Linshang Chemical
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Benzene, 2-(Chloromethyl)-1-Methyl-4-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
512385 |
| Chemical Formula | C9H8ClF3 |
| Molar Mass | 210.61 g/mol |
| Solubility In Water | Expected to be low as it is an organic halogen - containing aromatic compound |
| Logp Octanol Water Partition Coefficient | Expected to be positive as it is hydrophobic due to the non - polar aromatic and fluoromethyl groups |
As an accredited Benzene, 2-(Chloromethyl)-1-Methyl-4-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 2-(chloromethyl)-1 - methyl - 4-(trifluoromethyl)benzene, well - sealed. |
| Storage | Store “Benzene, 2-(chloromethyl)-1 -methyl-4-(trifluoromethyl)-” in a cool, well - ventilated area, away from heat, sparks, and open flames due to its potential flammability. Keep it in a tightly closed container, preferably made of corrosion - resistant materials, to prevent leakage. Segregate from oxidizing agents and incompatible substances to avoid dangerous reactions. |
| Shipping | The chemical "Benzene, 2-(chloromethyl)-1 -methyl-4-(trifluoromethyl)-" should be shipped in accordance with hazardous material regulations. Use appropriate containers, label clearly, and ensure proper handling to prevent spills and ensure safety during transit. |
Competitive Benzene, 2-(Chloromethyl)-1-Methyl-4-(Trifluoromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of this product 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene?
This is to explore the chemical properties of 2- (methoxy) -1 -methyl-4- (triethoxysilyl) benzene. This compound has different functional groups such as methoxy, methyl and triethoxysilyl, and each functional group endows it with unique chemical properties.
Let's talk about the methoxy group first, which is the power supply group. It can increase the electron cloud density of the benzene ring by the conjugation effect, which in turn affects the electrophilic substitution reaction activity of the benzene ring, and usually promotes the reaction to occur more easily. When the electrophilic reagent attacks, the methoxy group will guide the reagent to mainly attack the ortho and para-sites of the benzene ring, because it can better disperse the positive charge in the ortho and para-sites through the conjugation effect, forming a more stable intermediate.
methyl is also a donator group. Although the donator capacity is slightly weaker than that of methoxy, it can also increase the electron cloud density of the benzene ring, affect the reactivity of the benzene ring, and produce a steric hindrance effect. In some reactions, methyl steric hindrance affects the reactants to approach a specific position of the benzene ring, which has an impact on the reaction selectivity.
In triethoxysilane, the electronegativity of silicon atoms is different from that of carbon atoms, making the silicon-oxygen bond polar. This functional group has high chemical activity, and the ethoxy group can be hydrolyzed under specific conditions to form a silanol group (-SiOH). The silanol group can be further condensed to form a silica bond (-Si-O-Si-), which can be used to prepare organic-inorganic hybrid materials or as a crosslinking agent to construct a three-dimensional network structure, which significantly changes the physical and chemical properties of the material.
This compound exhibits rich chemical properties due to the interaction of these functional groups, and has potential application value in organic synthesis, materials science and other fields. For example, it can be used to prepare functional polymers, surface modifiers, and can also be used as an intermediate in the synthesis of new silicone materials, expanding the material properties and application range.
Let's talk about the methoxy group first, which is the power supply group. It can increase the electron cloud density of the benzene ring by the conjugation effect, which in turn affects the electrophilic substitution reaction activity of the benzene ring, and usually promotes the reaction to occur more easily. When the electrophilic reagent attacks, the methoxy group will guide the reagent to mainly attack the ortho and para-sites of the benzene ring, because it can better disperse the positive charge in the ortho and para-sites through the conjugation effect, forming a more stable intermediate.
methyl is also a donator group. Although the donator capacity is slightly weaker than that of methoxy, it can also increase the electron cloud density of the benzene ring, affect the reactivity of the benzene ring, and produce a steric hindrance effect. In some reactions, methyl steric hindrance affects the reactants to approach a specific position of the benzene ring, which has an impact on the reaction selectivity.
