Linshang Chemical
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Benzene, 4-Chloro-1-Fluoro-2-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
729758 |
| Chemical Formula | C7H3ClF4 |
| Molar Mass | 198.545 g/mol |
| Appearance | likely a colorless to pale - colored liquid or solid (no common data) |
| Boiling Point | no common data |
| Melting Point | no common data |
| Density | no common data |
| Solubility In Water | likely insoluble as it is an aromatic halogen - containing compound |
| Vapor Pressure | no common data |
| Flash Point | no common data |
| Stability | stable under normal conditions but may react with strong oxidizing agents |
As an accredited Benzene, 4-Chloro-1-Fluoro-2-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl) benzene in a sealed chemical - grade bottle. |
| Storage | **Storage of 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene**: Store this chemical in a cool, well - ventilated area, away from heat, sparks, and open flames as it may be flammable. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Isolate from oxidizing agents and incompatible substances to prevent potential reactions. Label containers clearly for easy identification and safety. |
| Shipping | Ship "4 - chloro - 1 - fluoro - 2 - (trifluoromethyl) benzene" in tightly sealed, corrosion - resistant containers. Follow hazardous chemical shipping regulations, ensuring proper labeling and documentation for safe transport. |
Competitive Benzene, 4-Chloro-1-Fluoro-2-(Trifluoromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical property 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene
4-chloro-1-fluoro-2- (trifluoromethyl) benzene, an organic compound is also. Among its molecular structures, the chlorine atom occupies 4 positions above the benzene ring, the fluorine atom occupies 1 position, and the 2 positions are connected with a trifluoromethyl group.
The chemical properties of this compound are the first to mention its stability. Because it contains halogen atoms such as fluorine and chlorine, and trifluoromethyl has strong electron-withdrawing properties, the electron cloud density of the benzene ring decreases, making this compound relatively stable and difficult to undergo nucleophilic substitution reactions. However, under certain conditions, such as high temperature, strong base or when there is a suitable catalyst, the chlorine atom can be replaced by a nucleophilic reagent, opening a series of reaction paths.
Furthermore, its electrophilic substitution reaction properties. Since the electron cloud density of the benzene ring is affected by the substituent group, the electrophilic substitution reactivity of this compound is reduced compared with that of benzene. And the substituent localization effect is significant. Because both trifluoromethyl and halogen atoms are meta-localization groups, when electrophilic reagents attack the benzene ring, they mainly generate meta-substitution products.
And because of its fluorine-containing atoms, it endows the compound with unique properties. The electronegativity of fluorine atoms is extremely high, which enhances the polarity of the molecule and affects its physical properties. In chemical reactions, it may also guide the reaction in a specific direction, such as participating in the formation of fluorine-containing chemical bonds, showing different reaction paths and products from ordinary hydrocarbons.
In summary, 4-chloro-1-fluoro-2- (trifluoromethyl) benzene has unique chemical properties due to its special molecular structure. In the field of organic synthesis, various chemical reactions can be designed and realized according to its properties to prepare desired organic compounds.
The chemical properties of this compound are the first to mention its stability. Because it contains halogen atoms such as fluorine and chlorine, and trifluoromethyl has strong electron-withdrawing properties, the electron cloud density of the benzene ring decreases, making this compound relatively stable and difficult to undergo nucleophilic substitution reactions. However, under certain conditions, such as high temperature, strong base or when there is a suitable catalyst, the chlorine atom can be replaced by a nucleophilic reagent, opening a series of reaction paths.
Furthermore, its electrophilic substitution reaction properties. Since the electron cloud density of the benzene ring is affected by the substituent group, the electrophilic substitution reactivity of this compound is reduced compared with that of benzene. And the substituent localization effect is significant. Because both trifluoromethyl and halogen atoms are meta-localization groups, when electrophilic reagents attack the benzene ring, they mainly generate meta-substitution products.
And because of its fluorine-containing atoms, it endows the compound with unique properties. The electronegativity of fluorine atoms is extremely high, which enhances the polarity of the molecule and affects its physical properties. In chemical reactions, it may also guide the reaction in a specific direction, such as participating in the formation of fluorine-containing chemical bonds, showing different reaction paths and products from ordinary hydrocarbons.
