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Benzene, 2-Chloro-4-Methoxy-1-Methyl-
Linshang Chemical
|
HS Code |
683636 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.61 g/mol |
| Appearance | Solid (predicted from structure) |
| Boiling Point | Estimated around 230 - 250 °C (predicted from structure) |
| Melting Point | Estimated (no common experimental data, prediction difficult without more data) |
| Density | Estimated around 1.1 - 1.2 g/cm³ (predicted from similar compounds) |
| Solubility In Water | Low solubility (hydrophobic due to non - polar benzene ring) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, chloroform |
| Vapor Pressure | Low vapor pressure (non - volatile solid, predicted) |
| Stability | Stable under normal conditions, may react with strong oxidizing or reducing agents |
As an accredited Benzene, 2-Chloro-4-Methoxy-1-Methyl- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - methoxy - 1 - methyl - benzene in a sealed, labeled chemical container. |
| Storage | Store “Benzene, 2 - chloro - 4 - methoxy - 1 - methyl -” in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container to prevent vapor leakage. As it is a potentially hazardous chemical, store it separately from oxidizing agents, acids, and bases, and ensure proper labeling for easy identification and safety compliance. |
| Shipping | The chemical "Benzene, 2 - chloro - 4 - methoxy - 1 - methyl -" should be shipped in tightly sealed, corrosion - resistant containers. Follow proper hazardous material shipping regulations, ensuring proper labeling for safe and compliant transportation. |
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Benzene, what's the chemistry of 2-chloro-4-methoxy-1-methyl-?
2-Chloro-4-methoxy-1-methylbenzene is an organic compound with unique chemical properties and typical properties of aromatic hydrocarbons.
First of all, this compound contains a benzene ring and has high stability because the benzene ring has a conjugated large π bond. In case of electrophilic reagents, electrophilic substitution reactions are prone to occur. Because of the presence of methyl, methoxy and chlorine atoms on the benzene ring, these substituents have an impact on the activity and position of the electrophilic substitution reaction. Methyl and methoxy are the power supply groups, which can increase the electron cloud density of the benzene ring, make the benzene ring more active, and are easily attacked by electrophilic reagents Although the chlorine atom is an electron-withdrawing group, it also has a specific guiding effect on the reaction due to its p-π conjugation effect.
Taking the nitrification reaction as an example, the electron cloud density of the adjacent and para-position between methyl and methoxy groups is relatively high, and the electrophilic reagent nitro positive ion is easy to attack these positions, generating products that introduce nitro groups into the adjacent and para-position of methyl or methoxy groups.
In the halogenation reaction, it is also affected by the substituent group and selectively introduces halogen atoms at specific positions. And because the chlorine atoms are connected, the compound may participate in some reactions involving carbon-chlorine bonds. For example, under suitable conditions, the carbon-chlorine bond can be substituted and replaced by other nucleophiles to generate new organic compounds.
In addition, the oxygen atom in the methoxy group has lone pair electrons, which can participate in some coordination or weak interaction-related reactions. Methyl groups can undergo some oxidation and other reactions. Under specific conditions, methyl groups can be oxidized to carboxyl and other functional groups.
In short, the chemical properties of 2-chloro-4-methoxy-1-methylbenzene are determined by its phenyl ring and various substituents, and have a variety of reaction performances and application potential in organic synthesis and other fields.
First of all, this compound contains a benzene ring and has high stability because the benzene ring has a conjugated large π bond. In case of electrophilic reagents, electrophilic substitution reactions are prone to occur. Because of the presence of methyl, methoxy and chlorine atoms on the benzene ring, these substituents have an impact on the activity and position of the electrophilic substitution reaction. Methyl and methoxy are the power supply groups, which can increase the electron cloud density of the benzene ring, make the benzene ring more active, and are easily attacked by electrophilic reagents Although the chlorine atom is an electron-withdrawing group, it also has a specific guiding effect on the reaction due to its p-π conjugation effect.
Taking the nitrification reaction as an example, the electron cloud density of the adjacent and para-position between methyl and methoxy groups is relatively high, and the electrophilic reagent nitro positive ion is easy to attack these positions, generating products that introduce nitro groups into the adjacent and para-position of methyl or methoxy groups.
