Linshang Chemical
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Benzene, (2-Chloroethoxy)-
Linshang Chemical
|
HS Code |
240442 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.61 g/mol |
| Solubility In Water | Low solubility, as benzene - based compounds are generally hydrophobic |
| Stability | Can be reactive under certain conditions, especially towards nucleophiles due to the chloroethoxy group |
As an accredited Benzene, (2-Chloroethoxy)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial packaging for (2 - chloroethoxy) - benzene chemical. |
| Storage | **Storage of (2 - chloroethoxy)benzene**: Store (2 - chloroethoxy)benzene in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Isolate it from oxidizing agents and incompatible substances. Label the storage clearly for easy identification and safety compliance. |
| Shipping | The chemical "(2 - chloroethoxy) - benzene" is shipped in accordance with strict hazardous material regulations. It's carefully packaged in appropriate containers to prevent leakage, and transported by carriers licensed for such chemicals. |
Competitive Benzene, (2-Chloroethoxy)- prices that fit your budget—flexible terms and customized quotes for every order.
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Benzene, (2-chloroethoxy) - what are the chemical properties
(2-Chloroethoxy) benzene is also an organic compound. Its chemical properties are particularly important and are widely used in the field of organic synthesis.
First of all, its physical properties, (2-chloroethoxy) benzene at room temperature, mostly colorless to pale yellow liquid shape, with a special smell. Its boiling point, melting point and other physical constants are specific due to the binding mode and interaction of atoms in the molecule, which is the key basis for separation, purification and identification.
When it comes to chemical activity, the existence of benzene rings lays the foundation for its properties. Benzene rings have a conjugated system and are rich in electron cloud density, so they are vulnerable to attack by electrophilic reagents. ( 2-Chloroethoxy) substituents also affect the electron cloud distribution of the benzene ring. The chlorine atom has an electron-absorbing effect, which reduces the electron cloud density of the benzene ring. In the electrophilic substitution reaction, the reactivity may change compared with benzene. And the chlorine atom can undergo nucleophilic substitution reaction under suitable conditions, which is one of the important reaction pathways of this compound.
In the electrophilic substitution reaction, (2-chloroethoxy) benzene can interact with electrophilic reagents such as bromine and nitric acid. Due to the positioning effect of the substituent, the reaction check point is selected. (2-chloroethoxy) is an ortho-and para-site group, and the ortho-and para-site substitution products are dominant in the reaction products.
In the nucleophilic substitution reaction, the chlorine atom can be replaced by nucleophiles such as hydroxyl groups and amino groups to form corresponding ether or amine derivatives. This reaction requires suitable reaction conditions, such as the presence of bases, appropriate temperatures and solvents.
In addition, the chemical properties of (2-chloroethoxy) benzene are also restricted by environmental factors. The reaction rate is accelerated when the temperature increases; the polarity and properties of the solvent affect the reaction mechanism and rate.
(2-chloroethoxy) benzene has complex and diverse chemical properties. In the field of organic synthesis chemistry, due to its unique reactive properties, it can prepare many organic compounds with special functions and is widely used in medicine, materials and other industries.
First of all, its physical properties, (2-chloroethoxy) benzene at room temperature, mostly colorless to pale yellow liquid shape, with a special smell. Its boiling point, melting point and other physical constants are specific due to the binding mode and interaction of atoms in the molecule, which is the key basis for separation, purification and identification.
When it comes to chemical activity, the existence of benzene rings lays the foundation for its properties. Benzene rings have a conjugated system and are rich in electron cloud density, so they are vulnerable to attack by electrophilic reagents. ( 2-Chloroethoxy) substituents also affect the electron cloud distribution of the benzene ring. The chlorine atom has an electron-absorbing effect, which reduces the electron cloud density of the benzene ring. In the electrophilic substitution reaction, the reactivity may change compared with benzene. And the chlorine atom can undergo nucleophilic substitution reaction under suitable conditions, which is one of the important reaction pathways of this compound.
In the electrophilic substitution reaction, (2-chloroethoxy) benzene can interact with electrophilic reagents such as bromine and nitric acid. Due to the positioning effect of the substituent, the reaction check point is selected. (2-chloroethoxy) is an ortho-and para-site group, and the ortho-and para-site substitution products are dominant in the reaction products.
In the nucleophilic substitution reaction, the chlorine atom can be replaced by nucleophiles such as hydroxyl groups and amino groups to form corresponding ether or amine derivatives. This reaction requires suitable reaction conditions, such as the presence of bases, appropriate temperatures and solvents.
