Linshang Chemical
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Benzene, 2-(Bromomethyl)-4-Chloro-1-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
510480 |
| Chemical Formula | C8H5BrClF3 |
| Molar Mass | 287.48 g/mol |
| Appearance | Solid (usually) |
| Solubility In Water | Low (organic compound, hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low (solid, relatively non - volatile) |
| Hazard Class | Irritant (can cause eye, skin and respiratory irritation), Toxicity data may vary |
As an accredited Benzene, 2-(Bromomethyl)-4-Chloro-1-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2-(bromomethyl)-4-chloro-1-(trifluoromethyl)benzene in a sealed, labeled bottle. |
| Storage | Store “Benzene, 2-(bromomethyl)-4-chloro-1-(trifluoromethyl)-” in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials due to its potentially reactive nature. Isolate it from incompatible substances like oxidizing agents, bases, and reducing agents to prevent dangerous reactions. |
| Shipping | The chemical "Benzene, 2-(bromomethyl)-4-chloro-1-(trifluoromethyl)-" should be shipped in accordance with strict hazardous material regulations. Use appropriate, well - sealed containers and ensure proper labeling for safe transportation. |
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What is the main use of this product 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene?
This product is called 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene, and it has a wide range of uses. In the field of medicine, it is a key intermediate for the preparation of specific drugs. Through specific chemical reactions, it can be cleverly combined with other chemical substances to build a molecular structure with unique pharmacological activities, thus laying a solid foundation for the development of new drugs.
In the field of pesticides, this substance plays a crucial role. It can be derived from pesticide products with high insecticidal, bactericidal or herbicidal effects. Due to its special chemical structure, it can precisely act on the specific physiological processes of pests, pathogens or weeds, achieving the purpose of efficient control, and has a relatively small impact on the environment, which meets the needs of the development of modern green agriculture.
Furthermore, in the field of materials science, it also has its place. It can be used as a synthetic raw material for functional materials, giving materials such as special optical, electrical or thermal properties. For example, after special processing, it can be used to prepare optical materials with high sensitivity to specific wavelengths of light, or electronic materials with excellent electrical conductivity, providing new opportunities for the innovation and development of materials science.
In conclusion, 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene plays an indispensable role in many fields such as medicine, pesticides and materials science, and is of great significance for promoting technological progress and innovation in related industries.
In the field of pesticides, this substance plays a crucial role. It can be derived from pesticide products with high insecticidal, bactericidal or herbicidal effects. Due to its special chemical structure, it can precisely act on the specific physiological processes of pests, pathogens or weeds, achieving the purpose of efficient control, and has a relatively small impact on the environment, which meets the needs of the development of modern green agriculture.
Furthermore, in the field of materials science, it also has its place. It can be used as a synthetic raw material for functional materials, giving materials such as special optical, electrical or thermal properties. For example, after special processing, it can be used to prepare optical materials with high sensitivity to specific wavelengths of light, or electronic materials with excellent electrical conductivity, providing new opportunities for the innovation and development of materials science.
In conclusion, 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene plays an indispensable role in many fields such as medicine, pesticides and materials science, and is of great significance for promoting technological progress and innovation in related industries.
What are the physical properties of 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene?
2-% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene, which is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is mostly colorless to light yellow liquid. It has good stability in light and air environments, but it also needs to be properly stored to prevent deterioration. It has a certain volatility. In a well-ventilated place, it can smell a specific smell, but this smell is not pungent and intolerable. However, it should not be inhaled in large quantities for a long time to prevent damage to health.
When it comes to solubility, it shows good solubility in many organic solvents, such as ethanol, ether, dichloromethane, etc. This property makes it in the field of organic synthesis, when used as a reactant or intermediate, it can be conveniently mixed with other organic reagents in the solution system, and then highly efficient chemical reaction occurs. However, its solubility in water is extremely low and almost insoluble. Due to the characteristics of the molecular structure of the compound, there is a lack of hydrophilic groups, so the interaction with water is weak.
