Linshang Chemical
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Benzene, 4-Chloro-2-Ethoxy-1-Fluoro-
Linshang Chemical
|
HS Code |
618644 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 176.599 g/mol |
| Density | Estimated around 1.2 - 1.3 g/cm³ based on similar halogen - containing aromatic ethers |
| Solubility In Water | Low, as it is an aromatic organic compound with non - polar groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, and dichloromethane |
| Vapor Pressure | Low, due to its relatively high molecular weight and non - volatile nature |
| Flash Point | Estimated around 80 - 100 °C based on related compounds |
As an accredited Benzene, 4-Chloro-2-Ethoxy-1-Fluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 2 - ethoxy - 1 - fluorobenzene in a sealed chemical - grade bottle. |
| Storage | Store "Benzene, 4 - chloro - 2 - ethoxy - 1 - fluoro -" in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Separate it from oxidizing agents, acids, and bases. Ensure the storage facility has proper spill - containment measures to prevent environmental contamination. |
| Shipping | "4 - Chloro - 2 - ethoxy - 1 - fluorobenzene" is shipped in containers suitable for hazardous chemicals. It's carefully packaged to prevent leakage. Shipment follows strict regulations due to its chemical nature, ensuring safe transport. |
Competitive Benzene, 4-Chloro-2-Ethoxy-1-Fluoro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading Benzene, 4-Chloro-2-Ethoxy-1-Fluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-ethoxy-1-fluorobenzene?
4-Bromo-2-ethyloxy-1-fluorobenzene, an organic compound, has important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate. With its unique chemical structure, it can participate in a variety of chemical reactions and undergo a series of transformations to construct complex compound molecules with specific pharmacological activities. For example, when developing new antibacterial drugs, this is used as a starting material to modify its side chain or halogen atoms to change the binding ability and metabolic characteristics of the drug to the target, helping to create better antibacterial agents with less side effects.
In the field of materials science, 4-bromo-2-ethyloxy-1-fluorobenzene also plays an important role. Because it contains halogen atoms and specific substituents, it can be used to synthesize materials with special photoelectric properties. For example, the preparation of organic Light Emitting Diode (OLED) materials, through precise molecular design and synthesis, the compound is introduced into the conjugate system to regulate the electron transport and luminescence properties of the material, achieve efficient luminescence and color control, and improve the display quality and performance of OLED display devices.
In addition, in the field of pesticide chemistry, it can be used as an important building block for the synthesis of new pesticides. Using its structural characteristics, pesticides with high selectivity, high inhibition or killing effect on specific pests can be designed and synthesized, while reducing the impact on the environment and non-target organisms, providing strong support for sustainable agricultural development.
In conclusion, 4-bromo-2-ethyloxy-1-fluorobenzene, with its unique structure, is used as a key starting material or intermediate in medicine, materials, pesticides and other fields to promote technological innovation and development in various fields.
In the field of medicinal chemistry, it is often a key intermediate. With its unique chemical structure, it can participate in a variety of chemical reactions and undergo a series of transformations to construct complex compound molecules with specific pharmacological activities. For example, when developing new antibacterial drugs, this is used as a starting material to modify its side chain or halogen atoms to change the binding ability and metabolic characteristics of the drug to the target, helping to create better antibacterial agents with less side effects.
In the field of materials science, 4-bromo-2-ethyloxy-1-fluorobenzene also plays an important role. Because it contains halogen atoms and specific substituents, it can be used to synthesize materials with special photoelectric properties. For example, the preparation of organic Light Emitting Diode (OLED) materials, through precise molecular design and synthesis, the compound is introduced into the conjugate system to regulate the electron transport and luminescence properties of the material, achieve efficient luminescence and color control, and improve the display quality and performance of OLED display devices.
