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Benzene, 4-Chloro-2-(Chloromethyl)-1-Methoxy-
Linshang Chemical
|
HS Code |
444323 |
| Chemical Formula | C8H8Cl2O |
| Molar Mass | 191.054 g/mol |
| Physical State At Room Temperature | Likely solid |
| Solubility In Water | Low solubility (aromatic and chlorinated compounds tend to be hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc. |
| Density | No standard value without specific measurement |
| Flash Point | No common value available without experimental determination |
| Vapor Pressure | Low vapor pressure due to its relatively high molecular weight and structure |
As an accredited Benzene, 4-Chloro-2-(Chloromethyl)-1-Methoxy- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2-(chloromethyl)-1 - methoxy - benzene in a sealed chemical - grade bottle. |
| Storage | Store "Benzene, 4 - chloro - 2-(chloromethyl)-1 - methoxy -" in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage. Due to its potential hazards, it should be segregated from incompatible substances and stored in accordance with local regulations for hazardous chemicals. |
| Shipping | For "Benzene, 4 - chloro - 2 - (chloromethyl)-1 - methoxy -", shipping requires compliance with chemical transport regulations. It should be in properly sealed containers, labeled clearly, and transported by approved carriers to ensure safety. |
Competitive Benzene, 4-Chloro-2-(Chloromethyl)-1-Methoxy- prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading Benzene, 4-Chloro-2-(Chloromethyl)-1-Methoxy- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of Benzene, 4-chloro-2- (chloromethyl) -1-methoxy-
4-Chloro-2- (chloromethyl) -1-methoxybenzene is one of the organic compounds. Its properties have unique characteristics and are related to physical and chemical properties.
As far as physical properties are concerned, the state, taste and color of this substance are all its characteristics. Under normal conditions, it may be a liquid state with a special odor, and its color may be colorless to slightly yellow. The number of its melting and boiling points is also an important physical constant. The level of melting point and boiling point is related to the force between molecules. Those with strong intermolecular forces have higher melting and boiling points; vice versa. Due to the molecular structure of this compound, there are van der Waals forces between molecules, which make its melting and boiling points different from others.
As for the chemical properties, the chlorine atom, chloromethyl group and methoxy group in this compound are all active check points. The chlorine atom has electron-absorbing properties, which can change the electron cloud density distribution of the benzene ring and affect the electrophilic substitution reaction activity of the benzene ring. In the electrophilic substitution reaction, the reaction check point may be different from that of benzene due to the electricity absorption of the chlorine atom. The chlorine in the chlorine methyl group has high activity and can participate in the nucleophilic substitution reaction. The nucleophilic reagent is easy to attack this chlorine atom, causing the chlorine methyl group to be replaced The methoxy group is the power supply group, which has the effect of electron cloud on the benzene ring, which can enhance the density of the electron cloud of the benzene ring and make the electrophilic substitution reaction more likely to occur in the adjacent and para-position.
In addition, this compound may participate in oxidation, reduction and other reactions. Under specific conditions, chloromethyl may be oxidized, and methoxy may undergo demethylation and other reactions due to different reaction conditions. Its chemical properties are determined by the interaction of each group in the molecule, and the electronic effect and space effect of each group are intertwined to co-shape the chemical activity and reaction law of this compound.
As far as physical properties are concerned, the state, taste and color of this substance are all its characteristics. Under normal conditions, it may be a liquid state with a special odor, and its color may be colorless to slightly yellow. The number of its melting and boiling points is also an important physical constant. The level of melting point and boiling point is related to the force between molecules. Those with strong intermolecular forces have higher melting and boiling points; vice versa. Due to the molecular structure of this compound, there are van der Waals forces between molecules, which make its melting and boiling points different from others.
As for the chemical properties, the chlorine atom, chloromethyl group and methoxy group in this compound are all active check points. The chlorine atom has electron-absorbing properties, which can change the electron cloud density distribution of the benzene ring and affect the electrophilic substitution reaction activity of the benzene ring. In the electrophilic substitution reaction, the reaction check point may be different from that of benzene due to the electricity absorption of the chlorine atom. The chlorine in the chlorine methyl group has high activity and can participate in the nucleophilic substitution reaction. The nucleophilic reagent is easy to attack this chlorine atom, causing the chlorine methyl group to be replaced The methoxy group is the power supply group, which has the effect of electron cloud on the benzene ring, which can enhance the density of the electron cloud of the benzene ring and make the electrophilic substitution reaction more likely to occur in the adjacent and para-position.
In addition, this compound may participate in oxidation, reduction and other reactions. Under specific conditions, chloromethyl may be oxidized, and methoxy may undergo demethylation and other reactions due to different reaction conditions. Its chemical properties are determined by the interaction of each group in the molecule, and the electronic effect and space effect of each group are intertwined to co-shape the chemical activity and reaction law of this compound.