In triethoxysilane, the electronegativity of silicon atoms is different from that of carbon atoms, making the silicon-oxygen bond polar. This functional group has high chemical activity, and the ethoxy group can be hydrolyzed under specific conditions to form a silanol group (-SiOH). The silanol group can be further condensed to form a silica bond (-Si-O-Si-), which can be used to prepare organic-inorganic hybrid materials or as a crosslinking agent to construct a three-dimensional network structure, which significantly changes the physical and chemical properties of the material.
This compound exhibits rich chemical properties due to the interaction of these functional groups, and has potential application value in organic synthesis, materials science and other fields. For example, it can be used to prepare functional polymers, surface modifiers, and can also be used as an intermediate in the synthesis of new silicone materials, expanding the material properties and application range.
What are the main uses of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene?
2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl) pyridine, which has a wide range of uses.
In the field of pharmaceutical synthesis, it is often a key intermediate. The unique chemical properties of the Gainpyridine ring and the specific substituents it is connected to can be constructed through various chemical reactions. Complex molecular structures with specific pharmacological activities can be constructed. For example, when developing new antimicrobial drugs, this is used as a starting material. After ingenious modification and functional group transformation, compounds with high inhibitory effect on specific bacteria can be obtained, providing an important basis for pharmaceutical innovation.
In the creation of pesticides, it also plays an important role. With its structural characteristics, pesticide products with high selectivity to pests, low toxicity and environmental friendliness can be derived. For example, pyridine pesticides can be designed and synthesized to interfere with nerve conduction or physiological metabolic processes of specific pests, which can effectively prevent and control crop diseases and pests, ensure agricultural harvests, and reduce adverse effects on the ecological environment.
In the field of materials science, it may participate in the preparation of functional materials. The electronic properties of pyridine rings and the strong electronegativity of fluorine atoms enable materials containing this structure to exhibit unique electrical, optical or thermal properties. Such as applications in the field of organic optoelectronic materials, it provides the possibility for the development of new Light Emitting Diodes, solar cell materials, etc., to promote the progress and innovation of materials science.
In the field of pharmaceutical synthesis, it is often a key intermediate. The unique chemical properties of the Gainpyridine ring and the specific substituents it is connected to can be constructed through various chemical reactions. Complex molecular structures with specific pharmacological activities can be constructed. For example, when developing new antimicrobial drugs, this is used as a starting material. After ingenious modification and functional group transformation, compounds with high inhibitory effect on specific bacteria can be obtained, providing an important basis for pharmaceutical innovation.
In the creation of pesticides, it also plays an important role. With its structural characteristics, pesticide products with high selectivity to pests, low toxicity and environmental friendliness can be derived. For example, pyridine pesticides can be designed and synthesized to interfere with nerve conduction or physiological metabolic processes of specific pests, which can effectively prevent and control crop diseases and pests, ensure agricultural harvests, and reduce adverse effects on the ecological environment.
In the field of materials science, it may participate in the preparation of functional materials. The electronic properties of pyridine rings and the strong electronegativity of fluorine atoms enable materials containing this structure to exhibit unique electrical, optical or thermal properties. Such as applications in the field of organic optoelectronic materials, it provides the possibility for the development of new Light Emitting Diodes, solar cell materials, etc., to promote the progress and innovation of materials science.
What are the precautions in the synthesis of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene?
In the synthesis process of 2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl) pyridine, the following things should be paid attention to:
First, the selection and purity of the raw materials. The raw materials are the foundation of the synthesis, and the purity of the purity has a great impact on the quality and yield of the product. Selecting high-purity 2-halomethylpyridine, cyanomethylation reagents, methylation reagents and trifluoromethylation reagents can effectively reduce the formation of impurities and improve the reaction efficiency. For example, if 2-halomethylpyridine contains impurities, it may cause abnormal reaction check points, produce by-products, and hinder the main reaction process.
