improve the physical and chemical properties of the material, such as improving the heat resistance, chemical corrosion resistance and mechanical properties of the material. Such materials with excellent properties have broad application prospects in high-end fields such as aerospace, electronics and electrical appliances.
In short, 1- (cyanomethyl) -3- (trifluoromethoxy) benzene, with its unique chemical properties, plays a key role in many fields such as medicine, pesticides, and materials, and has made great contributions to promoting technological innovation and development in various fields.
What are the synthesis methods of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
To prepare 1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene, the synthesis method is as follows:
The starting material can be selected from a compound containing a benzene ring, and the cyanomethyl group and trifluoromethoxy group are introduced through specific steps.
First, the cyanomethyl group is introduced before the benzene ring. Benzene and halogenated cyanomethane can react according to the mechanism of nucleophilic substitution in the presence of a suitable catalyst. For example, when cyanomethane chloride is catalyzed by Lewis acid such as aluminum trichloride, the cyanomethyl group of cyanomethane can replace the hydrogen atom on the benzene ring to form a benzene derivative containing cyanomethyl group. This reaction needs to be carried out in an anhydrous environment and at
Second, trifluoromethoxy is introduced. Reagents containing trifluoromethoxy can be used to react with benzene derivatives containing cyanomethyl groups obtained above. Commonly used trifluoromethoxylation reagents include sodium trifluoromethylsulfonate, etc. In alkaline conditions and suitable organic solvents, such as dimethyl sulfoxide (DMSO), sodium trifluoromethylsulfonate and benzene derivatives containing cyanomethyl groups undergo nucleophilic substitution processes, so that the trifluoromethoxy group replaces the hydrogen atom at a specific position on the benzene ring, and then the target product 1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene can be obtained.
Another idea is to introduce trifluoromethoxy groups before the benzene ring. Benzene is reacted with a suitable trifluoromethoxylation reagent under specific conditions, and then cyanomethyl is introduced through nucleophilic substitution and other reactions. In this process, the control of the reaction conditions of each step is extremely critical, such as the reaction temperature, the amount of reagent, the reaction time, etc., will affect the yield and purity of the product. And after each step of the reaction is completed, it needs to be separated and purified, such as extraction, distillation, column chromatography, etc., to remove impurities and obtain a pure intermediate product and the final target product 1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene.
The starting material can be selected from a compound containing a benzene ring, and the cyanomethyl group and trifluoromethoxy group are introduced through specific steps.
First, the cyanomethyl group is introduced before the benzene ring. Benzene and halogenated cyanomethane can react according to the mechanism of nucleophilic substitution in the presence of a suitable catalyst. For example, when cyanomethane chloride is catalyzed by Lewis acid such as aluminum trichloride, the cyanomethyl group of cyanomethane can replace the hydrogen atom on the benzene ring to form a benzene derivative containing cyanomethyl group. This reaction needs to be carried out in an anhydrous environment and at
Second, trifluoromethoxy is introduced. Reagents containing trifluoromethoxy can be used to react with benzene derivatives containing cyanomethyl groups obtained above. Commonly used trifluoromethoxylation reagents include sodium trifluoromethylsulfonate, etc. In alkaline conditions and suitable organic solvents, such as dimethyl sulfoxide (DMSO), sodium trifluoromethylsulfonate and benzene derivatives containing cyanomethyl groups undergo nucleophilic substitution processes, so that the trifluoromethoxy group replaces the hydrogen atom at a specific position on the benzene ring, and then the target product 1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene can be obtained.
Another idea is to introduce trifluoromethoxy groups before the benzene ring. Benzene is reacted with a suitable trifluoromethoxylation reagent under specific conditions, and then cyanomethyl is introduced through nucleophilic substitution and other reactions. In this process, the control of the reaction conditions of each step is extremely critical, such as the reaction temperature, the amount of reagent, the reaction time, etc., will affect the yield and purity of the product. And after each step of the reaction is completed, it needs to be separated and purified, such as extraction, distillation, column chromatography, etc., to remove impurities and obtain a pure intermediate product and the final target product 1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene.
What are the precautions for using 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
1 - (cyanomethyl) - 3 - (trifluoromethoxy) benzene is a highly toxic product. When using it, you must be careful and take many precautions not to be ignored.
First, it is related to the way of protection. Users must wear complete protective equipment, such as airtight gas masks, goggles, protective clothing and gloves that are resistant to chemical corrosion. This is a barrier to the close proximity of poisons. If the protection is slightly negligent, poisons can take advantage of the void and endanger lives.
Second, it is related to the place of operation. The operation should be done in a well-ventilated place or in a fume hood. This can quickly disperse poisons to avoid their accumulation and reduce the risk of poisoning. And the place of operation should be far away from fire and heat sources, because it is flammable, in case of open flame, hot topic, or cause fire or explosion.
Third, it is related to the method of use. When taking it, the action should be stable and accurate to avoid spillage. Once spilled, quickly cover it with inert materials such as sand and vermiculite, put it in a closed container, and dispose of it properly according to regulations. Do not dump it at will, the poison will spread and pollute the environment.
Fourth, it is related to storage regulations. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and stored and transported separately from oxidants and edible chemicals. The storage container must be sealed to prevent its leakage. Check the storage status regularly. If there is any abnormality, deal with it immediately.
Fifth, it is related to emergency measures. Users should be familiar with emergency treatment methods. If accidentally touching the skin, quickly rinse with a large amount of flowing water; if entering the eyes, lift the eyelids, rinse with flowing water or normal saline, and seek medical attention quickly. If inhaling, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties are given oxygen, artificial respiration will be performed when breathing stops, and emergency medical care will be taken.
First, it is related to the way of protection. Users must wear complete protective equipment, such as airtight gas masks, goggles, protective clothing and gloves that are resistant to chemical corrosion. This is a barrier to the close proximity of poisons. If the protection is slightly negligent, poisons can take advantage of the void and endanger lives.
Second, it is related to the place of operation. The operation should be done in a well-ventilated place or in a fume hood. This can quickly disperse poisons to avoid their accumulation and reduce the risk of poisoning. And the place of operation should be far away from fire and heat sources, because it is flammable, in case of open flame, hot topic, or cause fire or explosion.
Third, it is related to the method of use. When taking it, the action should be stable and accurate to avoid spillage. Once spilled, quickly cover it with inert materials such as sand and vermiculite, put it in a closed container, and dispose of it properly according to regulations. Do not dump it at will, the poison will spread and pollute the environment.
Fourth, it is related to storage regulations. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and stored and transported separately from oxidants and edible chemicals. The storage container must be sealed to prevent its leakage. Check the storage status regularly. If there is any abnormality, deal with it immediately.
Fifth, it is related to emergency measures. Users should be familiar with emergency treatment methods. If accidentally touching the skin, quickly rinse with a large amount of flowing water; if entering the eyes, lift the eyelids, rinse with flowing water or normal saline, and seek medical attention quickly. If inhaling, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties are given oxygen, artificial respiration will be performed when breathing stops, and emergency medical care will be taken.
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