In terms of melting point and boiling point, the melting point has been experimentally determined to be in a relatively low range, and the specific value can be obtained according to accurate measurement. The boiling point depends on factors such as ambient pressure. Under standard atmospheric pressure, the boiling point is [X] ° C. This boiling point characteristic makes it possible to separate and purify the compound according to the difference between its boiling point and other substances, and to achieve effective separation by means of distillation and other means.
In terms of density, its density is slightly higher than that of water. After mixing it with water and letting it stand, it will sink to the bottom of the water. This density characteristic plays an important indicative role in some operations involving liquid-liquid separation, which is convenient for experimenters to design a reasonable separation process according to the density difference.
The above physical properties of 2% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene have laid a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry. According to these properties, researchers can rationally plan its use mode and reaction conditions.
Viewed at room temperature, it is mostly colorless to light yellow liquid. It has good stability in light and air environments, but it also needs to be properly stored to prevent deterioration. It has a certain volatility. In a well-ventilated place, it can smell a specific smell, but this smell is not pungent and intolerable. However, it should not be inhaled in large quantities for a long time to prevent damage to health.
When it comes to solubility, it shows good solubility in many organic solvents, such as ethanol, ether, dichloromethane, etc. This property makes it in the field of organic synthesis, when used as a reactant or intermediate, it can be conveniently mixed with other organic reagents in the solution system, and then highly efficient chemical reaction occurs. However, its solubility in water is extremely low and almost insoluble. Due to the characteristics of the molecular structure of the compound, there is a lack of hydrophilic groups, so the interaction with water is weak.
In terms of melting point and boiling point, the melting point has been experimentally determined to be in a relatively low range, and the specific value can be obtained according to accurate measurement. The boiling point depends on factors such as ambient pressure. Under standard atmospheric pressure, the boiling point is [X] ° C. This boiling point characteristic makes it possible to separate and purify the compound according to the difference between its boiling point and other substances, and to achieve effective separation by means of distillation and other means.
In terms of density, its density is slightly higher than that of water. After mixing it with water and letting it stand, it will sink to the bottom of the water. This density characteristic plays an important indicative role in some operations involving liquid-liquid separation, which is convenient for experimenters to design a reasonable separation process according to the density difference.
The above physical properties of 2% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene have laid a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry. According to these properties, researchers can rationally plan its use mode and reaction conditions.
What are the chemical properties of 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene?
The chemical properties of 2 - (hydroxymethyl) -4 -chloro-1 - (trifluoromethyl) benzene are particularly important. This compound contains chlorine atoms, which have electron-withdrawing properties, which can affect the electron cloud distribution of molecules and reduce the electron cloud density of benzene rings. This property makes the compound different from ordinary benzene derivatives in electrophilic substitution reactions, and it is difficult to undergo electrophilic substitution because its attractiveness to electrophilic reagents is weakened.
also contains hydroxymethyl, and hydroxyl groups can participate in many reactions. It has certain nucleophilic properties and can react with electrophilic reagents. For example, it can be esterified with acyl chloride or acid anhydride to form corresponding ester compounds. And the hydroxyl group can undergo dehydration reaction. Under appropriate conditions, intramolecular or intermolecular dehydration can form ether or olefin substances.
Furthermore, trifluoromethyl is a strong electron-absorbing group, which has a great impact on the properties of the compound. It greatly increases the molecular polarity and affects the physical properties such as the solubility and boiling point of the compound. In chemical reactions, the presence of trifluoromethyl further reduces the electron cloud density of the benzene ring and strengthens the resistance of the benzene ring to electrophilic substitution. At the same time, the special structure of trifluoromethyl can affect the spatial configuration of the molecule, and affect the interaction between the compound and other molecules, such as hydrogen bonds, van der Waals forces, etc., which in turn affects its chemical activity and reaction selectivity.
In summary, the interaction of chlorine atoms, hydroxymethyl and trifluoromethyl in 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene presents unique chemical properties. In organic synthesis and related fields, careful consideration of the characteristics of each group is required to make full use of its properties to achieve specific synthetic goals.
also contains hydroxymethyl, and hydroxyl groups can participate in many reactions. It has certain nucleophilic properties and can react with electrophilic reagents. For example, it can be esterified with acyl chloride or acid anhydride to form corresponding ester compounds. And the hydroxyl group can undergo dehydration reaction. Under appropriate conditions, intramolecular or intermolecular dehydration can form ether or olefin substances.
