Linshang Chemical
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Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
780904 |
| Chemical Formula | C7H3ClF4 |
| Molar Mass | 214.547 g/mol |
| Solubility In Water | Expected to be low (non - polar nature) |
As an accredited Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottles of 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)benzene, well - sealed. |
| Storage | **Storage for 4 - Chloro - 2 - fluoro - 1 - (trifluoromethyl)benzene**: Store this chemical in a cool, well - ventilated area, away from heat sources, open flames, and ignition sources. Keep it in a tightly - sealed container to prevent vapor leakage. Since it is likely flammable and potentially harmful, ensure storage is separate from oxidizing agents and incompatible substances. Use appropriate secondary containment to prevent spills from spreading. |
| Shipping | Benzene, 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)- is a chemical. Shipping requires proper labeling as hazardous. It must be packaged securely in accordance with regulations to prevent spills during transit. |
Competitive Benzene, 4-Chloro-2-Fluoro-1-(Trifluoromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical property 4-chloro-2-fluoro-1- (trifluoromethyl) -benzene
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are unique and have common characteristics of aromatic hydrocarbons.
In this compound, the benzene ring is the core structure, and the substitution of chlorine, fluorine and trifluoromethyl on it greatly affects its properties. Chlorine and fluorine atoms have strong electronegativity, which can change the electron cloud density of the benzene ring, causing its electrophilic substitution reaction activity to be different from that of benzene. Generally speaking, chlorine and fluorine atoms reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult than benzene, and the localization effect is significant. Although chlorine and fluorine are ortho-sites, although they reduce the reaction activity, they guide the electrophilic reagents to attack the ortho-
Trifluoromethyl also has strong electron absorption, which further reduces the electron cloud density of benzene ring and strengthens the inhibition of electrophilic substitution reaction. At the same time, its steric resistance is large, which affects the proximity of the reactant to the benzene ring in the reaction, the left and right reaction paths and the product distribution.
In the oxidation reaction, due to the relatively stable benzene ring, this compound is not easy to be oxidized by general oxidants. However, in the case of strong oxidants, the benzene ring may be destroyed or the side chain trifluoromethyl is oxidized under severe conditions.
In addition, the physical properties of the compound are also related to its chemical properties. Due to the influence of molecular polarity and halogen atoms, its physical properties such as boiling point, melting point and solubility are different from those of The increase in the number of halogen atoms increases the intermolecular force and the melting boiling point increases. And because of its certain polarity, its solubility in polar solvents may be better than that of benzene.
The chemical properties of 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene are determined by the interaction between benzene ring and substituents. When applying in organic synthesis, medicinal chemistry and other fields, these properties need to be fully considered in order to rationally design the reaction path and obtain the expected product.
In this compound, the benzene ring is the core structure, and the substitution of chlorine, fluorine and trifluoromethyl on it greatly affects its properties. Chlorine and fluorine atoms have strong electronegativity, which can change the electron cloud density of the benzene ring, causing its electrophilic substitution reaction activity to be different from that of benzene. Generally speaking, chlorine and fluorine atoms reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult than benzene, and the localization effect is significant. Although chlorine and fluorine are ortho-sites, although they reduce the reaction activity, they guide the electrophilic reagents to attack the ortho-
Trifluoromethyl also has strong electron absorption, which further reduces the electron cloud density of benzene ring and strengthens the inhibition of electrophilic substitution reaction. At the same time, its steric resistance is large, which affects the proximity of the reactant to the benzene ring in the reaction, the left and right reaction paths and the product distribution.
In the oxidation reaction, due to the relatively stable benzene ring, this compound is not easy to be oxidized by general oxidants. However, in the case of strong oxidants, the benzene ring may be destroyed or the side chain trifluoromethyl is oxidized under severe conditions.
In addition, the physical properties of the compound are also related to its chemical properties. Due to the influence of molecular polarity and halogen atoms, its physical properties such as boiling point, melting point and solubility are different from those of The increase in the number of halogen atoms increases the intermolecular force and the melting boiling point increases. And because of its certain polarity, its solubility in polar solvents may be better than that of benzene.
The chemical properties of 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene are determined by the interaction between benzene ring and substituents. When applying in organic synthesis, medicinal chemistry and other fields, these properties need to be fully considered in order to rationally design the reaction path and obtain the expected product.
