Linshang Chemical
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Benzene, 2-Chloro-4-Nitro-1-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
408037 |
| Chemical Formula | C7H3ClF3NO2 |
| Molar Mass | 239.55 g/mol |
| Appearance | Solid (predicted) |
| Boiling Point | Estimated around 260 - 280 °C |
| Solubility In Water | Very low solubility |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Estimated around 1.6 - 1.7 g/cm³ |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Estimated to be relatively high, > 100 °C |
As an accredited Benzene, 2-Chloro-4-Nitro-1-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - chloro - 4 - nitro - 1 - (trifluoromethyl)benzene in a sealed, labeled chemical bottle. |
| Storage | 2 - chloro - 4 - nitro - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials due to its chemical nature. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
| Shipping | For the chemical "Benzene, 2 - chloro - 4 - nitro - 1 - (trifluoromethyl)-", it must be shipped in accordance with hazardous chemical regulations. Use proper containers, label clearly, and ensure compliance with safety and transportation standards. |
Competitive Benzene, 2-Chloro-4-Nitro-1-(Trifluoromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of this product 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
This substance is called 2-chloro-4-cyano-1 - (triethoxy) benzyl, and its chemical properties are quite complex and unique.
In the nucleophilic substitution reaction, this substance exhibits unique activity. Due to its molecular structure, chlorine atoms are connected to the benzene ring, and are affected by the electron cloud of the benzene ring, the activity of chlorine atoms can be improved, and it is more vulnerable to nucleophilic attack, which triggers nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be successfully replaced by other groups to form a series of derived compounds. This property is widely used in the field of organic synthesis and can be used to prepare organic compounds with various functions.
The cyanyl group in this substance cannot be ignored either. The cyanyl group has strong electron-absorbing properties, which can significantly affect the electron cloud density distribution of the benzene ring, resulting in a decrease in the density of the electron cloud of the benzene ring. This property not only affects its chemical activity, but also in some reactions, the cyanyl group itself can participate in the reaction, such as conversion to carboxyl group by hydrolysis reaction, or conversion to amine group by reduction reaction, which can greatly enrich the structural and functional diversity of the compound.
In addition, the triethoxy benzyl group part also plays an important role in the chemical properties of the whole molecule. The presence of ethoxy group can increase the lipid solubility of the molecule and affect its solubility in different solvents, which is related to the feasibility of the reaction and the separation and purification of the product in organic synthesis and drug development. At the same time, the structure of triethoxy benzyl is relatively stable, and it can provide a certain steric hindrance effect for the molecule under some reaction conditions, which affects the selectivity of the reaction and determines the direction of the main product of the reaction.
In terms of redox reactions, some groups in the substance can participate in it. For example, cyano groups can be reduced under the action of specific strong reducing agents, while benzene rings may also undergo oxidation reactions under suitable oxidizing agents and conditions to form quinones or phenolic compounds. These redox reactions further enrich their chemical properties and reaction pathways, providing many possibilities for their applications in organic synthesis and materials science.
In the nucleophilic substitution reaction, this substance exhibits unique activity. Due to its molecular structure, chlorine atoms are connected to the benzene ring, and are affected by the electron cloud of the benzene ring, the activity of chlorine atoms can be improved, and it is more vulnerable to nucleophilic attack, which triggers nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, chlorine atoms can be successfully replaced by other groups to form a series of derived compounds. This property is widely used in the field of organic synthesis and can be used to prepare organic compounds with various functions.
The cyanyl group in this substance cannot be ignored either. The cyanyl group has strong electron-absorbing properties, which can significantly affect the electron cloud density distribution of the benzene ring, resulting in a decrease in the density of the electron cloud of the benzene ring. This property not only affects its chemical activity, but also in some reactions, the cyanyl group itself can participate in the reaction, such as conversion to carboxyl group by hydrolysis reaction, or conversion to amine group by reduction reaction, which can greatly enrich the structural and functional diversity of the compound.
In addition, the triethoxy benzyl group part also plays an important role in the chemical properties of the whole molecule. The presence of ethoxy group can increase the lipid solubility of the molecule and affect its solubility in different solvents, which is related to the feasibility of the reaction and the separation and purification of the product in organic synthesis and drug development. At the same time, the structure of triethoxy benzyl is relatively stable, and it can provide a certain steric hindrance effect for the molecule under some reaction conditions, which affects the selectivity of the reaction and determines the direction of the main product of the reaction.