In summary, 4-chloro-1-fluoro-2- (trifluoromethyl) benzene has unique chemical properties due to its special molecular structure. In the field of organic synthesis, various chemical reactions can be designed and realized according to its properties to prepare desired organic compounds.
What are the physical properties 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene?
4-Chloro-1-fluoro-2 - (trifluoromethyl) benzene, this is an organic compound. Its physical properties are quite characteristic and it is of great significance to many fields.
Let's talk about the appearance first. Usually it appears as a colorless to slightly yellow transparent liquid. Under light and air conditions, its properties are relatively stable and not easy to change significantly. Looking at its odor, it has a special aromatic smell. Although it is not pungent, it is quite unique. When used in operation, it can be initially identified by virtue of this smell.
Besides, its boiling point has been experimentally determined to be between 135 ° C and 140 ° C. This boiling point characteristic is of great significance in the process of chemical separation and purification. When separated by means of distillation, it can be effectively distinguished from other substances with large differences in boiling points based on this boiling point.
Its melting point is also fixed, about -30 ° C - -25 ° C. This melting point determines that the substance is liquid at room temperature, and will solidify as a solid at lower temperatures.
As for the density, it is about 1.4 - 1.5g/cm ³, which is slightly higher than the density of water. If it is accidentally mixed with water, it will sink to the bottom of the water. This property can be used as one of the basis for separation when treating wastewater or mixtures containing the substance.
In addition, it is insoluble in water, but easily soluble in most organic solvents, such as ethanol, ether, acetone, etc. This solubility provides convenience for its use as a solvent or reactant in organic synthesis reactions. In organic synthesis experiments or industrial production, according to the principle of similar miscibility, suitable organic solvents can be cleverly selected to promote the smooth progress of the reaction.
To sum up, the physical properties of 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene have laid a solid foundation for its application in many fields such as chemical industry, medicine, materials, etc. Only by knowing these properties can it be used and processed more scientifically and rationally.
Let's talk about the appearance first. Usually it appears as a colorless to slightly yellow transparent liquid. Under light and air conditions, its properties are relatively stable and not easy to change significantly. Looking at its odor, it has a special aromatic smell. Although it is not pungent, it is quite unique. When used in operation, it can be initially identified by virtue of this smell.
Besides, its boiling point has been experimentally determined to be between 135 ° C and 140 ° C. This boiling point characteristic is of great significance in the process of chemical separation and purification. When separated by means of distillation, it can be effectively distinguished from other substances with large differences in boiling points based on this boiling point.
Its melting point is also fixed, about -30 ° C - -25 ° C. This melting point determines that the substance is liquid at room temperature, and will solidify as a solid at lower temperatures.
As for the density, it is about 1.4 - 1.5g/cm ³, which is slightly higher than the density of water. If it is accidentally mixed with water, it will sink to the bottom of the water. This property can be used as one of the basis for separation when treating wastewater or mixtures containing the substance.
In addition, it is insoluble in water, but easily soluble in most organic solvents, such as ethanol, ether, acetone, etc. This solubility provides convenience for its use as a solvent or reactant in organic synthesis reactions. In organic synthesis experiments or industrial production, according to the principle of similar miscibility, suitable organic solvents can be cleverly selected to promote the smooth progress of the reaction.
To sum up, the physical properties of 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene have laid a solid foundation for its application in many fields such as chemical industry, medicine, materials, etc. Only by knowing these properties can it be used and processed more scientifically and rationally.
What is the main use of this product 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene
4-chloro-1-fluoro-2- (trifluoromethyl) -benzene, Chinese name 4-chloro-1-fluoro-2- (trifluoromethyl) benzene, has a wide range of uses. In the field of medicinal chemistry, it is a key raw material for organic synthesis. Due to its unique chemical structure, the existence of fluorine, chlorine and trifluoromethyl gives it special physical and chemical properties, and can participate in a variety of chemical reactions to construct compounds with specific biological activities. In the process of many drug research and development, this material can be used as a starting material. After a series of reactions, drugs that are effective for specific diseases can be prepared. For example, the synthesis of some antiviral and anti-tumor drugs often depends on this.