4-chloro-2-fluoro-1- (trifluoromethyl) -benzene is used in which fields
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene, this compound is used in the fields of medicine, pesticides, and materials.
In the field of medicine, it can be used as a key intermediate for the creation of new drugs. Due to the special structure of fluorine, chlorine and trifluoromethyl, the compound is endowed with unique physicochemical and bioactive properties. It may enhance the lipophilicity of the drug, which is conducive to the drug passing through the biofilm, enhancing absorption and distribution, and thus enhancing the efficacy of the drug. For example, after ingenious design and modification, it can be used to develop antibacterial drugs that interfere with bacterial physiological processes with their special structures to achieve antibacterial effect; or it can be used to develop anti-cancer drugs that target specific targets of cancer cells and inhibit the growth and spread of cancer cells
In the field of pesticides, 4-chloro-2-fluoro-1- (trifluoromethyl) benzene is also an important raw material. Due to its special structure, the prepared pesticides may have the characteristics of high efficiency, low toxicity and low residue. For example, when made into an insecticide, it can precisely act on the nervous system of pests or other key physiological links, effectively killing pests, while having a small impact on the environment, meeting the needs of modern green agriculture; made into a herbicide, it can specifically inhibit the growth of weeds, but has little impact on crops, ensuring the efficiency and safety of agricultural production.
In the field of materials, this compound can participate in the synthesis of special materials. Due to the presence of fluorine atoms and trifluoromethyl, the material is endowed with excellent chemical stability, thermal stability and weather resistance. For example, it is used to synthesize high-performance engineering plastics, which are used in aerospace, automobile manufacturing and other fields to maintain good performance under extreme conditions; or it is used to prepare functional coatings to improve the wear resistance and corrosion resistance of coatings. It is widely used in construction, marine and other industries to prolong the service life of materials and reduce maintenance costs.
In the field of medicine, it can be used as a key intermediate for the creation of new drugs. Due to the special structure of fluorine, chlorine and trifluoromethyl, the compound is endowed with unique physicochemical and bioactive properties. It may enhance the lipophilicity of the drug, which is conducive to the drug passing through the biofilm, enhancing absorption and distribution, and thus enhancing the efficacy of the drug. For example, after ingenious design and modification, it can be used to develop antibacterial drugs that interfere with bacterial physiological processes with their special structures to achieve antibacterial effect; or it can be used to develop anti-cancer drugs that target specific targets of cancer cells and inhibit the growth and spread of cancer cells
In the field of pesticides, 4-chloro-2-fluoro-1- (trifluoromethyl) benzene is also an important raw material. Due to its special structure, the prepared pesticides may have the characteristics of high efficiency, low toxicity and low residue. For example, when made into an insecticide, it can precisely act on the nervous system of pests or other key physiological links, effectively killing pests, while having a small impact on the environment, meeting the needs of modern green agriculture; made into a herbicide, it can specifically inhibit the growth of weeds, but has little impact on crops, ensuring the efficiency and safety of agricultural production.
In the field of materials, this compound can participate in the synthesis of special materials. Due to the presence of fluorine atoms and trifluoromethyl, the material is endowed with excellent chemical stability, thermal stability and weather resistance. For example, it is used to synthesize high-performance engineering plastics, which are used in aerospace, automobile manufacturing and other fields to maintain good performance under extreme conditions; or it is used to prepare functional coatings to improve the wear resistance and corrosion resistance of coatings. It is widely used in construction, marine and other industries to prolong the service life of materials and reduce maintenance costs.
What are the preparation methods of 4-chloro-2-fluoro-1- (trifluoromethyl) -benzene
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene, a method of preparation, often with specific chemical raw materials, through several reaction steps.
One method can also be used as a starting material for benzene compounds containing chlorine and fluorine. Introduce chlorine atoms on the benzene ring first, and this step may be achieved by chlorination reaction. Select suitable chlorination reagents, such as chlorine gas, thionyl chloride, etc., under specific reaction conditions, such as controlling temperature, pressure and catalyst dosage, so that chlorine atoms fall precisely at the predetermined position in the benzene ring.
Next, introduce fluorine atoms. In this process, a nucleophilic substitution reaction can be used to replace specific atoms on the benzene ring with fluorine-containing reagents, such as potassium fluoride, in a suitable solvent, with the help of heating and phase transfer catalysts, and then generate chlorine-containing and fluorine-containing benzene derivatives.