In terms of redox reactions, some groups in the substance can participate in it. For example, cyano groups can be reduced under the action of specific strong reducing agents, while benzene rings may also undergo oxidation reactions under suitable oxidizing agents and conditions to form quinones or phenolic compounds. These redox reactions further enrich their chemical properties and reaction pathways, providing many possibilities for their applications in organic synthesis and materials science.
What are the main uses of 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
2 + -Amino-4-amino-1- (triethylamino) naphthalene, this is a class of organic compounds with a wide range of uses and important functions in many fields.
In the field of medicinal chemistry, this compound can be used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can combine with other molecules through specific chemical reactions to construct drug molecules with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs or anti-tumor drugs, 2 + -ammonia-4-amino-1- (triethylamino) naphthalene can participate in the key link. By modifying and modifying its structure, the final drug is endowed with good biological activity, pharmacokinetic properties and targeting, thereby improving drug efficacy and reducing adverse reactions.
In the field of materials science, it also shows unique advantages. It can be used to prepare functional polymer materials, such as optoelectronic materials. Because its structure contains specific functional groups, it can endow the material with special optical or electrical properties. Introducing it into the polymer system can make the material have fluorescence properties, which can be used in the fields of Light Emitting Diode, fluorescence sensors and so on. The special structure of this compound can affect the charge transport properties of the material, and it is expected to develop high-performance organic semiconductor materials for electronic devices such as organic field effect transistors.
In dye chemistry, 2 + -ammonia-4-amino-1- (triethylamino) naphthalene also has a place. It can be used as a raw material for the synthesis of new dyes. Because the molecular structure can absorb specific wavelengths of light, after appropriate modification, it can develop dyes with bright colors and good stability. Such dyes can be used in the textile printing and dyeing industry to make fabrics have good dye fastness and bright color; they can also be used in ink manufacturing and other fields to meet different printing needs. With its unique chemical structure, 2 + -ammonia-4-amino-1- (triethylamino) naphthalene plays an indispensable role in many fields such as medicine, materials, dyes, etc. It provides important material basis and technical support for the development of related fields.
In the field of medicinal chemistry, this compound can be used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can combine with other molecules through specific chemical reactions to construct drug molecules with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs or anti-tumor drugs, 2 + -ammonia-4-amino-1- (triethylamino) naphthalene can participate in the key link. By modifying and modifying its structure, the final drug is endowed with good biological activity, pharmacokinetic properties and targeting, thereby improving drug efficacy and reducing adverse reactions.
In the field of materials science, it also shows unique advantages. It can be used to prepare functional polymer materials, such as optoelectronic materials. Because its structure contains specific functional groups, it can endow the material with special optical or electrical properties. Introducing it into the polymer system can make the material have fluorescence properties, which can be used in the fields of Light Emitting Diode, fluorescence sensors and so on. The special structure of this compound can affect the charge transport properties of the material, and it is expected to develop high-performance organic semiconductor materials for electronic devices such as organic field effect transistors.
In dye chemistry, 2 + -ammonia-4-amino-1- (triethylamino) naphthalene also has a place. It can be used as a raw material for the synthesis of new dyes. Because the molecular structure can absorb specific wavelengths of light, after appropriate modification, it can develop dyes with bright colors and good stability. Such dyes can be used in the textile printing and dyeing industry to make fabrics have good dye fastness and bright color; they can also be used in ink manufacturing and other fields to meet different printing needs. With its unique chemical structure, 2 + -ammonia-4-amino-1- (triethylamino) naphthalene plays an indispensable role in many fields such as medicine, materials, dyes, etc. It provides important material basis and technical support for the development of related fields.
What is the production method of 2-chloro-4-nitro-1 - (trifluoromethyl) benzene?
To prepare 2-cyanogen-4-amino-1- (triethoxy) benzene, the following ancient method can be used.
First take an appropriate amount of starting materials, when it contains a benzene ring and has a modifiable check point compound is appropriate. Take benzene as the group and introduce the desired group in sequence.
The first cyanide group is often used for nucleophilic substitution. Choose a suitable halogenated benzene derivative, such as a halogen atom attached to a specific position of the benzene ring, and mix it with a cyanide reagent, such as potassium cyanide or sodium cyanide, in a suitable solvent, such as dimethyl sulfoxide (DMSO), heat and stir. In this process, the cyanide anion nucleophilic attack halogen atom of halogenated benzene attached to the carbon site, the halogen atom away, then obtained benzene derivatives containing cyanide groups. It is necessary to carefully check the reaction conditions, the temperature should not be too high or too low, too high will be a cluster of side reactions, too low will slow the reaction, generally temperature control between tens of degrees Celsius, depending on the specific reactants.
