Linshang Chemical
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Benzene, 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-
Linshang Chemical
|
HS Code |
299848 |
| Chemical Formula | C15H13BrClFO |
| Molecular Weight | 345.62 |
As an accredited Benzene, 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 1 - chloro - 2 - [(4 - ethoxy - 3 - fluorophenyl)methyl]benzene in sealed chemical - grade vial. |
| Storage | Store “Benzene, 4 - bromo - 1 - chloro - 2 - [(4 - ethoxy - 3 - fluorophenyl)methyl] -” in a cool, dry, well - ventilated area away from heat sources, ignition sources, and incompatible substances. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and maintain its chemical integrity. |
| Shipping | The chemical "Benzene, 4 - bromo - 1 - chloro - 2 - [(4 - ethoxy - 3 - fluorophenyl)methyl] -" will be shipped in properly sealed, corrosion - resistant containers. Shipment follows strict hazardous material regulations to ensure safe transit. |
Competitive Benzene, 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Where to Buy Benzene, 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]- in China?
As a trusted Benzene, 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]- manufacturer, we deliver:
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What is the chemistry of this product "4-Bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene"?
The chemical properties of this "4-bromo-1-fluoro-2- [ (4-ethoxy-3-chlorobenzyl) methyl] benzene" are quite complex.
From the perspective of the characteristics of halogen atoms, bromine (Br) and fluorine (F) atoms occupy specific positions in molecules. Bromine atoms have relatively large atomic radii and high electronegativity, which make them exhibit unique activities in chemical reactions. They can participate in nucleophilic substitution reactions. Because bromine-carbon bonds have a certain polarity, nucleophilic reagents are easy to attack carbon atoms connected to bromine, causing bromine atoms to leave and form new organic compounds.
Although fluorine atoms have a small atomic radius, their electronegativity is extremely high, which has a significant impact on the distribution of molecular electron clouds. It can enhance molecular polarity, which in turn affects molecular physical and chemical properties, such as boiling point, solubility, etc. And fluorine-containing compounds often have unique performance in biological activity, or can enhance the interaction of the substance with biological targets.
Looking at the benzene ring part, as a stable conjugate system, it endows the substance with certain chemical stability. But at the same time, the substituents on the benzene ring will change its electron cloud density distribution. In this compound, 4-ethoxy-3-chlorobenzyl and methyl are connected to a specific position of the benzene ring, and the lone pair electrons of the oxygen atom in the ethoxy group (-OCH < unk > CH < unk >) can be conjugated with the benzene ring to increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution. The chlorine atom has an electron-absorbing effect, which will reduce the electron cloud density of the benzene ring and hinder the electrophilic substitution reaction to a certain extent. These two effects compete with each other and together affect the activity of the substance in reactions involving the benzene ring
This compound may be a key intermediate in the field of organic synthesis due to the interaction of various groups, and through different chemical reaction pathways, more complex organic molecular structures can be constructed; in the field of medicinal chemistry, its unique chemical properties may endow potential biological activity, and further modification and optimization may be developed into drugs with specific pharmacological effects.
From the perspective of the characteristics of halogen atoms, bromine (Br) and fluorine (F) atoms occupy specific positions in molecules. Bromine atoms have relatively large atomic radii and high electronegativity, which make them exhibit unique activities in chemical reactions. They can participate in nucleophilic substitution reactions. Because bromine-carbon bonds have a certain polarity, nucleophilic reagents are easy to attack carbon atoms connected to bromine, causing bromine atoms to leave and form new organic compounds.
Although fluorine atoms have a small atomic radius, their electronegativity is extremely high, which has a significant impact on the distribution of molecular electron clouds. It can enhance molecular polarity, which in turn affects molecular physical and chemical properties, such as boiling point, solubility, etc. And fluorine-containing compounds often have unique performance in biological activity, or can enhance the interaction of the substance with biological targets.
Looking at the benzene ring part, as a stable conjugate system, it endows the substance with certain chemical stability. But at the same time, the substituents on the benzene ring will change its electron cloud density distribution. In this compound, 4-ethoxy-3-chlorobenzyl and methyl are connected to a specific position of the benzene ring, and the lone pair electrons of the oxygen atom in the ethoxy group (-OCH < unk > CH < unk >) can be conjugated with the benzene ring to increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution. The chlorine atom has an electron-absorbing effect, which will reduce the electron cloud density of the benzene ring and hinder the electrophilic substitution reaction to a certain extent. These two effects compete with each other and together affect the activity of the substance in reactions involving the benzene ring
This compound may be a key intermediate in the field of organic synthesis due to the interaction of various groups, and through different chemical reaction pathways, more complex organic molecular structures can be constructed; in the field of medicinal chemistry, its unique chemical properties may endow potential biological activity, and further modification and optimization may be developed into drugs with specific pharmacological effects.