As for the introduction of trifluoromethyl, reagents containing trifluoromethyl, such as trifluoromethylation reagents, can be selected. Trifluoromethyl is attached to the benzene ring through a suitable reaction mechanism, such as a free radical reaction or a nucleophilic substitution reaction. During the reaction, the reaction conditions need to be carefully adjusted to ensure the selectivity and yield of the reaction.
There are other methods, which can first construct the benzene ring parent containing trifluoromethyl, and then introduce chlorine atoms and fluorine atoms in It is also necessary to carefully select the reaction reagents and conditions according to the reaction characteristics to efficiently prepare 4-chloro-2-fluoro-1- (trifluoromethyl) benzene. After each step of the reaction, it is often necessary to separate and purify to remove impurities and obtain pure products.
One method can also be used as a starting material for benzene compounds containing chlorine and fluorine. Introduce chlorine atoms on the benzene ring first, and this step may be achieved by chlorination reaction. Select suitable chlorination reagents, such as chlorine gas, thionyl chloride, etc., under specific reaction conditions, such as controlling temperature, pressure and catalyst dosage, so that chlorine atoms fall precisely at the predetermined position in the benzene ring.
Next, introduce fluorine atoms. In this process, a nucleophilic substitution reaction can be used to replace specific atoms on the benzene ring with fluorine-containing reagents, such as potassium fluoride, in a suitable solvent, with the help of heating and phase transfer catalysts, and then generate chlorine-containing and fluorine-containing benzene derivatives.
As for the introduction of trifluoromethyl, reagents containing trifluoromethyl, such as trifluoromethylation reagents, can be selected. Trifluoromethyl is attached to the benzene ring through a suitable reaction mechanism, such as a free radical reaction or a nucleophilic substitution reaction. During the reaction, the reaction conditions need to be carefully adjusted to ensure the selectivity and yield of the reaction.
There are other methods, which can first construct the benzene ring parent containing trifluoromethyl, and then introduce chlorine atoms and fluorine atoms in It is also necessary to carefully select the reaction reagents and conditions according to the reaction characteristics to efficiently prepare 4-chloro-2-fluoro-1- (trifluoromethyl) benzene. After each step of the reaction, it is often necessary to separate and purify to remove impurities and obtain pure products.
4-chloro-2-fluoro-1- (trifluoromethyl) -benzene market prospects
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene, an organic compound, is widely used in the chemical and pharmaceutical fields. Looking at its market prospects, it can be analyzed from multiple ends.
First, in the chemical industry, it is a key intermediate. It can be used to prepare special engineering plastics. Such plastics have hot topic stability, chemical stability and mechanical properties, and are increasingly in demand in high-end fields such as aerospace and electronics. With the development of science and technology, the trend of miniaturization and high performance of electronic equipment is obvious, and the demand for special engineering plastics will continue to rise. Therefore, the market for 4-chloro-2-fluoro-1- (trifluoromethyl) benzene as a raw material will also expand.
Furthermore, in the field of pharmaceutical research and development, it also plays an important role. It can be chemically modified to synthesize new drugs for specific diseases such as tumors and cardiovascular diseases. Nowadays, human beings pay more attention to health, and there is an urgent demand for new special drugs. Pharmaceutical companies continue to increase their investment in research and development. If they successfully develop new drugs based on this compound, the market potential is immeasurable.
However, its market prospects also pose challenges. The process of preparing this compound may be complicated and expensive, which may limit its large-scale application. And the environmental protection requirements are becoming stricter, and the production process needs to meet strict environmental protection standards, otherwise it may be limited or stopped, increasing production costs and operating risks.
Overall, 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene has unique uses in the chemical and pharmaceutical fields, and the market prospect is broad. However, practitioners need to deal with problems such as cost and environmental protection in order to seize the opportunity and enjoy the market growth dividend.
First, in the chemical industry, it is a key intermediate. It can be used to prepare special engineering plastics. Such plastics have hot topic stability, chemical stability and mechanical properties, and are increasingly in demand in high-end fields such as aerospace and electronics. With the development of science and technology, the trend of miniaturization and high performance of electronic equipment is obvious, and the demand for special engineering plastics will continue to rise. Therefore, the market for 4-chloro-2-fluoro-1- (trifluoromethyl) benzene as a raw material will also expand.