In addition, in the field of pesticide chemistry, it can be used as an important building block for the synthesis of new pesticides. Using its structural characteristics, pesticides with high selectivity, high inhibition or killing effect on specific pests can be designed and synthesized, while reducing the impact on the environment and non-target organisms, providing strong support for sustainable agricultural development.
In conclusion, 4-bromo-2-ethyloxy-1-fluorobenzene, with its unique structure, is used as a key starting material or intermediate in medicine, materials, pesticides and other fields to promote technological innovation and development in various fields.
What are the physical properties of 4-chloro-2-ethoxy-1-fluorobenzene?
4-Cyanogen-2-ethoxy-1-naphthalaldehyde is one of the organic compounds. Its physical properties are as follows:
Looking at its color state, under room temperature, 4-cyanogen-2-ethoxy-1-naphthalaldehyde is often in a solid state. Due to the intermolecular force, the molecules are arranged in an orderly manner, resulting in a solid state. Its crystal structure also affects its appearance. The specific crystal form needs to be determined in detail by means of X-ray diffraction.
When it comes to melting point, this compound has a specific melting point. For melting point, the temperature at which the substance changes from solid state to liquid state. The melting point of 4-cyanogen-2-ethoxy-1-naphthalaldehyde is its inherent physical properties and can be an important basis for identifying this compound. However, the exact melting point value varies slightly due to factors such as preparation method and purity, and is generally within a certain temperature range, which needs to be determined by precise experiments.
As for solubility, in organic solvents, 4-cyanogen-2-ethoxy-1-naphthalaldehyde exhibits different solubility properties. It has a certain solubility in common organic solvents such as ethanol, ethyl ether, dichloromethane, etc. This is due to the principle of "similar phase dissolution". The molecular structure of the compound and the molecules of the organic solvent can form a certain intermolecular force, such as van der Waals force, hydrogen bond, etc., to promote its dissolution. However, in water, its solubility is extremely low, because water is a highly polar solvent, which is quite different from the molecular structure of the compound, and the intermolecular force is difficult to form effectively, so it is difficult to dissolve.
When it comes to density, the density of 4-cyanogen-2-ethoxy-1-naphthalene formaldehyde is also an important physical property. Density, the mass of the substance per unit volume. Although its exact density value needs to be accurately measured experimentally, its density is related to the molecular structure and relative molecular mass. The relative molecular weight is large, and the degree of molecular arrangement is different, which affects its density. This density property may be of great significance in the separation, purification and related chemical production processes.
In addition, 4-cyanogen-2-ethoxy-1-naphthalaldehyde also has a certain stability to light and heat. It can exist stably under normal temperature and dark environment. However, when the heat or light conditions change, or the molecular structure changes, causing it to undergo chemical reactions, which is also a matter of concern when studying its physical and chemical properties.
Looking at its color state, under room temperature, 4-cyanogen-2-ethoxy-1-naphthalaldehyde is often in a solid state. Due to the intermolecular force, the molecules are arranged in an orderly manner, resulting in a solid state. Its crystal structure also affects its appearance. The specific crystal form needs to be determined in detail by means of X-ray diffraction.
When it comes to melting point, this compound has a specific melting point. For melting point, the temperature at which the substance changes from solid state to liquid state. The melting point of 4-cyanogen-2-ethoxy-1-naphthalaldehyde is its inherent physical properties and can be an important basis for identifying this compound. However, the exact melting point value varies slightly due to factors such as preparation method and purity, and is generally within a certain temperature range, which needs to be determined by precise experiments.
As for solubility, in organic solvents, 4-cyanogen-2-ethoxy-1-naphthalaldehyde exhibits different solubility properties. It has a certain solubility in common organic solvents such as ethanol, ethyl ether, dichloromethane, etc. This is due to the principle of "similar phase dissolution". The molecular structure of the compound and the molecules of the organic solvent can form a certain intermolecular force, such as van der Waals force, hydrogen bond, etc., to promote its dissolution. However, in water, its solubility is extremely low, because water is a highly polar solvent, which is quite different from the molecular structure of the compound, and the intermolecular force is difficult to form effectively, so it is difficult to dissolve.
