Linshang Chemical
PRODUCTS
Benzene, 4-Chloro-1-Methyl-2-Nitro-
Linshang Chemical
|
HS Code |
380834 |
| Chemical Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 |
| Solubility In Water | Low (organic compound) |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Stability | Stable under normal conditions |
| Hazard Class | May be toxic, irritant; depends on exposure |
As an accredited Benzene, 4-Chloro-1-Methyl-2-Nitro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - chloro - 1 - methyl - 2 - nitro - benzene in a sealed, labeled chemical drum. |
| Storage | **Storage of 4 - chloro - 1 - methyl - 2 - nitrobenzene**: Store this chemical in a cool, well - ventilated area, away from heat, sparks, and open flames as it is potentially flammable. Keep it in a tightly closed container to prevent vapor release. Separate it from oxidizing agents, reducing agents, and bases to avoid dangerous reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | The chemical "Benzene, 4 - chloro - 1 - methyl - 2 - nitro -" is likely shipped in sealed, corrosion - resistant containers. Due to its potentially hazardous nature, shipping follows strict regulations, ensuring proper labeling and handling during transit. |
Competitive Benzene, 4-Chloro-1-Methyl-2-Nitro- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of this product 4-chloro-1-methyl-2-nitrobenzene
This substance is called 4-bromo-1-methyl-2-nitrobenzene and is one of the organic compounds. Its chemical properties are unique, so let me explain them one by one.
First of all, the presence of nitro groups imparts certain oxidizing properties. Nitrogen atoms in nitro groups are in a high valence state and have an electron tendency. When encountering reducing agents, nitro groups can be reduced, and the common reduction products are amino groups. Under appropriate conditions, the nitro group of this substance can be reduced to amino groups by systems such as iron and hydrochloric acid, thereby deriving new compounds containing amino groups. This is of great significance in the field of organic synthesis, because amino groups can participate in many reactions, such as amidation, diazotization, etc.
Furthermore, the characteristics of bromine atoms cannot be ignored. The bromine atom is a good leaving group and is active in nucleophilic substitution reactions. If there is a nucleophilic reagent, the bromine atom can be replaced by a nucleophilic reagent. For example, when encountering nucleophilic reagents such as hydroxyl anions, the bromine atom may be replaced by hydroxyl groups to form compounds containing hydroxyl groups. And due to the electronegativity of the bromine atom, it also affects the electron cloud density distribution of the benzene ring, resulting in a relatively low electron cloud density of the adjacent and para-sites of the benzene ring, and a relatively high electron cloud density of the meta-site. This has a significant effect on the localization effect of the electrophilic substitution reaction, and the electrophilic reagents are more inclined to attack the meta-site.
In addition, the methyl group is attached to the benzene ring, which also The electron cloud density of the benzene ring is increased by inducing effect and superconjugation effect, which makes the benzene ring more prone to electrophilic substitution reaction, and the localization effect is ortho and para-localization. However, it interacts with the localization effect of nitro group, and the substitution position in the actual reaction needs to be comprehensively considered.
This 4-bromo-1-methyl-2-nitrobenzene has rich chemical properties, and the groups interact with each other, which is of great value in organic synthesis and related chemical research fields.
First of all, the presence of nitro groups imparts certain oxidizing properties. Nitrogen atoms in nitro groups are in a high valence state and have an electron tendency. When encountering reducing agents, nitro groups can be reduced, and the common reduction products are amino groups. Under appropriate conditions, the nitro group of this substance can be reduced to amino groups by systems such as iron and hydrochloric acid, thereby deriving new compounds containing amino groups. This is of great significance in the field of organic synthesis, because amino groups can participate in many reactions, such as amidation, diazotization, etc.
Furthermore, the characteristics of bromine atoms cannot be ignored. The bromine atom is a good leaving group and is active in nucleophilic substitution reactions. If there is a nucleophilic reagent, the bromine atom can be replaced by a nucleophilic reagent. For example, when encountering nucleophilic reagents such as hydroxyl anions, the bromine atom may be replaced by hydroxyl groups to form compounds containing hydroxyl groups. And due to the electronegativity of the bromine atom, it also affects the electron cloud density distribution of the benzene ring, resulting in a relatively low electron cloud density of the adjacent and para-sites of the benzene ring, and a relatively high electron cloud density of the meta-site. This has a significant effect on the localization effect of the electrophilic substitution reaction, and the electrophilic reagents are more inclined to attack the meta-site.