Furthermore, in the field of pharmaceutical research and development, it also plays an important role. It can be chemically modified to synthesize new drugs for specific diseases such as tumors and cardiovascular diseases. Nowadays, human beings pay more attention to health, and there is an urgent demand for new special drugs. Pharmaceutical companies continue to increase their investment in research and development. If they successfully develop new drugs based on this compound, the market potential is immeasurable.
However, its market prospects also pose challenges. The process of preparing this compound may be complicated and expensive, which may limit its large-scale application. And the environmental protection requirements are becoming stricter, and the production process needs to meet strict environmental protection standards, otherwise it may be limited or stopped, increasing production costs and operating risks.
Overall, 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene has unique uses in the chemical and pharmaceutical fields, and the market prospect is broad. However, practitioners need to deal with problems such as cost and environmental protection in order to seize the opportunity and enjoy the market growth dividend.
What are the advantages of 4-chloro-2-fluoro-1- (trifluoromethyl) -benzene over other similar compounds?
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene, this compound has several advantages over other similar compounds.
First, its unique structure endows it with excellent chemical stability. On the benzene ring, chlorine, fluorine and trifluoromethyl are cleverly arranged, as if to build a solid barrier, so that the compound can be as stable as a rock in many chemical reactions and environments, and is not easily disturbed by external factors and decomposed or deteriorated. This property is crucial in many fields, such as materials science. Materials synthesized on its basis can last for a long time and have good performance, just like ancient buildings that have withstood wind and rain.
Second, the electronic properties of this compound are unique. Fluorine atoms are extremely electronegative, and together with the strong electron-absorbing effect of trifluoromethyl, the electron cloud density of the benzene ring is redistributed. This unique electronic structure, in the field of organic synthesis, is like a precise key that can open the door to many specific reactions, making it an ideal starting material for the synthesis of compounds with specific functions, guiding the reaction to the desired direction accurately, just like a wise man leading everyone along the established path.
Third, its physical properties are also remarkable. Moderate solubility and volatility, in the chemical production process, like a skilled craftsman, easy to operate and control. When preparing various products, the way and degree of participation in the reaction can be flexibly adjusted according to actual needs to ensure a smooth and smooth production process without excessive blockage, just like a boat on a smooth river, smooth sailing.
Fourth, from an environmental perspective, compared with some similar compounds, the degradation process of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene in the environment is more gentle and orderly. Its decomposition products are relatively harmless to the environment, just like a humble gentleman, leaving traces in the world are relatively friendly. In today's increasingly stringent era of environmental protection requirements, this advantage undoubtedly makes it stand out among many similar compounds and is very popular.
First, its unique structure endows it with excellent chemical stability. On the benzene ring, chlorine, fluorine and trifluoromethyl are cleverly arranged, as if to build a solid barrier, so that the compound can be as stable as a rock in many chemical reactions and environments, and is not easily disturbed by external factors and decomposed or deteriorated. This property is crucial in many fields, such as materials science. Materials synthesized on its basis can last for a long time and have good performance, just like ancient buildings that have withstood wind and rain.
Second, the electronic properties of this compound are unique. Fluorine atoms are extremely electronegative, and together with the strong electron-absorbing effect of trifluoromethyl, the electron cloud density of the benzene ring is redistributed. This unique electronic structure, in the field of organic synthesis, is like a precise key that can open the door to many specific reactions, making it an ideal starting material for the synthesis of compounds with specific functions, guiding the reaction to the desired direction accurately, just like a wise man leading everyone along the established path.
Third, its physical properties are also remarkable. Moderate solubility and volatility, in the chemical production process, like a skilled craftsman, easy to operate and control. When preparing various products, the way and degree of participation in the reaction can be flexibly adjusted according to actual needs to ensure a smooth and smooth production process without excessive blockage, just like a boat on a smooth river, smooth sailing.
Fourth, from an environmental perspective, compared with some similar compounds, the degradation process of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene in the environment is more gentle and orderly. Its decomposition products are relatively harmless to the environment, just like a humble gentleman, leaving traces in the world are relatively friendly. In today's increasingly stringent era of environmental protection requirements, this advantage undoubtedly makes it stand out among many similar compounds and is very popular.
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