What are the main uses of Benzene, 4-chloro-2- (chloromethyl) -1-methoxy-
4-Chloro-2- (chloromethyl) -1-methoxybenzene is useful in various fields. In the field of medicinal chemistry, this compound is often a key intermediary. Due to its molecular structure containing chlorine atoms, chloromethyl groups and methoxy groups, it is endowed with specific reactivity and pharmacological properties. Or it can be chemically modified to create new drugs with specific biological activities, such as antibacterial, anti-inflammatory or anti-tumor drugs.
In the field of materials science, it also has potential uses. Its structural characteristics may enable it to participate in polymerization reactions to construct polymer materials with special properties, such as those with specific electrical, optical or mechanical properties, and then used in electronic devices, optical materials and other fields.
Furthermore, in organic synthetic chemistry, it is an important synthetic building block. Due to the existence of different functional groups, various organic compounds with diverse structures can be derived through various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., providing rich raw materials and possibilities for organic synthetic chemists to explore the structure and properties of novel compounds. Its unique structure makes it possible to have many choices in the design of chemical synthesis paths, which promotes the development of organic synthetic chemistry.
In the field of materials science, it also has potential uses. Its structural characteristics may enable it to participate in polymerization reactions to construct polymer materials with special properties, such as those with specific electrical, optical or mechanical properties, and then used in electronic devices, optical materials and other fields.
Furthermore, in organic synthetic chemistry, it is an important synthetic building block. Due to the existence of different functional groups, various organic compounds with diverse structures can be derived through various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., providing rich raw materials and possibilities for organic synthetic chemists to explore the structure and properties of novel compounds. Its unique structure makes it possible to have many choices in the design of chemical synthesis paths, which promotes the development of organic synthetic chemistry.
What is the synthesis method of Benzene, 4-chloro-2- (chloromethyl) -1-methoxy-?
To prepare 4-chloro-2 - (chloromethyl) -1 -methoxybenzene, the following route can be started.
The starting material is selected from methoxytoluene, which is a readily available compound.
In the first step, p-methoxytoluene will be chloromethylated. In a suitable reaction vessel, add p-methoxytoluene, paraformaldehyde, concentrated hydrochloric acid, and zinc chloride as a catalyst to heat the reaction. In this process, paraformaldehyde is depolymerized into formaldehyde under the action of concentrated hydrochloric acid, formaldehyde reacts with hydrogen chloride to form chloromethyl ether intermediate, and then undergoes electrophilic substitution reaction with p-methoxytoluene. Chloromethyl is introduced at the methyl ortho-position to generate 2- (chloromethyl) -1 -methoxybenzene. In this step, attention should be paid to controlling the reaction temperature and the ratio of reactants. If the temperature is too high, it is easy to initiate polychlorination side reactions, which affects the yield and purity of the target product.
In the second step, chlorination of 2- (chloromethyl) -1 -methoxybenzene is carried out. The product of the previous step is dissolved in a suitable organic solvent, such as dichloromethane, and chlorine gas is slowly Because the methoxy group is an ortho-para-position group, the chlorine atom mainly replaces the methyl ortho-position (the other ortho-position has been occupied by chloromethyl) or the para-position hydrogen atom on the benzene ring. The main product can be 4-chloro-2- (chloromethyl) -1-methoxybenzene by controlling the amount of chlorine and the reaction time.
After each step of the reaction, it is necessary to separate and purify. First, the organic phase is preliminarily separated by means of liquid separation, and then fine operations such as column chromatography and recrystallization are carried out to obtain high-purity target products. The whole synthesis process requires strict control of the reaction conditions and attention to safety. Because it involves dangerous chemicals such as chlorine, protection and tail gas treatment must be done well.
The starting material is selected from methoxytoluene, which is a readily available compound.
In the first step, p-methoxytoluene will be chloromethylated. In a suitable reaction vessel, add p-methoxytoluene, paraformaldehyde, concentrated hydrochloric acid, and zinc chloride as a catalyst to heat the reaction. In this process, paraformaldehyde is depolymerized into formaldehyde under the action of concentrated hydrochloric acid, formaldehyde reacts with hydrogen chloride to form chloromethyl ether intermediate, and then undergoes electrophilic substitution reaction with p-methoxytoluene. Chloromethyl is introduced at the methyl ortho-position to generate 2- (chloromethyl) -1 -methoxybenzene. In this step, attention should be paid to controlling the reaction temperature and the ratio of reactants. If the temperature is too high, it is easy to initiate polychlorination side reactions, which affects the yield and purity of the target product.
In the second step, chlorination of 2- (chloromethyl) -1 -methoxybenzene is carried out. The product of the previous step is dissolved in a suitable organic solvent, such as dichloromethane, and chlorine gas is slowly Because the methoxy group is an ortho-para-position group, the chlorine atom mainly replaces the methyl ortho-position (the other ortho-position has been occupied by chloromethyl) or the para-position hydrogen atom on the benzene ring. The main product can be 4-chloro-2- (chloromethyl) -1-methoxybenzene by controlling the amount of chlorine and the reaction time.