In addition, the methyl group is attached to the benzene ring, which also The electron cloud density of the benzene ring is increased by inducing effect and superconjugation effect, which makes the benzene ring more prone to electrophilic substitution reaction, and the localization effect is ortho and para-localization. However, it interacts with the localization effect of nitro group, and the substitution position in the actual reaction needs to be comprehensively considered.
This 4-bromo-1-methyl-2-nitrobenzene has rich chemical properties, and the groups interact with each other, which is of great value in organic synthesis and related chemical research fields.
What are the main uses of 4-chloro-1-methyl-2-nitrobenzene?
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1. Pharmaceutical field
This compound is very useful in the preparation of medicine. Its unique structure can be used as an intermediary for drug synthesis. For example, when developing new drugs for specific diseases, with its structural characteristics, it can precisely target biological targets in the body. Taking the treatment of inflammatory diseases as an example, this compound can be modified to interact with inflammation-related receptors, regulate inflammatory signaling pathways, and achieve the purpose of reducing inflammatory reactions. And because of its specific chemical groups, it has excellent performance in pharmacokinetics, which helps to improve drug bioavailability, enable drugs to reach the site of action more efficiently, reduce the distribution in non-target tissues, and reduce the chance of adverse reactions.
2. The field of organic synthesis
is a key building block for organic synthesis. Organic synthesis aims to build complex organic molecules, which contain specific carbon-carbon bonds and functional groups, and can participate in many classical organic reactions, such as nucleophilic substitution, addition reactions, etc. For example, when constructing bioactive natural product analogs, using them as the starting material, through a series of reactions, other key functional groups can be introduced to gradually build a complex molecular skeleton. At the same time, due to the balance of structural stability and reactivity, the synthesis route is more controllable and operable, providing broad space for organic chemists to design novel synthesis strategies.
3. The field of materials science
also has important applications in materials science. Can be used as a structural unit of functional materials. When designing new optoelectronic materials, their structures can endow materials with special electrical and optical properties. For example, introducing them into polymer systems can regulate the interaction between polymer molecular chains, change the energy level structure of materials, and then affect the luminous efficiency and carrier transport properties of materials. When preparing high-performance organic semiconductor materials, it can optimize the crystallinity and molecular arrangement of materials, improve the electrical properties and stability of materials, and play a key role in the fabrication of organic field effect transistors, organic Light Emitting Diodes and other devices.
1. Pharmaceutical field
This compound is very useful in the preparation of medicine. Its unique structure can be used as an intermediary for drug synthesis. For example, when developing new drugs for specific diseases, with its structural characteristics, it can precisely target biological targets in the body. Taking the treatment of inflammatory diseases as an example, this compound can be modified to interact with inflammation-related receptors, regulate inflammatory signaling pathways, and achieve the purpose of reducing inflammatory reactions. And because of its specific chemical groups, it has excellent performance in pharmacokinetics, which helps to improve drug bioavailability, enable drugs to reach the site of action more efficiently, reduce the distribution in non-target tissues, and reduce the chance of adverse reactions.
2. The field of organic synthesis
is a key building block for organic synthesis. Organic synthesis aims to build complex organic molecules, which contain specific carbon-carbon bonds and functional groups, and can participate in many classical organic reactions, such as nucleophilic substitution, addition reactions, etc. For example, when constructing bioactive natural product analogs, using them as the starting material, through a series of reactions, other key functional groups can be introduced to gradually build a complex molecular skeleton. At the same time, due to the balance of structural stability and reactivity, the synthesis route is more controllable and operable, providing broad space for organic chemists to design novel synthesis strategies.
3. The field of materials science
also has important applications in materials science. Can be used as a structural unit of functional materials. When designing new optoelectronic materials, their structures can endow materials with special electrical and optical properties. For example, introducing them into polymer systems can regulate the interaction between polymer molecular chains, change the energy level structure of materials, and then affect the luminous efficiency and carrier transport properties of materials. When preparing high-performance organic semiconductor materials, it can optimize the crystallinity and molecular arrangement of materials, improve the electrical properties and stability of materials, and play a key role in the fabrication of organic field effect transistors, organic Light Emitting Diodes and other devices.
What is the production method of 4-chloro-1-methyl-2-nitrobenzene?
To prepare 4-bromo-1-methyl-2-nitrobenzene, you can follow the method of "Tiangong Kaiwu" and use the ancient chemical method to obtain it.
First take toluene as the initial material, toluene, aromatic ring structure and methyl side chain. By bromination, the bromine atom replaces the hydrogen at a specific position of the benzene ring. This bromination process requires the power of a catalyst, such as iron filings or iron tribromide. Because the benzene ring is stable, the catalyst needs to be activated before bromine can be introduced into the ring. At appropriate temperature and reaction environment, the bromine atom preferentially selects methyl ortho and para-sites. After reaction, bromotoluene can be obtained.