Furthermore, trifluoromethyl is a strong electron-absorbing group, which has a great impact on the properties of the compound. It greatly increases the molecular polarity and affects the physical properties such as the solubility and boiling point of the compound. In chemical reactions, the presence of trifluoromethyl further reduces the electron cloud density of the benzene ring and strengthens the resistance of the benzene ring to electrophilic substitution. At the same time, the special structure of trifluoromethyl can affect the spatial configuration of the molecule, and affect the interaction between the compound and other molecules, such as hydrogen bonds, van der Waals forces, etc., which in turn affects its chemical activity and reaction selectivity.
In summary, the interaction of chlorine atoms, hydroxymethyl and trifluoromethyl in 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene presents unique chemical properties. In organic synthesis and related fields, careful consideration of the characteristics of each group is required to make full use of its properties to achieve specific synthetic goals.
What are the applications of 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene in synthesis?
In the synthesis of 2-% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene, it is often used in various delicate reactions.
First, in the nucleophilic substitution reaction, this compound has good separation of chlorine atoms due to its special structure. When encountering suitable nucleophilic reagents, such as alkoxides and amines, the nucleophilic reagents are like smart pawns, attacking the position occupied by the chlorine atom, replacing the chlorine atom, and then deriving novel compounds. This process is like a delicate art of war exercise. The reactants follow the rules of chemistry and are ordered to combine and change to form new material forms.
Furthermore, in the field of metal catalysis, 2% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene also plays a key role. Metals such as palladium and nickel are used as catalysts to promote coupling reactions with carbon-containing nucleophiles. In such reactions, metal catalysts are like highly skilled conductors, guiding the precise binding of different reactants and forming carbon-carbon bonds. In this way, the carbon skeleton of the molecule can be effectively expanded, laying the foundation for the synthesis of more complex organic compounds.
In addition, due to the presence of hydroxymethyl groups, this compound can participate in many reactions involving alcohol hydroxyl groups. For example, under appropriate conditions, hydroxymethyl groups can be oxidized to aldehyde groups or carboxyl groups to achieve the transformation of functional groups. Or, hydroxymethyl groups can be esterified with acids to form corresponding ester compounds. These reactions are like clever tricks, giving compounds new properties and uses through rational transformation and modification of functional groups.
In summary, 2% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene has shown important application value in various reactions such as nucleophilic substitution, metal catalytic coupling, and functional group conversion on the stage of organic synthesis due to its unique structure, which contributes to the development of organic synthesis chemistry and helps chemists create a colorful world of organic compounds.
First, in the nucleophilic substitution reaction, this compound has good separation of chlorine atoms due to its special structure. When encountering suitable nucleophilic reagents, such as alkoxides and amines, the nucleophilic reagents are like smart pawns, attacking the position occupied by the chlorine atom, replacing the chlorine atom, and then deriving novel compounds. This process is like a delicate art of war exercise. The reactants follow the rules of chemistry and are ordered to combine and change to form new material forms.
Furthermore, in the field of metal catalysis, 2% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene also plays a key role. Metals such as palladium and nickel are used as catalysts to promote coupling reactions with carbon-containing nucleophiles. In such reactions, metal catalysts are like highly skilled conductors, guiding the precise binding of different reactants and forming carbon-carbon bonds. In this way, the carbon skeleton of the molecule can be effectively expanded, laying the foundation for the synthesis of more complex organic compounds.
In addition, due to the presence of hydroxymethyl groups, this compound can participate in many reactions involving alcohol hydroxyl groups. For example, under appropriate conditions, hydroxymethyl groups can be oxidized to aldehyde groups or carboxyl groups to achieve the transformation of functional groups. Or, hydroxymethyl groups can be esterified with acids to form corresponding ester compounds. These reactions are like clever tricks, giving compounds new properties and uses through rational transformation and modification of functional groups.