In what fields is "4-Bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene" used?
"4-Hydroxy-1-aldehyde-2- [ (4-acetoxy-3-methoxyphenyl) methyl] benzene" is widely used and has important applications in medicine, chemical industry and other fields.
In the field of medicine, it can be used as a key intermediate to synthesize a variety of drugs. Taking cardiovascular drugs as an example, it can be cleverly combined with other compounds through specific chemical reactions to build active ingredients that regulate cardiovascular function. For some drugs that need to precisely regulate blood pressure and blood lipids, the unique structure of this compound can play a key role in helping to optimize drug efficacy and reduce adverse reactions. In the research and development of anti-tumor drugs, it has also made its mark. By participating in complex synthesis pathways, it provides the possibility to create new anti-cancer drugs, or can affect the growth, proliferation and metastasis of cancer cells.
In the chemical industry, it is of great significance in material synthesis. It can be used as a functional monomer to participate in the synthesis of polymer materials. For example, when preparing polymers with special optical and electrical properties, introducing them into the main chain or side chain of the polymer can endow the material with unique properties. Because it contains specific functional groups, it can polymerize with other monomers to generate materials with good solubility, stability and specific responsiveness, showing potential application value in optoelectronic devices and sensor materials. In the coatings industry, its rational application may enhance the adhesion, corrosion resistance, and other properties of coatings, thus contributing to the optimization of coating product performance.
In the field of medicine, it can be used as a key intermediate to synthesize a variety of drugs. Taking cardiovascular drugs as an example, it can be cleverly combined with other compounds through specific chemical reactions to build active ingredients that regulate cardiovascular function. For some drugs that need to precisely regulate blood pressure and blood lipids, the unique structure of this compound can play a key role in helping to optimize drug efficacy and reduce adverse reactions. In the research and development of anti-tumor drugs, it has also made its mark. By participating in complex synthesis pathways, it provides the possibility to create new anti-cancer drugs, or can affect the growth, proliferation and metastasis of cancer cells.
In the chemical industry, it is of great significance in material synthesis. It can be used as a functional monomer to participate in the synthesis of polymer materials. For example, when preparing polymers with special optical and electrical properties, introducing them into the main chain or side chain of the polymer can endow the material with unique properties. Because it contains specific functional groups, it can polymerize with other monomers to generate materials with good solubility, stability and specific responsiveness, showing potential application value in optoelectronic devices and sensor materials. In the coatings industry, its rational application may enhance the adhesion, corrosion resistance, and other properties of coatings, thus contributing to the optimization of coating product performance.
What are the methods for synthesizing "4-Bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene"?
To prepare "4-ether-1-alkane-2- [ (4-ethoxy-3-chlorobenzyl) methyl] benzene", the synthesis method can be carried out according to the following steps.
First take the appropriate starting material, to obtain "4-ether-1-alkane-2- [ (4-ethoxy-3-chlorobenzyl) methyl] benzene", you can start with the construction of key carbon-carbon bonds and the introduction of specific functional groups.
First, suitable halogenated aromatics can be found, such as chlorine-containing halogenated benzyl, and ethoxy-containing benzene derivatives. In the presence of appropriate bases and catalysts, the nucleophilic substitution reaction is used to construct benzyl connections. Bases such as potassium carbonate, etc., the catalyst can be selected as copper-based catalysts, such as cuprous iodide, etc. Under this reaction condition, the halogen atom of halogenated benzene is substituted with the active check point of benzene derivatives, and the benzene structure containing ethoxy and chlorobenzyl is initially formed.
Second, for the introduction of alkoxy groups, the Williamson ether synthesis method of alcohol and corresponding halogenated hydrocarbons under basic conditions can be used. Take a suitable alcohol, make it into sodium alcohol or potassium alcohol, and react with halogenated hydrocarbons to introduce ether bonds to form the structural part of "4-ether-1-alkane".
Third, during the reaction process, attention should be paid to the control of reaction conditions. Too high or too low temperature can affect the reaction rate and product selectivity. Usually, the temperature of nucleophilic substitution can be controlled in a moderate range, such as between 50 and 100 ° C, depending on the specific reactants and solvents. The reaction solvent is also very critical. Commonly used polar aprotic solvents, such as N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., can promote the reaction.
Fourth, after the key steps are completed, the product is separated and purified. Column chromatography can be used to select suitable silica gel as the stationary phase, and different proportions of polar and non-polar solvent mixtures can be used as the mobile phase. According to the difference in the partition coefficient between the fixed phase and the mobile phase between the product and the impurities, the product can be purified. Recrystallization can also be used to select a suitable solvent, so that the product is dissolved in a hot solvent, cooled and crystallized to precipitate, remove impurities, and obtain pure "4-ether-1-alkane-2-[ (4-ethoxy-3-chlorobenzyl) methyl] benzene".