In the halogenation reaction, it is also affected by the substituent group and selectively introduces halogen atoms at specific positions. And because the chlorine atoms are connected, the compound may participate in some reactions involving carbon-chlorine bonds. For example, under suitable conditions, the carbon-chlorine bond can be substituted and replaced by other nucleophiles to generate new organic compounds.
In addition, the oxygen atom in the methoxy group has lone pair electrons, which can participate in some coordination or weak interaction-related reactions. Methyl groups can undergo some oxidation and other reactions. Under specific conditions, methyl groups can be oxidized to carboxyl and other functional groups.
In short, the chemical properties of 2-chloro-4-methoxy-1-methylbenzene are determined by its phenyl ring and various substituents, and have a variety of reaction performances and application potential in organic synthesis and other fields.
Benzene, what are the physical properties of 2-chloro-4-methoxy-1-methyl-?
2-Chloro-4-methoxy-1-methylbenzene is an organic compound. Its physical properties are crucial and related to many practical applications.
Looking at its properties, under room temperature and pressure, it is mostly liquid, with a specific flowing state, like smart water, but not water. Its color is often colorless or slightly yellowish, like the shimmer of morning light, pure and slightly blurred.
Smell its smell and emit a fragrant smell. However, this fragrance is unusually pleasant and irritating. If you are in it, your nasal cavity may feel uncomfortable, as if warning of its chemical properties.
As for the boiling point, it is about a specific temperature range. At this temperature, the liquid state will turn into a gaseous state and rise. This temperature may vary slightly due to changes in environmental pressure. Just like the boiling of water, it will change its form when it reaches a certain heat.
Melting point is also an important physical property. Under a specific low temperature, it will condense from a liquid state to a solid state, just like the solidification of life, from smart to stable.
In terms of solubility, in organic solvents, such as ethanol, ether, etc., it is quite compatible, just like a fish swimming freely in water, while in water, the solubility is very small, just like the barrier between oil and water, it is difficult to be intimate.
The density of this compound is lighter or heavier than that of water. If it is lighter than water, it floats on the water. If it is heavier than water, it sinks to the bottom of the water, just like objects of different materials are thrown into water, each with its own state.
The physical properties of this compound, like its external appearance, lay the foundation for its understanding and application, and are important guidelines in the fields of chemical industry, medicine and so on.
Looking at its properties, under room temperature and pressure, it is mostly liquid, with a specific flowing state, like smart water, but not water. Its color is often colorless or slightly yellowish, like the shimmer of morning light, pure and slightly blurred.
Smell its smell and emit a fragrant smell. However, this fragrance is unusually pleasant and irritating. If you are in it, your nasal cavity may feel uncomfortable, as if warning of its chemical properties.
As for the boiling point, it is about a specific temperature range. At this temperature, the liquid state will turn into a gaseous state and rise. This temperature may vary slightly due to changes in environmental pressure. Just like the boiling of water, it will change its form when it reaches a certain heat.
Melting point is also an important physical property. Under a specific low temperature, it will condense from a liquid state to a solid state, just like the solidification of life, from smart to stable.
In terms of solubility, in organic solvents, such as ethanol, ether, etc., it is quite compatible, just like a fish swimming freely in water, while in water, the solubility is very small, just like the barrier between oil and water, it is difficult to be intimate.
The density of this compound is lighter or heavier than that of water. If it is lighter than water, it floats on the water. If it is heavier than water, it sinks to the bottom of the water, just like objects of different materials are thrown into water, each with its own state.
The physical properties of this compound, like its external appearance, lay the foundation for its understanding and application, and are important guidelines in the fields of chemical industry, medicine and so on.
Benzene, what are the common uses of 2-chloro-4-methoxy-1-methyl-?
To prepare 2-chloro-4-methoxy-1-methylbenzene, there are several common methods as follows.
One can be started from 1-methyl-4-methoxylbenzene. In this compound, both methyl and methoxy groups are electron donor groups, which can increase the electron cloud density of the benzene ring and make the benzene ring more prone to electrophilic substitution. With chlorine as the chlorine source, under the action of an appropriate catalyst, such as ferric chloride, chlorine gas isoclasts into chlorine positive ions, which attack the benzene ring as an electrophilic agent. Due to the positioning effect of methyl and methoxy groups, both are ortho and para-sites. Under the combined influence, chlorine positive ions are more inclined to attack methoxy para-sites and methyl ortho-sites, so that the target product 2-chloro-4-methoxy-1-methylbenzene can be obtained. This reaction condition is relatively mild and the operation is relatively simple. However, it is necessary to pay attention to the toxicity and corrosiveness of chlorine gas. Protective measures must be taken during the operation.