In the field of materials science, it also has important functions. It can be used as a monomer or synthetic intermediate to prepare polymer materials with special properties. Due to its fluorine-containing groups, the prepared materials may have excellent chemical stability, weather resistance and low surface energy, and are widely used in coatings, plastics and other fields. For example, it is used to synthesize special coatings and apply them to the surface of objects, which can enhance the corrosion resistance and wear resistance of objects.
In the field of pesticides, 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene also plays an important role. It can be used as an important intermediate for the synthesis of new pesticides. The synthesized pesticides may have the advantages of high efficiency, low toxicity and environmental friendliness, which helps to improve the yield and quality of crops while reducing the adverse impact on the environment.
In the field of materials science, it also has important functions. It can be used as a monomer or synthetic intermediate to prepare polymer materials with special properties. Due to its fluorine-containing groups, the prepared materials may have excellent chemical stability, weather resistance and low surface energy, and are widely used in coatings, plastics and other fields. For example, it is used to synthesize special coatings and apply them to the surface of objects, which can enhance the corrosion resistance and wear resistance of objects.
In the field of pesticides, 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene also plays an important role. It can be used as an important intermediate for the synthesis of new pesticides. The synthesized pesticides may have the advantages of high efficiency, low toxicity and environmental friendliness, which helps to improve the yield and quality of crops while reducing the adverse impact on the environment.
What are the synthesis methods 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene?
The synthesis methods of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene are quite diverse, and now it is your way.
First, it can be prepared by the nucleophilic substitution reaction of halogenated aromatics. First, take the aromatic hydrocarbon containing the appropriate substituent, and make it react with chlorinated reagents such as thionyl chloride and phosphorus trichloride to obtain chlorinated aromatics. Next, make it and fluorinated reagents, such as potassium fluoride, cesium fluoride, etc., under suitable reaction conditions, carry out nucleophilic substitution and introduce fluorine atoms. Then through specific reaction steps, introduce trifluoromethyl. In this process, the control of reaction conditions is extremely critical, such as reaction temperature, reaction time, and solvent selection, which all affect the yield and purity of the product.
Second, the direct halogenation of aromatic hydrocarbons is combined with the trifluoromethylation reaction. First, the aromatic hydrocarbons are chlorinated and fluorinated to obtain chlorine-containing and fluorine-containing aromatic hydrocarbon derivatives. Then, trifluoromethylation reagents, such as trifluoromethyl magnesium halide and sodium trifluoromethanesulfonate, are used to introduce trifluoromethyl into the aromatic ring through a suitable reaction path. This approach requires attention to the sequence and reaction selectivity of halogenation and trifluoromethylation, and strives to generate the target product efficiently.
Third, the reaction is catalyzed by transition metals. For example, transition metal catalysts such as palladium and copper are used to catalyze the reaction between halogenated aromatics and trifluoromethylated reagents. Such reactions usually have high selectivity and efficiency, but the cost of catalysts and post-reaction treatment may be factors to consider. In the reaction, the appropriate amount of catalyst, ligand types and reaction conditions can optimize the reaction process and improve the yield of the product.
In summary, the synthesis of 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can be based on actual needs and conditions, and the appropriate synthesis method can be selected, and the reaction parameters can be precisely adjusted to achieve the desired synthesis effect.
First, it can be prepared by the nucleophilic substitution reaction of halogenated aromatics. First, take the aromatic hydrocarbon containing the appropriate substituent, and make it react with chlorinated reagents such as thionyl chloride and phosphorus trichloride to obtain chlorinated aromatics. Next, make it and fluorinated reagents, such as potassium fluoride, cesium fluoride, etc., under suitable reaction conditions, carry out nucleophilic substitution and introduce fluorine atoms. Then through specific reaction steps, introduce trifluoromethyl. In this process, the control of reaction conditions is extremely critical, such as reaction temperature, reaction time, and solvent selection, which all affect the yield and purity of the product.