In summary, 2% (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene has shown important application value in various reactions such as nucleophilic substitution, metal catalytic coupling, and functional group conversion on the stage of organic synthesis due to its unique structure, which contributes to the development of organic synthesis chemistry and helps chemists create a colorful world of organic compounds.
What are the preparation methods of 2- (bromomethyl) -4-chloro-1- (trifluoromethyl) benzene?
To prepare 2 - (hydroxymethyl) - 4 - chloro - 1 - (trifluoromethyl) benzene, the method is as follows:
First take an appropriate reaction vessel, wash and dry to ensure an anhydrous and oxygen-free environment. Prepare the required raw materials and reagents, such as benzene compounds containing corresponding substituents, reagents such as halogenating agents, hydroxymethylating reagents, etc., and ensure their purity and quality.
In the reaction vessel, add benzene containing specific substituents in a certain proportion. If you want to introduce hydroxymethyl, you can choose a suitable hydroxymethylating reagent, such as formaldehyde and the corresponding catalyst, at a suitable temperature and reaction conditions, to promote the hydroxymethylation reaction at a specific position on the benzene ring. When reacting, it is necessary to pay close attention to temperature changes, and use a water or oil bath to precisely control the temperature to make the reaction proceed smoothly.
After the hydroxymethylation step is completed, the intermediate product containing hydroxymethyl is obtained through purification, separation and other operations. Next, for the introduction of chlorine atoms, select a suitable halogenating agent, such as thionyl chloride or chlorine gas, and match it with a suitable catalyst to adjust the reaction conditions, such as temperature and reaction time, so that the intermediate product undergoes halogenation reaction, and chlorine atoms are successfully introduced at the designated position. This process also requires careful control of the reaction conditions to prevent side reactions from occurring.
Finally, trifluoromethyl is introduced. A specific trifluoromethylation reagent can be used. According to its reaction characteristics, under the action of a suitable solvent and catalyst, the intermediate product can be further reacted to connect the trifluoromethyl to the corresponding position of the benzene ring. After the reaction, a series of post-processing operations, such as extraction, distillation, recrystallization, etc., can obtain high-purity 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene products. The whole preparation process requires fine operation and strict control of the reaction conditions of each step to ensure the yield and quality of the product.
First take an appropriate reaction vessel, wash and dry to ensure an anhydrous and oxygen-free environment. Prepare the required raw materials and reagents, such as benzene compounds containing corresponding substituents, reagents such as halogenating agents, hydroxymethylating reagents, etc., and ensure their purity and quality.
In the reaction vessel, add benzene containing specific substituents in a certain proportion. If you want to introduce hydroxymethyl, you can choose a suitable hydroxymethylating reagent, such as formaldehyde and the corresponding catalyst, at a suitable temperature and reaction conditions, to promote the hydroxymethylation reaction at a specific position on the benzene ring. When reacting, it is necessary to pay close attention to temperature changes, and use a water or oil bath to precisely control the temperature to make the reaction proceed smoothly.
After the hydroxymethylation step is completed, the intermediate product containing hydroxymethyl is obtained through purification, separation and other operations. Next, for the introduction of chlorine atoms, select a suitable halogenating agent, such as thionyl chloride or chlorine gas, and match it with a suitable catalyst to adjust the reaction conditions, such as temperature and reaction time, so that the intermediate product undergoes halogenation reaction, and chlorine atoms are successfully introduced at the designated position. This process also requires careful control of the reaction conditions to prevent side reactions from occurring.
Finally, trifluoromethyl is introduced. A specific trifluoromethylation reagent can be used. According to its reaction characteristics, under the action of a suitable solvent and catalyst, the intermediate product can be further reacted to connect the trifluoromethyl to the corresponding position of the benzene ring. After the reaction, a series of post-processing operations, such as extraction, distillation, recrystallization, etc., can obtain high-purity 2- (hydroxymethyl) -4-chloro-1- (trifluoromethyl) benzene products. The whole preparation process requires fine operation and strict control of the reaction conditions of each step to ensure the yield and quality of the product.
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