Then add the amino group. Usually by nitro reduction method. In cyanogen-containing benzene derivatives, mixed acid of concentrated nitric acid and concentrated sulfuric acid is treated at low temperature (such as 0-10 ° C) to introduce nitro groups into the specific position of the benzene ring. Then the nitro group is converted into amino group by reduction means. Iron and hydrochloric acid system can be selected, or hydrogen can be reduced under palladium carbon catalysis. In the iron and hydrochloric acid system, iron is the reducing agent, and the nitro group is gradually reduced to amino group. This reaction is mild, but the post-treatment is slightly more complex. Hydrogen is reduced under palladium carbon catalysis, and the conditions are relatively clean and the yield is also good. However, attention should be paid to the safe use of hydrogen.
Finally, triethoxy is introduced. Choose a suitable alcohol, such as ethanol, and react with benzene derivatives containing cyanide groups and amino groups under acid catalysis or base catalysis. When acid catalysis is used, such as strong acids such as sulfuric acid or strong bases such as sodium hydride, the ethoxy group of ethanol is substituted for the appropriate leaving group at a specific position of the benzene ring to obtain 2-cyano- 4-amino-1 - (triethoxy) benzene. After the reaction is completed, the pure product is obtained by conventional separation and purification methods, such as extraction, column chromatography, etc.
First take an appropriate amount of starting materials, when it contains a benzene ring and has a modifiable check point compound is appropriate. Take benzene as the group and introduce the desired group in sequence.
The first cyanide group is often used for nucleophilic substitution. Choose a suitable halogenated benzene derivative, such as a halogen atom attached to a specific position of the benzene ring, and mix it with a cyanide reagent, such as potassium cyanide or sodium cyanide, in a suitable solvent, such as dimethyl sulfoxide (DMSO), heat and stir. In this process, the cyanide anion nucleophilic attack halogen atom of halogenated benzene attached to the carbon site, the halogen atom away, then obtained benzene derivatives containing cyanide groups. It is necessary to carefully check the reaction conditions, the temperature should not be too high or too low, too high will be a cluster of side reactions, too low will slow the reaction, generally temperature control between tens of degrees Celsius, depending on the specific reactants.
Then add the amino group. Usually by nitro reduction method. In cyanogen-containing benzene derivatives, mixed acid of concentrated nitric acid and concentrated sulfuric acid is treated at low temperature (such as 0-10 ° C) to introduce nitro groups into the specific position of the benzene ring. Then the nitro group is converted into amino group by reduction means. Iron and hydrochloric acid system can be selected, or hydrogen can be reduced under palladium carbon catalysis. In the iron and hydrochloric acid system, iron is the reducing agent, and the nitro group is gradually reduced to amino group. This reaction is mild, but the post-treatment is slightly more complex. Hydrogen is reduced under palladium carbon catalysis, and the conditions are relatively clean and the yield is also good. However, attention should be paid to the safe use of hydrogen.
Finally, triethoxy is introduced. Choose a suitable alcohol, such as ethanol, and react with benzene derivatives containing cyanide groups and amino groups under acid catalysis or base catalysis. When acid catalysis is used, such as strong acids such as sulfuric acid or strong bases such as sodium hydride, the ethoxy group of ethanol is substituted for the appropriate leaving group at a specific position of the benzene ring to obtain 2-cyano- 4-amino-1 - (triethoxy) benzene. After the reaction is completed, the pure product is obtained by conventional separation and purification methods, such as extraction, column chromatography, etc.
What are the precautions for storing and transporting 2-chloro-4-nitro-1- (trifluoromethyl) benzene?
2 + -Tritium-4-amino-1- (triethylamino) quinoline This material requires careful attention during storage and transportation.
When storing, choose the first environment. You should find a cool, dry and well-ventilated place. Tritium is radioactive. If the environmental humidity is too high, or it causes packaging rust, the risk of radioactive material leakage will increase greatly; if the temperature is too high, the stability of the material will be damaged, or chemical reactions will occur for no reason. Be sure to keep away from fire and heat sources. This material may be flammable. In case of open flames, hot topics, or trigger combustion or even explosion, endangering the safety of the surrounding area.
Furthermore, the storage area needs to be separated from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances, or severe chemical reactions, the consequences are unimaginable. At the same time, the storage area should be set up with obvious warning signs, indicating the characteristics and hazards of the substances, so that everyone who is close can be alert.