However, the substitution position of bromine in this product may not be accurate to the target. At this time, nitrogenation reaction can be used to adjust. Concentrated sulfuric acid and concentrated nitric acid are mixed to form a mixed acid, which has strong oxidizing and nitrogenation ability. Bromotoluene is slowly added to the mixed acid system to control the reaction temperature and time. Nitro (-NO ²) is affected by the localization effect of bromine and methyl, and replaces hydrogen atoms at specific positions. After fine regulation, nitro can be introduced into the ortho-position of bromine and the interposition of methyl, which is in line with the structure of 4-bromo-1-methyl-2-nitrobenzene.
After the reaction is completed, the product is mixed in the reaction system and needs to be separated and purified. First, the organic phase was separated by the method of liquid separation, according to the density and solubility difference between the product and the reaction solution. Then, by distillation, using the different boiling points of each component to obtain pure 4-bromo-1-methyl-2-nitrobenzene. The whole process requires strict adherence to the reaction conditions, control the proportion of materials, and fine operation to obtain the desired product.
First take toluene as the initial material, toluene, aromatic ring structure and methyl side chain. By bromination, the bromine atom replaces the hydrogen at a specific position of the benzene ring. This bromination process requires the power of a catalyst, such as iron filings or iron tribromide. Because the benzene ring is stable, the catalyst needs to be activated before bromine can be introduced into the ring. At appropriate temperature and reaction environment, the bromine atom preferentially selects methyl ortho and para-sites. After reaction, bromotoluene can be obtained.
However, the substitution position of bromine in this product may not be accurate to the target. At this time, nitrogenation reaction can be used to adjust. Concentrated sulfuric acid and concentrated nitric acid are mixed to form a mixed acid, which has strong oxidizing and nitrogenation ability. Bromotoluene is slowly added to the mixed acid system to control the reaction temperature and time. Nitro (-NO ²) is affected by the localization effect of bromine and methyl, and replaces hydrogen atoms at specific positions. After fine regulation, nitro can be introduced into the ortho-position of bromine and the interposition of methyl, which is in line with the structure of 4-bromo-1-methyl-2-nitrobenzene.
After the reaction is completed, the product is mixed in the reaction system and needs to be separated and purified. First, the organic phase was separated by the method of liquid separation, according to the density and solubility difference between the product and the reaction solution. Then, by distillation, using the different boiling points of each component to obtain pure 4-bromo-1-methyl-2-nitrobenzene. The whole process requires strict adherence to the reaction conditions, control the proportion of materials, and fine operation to obtain the desired product.
What to pay attention to when storing and transporting 4-chloro-1-methyl-2-nitrobenzene
When storing and transporting 4-alkane-1-methyl-2-carbonylbenzene, the following matters should be paid attention to:
First, temperature control is essential. The properties of this compound may change due to temperature fluctuations, and the reaction may be accelerated or even dangerous due to high temperature. Therefore, the temperature at the storage place should be stable and moderate, and direct sunlight and heat sources should be avoided to prevent it from being deteriorated or safe.
Second, the humidity environment should not be underestimated. Humid gas may react with the compound, affecting its quality and stability. The storage place should be kept dry, and a desiccant can be placed next to it to absorb excess water vapor and keep it dry.
Third, the choice of container is a lot of consideration. Choose a container that is chemically stable and does not react with 4-alkane-1-methyl-2-carbonylbenzene. It must be well sealed to prevent leakage from contacting with air. Metal containers that may react with compounds should be discarded. Glass or specific plastic containers can be selected to ensure safe storage.
Fourth, when transporting, strictly abide by relevant regulations. Professional transportation tools are required, and transporters should be familiar with their characteristics and emergency methods. Be careful during loading and unloading to avoid collisions and dumping to prevent leakage due to damaged packaging.
Fifth, classified storage cannot be ignored. Do not store and transport it with oxidizing, reducing substances, acids, alkalis, etc., because of its chemical properties or violent reactions with it, which may cause danger. It should be properly classified according to its characteristics to ensure the safety of storage and transportation.
First, temperature control is essential. The properties of this compound may change due to temperature fluctuations, and the reaction may be accelerated or even dangerous due to high temperature. Therefore, the temperature at the storage place should be stable and moderate, and direct sunlight and heat sources should be avoided to prevent it from being deteriorated or safe.
Second, the humidity environment should not be underestimated. Humid gas may react with the compound, affecting its quality and stability. The storage place should be kept dry, and a desiccant can be placed next to it to absorb excess water vapor and keep it dry.