Second, the control of reaction conditions. Temperature, pressure, reaction time and solvent are all key factors. If the temperature is too high, or the reaction is too violent, causing side reactions, such as ring opening of the pyridine ring or overreaction of the substituent; if the temperature is too low, the reaction rate will be delayed and the yield will be reduced. The control of pressure should not be underestimated. For some reactions involving gases, the appropriate pressure can promote the positive progress of the reaction. The reaction time needs to be accurately controlled. If it is too short, the reaction will be incomplete, and if it is too long, it may cause the product to decompose. The properties of the solvent will affect the solubility and reactivity of the reactants, and a suitable solvent should be selected according to the reaction characteristics.
Third, the separation and purification of the intermediate. The purity of the intermediate generated in the synthesis process has a great impact on the subsequent reaction. It is necessary to use suitable separation methods, such as extraction, distillation, column chromatography, etc., to obtain high-purity If the intermediate impurities are not removed, impurities will be introduced into the subsequent reaction, interfering with the reaction path, and reducing the quality of the final product.
Fourth, safety issues. Many reagents involved in synthesis, such as cyanide, halogenated compounds, etc., are toxic and corrosive. Safety procedures must be strictly followed during operation. Work with good ventilation, and wear protective clothing, gloves, and goggles. At the same time, properly dispose of waste to avoid environmental pollution and personal injury.
Fifth, the use of catalysts. Appropriate catalysts can reduce the activation energy of the reaction, speed up the reaction rate, and improve selectivity. However, the amount, activity and stability of catalysts need to be carefully considered. Excessive dosage or side reactions, poor activity and stability will affect the reaction effect and reusability.
First, the selection and purity of the raw materials. The raw materials are the foundation of the synthesis, and the purity of the purity has a great impact on the quality and yield of the product. Selecting high-purity 2-halomethylpyridine, cyanomethylation reagents, methylation reagents and trifluoromethylation reagents can effectively reduce the formation of impurities and improve the reaction efficiency. For example, if 2-halomethylpyridine contains impurities, it may cause abnormal reaction check points, produce by-products, and hinder the main reaction process.
Second, the control of reaction conditions. Temperature, pressure, reaction time and solvent are all key factors. If the temperature is too high, or the reaction is too violent, causing side reactions, such as ring opening of the pyridine ring or overreaction of the substituent; if the temperature is too low, the reaction rate will be delayed and the yield will be reduced. The control of pressure should not be underestimated. For some reactions involving gases, the appropriate pressure can promote the positive progress of the reaction. The reaction time needs to be accurately controlled. If it is too short, the reaction will be incomplete, and if it is too long, it may cause the product to decompose. The properties of the solvent will affect the solubility and reactivity of the reactants, and a suitable solvent should be selected according to the reaction characteristics.
Third, the separation and purification of the intermediate. The purity of the intermediate generated in the synthesis process has a great impact on the subsequent reaction. It is necessary to use suitable separation methods, such as extraction, distillation, column chromatography, etc., to obtain high-purity If the intermediate impurities are not removed, impurities will be introduced into the subsequent reaction, interfering with the reaction path, and reducing the quality of the final product.
Fourth, safety issues. Many reagents involved in synthesis, such as cyanide, halogenated compounds, etc., are toxic and corrosive. Safety procedures must be strictly followed during operation. Work with good ventilation, and wear protective clothing, gloves, and goggles. At the same time, properly dispose of waste to avoid environmental pollution and personal injury.
Fifth, the use of catalysts. Appropriate catalysts can reduce the activation energy of the reaction, speed up the reaction rate, and improve selectivity. However, the amount, activity and stability of catalysts need to be carefully considered. Excessive dosage or side reactions, poor activity and stability will affect the reaction effect and reusability.