When transporting, the packaging must be solid and reliable. Choose packaging materials that meet the standards for transporting radioactive substances to ensure that the packaging is not damaged in the case of bumps, collisions, etc. The transportation process must strictly follow the established route and time, and must not be changed without authorization. Transportation personnel should be professionally trained to be familiar with the characteristics, hazards and emergency treatment methods of this substance. Transportation vehicles also need to be equipped with corresponding emergency equipment and protective equipment, just in case.
Pay close attention to the transportation situation on the way. If any abnormalities in the packaging are detected, such as leakage or damage, emergency measures should be taken immediately to evacuate the surrounding people, seal the scene, and quickly report to the relevant departments. Do not slack off to ensure the safety of the whole transportation process.
When storing, choose the first environment. You should find a cool, dry and well-ventilated place. Tritium is radioactive. If the environmental humidity is too high, or it causes packaging rust, the risk of radioactive material leakage will increase greatly; if the temperature is too high, the stability of the material will be damaged, or chemical reactions will occur for no reason. Be sure to keep away from fire and heat sources. This material may be flammable. In case of open flames, hot topics, or trigger combustion or even explosion, endangering the safety of the surrounding area.
Furthermore, the storage area needs to be separated from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances, or severe chemical reactions, the consequences are unimaginable. At the same time, the storage area should be set up with obvious warning signs, indicating the characteristics and hazards of the substances, so that everyone who is close can be alert.
When transporting, the packaging must be solid and reliable. Choose packaging materials that meet the standards for transporting radioactive substances to ensure that the packaging is not damaged in the case of bumps, collisions, etc. The transportation process must strictly follow the established route and time, and must not be changed without authorization. Transportation personnel should be professionally trained to be familiar with the characteristics, hazards and emergency treatment methods of this substance. Transportation vehicles also need to be equipped with corresponding emergency equipment and protective equipment, just in case.
Pay close attention to the transportation situation on the way. If any abnormalities in the packaging are detected, such as leakage or damage, emergency measures should be taken immediately to evacuate the surrounding people, seal the scene, and quickly report to the relevant departments. Do not slack off to ensure the safety of the whole transportation process.
What are the effects of 2-chloro-4-nitro-1- (trifluoromethyl) benzene on the environment and human health?
2 + -Hydroxy- 4 -amino-1- (triethylamino) naphthalene This substance has an impact on both the environment and human health.
It may exist in water bodies and soils for the environment. If it enters water bodies, it can cause water pollution and affect the survival and reproduction of aquatic organisms. Aquatic organisms enrich it, or pass through the food chain, amplify it, causing higher nutrient level organisms to be affected. In the soil, it may affect the community structure and function of soil microorganisms, hinder the material cycle and energy conversion of soil ecosystems, and then affect plant growth.
In terms of human health, this substance may be ingested into the human body through respiration, skin contact, and diet. After entering the body, it may interfere with the normal physiological functions of the human body. Active groups such as amino groups and hydroxyl groups may react with human biological macromolecules, such as proteins and nucleic acids, resulting in changes in their structure and function. Long-term exposure may damage the human nervous system, causing headaches, dizziness, fatigue, etc.; or affect the immune system, causing the body's immunity to decline and susceptible to diseases; it may also have potential carcinogenicity, and long-term exposure will increase the risk of cancer.
Therefore, the impact of such substances on the environment and human health should be taken seriously, and corresponding measures should be taken to reduce their emissions and exposure, so as to protect the ecological environment and human health.
It may exist in water bodies and soils for the environment. If it enters water bodies, it can cause water pollution and affect the survival and reproduction of aquatic organisms. Aquatic organisms enrich it, or pass through the food chain, amplify it, causing higher nutrient level organisms to be affected. In the soil, it may affect the community structure and function of soil microorganisms, hinder the material cycle and energy conversion of soil ecosystems, and then affect plant growth.
In terms of human health, this substance may be ingested into the human body through respiration, skin contact, and diet. After entering the body, it may interfere with the normal physiological functions of the human body. Active groups such as amino groups and hydroxyl groups may react with human biological macromolecules, such as proteins and nucleic acids, resulting in changes in their structure and function. Long-term exposure may damage the human nervous system, causing headaches, dizziness, fatigue, etc.; or affect the immune system, causing the body's immunity to decline and susceptible to diseases; it may also have potential carcinogenicity, and long-term exposure will increase the risk of cancer.
Therefore, the impact of such substances on the environment and human health should be taken seriously, and corresponding measures should be taken to reduce their emissions and exposure, so as to protect the ecological environment and human health.
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