First take the appropriate starting material, to obtain "4-ether-1-alkane-2- [ (4-ethoxy-3-chlorobenzyl) methyl] benzene", you can start with the construction of key carbon-carbon bonds and the introduction of specific functional groups.
First, suitable halogenated aromatics can be found, such as chlorine-containing halogenated benzyl, and ethoxy-containing benzene derivatives. In the presence of appropriate bases and catalysts, the nucleophilic substitution reaction is used to construct benzyl connections. Bases such as potassium carbonate, etc., the catalyst can be selected as copper-based catalysts, such as cuprous iodide, etc. Under this reaction condition, the halogen atom of halogenated benzene is substituted with the active check point of benzene derivatives, and the benzene structure containing ethoxy and chlorobenzyl is initially formed.
Second, for the introduction of alkoxy groups, the Williamson ether synthesis method of alcohol and corresponding halogenated hydrocarbons under basic conditions can be used. Take a suitable alcohol, make it into sodium alcohol or potassium alcohol, and react with halogenated hydrocarbons to introduce ether bonds to form the structural part of "4-ether-1-alkane".
Third, during the reaction process, attention should be paid to the control of reaction conditions. Too high or too low temperature can affect the reaction rate and product selectivity. Usually, the temperature of nucleophilic substitution can be controlled in a moderate range, such as between 50 and 100 ° C, depending on the specific reactants and solvents. The reaction solvent is also very critical. Commonly used polar aprotic solvents, such as N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., can promote the reaction.
Fourth, after the key steps are completed, the product is separated and purified. Column chromatography can be used to select suitable silica gel as the stationary phase, and different proportions of polar and non-polar solvent mixtures can be used as the mobile phase. According to the difference in the partition coefficient between the fixed phase and the mobile phase between the product and the impurities, the product can be purified. Recrystallization can also be used to select a suitable solvent, so that the product is dissolved in a hot solvent, cooled and crystallized to precipitate, remove impurities, and obtain pure "4-ether-1-alkane-2-[ (4-ethoxy-3-chlorobenzyl) methyl] benzene".
What is the market outlook for "4-Bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene"?
Guanfu "4-hydroxy-1-aldehyde-2- [ (4-acetoxy-3-methoxybenzyl) methyl] benzene" has a lot to see in the prospect of market conditions.
In today's world, the field of pharmaceutical and chemical industry is booming, and the demand for many new materials and new drugs is on the rise. This compound has a unique chemical structure, or it holds great opportunities in the creation of medicine. To cover the research and development of medicine, it often relies on compounds with various characteristic structures as the basis to explore new ways to cure diseases. The genus of 4-hydroxyl and aldehyde groups may be able to precisely interact with targets in organisms, forming the beginning of pharmacological effects. The [ (4-acetoxy-3-methoxybenzyl) methyl] benzene part adds a complex conformation to it, increasing the possibility of compatibility with biological macromolecules.
Furthermore, in the field of chemical materials, there may be a place for it. The research of new functional materials often requires small molecules with specific structures as building units. The structural characteristics of this compound may introduce polymer systems to give materials different properties, such as optics and electricity, opening up new avenues for material innovation.
However, looking at the road ahead in its market, there are also thorns. The huge cost of research and development and the high technical barriers are all obstacles. In order to push this compound from the laboratory to the market, it must go through many rigorous tests, such as pharmacology and toxicology, clinical verification, etc., all of which are indispensable, time-consuming and laborious, and cannot be done without strong resources and exquisite technology. And the market competition is very fierce, and similar alternatives may already exist. If you want to stand out, you must have unique advantages in performance, efficacy and cost control.
To sum up, "4-hydroxyl-1-aldehyde-2 - [ (4-acetoxy-3-methoxybenzyl) methyl] benzene" has unlimited potential in the field of medicine and chemical industry, but it still needs to break through many difficulties. With time and careful planning, there is hope for great success.
In today's world, the field of pharmaceutical and chemical industry is booming, and the demand for many new materials and new drugs is on the rise. This compound has a unique chemical structure, or it holds great opportunities in the creation of medicine. To cover the research and development of medicine, it often relies on compounds with various characteristic structures as the basis to explore new ways to cure diseases. The genus of 4-hydroxyl and aldehyde groups may be able to precisely interact with targets in organisms, forming the beginning of pharmacological effects. The [ (4-acetoxy-3-methoxybenzyl) methyl] benzene part adds a complex conformation to it, increasing the possibility of compatibility with biological macromolecules.
Furthermore, in the field of chemical materials, there may be a place for it. The research of new functional materials often requires small molecules with specific structures as building units. The structural characteristics of this compound may introduce polymer systems to give materials different properties, such as optics and electricity, opening up new avenues for material innovation.