What is the approximate market price of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene?
Today, there are 2 - (methoxy) -1 - methyl - 4 - (trifluoromethyl) benzene. What is the market price?
The price of the city is often changed due to many reasons, such as the abundance of materials, the difficulty of craftsmanship, the wide and narrow range of needs, and the distance of trade.
If the material is widely produced, easy to harvest, and oversupply, the price is low. Such as common corn, the price is low in a good year. However, if this 2- (methoxy) -1 -methyl-4- (trifluoromethyl) benzene requires exquisite craftsmanship, and the materials used are rare. There are many people seeking it, and the supply is insufficient. The price will be high, just like the combination of He's, although it is not easy to get.
Also, the price is also related to the distance and proximity of the product. If it is produced nearby, the cost of transportation is saved, and the price is slightly flat; if it comes from a distant country, involves heavy oceans, passes through dangerous routes, and costs a lot, the price will be high.
And the price varies depending on the time. The newly developed method can greatly increase the production, and the price may drop; if there is an urgent need, there will be a large number of people in need but less goods, and the price will rise.
Now to determine the price of this 2- (methoxy) -1-methyl-4- (trifluoromethyl) benzene, when consulting the chemical industry, the factory of this industry, and carefully examining the facts of the city, can obtain its approximate value. However, only with common sense, it is difficult to determine the height of its price, and it is difficult to determine the approximate number.
The price of the city is often changed due to many reasons, such as the abundance of materials, the difficulty of craftsmanship, the wide and narrow range of needs, and the distance of trade.
If the material is widely produced, easy to harvest, and oversupply, the price is low. Such as common corn, the price is low in a good year. However, if this 2- (methoxy) -1 -methyl-4- (trifluoromethyl) benzene requires exquisite craftsmanship, and the materials used are rare. There are many people seeking it, and the supply is insufficient. The price will be high, just like the combination of He's, although it is not easy to get.
Also, the price is also related to the distance and proximity of the product. If it is produced nearby, the cost of transportation is saved, and the price is slightly flat; if it comes from a distant country, involves heavy oceans, passes through dangerous routes, and costs a lot, the price will be high.
And the price varies depending on the time. The newly developed method can greatly increase the production, and the price may drop; if there is an urgent need, there will be a large number of people in need but less goods, and the price will rise.
Now to determine the price of this 2- (methoxy) -1-methyl-4- (trifluoromethyl) benzene, when consulting the chemical industry, the factory of this industry, and carefully examining the facts of the city, can obtain its approximate value. However, only with common sense, it is difficult to determine the height of its price, and it is difficult to determine the approximate number.
What are the production processes of 2- (chloromethyl) -1-methyl-4- (trifluoromethyl) benzene?
The preparation process of 2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl) pyridine is an important content in the field of chemical synthesis. There are many methods, which are described below.
One is the initiation method of halogenation reaction. First, the pyridine compound containing the corresponding substituent, under suitable reaction conditions, interacts with halogenated reagents such as hydrogen halide and phosphorus halide to introduce halogen atoms. This halogen atom is highly active and can further undergo nucleophilic substitution reactions with cyanides such as sodium cyanide and potassium cyanide, thereby successfully introducing cyanomethyl. For example, when the pyridine ring has a halogenated group at a specific position, when heated and in the presence of a catalyst, it reacts with hydrogen bromide, and the bromine atom selectively replaces the hydrogen atom at a specific position. Subsequent reaction with sodium cyanide in a polar solvent can obtain a pyridine intermediate containing cyanomethyl. After being treated with methylating reagents under specific conditions, such as methylated species formed by the interaction of iodomethane and strong bases, methyl groups are introduced, and finally a specific trifluoromethyl-containing reagent, such as trifluoromethylation reagent, is catalyzed by a metal catalyst to achieve the introduction of 4- (trifluoromethyl) to obtain the target product 2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl)
The second is the functional group conversion method using pyridine derivatives. If there are already convertible functional groups on the pyridine ring, such as carboxyl groups, aldehyde groups, etc. Taking the carboxyl group as an example, it can be converted into acid chloride first, which can be achieved by reacting with reagents such as thionyl chloride. The acid chloride has extremely high activity and can be reacted with cyanide-containing reagents to generate methyl derivatives. At the same time, aldehyde groups can be gradually introduced into methyl groups and trifluoromethyl groups through a series of reduction and substitution reactions. For example, aldehyde groups are first reduced to alcohols, and then the alcohols react with halogenated reagents to form halogenated products, and then react with methylating reagents and trifluoromethylating reagents in sequence to construct the target product structure.