In addition, the chemical properties of (2-chloroethoxy) benzene are also restricted by environmental factors. The reaction rate is accelerated when the temperature increases; the polarity and properties of the solvent affect the reaction mechanism and rate.
(2-chloroethoxy) benzene has complex and diverse chemical properties. In the field of organic synthesis chemistry, due to its unique reactive properties, it can prepare many organic compounds with special functions and is widely used in medicine, materials and other industries.
What are the physical properties of Benzene, (2-chloroethoxy)?
(2-Chloroethoxy) benzene is an organic compound. Its physical properties are quite unique. Looking at its properties, it is mostly a colorless to light yellow liquid at room temperature, clear and transparent, like the crystal of autumn dew. Its smell is special, emitting a unique aromatic smell of organic substances. Although it is not strong and pungent, it is also unique, which can make people feel its unique chemical charm.
When it comes to boiling point, due to the molecular structure, the boiling point of (2-chloroethoxy) benzene is in a certain range, about [X] ° C. This boiling point characteristic makes it have a specific performance in operations such as heating and separation. When the temperature gradually rises to the boiling point, it gradually changes from liquid to gaseous state, just like the rise of clouds, following the law of material state transformation.
Besides the melting point, the melting point of (2-chloroethoxy) benzene is about [X] ° C. Below the melting point, it condenses as a solid state, and the structure tends to be regular and orderly, similar to the arrangement of ice crystals.
The density of (2-chloroethoxy) benzene is also an important physical property. Compared with water, its density is about [X] g/cm ³, which is slightly greater or less than the density of water. This property determines its state when mixed with water. If the density is greater than water, it sinks at the bottom of the water, just like a stone falling into a deep pool; if it is less than water, it floats on the water surface, just like oil floating on the water.
In terms of solubility, (2-chloroethoxy) benzene is soluble in many organic solvents, such as ethanol, ether, etc., just like fish get water, and the two dissolve to form a uniform mixed system. However, its solubility in water is not good. Due to the large difference between the polarity of water molecules and the molecular structure of (2-chloroethoxy) benzene, it is difficult for the two to blend with each other, just like the incompatibility of water and fire.
In addition, (2-chloroethoxy) benzene has moderate volatility and can evaporate slowly in air. The molecules are scattered in the surrounding space and gradually diluted. This property needs to be paid attention to during storage and use.
When it comes to boiling point, due to the molecular structure, the boiling point of (2-chloroethoxy) benzene is in a certain range, about [X] ° C. This boiling point characteristic makes it have a specific performance in operations such as heating and separation. When the temperature gradually rises to the boiling point, it gradually changes from liquid to gaseous state, just like the rise of clouds, following the law of material state transformation.
Besides the melting point, the melting point of (2-chloroethoxy) benzene is about [X] ° C. Below the melting point, it condenses as a solid state, and the structure tends to be regular and orderly, similar to the arrangement of ice crystals.
The density of (2-chloroethoxy) benzene is also an important physical property. Compared with water, its density is about [X] g/cm ³, which is slightly greater or less than the density of water. This property determines its state when mixed with water. If the density is greater than water, it sinks at the bottom of the water, just like a stone falling into a deep pool; if it is less than water, it floats on the water surface, just like oil floating on the water.
In terms of solubility, (2-chloroethoxy) benzene is soluble in many organic solvents, such as ethanol, ether, etc., just like fish get water, and the two dissolve to form a uniform mixed system. However, its solubility in water is not good. Due to the large difference between the polarity of water molecules and the molecular structure of (2-chloroethoxy) benzene, it is difficult for the two to blend with each other, just like the incompatibility of water and fire.
In addition, (2-chloroethoxy) benzene has moderate volatility and can evaporate slowly in air. The molecules are scattered in the surrounding space and gradually diluted. This property needs to be paid attention to during storage and use.
Benzene, (2-chloroethoxy) - what is the main use of
(2-Chloroethoxy) benzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its structure, chloroethoxy is connected to the benzene ring, giving it unique chemical activity. It can construct more complex organic molecular structures through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc.
In the field of pharmaceutical chemistry, it may participate in the construction of drug molecules. Taking some drugs with specific biological activities as an example, the structural fragments of (2-chloroethoxy) benzene can be modified and modified to optimize the pharmacological properties of drugs, such as improving the solubility of drugs and enhancing their affinity with targets, which greatly contributes to the research and development of new drugs.
Furthermore, in the field of materials science, there is no shortage of its figures. Or it can be used as a raw material for the synthesis of special functional materials, through polymerization or other reactions, to prepare polymer materials with specific properties, such as affecting the electrical and optical properties of materials, so as to meet the special needs of materials in different fields.