Second, 1-chloro-2-methylbenzene can also be used as the starting material. Methoxy is first introduced through the Fu-gram alkylation reaction. Using sodium methoxide as a methoxylation reagent, in an appropriate solvent, the methoxy negative ion of sodium methoxide attacks the benzene ring of 1-chloro-2-methylbenzene, and a nucleophilic substitution reaction occurs. Since methyl is an ortho-and para-localization group, methoxy preferentially replaces the ortho or para-position of the chlorine atom, and the methoxy group can be conditionally regulated to mainly introduce the para-position of the chlorine atom to obtain 2-chloro-4-methoxy-1-methylbenzene. This approach requires attention to the choice of reaction solvent, which should ensure that it is stable to the methoxylation reagent and conducive to the reaction.
Furthermore, the target molecule can also be constructed through multi-step reaction. First, suitable substituted phenylboronic acids are prepared, and then different substituents are gradually introduced into the benzene ring by coupling reactions such as Suzuki reaction. For example, phenylboronic acid containing methyl and boric acid groups, and halogenated aromatics containing chlorine and methoxy groups are prepared, and the coupling reaction occurs under the action of palladium catalyst. Although this method is a little complicated, it has high selectivity for substrates, can accurately construct the structure of the target product, and can effectively avoid some side reactions. It is suitable for situations where the purity of the product is required.
One can be started from 1-methyl-4-methoxylbenzene. In this compound, both methyl and methoxy groups are electron donor groups, which can increase the electron cloud density of the benzene ring and make the benzene ring more prone to electrophilic substitution. With chlorine as the chlorine source, under the action of an appropriate catalyst, such as ferric chloride, chlorine gas isoclasts into chlorine positive ions, which attack the benzene ring as an electrophilic agent. Due to the positioning effect of methyl and methoxy groups, both are ortho and para-sites. Under the combined influence, chlorine positive ions are more inclined to attack methoxy para-sites and methyl ortho-sites, so that the target product 2-chloro-4-methoxy-1-methylbenzene can be obtained. This reaction condition is relatively mild and the operation is relatively simple. However, it is necessary to pay attention to the toxicity and corrosiveness of chlorine gas. Protective measures must be taken during the operation.
Second, 1-chloro-2-methylbenzene can also be used as the starting material. Methoxy is first introduced through the Fu-gram alkylation reaction. Using sodium methoxide as a methoxylation reagent, in an appropriate solvent, the methoxy negative ion of sodium methoxide attacks the benzene ring of 1-chloro-2-methylbenzene, and a nucleophilic substitution reaction occurs. Since methyl is an ortho-and para-localization group, methoxy preferentially replaces the ortho or para-position of the chlorine atom, and the methoxy group can be conditionally regulated to mainly introduce the para-position of the chlorine atom to obtain 2-chloro-4-methoxy-1-methylbenzene. This approach requires attention to the choice of reaction solvent, which should ensure that it is stable to the methoxylation reagent and conducive to the reaction.
Furthermore, the target molecule can also be constructed through multi-step reaction. First, suitable substituted phenylboronic acids are prepared, and then different substituents are gradually introduced into the benzene ring by coupling reactions such as Suzuki reaction. For example, phenylboronic acid containing methyl and boric acid groups, and halogenated aromatics containing chlorine and methoxy groups are prepared, and the coupling reaction occurs under the action of palladium catalyst. Although this method is a little complicated, it has high selectivity for substrates, can accurately construct the structure of the target product, and can effectively avoid some side reactions. It is suitable for situations where the purity of the product is required.
Benzene, what is 2-chloro-4-methoxy-1-methyl- synthesis?
To prepare 2-chloro-4-methoxy-1-methylbenzene, the following ancient method can be used.
First take toluene as the starting material, because its methyl group is an ortho-para-localization group, which has the effect of activating the benzene ring. Sulfuric acid and nitric acid are mixed to form a mixed acid to nitrate toluene. In this reaction, nitric acid generates nitroyl positive ions under the action of sulfuric acid, which is an electrophilic agent to attack the toluene ring. Due to the localization effect of methyl groups, o-nitrotoluene and p-nitrotoluene are mainly generated. After separation, p-nitrotoluene can be obtained.