After each step of the reaction, it is necessary to separate and purify. First, the organic phase is preliminarily separated by means of liquid separation, and then fine operations such as column chromatography and recrystallization are carried out to obtain high-purity target products. The whole synthesis process requires strict control of the reaction conditions and attention to safety. Because it involves dangerous chemicals such as chlorine, protection and tail gas treatment must be done well.
Benzene, 4-chloro-2- (chloromethyl) -1-methoxy- what to pay attention to when storing and transporting
"Tiangong Kaiwu" is an ancient scientific and technological book. In ancient classical Chinese, the answer to this question should be as follows:
Fu 4-chloro-2- (chloromethyl) -1-methoxybenzene This material should be handled with caution during storage and transportation. Its nature may be unstable, and it is easy to react with other things. When storing, the first thing to choose is a cool and dry place, away from direct sunlight, to prevent it from being heated and changing. It is better to pass air in the warehouse to avoid its gas accumulation and danger. Furthermore, it must be separated from other things, especially flammable, perishable, and chemical things, so as not to cause danger.
When transporting, it should also be taken care of. The vehicle must be clean and airtight to prevent it from leaking outside. Avoid high temperature and vibration on the way, and the escort should know the nature of this object and prepare emergency measures. If it leaks outside, take measures quickly, surround it with leaks, do not let it escape, cover it with sand, etc., and collect it properly. When handling, handle it with care, and do not damage its equipment, causing it to be dangerous when it comes out. In this way, the safety of storage and transportation can be guaranteed, so as to avoid unexpected disasters.
Fu 4-chloro-2- (chloromethyl) -1-methoxybenzene This material should be handled with caution during storage and transportation. Its nature may be unstable, and it is easy to react with other things. When storing, the first thing to choose is a cool and dry place, away from direct sunlight, to prevent it from being heated and changing. It is better to pass air in the warehouse to avoid its gas accumulation and danger. Furthermore, it must be separated from other things, especially flammable, perishable, and chemical things, so as not to cause danger.
When transporting, it should also be taken care of. The vehicle must be clean and airtight to prevent it from leaking outside. Avoid high temperature and vibration on the way, and the escort should know the nature of this object and prepare emergency measures. If it leaks outside, take measures quickly, surround it with leaks, do not let it escape, cover it with sand, etc., and collect it properly. When handling, handle it with care, and do not damage its equipment, causing it to be dangerous when it comes out. In this way, the safety of storage and transportation can be guaranteed, so as to avoid unexpected disasters.
What are the effects of Benzene, 4-chloro-2- (chloromethyl) -1-methoxy- on the environment and human health?
"Tiangong Wuwu" is a masterpiece of science and technology written by Song Yuxing in the Ming Dynasty. It is said in ancient Chinese, and today the answer is as follows:
4-chloro-2- (chloromethyl) -1-methoxybenzene This substance has an important impact on the environment and human health.
In terms of the environment, this chlorine-containing substance is easy to degrade if it is natural. It may enter the soil, destroy the fertility of the soil, cause disorder of the soil microbial community, and cause the amount of products produced to be affected by it. If it flows into the water, it may affect the physiological function of the animal and aquatic organisms, hinder the reproduction, and even cause the splitting of the plant.
When it comes to human health, if this compound is inhaled, exposed to the skin or eaten, it is very harmful. It contains chlorine, or a normal substitute for dry humans. Such as invading the liver and other detoxification and excretion organs, causing its function to be affected, toxin accumulation. It may also affect the health system, causing people to suffer from health problems, fatigue, fatigue and other diseases. Exposure during the period is more likely to cause gene outbursts and increase the risk of cancer.
As a result, this 4-chloro-2 - (chloromethyl) -1-methoxybenzene is harmful to both the environment and human health. Be careful to prevent its use and not discharge, so as to keep the environment safe and people healthy.
4-chloro-2- (chloromethyl) -1-methoxybenzene This substance has an important impact on the environment and human health.
In terms of the environment, this chlorine-containing substance is easy to degrade if it is natural. It may enter the soil, destroy the fertility of the soil, cause disorder of the soil microbial community, and cause the amount of products produced to be affected by it. If it flows into the water, it may affect the physiological function of the animal and aquatic organisms, hinder the reproduction, and even cause the splitting of the plant.
When it comes to human health, if this compound is inhaled, exposed to the skin or eaten, it is very harmful. It contains chlorine, or a normal substitute for dry humans. Such as invading the liver and other detoxification and excretion organs, causing its function to be affected, toxin accumulation. It may also affect the health system, causing people to suffer from health problems, fatigue, fatigue and other diseases. Exposure during the period is more likely to cause gene outbursts and increase the risk of cancer.
As a result, this 4-chloro-2 - (chloromethyl) -1-methoxybenzene is harmful to both the environment and human health. Be careful to prevent its use and not discharge, so as to keep the environment safe and people healthy.
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