Second, the direct halogenation of aromatic hydrocarbons is combined with the trifluoromethylation reaction. First, the aromatic hydrocarbons are chlorinated and fluorinated to obtain chlorine-containing and fluorine-containing aromatic hydrocarbon derivatives. Then, trifluoromethylation reagents, such as trifluoromethyl magnesium halide and sodium trifluoromethanesulfonate, are used to introduce trifluoromethyl into the aromatic ring through a suitable reaction path. This approach requires attention to the sequence and reaction selectivity of halogenation and trifluoromethylation, and strives to generate the target product efficiently.
Third, the reaction is catalyzed by transition metals. For example, transition metal catalysts such as palladium and copper are used to catalyze the reaction between halogenated aromatics and trifluoromethylated reagents. Such reactions usually have high selectivity and efficiency, but the cost of catalysts and post-reaction treatment may be factors to consider. In the reaction, the appropriate amount of catalyst, ligand types and reaction conditions can optimize the reaction process and improve the yield of the product.
In summary, the synthesis of 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can be based on actual needs and conditions, and the appropriate synthesis method can be selected, and the reaction parameters can be precisely adjusted to achieve the desired synthesis effect.
What are the precautions for the product 4-chloro-1-fluoro-2- (trifluoromethyl) -benzene during storage and transportation?
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene is also an organic compound. During storage and transportation, many matters must not be ignored.
The first word for storage, this compound is active and sensitive to environmental factors. It should be stored in a cool, dry and well-ventilated place. If placed in a high temperature place, the reaction may be exacerbated by heat, and even there is a risk of explosion. Cover high temperature can promote the molecular movement to intensify, which greatly increases the chemical activity. As for humid places, it should not be stored, because it may react with water vapor, resulting in quality damage.
And pay attention to its isolation from other things. Because of its certain chemical activity, if it coexists with oxidizing or reducing substances, it is easy to cause chemical reactions. If it encounters a strong oxidizing agent or causes a violent oxidation reaction, this cannot be prevented. Therefore, it should be stored separately, or according to its chemical properties, it should be stored in a separate area with suitable materials.
Second talk about transportation, during transportation, the choice of containers is the key. A strong and well-sealed container is required to prevent leakage. Because it may be toxic and corrosive, once it leaks, it will not only damage the goods, but also endanger the transportation personnel and the surrounding environment. The means of transportation should also be clean and free of other residues to avoid impurities from reacting with the compound.
The temperature and vibration during transportation also need to be controlled. Avoid large fluctuations in temperature to prevent changes in the properties of the compound. Excessive vibration may cause damage to the container and cause leakage. And transportation personnel should be familiar with the characteristics of the compound and know the emergency response methods. In case of a situation, they can respond quickly and reduce the damage.
In short, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene has many meticulous requirements in terms of environment, container, isolation and personnel during storage and transportation. It is necessary to be cautious to ensure safety.
The first word for storage, this compound is active and sensitive to environmental factors. It should be stored in a cool, dry and well-ventilated place. If placed in a high temperature place, the reaction may be exacerbated by heat, and even there is a risk of explosion. Cover high temperature can promote the molecular movement to intensify, which greatly increases the chemical activity. As for humid places, it should not be stored, because it may react with water vapor, resulting in quality damage.
And pay attention to its isolation from other things. Because of its certain chemical activity, if it coexists with oxidizing or reducing substances, it is easy to cause chemical reactions. If it encounters a strong oxidizing agent or causes a violent oxidation reaction, this cannot be prevented. Therefore, it should be stored separately, or according to its chemical properties, it should be stored in a separate area with suitable materials.
Second talk about transportation, during transportation, the choice of containers is the key. A strong and well-sealed container is required to prevent leakage. Because it may be toxic and corrosive, once it leaks, it will not only damage the goods, but also endanger the transportation personnel and the surrounding environment. The means of transportation should also be clean and free of other residues to avoid impurities from reacting with the compound.
The temperature and vibration during transportation also need to be controlled. Avoid large fluctuations in temperature to prevent changes in the properties of the compound. Excessive vibration may cause damage to the container and cause leakage. And transportation personnel should be familiar with the characteristics of the compound and know the emergency response methods. In case of a situation, they can respond quickly and reduce the damage.
In short, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene has many meticulous requirements in terms of environment, container, isolation and personnel during storage and transportation. It is necessary to be cautious to ensure safety.
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