In addition, in the preparation of fine chemical products, (2-chloroethoxy) benzene also plays an important role. It can be used to synthesize fine chemicals such as fragrances and dyes, giving the product unique properties and functions. In short, (2-chloroethoxy) benzene has important uses in many fields due to its unique structure and reactivity, promoting the development and progress of related fields.
In the field of pharmaceutical chemistry, it may participate in the construction of drug molecules. Taking some drugs with specific biological activities as an example, the structural fragments of (2-chloroethoxy) benzene can be modified and modified to optimize the pharmacological properties of drugs, such as improving the solubility of drugs and enhancing their affinity with targets, which greatly contributes to the research and development of new drugs.
Furthermore, in the field of materials science, there is no shortage of its figures. Or it can be used as a raw material for the synthesis of special functional materials, through polymerization or other reactions, to prepare polymer materials with specific properties, such as affecting the electrical and optical properties of materials, so as to meet the special needs of materials in different fields.
In addition, in the preparation of fine chemical products, (2-chloroethoxy) benzene also plays an important role. It can be used to synthesize fine chemicals such as fragrances and dyes, giving the product unique properties and functions. In short, (2-chloroethoxy) benzene has important uses in many fields due to its unique structure and reactivity, promoting the development and progress of related fields.
Benzene, (2-chloroethoxy) - what is the preparation method
The method for preparing (2-chloroethoxy) benzene, although not detailed in the ancient book "Tiangong Kaiwu", can now be obtained by common organic synthesis methods.
The first method is to use phenol and 2-chloroethanol as raw materials, base as catalyst, and the two can undergo nucleophilic substitution under suitable reaction conditions. The phenolic hydroxyl group of phenol is nucleophilic, and the chlorine atom of 2-chloroethanol is a good leaving group. Dissolve phenol in an appropriate amount of organic solvent, such as N, N-dimethylformamide (DMF) or dimethylsulfoxide (DMSO), add an appropriate amount of base, such as potassium carbonate or sodium hydroxide, stir well to alkalize the system. Subsequently, 2-chloroethanol is slowly added dropwise, and the reaction temperature is controlled in an appropriate range, such as 50-80 ° C, for several hours. In this process, the alkali captures the hydrogen of the phenolic hydroxyl group of phenol to form phenoxy negative ions. The phenoxy negative ions attack the α-carbon atom of 2-chloroethanol, and the chloride ions leave to obtain (2-chloroethoxy) benzene. After the reaction is completed, the unreacted raw materials, by-products and solvents are removed by conventional separation and purification methods, such as vacuum distillation, column chromatography, etc., to obtain a pure product.
The second method uses phenoxyethanol as the starting material and is prepared by chlorination reaction. Phenoxyethanol is placed in a reaction vessel and an appropriate amount of chlorination reagent is added, such as thionyl chloride or phosphorus trichloride. When thionyl chloride reacts with phenoxyethanol, the chlorine atom of thionyl chloride replaces the hydrogen of the phenoxyethanol hydroxyl group to produce (2-chloroethoxy) benzene, while by-producing sulfur dioxide and hydrogen chloride gas. The reaction is usually carried out at a lower temperature, such as 0-30 ° C, to control the reaction rate and selectivity. After the reaction is completed, the excess chlorinated reagents and by-products are removed by distillation, and then further refined, such as recrystallization or distillation, to obtain the target product.
These two methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider the availability of raw materials, cost, ease of control of reaction conditions, and purity requirements of the product, and choose the best one.
The first method is to use phenol and 2-chloroethanol as raw materials, base as catalyst, and the two can undergo nucleophilic substitution under suitable reaction conditions. The phenolic hydroxyl group of phenol is nucleophilic, and the chlorine atom of 2-chloroethanol is a good leaving group. Dissolve phenol in an appropriate amount of organic solvent, such as N, N-dimethylformamide (DMF) or dimethylsulfoxide (DMSO), add an appropriate amount of base, such as potassium carbonate or sodium hydroxide, stir well to alkalize the system. Subsequently, 2-chloroethanol is slowly added dropwise, and the reaction temperature is controlled in an appropriate range, such as 50-80 ° C, for several hours. In this process, the alkali captures the hydrogen of the phenolic hydroxyl group of phenol to form phenoxy negative ions. The phenoxy negative ions attack the α-carbon atom of 2-chloroethanol, and the chloride ions leave to obtain (2-chloroethoxy) benzene. After the reaction is completed, the unreacted raw materials, by-products and solvents are removed by conventional separation and purification methods, such as vacuum distillation, column chromatography, etc., to obtain a pure product.