Third, the choice of container is a lot of consideration. Choose a container that is chemically stable and does not react with 4-alkane-1-methyl-2-carbonylbenzene. It must be well sealed to prevent leakage from contacting with air. Metal containers that may react with compounds should be discarded. Glass or specific plastic containers can be selected to ensure safe storage.
Fourth, when transporting, strictly abide by relevant regulations. Professional transportation tools are required, and transporters should be familiar with their characteristics and emergency methods. Be careful during loading and unloading to avoid collisions and dumping to prevent leakage due to damaged packaging.
Fifth, classified storage cannot be ignored. Do not store and transport it with oxidizing, reducing substances, acids, alkalis, etc., because of its chemical properties or violent reactions with it, which may cause danger. It should be properly classified according to its characteristics to ensure the safety of storage and transportation.
What are the effects of 4-chloro-1-methyl-2-nitrobenzene on the environment and human health?
6-Deuterium-1-methyl-2-ethylnaphthalene has a significant impact on the environment and human health.
First of all, discuss its effect on the environment. If this substance escapes from nature, it can exist in the atmosphere, water, and soil. In the atmosphere, or through photochemical reactions, other harmful substances can be derived, which disturbs the chemical balance of the atmosphere and damages air quality. In water bodies, its hydrophobicity makes it easy to adsorb on suspended particles, settle to the bottom of the water, and get tired in the bottom mud, endangering aquatic organisms. Benthic organisms bear the brunt, or due to the ingestion of sediments containing this substance, physiological dysfunction, growth and reproduction are hindered. And this substance may be transmitted and enriched through the food chain, from primary producers to high consumers, the concentration gradually rises, endangering the stability of aquatic ecosystems. In soil, it will inhibit the activity of soil microorganisms, hinder the decomposition of organic matter and nutrient circulation, change soil structure and fertility, and affect plant growth.
Second talk about its harm to human health. Entering the body through respiration, diet, and skin contact. Inhalation of the respiratory tract can stab the mucosa of the respiratory tract, causing cough, asthma, etc., and long-term exposure or increased risk of respiratory diseases. Eating food containing this substance, or absorbing it through the digestive tract, tires the body. It is fat-soluble, easy to store in adipose tissue, disrupts the endocrine system, affects hormone synthesis, secretion and regulation, and causes reproductive and developmental abnormalities. Animal experiments have shown that it can cause germ cell mutations, reduce fertility, and increase the risk of fetal malformations. It may also damage the nervous system, cause headache, dizziness, fatigue, long-term exposure or cause cognitive and neurobehavioral disorders.
In summary, 6-deuterium-1-methyl-2-ethylnaphthalene poses a potential threat to the environment and human health. When treated with caution, its emissions should be controlled to reduce its harm.
First of all, discuss its effect on the environment. If this substance escapes from nature, it can exist in the atmosphere, water, and soil. In the atmosphere, or through photochemical reactions, other harmful substances can be derived, which disturbs the chemical balance of the atmosphere and damages air quality. In water bodies, its hydrophobicity makes it easy to adsorb on suspended particles, settle to the bottom of the water, and get tired in the bottom mud, endangering aquatic organisms. Benthic organisms bear the brunt, or due to the ingestion of sediments containing this substance, physiological dysfunction, growth and reproduction are hindered. And this substance may be transmitted and enriched through the food chain, from primary producers to high consumers, the concentration gradually rises, endangering the stability of aquatic ecosystems. In soil, it will inhibit the activity of soil microorganisms, hinder the decomposition of organic matter and nutrient circulation, change soil structure and fertility, and affect plant growth.
Second talk about its harm to human health. Entering the body through respiration, diet, and skin contact. Inhalation of the respiratory tract can stab the mucosa of the respiratory tract, causing cough, asthma, etc., and long-term exposure or increased risk of respiratory diseases. Eating food containing this substance, or absorbing it through the digestive tract, tires the body. It is fat-soluble, easy to store in adipose tissue, disrupts the endocrine system, affects hormone synthesis, secretion and regulation, and causes reproductive and developmental abnormalities. Animal experiments have shown that it can cause germ cell mutations, reduce fertility, and increase the risk of fetal malformations. It may also damage the nervous system, cause headache, dizziness, fatigue, long-term exposure or cause cognitive and neurobehavioral disorders.
In summary, 6-deuterium-1-methyl-2-ethylnaphthalene poses a potential threat to the environment and human health. When treated with caution, its emissions should be controlled to reduce its harm.
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