The third is the catalytic coupling method of transition metals With the help of transition metal catalysts such as palladium, nickel, etc., halogenated pyridine derivatives containing different substituents are coupled with reagents containing cyanomethyl, methyl, and trifluoromethyl. For example, halogenated pyridine and cyanomethyl borate undergo Suzuki coupling reaction in the presence of palladium catalyst and base, forming a carbon-carbon bond to introduce cyanomethyl; similarly, it reacts with methyl borate, trifluoromethyl borate, etc., and introduces corresponding groups in sequence to precisely synthesize 2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl) pyridine. This method has the advantages of mild reaction conditions and high selectivity, and is widely used in modern organic synthesis.
One is the initiation method of halogenation reaction. First, the pyridine compound containing the corresponding substituent, under suitable reaction conditions, interacts with halogenated reagents such as hydrogen halide and phosphorus halide to introduce halogen atoms. This halogen atom is highly active and can further undergo nucleophilic substitution reactions with cyanides such as sodium cyanide and potassium cyanide, thereby successfully introducing cyanomethyl. For example, when the pyridine ring has a halogenated group at a specific position, when heated and in the presence of a catalyst, it reacts with hydrogen bromide, and the bromine atom selectively replaces the hydrogen atom at a specific position. Subsequent reaction with sodium cyanide in a polar solvent can obtain a pyridine intermediate containing cyanomethyl. After being treated with methylating reagents under specific conditions, such as methylated species formed by the interaction of iodomethane and strong bases, methyl groups are introduced, and finally a specific trifluoromethyl-containing reagent, such as trifluoromethylation reagent, is catalyzed by a metal catalyst to achieve the introduction of 4- (trifluoromethyl) to obtain the target product 2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl)
The second is the functional group conversion method using pyridine derivatives. If there are already convertible functional groups on the pyridine ring, such as carboxyl groups, aldehyde groups, etc. Taking the carboxyl group as an example, it can be converted into acid chloride first, which can be achieved by reacting with reagents such as thionyl chloride. The acid chloride has extremely high activity and can be reacted with cyanide-containing reagents to generate methyl derivatives. At the same time, aldehyde groups can be gradually introduced into methyl groups and trifluoromethyl groups through a series of reduction and substitution reactions. For example, aldehyde groups are first reduced to alcohols, and then the alcohols react with halogenated reagents to form halogenated products, and then react with methylating reagents and trifluoromethylating reagents in sequence to construct the target product structure.
The third is the catalytic coupling method of transition metals With the help of transition metal catalysts such as palladium, nickel, etc., halogenated pyridine derivatives containing different substituents are coupled with reagents containing cyanomethyl, methyl, and trifluoromethyl. For example, halogenated pyridine and cyanomethyl borate undergo Suzuki coupling reaction in the presence of palladium catalyst and base, forming a carbon-carbon bond to introduce cyanomethyl; similarly, it reacts with methyl borate, trifluoromethyl borate, etc., and introduces corresponding groups in sequence to precisely synthesize 2-% (cyanomethyl) -1-methyl-4- (trifluoromethyl) pyridine. This method has the advantages of mild reaction conditions and high selectivity, and is widely used in modern organic synthesis.
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