However, looking at the road ahead in its market, there are also thorns. The huge cost of research and development and the high technical barriers are all obstacles. In order to push this compound from the laboratory to the market, it must go through many rigorous tests, such as pharmacology and toxicology, clinical verification, etc., all of which are indispensable, time-consuming and laborious, and cannot be done without strong resources and exquisite technology. And the market competition is very fierce, and similar alternatives may already exist. If you want to stand out, you must have unique advantages in performance, efficacy and cost control.
To sum up, "4-hydroxyl-1-aldehyde-2 - [ (4-acetoxy-3-methoxybenzyl) methyl] benzene" has unlimited potential in the field of medicine and chemical industry, but it still needs to break through many difficulties. With time and careful planning, there is hope for great success.
What are the precautions in the preparation of "4-Bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene"?
In the preparation process of "4-ether-1-alkane-2- [ (4-ethoxy-3-hydroxybenzyl) methyl] benzyl", the following things should be paid attention to:
The quality of the first raw material. To prepare this compound, all kinds of raw materials are required, and their purity and properties are all related to the quality of the product. For example, 4-ethoxy-3-hydroxybenzyl related raw materials, high purity must be selected. If there are many impurities, the reaction or by-products will cause the product to be impure, and the subsequent separation and purification will be difficult.
Second inspection of the reaction conditions. Temperature control is the key, and different stages of the reaction have different temperature requirements. At the beginning of the reaction, the temperature should be stable. If the temperature changes suddenly, the reaction rate may be chaotic, which will affect the formation of the product. Another example is the pressure during the reaction, which also needs to be constant. For a specific reaction, the appropriate pressure can promote the positive progress of the reaction. Improper pressure, or the reaction may be stalled, or even there is a risk of safety.
Furthermore, the use of catalysts should not be underestimated. Choosing the right catalyst can increase the reaction rate and reduce the reaction energy consumption. However, the amount of catalyst must be accurate. If the amount of catalyst is less, the catalytic effect will be poor and the reaction will be slow; if it is more, it may cause overreaction and increase the cost. When using, the timing of addition should also be appropriate. Adding early or late can affect the reaction process.
Monitoring the reaction By means of modern analytical methods, such as chromatography, spectroscopy, etc., the reaction process can be observed in real time, so that the conditions can be adjusted in a timely manner. If the monitoring is not timely, the reaction is too late, and the product may lose the expected quality.
After separation and purification. After the reaction is completed, the product is mixed in the system, containing impurities, unreacted raw materials, etc. It is crucial to choose a suitable separation method, such as distillation, extraction, recrystallization, etc. During operation, the method should be fine to ensure maximum purification of the product without damaging the structure and purity of the product.
All of these, the preparation of "4-ether-1-alkane-2 - [ (4-ethoxy-3-hydroxybenzyl) methyl] benzyl" requires caution to obtain high-quality products.
The quality of the first raw material. To prepare this compound, all kinds of raw materials are required, and their purity and properties are all related to the quality of the product. For example, 4-ethoxy-3-hydroxybenzyl related raw materials, high purity must be selected. If there are many impurities, the reaction or by-products will cause the product to be impure, and the subsequent separation and purification will be difficult.
Second inspection of the reaction conditions. Temperature control is the key, and different stages of the reaction have different temperature requirements. At the beginning of the reaction, the temperature should be stable. If the temperature changes suddenly, the reaction rate may be chaotic, which will affect the formation of the product. Another example is the pressure during the reaction, which also needs to be constant. For a specific reaction, the appropriate pressure can promote the positive progress of the reaction. Improper pressure, or the reaction may be stalled, or even there is a risk of safety.
Furthermore, the use of catalysts should not be underestimated. Choosing the right catalyst can increase the reaction rate and reduce the reaction energy consumption. However, the amount of catalyst must be accurate. If the amount of catalyst is less, the catalytic effect will be poor and the reaction will be slow; if it is more, it may cause overreaction and increase the cost. When using, the timing of addition should also be appropriate. Adding early or late can affect the reaction process.
Monitoring the reaction By means of modern analytical methods, such as chromatography, spectroscopy, etc., the reaction process can be observed in real time, so that the conditions can be adjusted in a timely manner. If the monitoring is not timely, the reaction is too late, and the product may lose the expected quality.
After separation and purification. After the reaction is completed, the product is mixed in the system, containing impurities, unreacted raw materials, etc. It is crucial to choose a suitable separation method, such as distillation, extraction, recrystallization, etc. During operation, the method should be fine to ensure maximum purification of the product without damaging the structure and purity of the product.
All of these, the preparation of "4-ether-1-alkane-2 - [ (4-ethoxy-3-hydroxybenzyl) methyl] benzyl" requires caution to obtain high-quality products.
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