When it comes to density, the density of 4-cyanogen-2-ethoxy-1-naphthalene formaldehyde is also an important physical property. Density, the mass of the substance per unit volume. Although its exact density value needs to be accurately measured experimentally, its density is related to the molecular structure and relative molecular mass. The relative molecular weight is large, and the degree of molecular arrangement is different, which affects its density. This density property may be of great significance in the separation, purification and related chemical production processes.
In addition, 4-cyanogen-2-ethoxy-1-naphthalaldehyde also has a certain stability to light and heat. It can exist stably under normal temperature and dark environment. However, when the heat or light conditions change, or the molecular structure changes, causing it to undergo chemical reactions, which is also a matter of concern when studying its physical and chemical properties.
What are the chemical properties of 4-chloro-2-ethoxy-1-fluorobenzene?
4-Cyanogen-2-ethoxy-1-naphthalene formaldehyde, the physical properties are as follows:
Its appearance is often crystalline, and the color may be light yellow to light brown. At room temperature, it is a solid state with a fixed melting point, about a specific range, because the exact value needs to be determined by the experiment.
When it comes to solubility, in organic solvents such as ethanol and ether, there is a certain ability to dissolve. Due to the principle of similar compatibility, its molecular structure is compatible with organic solvents, so it is soluble. However, in water, it dissolves very little, because its molecular polarity is quite different from that of water molecules, and it is difficult to miscible with each other.
In terms of chemical activity, aldehyde groups are active groups and can participate in many reactions. If nucleophilic addition can occur with nucleophilic reagents, like with alcohols, acetals can be formed under suitable conditions. This reaction is often used to protect aldehyde groups in organic synthesis. Cyanyl groups are also non-inert and can be converted into carboxyl groups by hydrolysis, or participate in cyclization and other reactions under the action of specific reagents, providing a way to build complex organic structures. Although ethoxy groups are relatively stable, they may also undergo reactions such as cracking under extreme conditions such as strong acidity or alkalinity and high temperature.
In addition, the compound has a conjugated system. Due to the conjugation of the naphthalene ring with an aldehyde group and a cyano group, it has unique spectral properties and a specific absorption peak in the ultraviolet-visible spectrum. It can be used for qualitative and quantitative analysis, which helps to detect and determine its purity in research and production.
Its appearance is often crystalline, and the color may be light yellow to light brown. At room temperature, it is a solid state with a fixed melting point, about a specific range, because the exact value needs to be determined by the experiment.
When it comes to solubility, in organic solvents such as ethanol and ether, there is a certain ability to dissolve. Due to the principle of similar compatibility, its molecular structure is compatible with organic solvents, so it is soluble. However, in water, it dissolves very little, because its molecular polarity is quite different from that of water molecules, and it is difficult to miscible with each other.
In terms of chemical activity, aldehyde groups are active groups and can participate in many reactions. If nucleophilic addition can occur with nucleophilic reagents, like with alcohols, acetals can be formed under suitable conditions. This reaction is often used to protect aldehyde groups in organic synthesis. Cyanyl groups are also non-inert and can be converted into carboxyl groups by hydrolysis, or participate in cyclization and other reactions under the action of specific reagents, providing a way to build complex organic structures. Although ethoxy groups are relatively stable, they may also undergo reactions such as cracking under extreme conditions such as strong acidity or alkalinity and high temperature.
In addition, the compound has a conjugated system. Due to the conjugation of the naphthalene ring with an aldehyde group and a cyano group, it has unique spectral properties and a specific absorption peak in the ultraviolet-visible spectrum. It can be used for qualitative and quantitative analysis, which helps to detect and determine its purity in research and production.
What are the synthesis methods of 4-chloro-2-ethoxy-1-fluorobenzene?
To prepare 4-bromo-2-ethoxy-1-fluorobenzene, the following methods can be used.