Then, p-nitrotoluene is chlorinated. In the presence of a suitable catalyst such as ferric chloride, chlorine gas is introduced. Due to the interaction of nitro as a meta-site group and methyl as an o-para-site group, the chlorine atom mainly replaces the hydrogen in the ortho-site of methyl (in the meta-position with the nitro group) to obtain 2-chloro-4-nitrotoluene.
Then 2-chloro-4-nitrotoluene is reduced to nitro. A reduction system such as iron powder and hydrochloric acid can be used to convert the nitro group into an amino group to obtain 2-chloro-4-aminotoluene. After
, 2-chloro-4-aminotoluene is diazotized. After treatment with sodium nitrite and hydrochloric acid at low temperature, the amino group is converted into a diazonium salt. The diazonium salt is active in nature, and then interacts with sodium methanol solution. The diazonium group is replaced by methoxy group to obtain 2-chloro-4-methoxy-1-methylbenzene.
During the whole synthesis process, attention should be paid to the control of the conditions of each step of the reaction, such as temperature, reagent dosage, reaction time, etc., and the separation and purification of each step is also the key, so that the target product can be obtained.
First take toluene as the starting material, because its methyl group is an ortho-para-localization group, which has the effect of activating the benzene ring. Sulfuric acid and nitric acid are mixed to form a mixed acid to nitrate toluene. In this reaction, nitric acid generates nitroyl positive ions under the action of sulfuric acid, which is an electrophilic agent to attack the toluene ring. Due to the localization effect of methyl groups, o-nitrotoluene and p-nitrotoluene are mainly generated. After separation, p-nitrotoluene can be obtained.
Then, p-nitrotoluene is chlorinated. In the presence of a suitable catalyst such as ferric chloride, chlorine gas is introduced. Due to the interaction of nitro as a meta-site group and methyl as an o-para-site group, the chlorine atom mainly replaces the hydrogen in the ortho-site of methyl (in the meta-position with the nitro group) to obtain 2-chloro-4-nitrotoluene.
Then 2-chloro-4-nitrotoluene is reduced to nitro. A reduction system such as iron powder and hydrochloric acid can be used to convert the nitro group into an amino group to obtain 2-chloro-4-aminotoluene. After
, 2-chloro-4-aminotoluene is diazotized. After treatment with sodium nitrite and hydrochloric acid at low temperature, the amino group is converted into a diazonium salt. The diazonium salt is active in nature, and then interacts with sodium methanol solution. The diazonium group is replaced by methoxy group to obtain 2-chloro-4-methoxy-1-methylbenzene.
During the whole synthesis process, attention should be paid to the control of the conditions of each step of the reaction, such as temperature, reagent dosage, reaction time, etc., and the separation and purification of each step is also the key, so that the target product can be obtained.
Benzene, 2-chloro-4-methoxy-1-methyl- in what areas
2-Chloro-4-methoxy-1-methylbenzene, which has a wide range of uses, is often used as a key intermediate in the field of medicine and chemical industry. In the pharmaceutical industry, it can use its unique structure to synthesize specific drugs through a series of delicate reactions. For example, based on it, or specific active molecules can be constructed, which has great potential for the treatment of certain diseases.
In the field of materials science, it is also useful. It can be chemically modified to give it special properties, or used to create new organic materials. In optics, electrical materials, etc., it can show excellent properties and contribute to material innovation.
Furthermore, in the field of fine chemicals, it can be used as an important raw material for the synthesis of fine chemicals such as fragrances and dyes. With its chemical properties, it can derive a variety of structures, endow products with unique color and aroma, and improve the quality and diversity of fine chemical products. It has potential applications in daily chemical, textile printing and dyeing and other industries to help industry product upgrades.
In the field of materials science, it is also useful. It can be chemically modified to give it special properties, or used to create new organic materials. In optics, electrical materials, etc., it can show excellent properties and contribute to material innovation.
Furthermore, in the field of fine chemicals, it can be used as an important raw material for the synthesis of fine chemicals such as fragrances and dyes. With its chemical properties, it can derive a variety of structures, endow products with unique color and aroma, and improve the quality and diversity of fine chemical products. It has potential applications in daily chemical, textile printing and dyeing and other industries to help industry product upgrades.
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