The second method uses phenoxyethanol as the starting material and is prepared by chlorination reaction. Phenoxyethanol is placed in a reaction vessel and an appropriate amount of chlorination reagent is added, such as thionyl chloride or phosphorus trichloride. When thionyl chloride reacts with phenoxyethanol, the chlorine atom of thionyl chloride replaces the hydrogen of the phenoxyethanol hydroxyl group to produce (2-chloroethoxy) benzene, while by-producing sulfur dioxide and hydrogen chloride gas. The reaction is usually carried out at a lower temperature, such as 0-30 ° C, to control the reaction rate and selectivity. After the reaction is completed, the excess chlorinated reagents and by-products are removed by distillation, and then further refined, such as recrystallization or distillation, to obtain the target product.
These two methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider the availability of raw materials, cost, ease of control of reaction conditions, and purity requirements of the product, and choose the best one.
Benzene, (2-chloroethoxy) - What is the environmental impact?
The impact of (2-chloroethoxy) benzene on the environment is related to the ecological balance and the survival of all things, and cannot be ignored.
When this compound enters the natural environment, the first to bear the brunt is the water body. If it accidentally flows into rivers, lakes and seas, its chlorine-containing structure has certain chemical stability, or it is difficult to degrade rapidly. In aquatic ecosystems, it may interfere with the normal physiological functions of aquatic organisms. For example, fish, shellfish and other organisms, long-term exposure to water containing (2-chloroethoxy) benzene may cause reproductive, immune and nervous system disorders. And this compound may be enriched through the food chain. Small fish accidentally eat plankton containing this substance, and big fish eat small fish. If it accumulates layer by layer, the concentration of this substance in the organisms at the top of the food chain may be extremely high, which will eventually affect the entire aquatic ecological balance.
In the soil environment, (2-chloroethoxy) benzene may be adsorbed on the surface of soil particles, affecting the structure and function of soil microbial community. Soil microorganisms are essential for soil nutrient cycling and organic matter decomposition, and the existence of this compound may inhibit the growth and reproduction of some beneficial microorganisms, resulting in a decrease in soil fertility and affecting plant growth. If the substance is absorbed by crops planted in contaminated soil, it may accumulate in the crops and be transmitted to the human body through the food chain, threatening human health.
In the atmospheric environment, if (2-chloroethoxy) benzene evaporates into the air, or participates in photochemical reactions, it generates secondary pollutants, such as ozone, which aggravates air pollution and affects air quality. Human inhalation of air containing this substance may cause health problems such as respiratory irritation and nervous system damage.
Therefore, (2-chloroethoxy) benzene in the environment, due to its chemical properties, poses potential hazards to water, soil, atmosphere and organisms. Its production, use and disposal process need to be treated with caution to prevent its release into the environment in large quantities to protect the health of the ecological environment.
When this compound enters the natural environment, the first to bear the brunt is the water body. If it accidentally flows into rivers, lakes and seas, its chlorine-containing structure has certain chemical stability, or it is difficult to degrade rapidly. In aquatic ecosystems, it may interfere with the normal physiological functions of aquatic organisms. For example, fish, shellfish and other organisms, long-term exposure to water containing (2-chloroethoxy) benzene may cause reproductive, immune and nervous system disorders. And this compound may be enriched through the food chain. Small fish accidentally eat plankton containing this substance, and big fish eat small fish. If it accumulates layer by layer, the concentration of this substance in the organisms at the top of the food chain may be extremely high, which will eventually affect the entire aquatic ecological balance.
In the soil environment, (2-chloroethoxy) benzene may be adsorbed on the surface of soil particles, affecting the structure and function of soil microbial community. Soil microorganisms are essential for soil nutrient cycling and organic matter decomposition, and the existence of this compound may inhibit the growth and reproduction of some beneficial microorganisms, resulting in a decrease in soil fertility and affecting plant growth. If the substance is absorbed by crops planted in contaminated soil, it may accumulate in the crops and be transmitted to the human body through the food chain, threatening human health.
In the atmospheric environment, if (2-chloroethoxy) benzene evaporates into the air, or participates in photochemical reactions, it generates secondary pollutants, such as ozone, which aggravates air pollution and affects air quality. Human inhalation of air containing this substance may cause health problems such as respiratory irritation and nervous system damage.
Therefore, (2-chloroethoxy) benzene in the environment, due to its chemical properties, poses potential hazards to water, soil, atmosphere and organisms. Its production, use and disposal process need to be treated with caution to prevent its release into the environment in large quantities to protect the health of the ecological environment.
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