First, the phenolic compound is used as the starting material. First, the phenol is reacted with halogenated ethane in an alkaline environment, and the hydroxyl group of the phenol is nucleophilically substituted with halogenated ethane to obtain an ethoxylated product. Then the product is reacted with brominated reagents and fluorinated reagents in a specific order and conditions. If brominated first, liquid bromine can be selected to react in a low temperature and inert solvent under the catalysis of a suitable catalyst such as iron powder, and the bromine atom replaces the hydrogen atom at a specific position in the benzene ring; for refluorination, a nucleophilic fluorination reagent can be used. In the presence of a phase transfer catalyst, the reaction is heated, and the fluorine atom replaces the hydrogen atom at another specific position, and the target product is obtained.
Second, a halogenated benzene derivative is used as the starting material. If the starting material is a suitable halogenated benzene, an ethoxy group can be introduced first. The halogenated benzene is heated with an alkoxylation reagent such as sodium ethanol in an aprotic polar solvent, and the halogen atom is replaced by an ethoxy group. After that, If N-bromosuccinimide (NBS) is first brominated under the action of an initiator, and then alkali metal fluorides such as potassium fluoride are fluorinated in the presence of catalysts such as crown ethers, 4-bromo-2-ethoxy-1-fluorobenzene can also be obtained.
Third, with the help of coupling reaction strategies such as Suzuki coupling. First prepare different aryl boric acids or borate esters containing ethoxy, bromine, and fluorine, respectively, and then react with suitable halogenated aromatics in an alkaline environment and a specific organic solvent under the catalysis of transition metal catalysts such as palladium catalysts. The target molecule 4-bromo-2-ethoxy-1-fluorobenzene was constructed through the coupling reaction by rationally designing the structure and reaction conditions of the reactants, so that the target molecule 4-bromo-2-ethoxy-1-fluorobenzene could be constructed. During the reaction, attention should be paid to the influence of factors such as catalyst activity, ligand selection and ratio of reactants on the yield and selectivity of the reaction.
First, the phenolic compound is used as the starting material. First, the phenol is reacted with halogenated ethane in an alkaline environment, and the hydroxyl group of the phenol is nucleophilically substituted with halogenated ethane to obtain an ethoxylated product. Then the product is reacted with brominated reagents and fluorinated reagents in a specific order and conditions. If brominated first, liquid bromine can be selected to react in a low temperature and inert solvent under the catalysis of a suitable catalyst such as iron powder, and the bromine atom replaces the hydrogen atom at a specific position in the benzene ring; for refluorination, a nucleophilic fluorination reagent can be used. In the presence of a phase transfer catalyst, the reaction is heated, and the fluorine atom replaces the hydrogen atom at another specific position, and the target product is obtained.
Second, a halogenated benzene derivative is used as the starting material. If the starting material is a suitable halogenated benzene, an ethoxy group can be introduced first. The halogenated benzene is heated with an alkoxylation reagent such as sodium ethanol in an aprotic polar solvent, and the halogen atom is replaced by an ethoxy group. After that, If N-bromosuccinimide (NBS) is first brominated under the action of an initiator, and then alkali metal fluorides such as potassium fluoride are fluorinated in the presence of catalysts such as crown ethers, 4-bromo-2-ethoxy-1-fluorobenzene can also be obtained.
Third, with the help of coupling reaction strategies such as Suzuki coupling. First prepare different aryl boric acids or borate esters containing ethoxy, bromine, and fluorine, respectively, and then react with suitable halogenated aromatics in an alkaline environment and a specific organic solvent under the catalysis of transition metal catalysts such as palladium catalysts. The target molecule 4-bromo-2-ethoxy-1-fluorobenzene was constructed through the coupling reaction by rationally designing the structure and reaction conditions of the reactants, so that the target molecule 4-bromo-2-ethoxy-1-fluorobenzene could be constructed. During the reaction, attention should be paid to the influence of factors such as catalyst activity, ligand selection and ratio of reactants on the yield and selectivity of the reaction.
What are the precautions for using 4-chloro-2-ethoxy-1-fluorobenzene?
4-Cyanogen-2-ethoxy-1-naphthaldehyde is a key intermediate in organic synthesis. During use, the following matters should be paid attention to:
First, safety protection must not be forgotten. This substance is toxic and irritating, and contact with the skin, eyes or inhalation of its dust and steam may cause adverse consequences. Therefore, when operating, be sure to wear protective equipment, such as laboratory clothes, gloves and protective glasses, and the operation should be carried out in a well-ventilated environment, preferably in a fume hood, to prevent the accumulation of harmful steam. If you accidentally come into contact with this substance, you should immediately rinse the contact area with a large amount of water. If the situation is serious, you need to seek medical treatment as soon as possible.
Second, the storage conditions must be suitable. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is more sensitive to light and air, it should be sealed and stored to avoid long-term exposure to air to prevent oxidation or other deterioration reactions. At the same time, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid dangerous chemical reactions.
Third, the operation of access is rigorous and meticulous. When taking 4-cyanogen-2-ethoxy-1-naphthalaldehyde, use clean and dry tools to prevent impurities from mixing in. Weigh the dose must be accurate, and operate according to the amount required for the experiment or production to avoid waste. After taking it, the container should be sealed in time and placed back in the specified storage location.
Fourth, the chemical reaction conditions should be strictly controlled. When carrying out a chemical reaction with 4-cyanogen-2-ethoxy-1-naphthaldehyde as a raw material, it is necessary to strictly control the reaction temperature, time, and proportion of reactants according to the specific reaction requirements. Due to its active chemical nature, a slight deviation in the reaction conditions may lead to poor reaction results or generate by-products, which will affect the purity and yield of the products.
In short, when using 4-cyanogen-2-ethoxy-1-naphthalaldehyde, no matter what step, it is necessary to be careful and strictly abide by the relevant operating procedures and safety regulations, so as to ensure the safety of the operation process and obtain the ideal experimental or production results.
First, safety protection must not be forgotten. This substance is toxic and irritating, and contact with the skin, eyes or inhalation of its dust and steam may cause adverse consequences. Therefore, when operating, be sure to wear protective equipment, such as laboratory clothes, gloves and protective glasses, and the operation should be carried out in a well-ventilated environment, preferably in a fume hood, to prevent the accumulation of harmful steam. If you accidentally come into contact with this substance, you should immediately rinse the contact area with a large amount of water. If the situation is serious, you need to seek medical treatment as soon as possible.
Second, the storage conditions must be suitable. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is more sensitive to light and air, it should be sealed and stored to avoid long-term exposure to air to prevent oxidation or other deterioration reactions. At the same time, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid dangerous chemical reactions.
Third, the operation of access is rigorous and meticulous. When taking 4-cyanogen-2-ethoxy-1-naphthalaldehyde, use clean and dry tools to prevent impurities from mixing in. Weigh the dose must be accurate, and operate according to the amount required for the experiment or production to avoid waste. After taking it, the container should be sealed in time and placed back in the specified storage location.
Fourth, the chemical reaction conditions should be strictly controlled. When carrying out a chemical reaction with 4-cyanogen-2-ethoxy-1-naphthaldehyde as a raw material, it is necessary to strictly control the reaction temperature, time, and proportion of reactants according to the specific reaction requirements. Due to its active chemical nature, a slight deviation in the reaction conditions may lead to poor reaction results or generate by-products, which will affect the purity and yield of the products.
In short, when using 4-cyanogen-2-ethoxy-1-naphthalaldehyde, no matter what step, it is necessary to be careful and strictly abide by the relevant operating procedures and safety regulations, so as to ensure the safety of the operation process and obtain the ideal experimental or production results.
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