Linshang Chemical
PRODUCTS
Benzene, 4-(Chloromethyl)-1-Fluoro-2-Methoxy-
Linshang Chemical
|
HS Code |
147875 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 174.599 g/mol |
As an accredited Benzene, 4-(Chloromethyl)-1-Fluoro-2-Methoxy- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottles containing 4-(chloromethyl)-1 - fluoro - 2 - methoxy - benzene. |
| Storage | Store "Benzene, 4-(chloromethyl)-1-fluoro-2-methoxy-" in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be stored in a tightly - sealed container made of materials compatible with the chemical, such as corrosion - resistant metals or certain plastics. Keep it segregated from oxidizing agents and reactive substances to prevent dangerous reactions. |
| Shipping | Shipment of "Benzene, 4-(chloromethyl)-1-fluoro -2-methoxy -" must follow strict chemical transport regulations. It should be properly packaged in suitable containers to prevent leakage, and shipped with appropriate hazard labels. |
Competitive Benzene, 4-(Chloromethyl)-1-Fluoro-2-Methoxy- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy Benzene, 4-(Chloromethyl)-1-Fluoro-2-Methoxy- in China?
As a trusted Benzene, 4-(Chloromethyl)-1-Fluoro-2-Methoxy- manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading Benzene, 4-(Chloromethyl)-1-Fluoro-2-Methoxy- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of Benzene, 4- (chloromethyl) -1-fluoro-2-methoxy-
This is 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, and its chemical properties are very interesting.
In this compound, the benzene ring is the main structure, and the stability of the benzene ring gives the substance a certain degree of chemical inertness. However, the substituents attached to the benzene ring greatly affect its chemical activity.
First of all, the fluorine atom is extremely electronegative and has a strong electron-absorbing induction effect. This effect can reduce the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by electrophilic reagents, but it also increases the difficulty of reacting with nucleophiles. Fluorine atoms can also enhance the polarity of molecules, which affects the physical and chemical properties of compounds.
As for methoxy, which belongs to the power supply group, through the p-π conjugation effect, the electron cloud density of the benzene ring is increased, which makes the position more prone to electrophilic substitution. The interaction of methoxy and fluorine atoms is intertwined, which jointly affects the reactivity and regioselectivity of the benzene ring.
As for chloromethyl, the electron-absorbing induction effect of the chlorine atom is significant, while the methylene can be used as a reaction check point. The chlorine atom is easy to leave, and nucleophilic substitution reactions can occur, such as with nucleophiles, chlorine is replaced to form new compounds.
The compound may participate in a variety of organic reactions, such as electrophilic substitution reaction. Due to the influence of fluorine and methoxy on the electron cloud density of the benzene ring, the electrophilic reagent attack check point has a specific selectivity. In the nucleophilic substitution reaction, the chlorine of chloromethyl can be replaced by other nucleophilic groups to achieve functional group transformation. Due to its unique chemical properties, it can be used as an important intermediate in the field of organic synthesis to create complex organic compounds, which contribute to organic synthesis chemistry.
In this compound, the benzene ring is the main structure, and the stability of the benzene ring gives the substance a certain degree of chemical inertness. However, the substituents attached to the benzene ring greatly affect its chemical activity.
First of all, the fluorine atom is extremely electronegative and has a strong electron-absorbing induction effect. This effect can reduce the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by electrophilic reagents, but it also increases the difficulty of reacting with nucleophiles. Fluorine atoms can also enhance the polarity of molecules, which affects the physical and chemical properties of compounds.
As for methoxy, which belongs to the power supply group, through the p-π conjugation effect, the electron cloud density of the benzene ring is increased, which makes the position more prone to electrophilic substitution. The interaction of methoxy and fluorine atoms is intertwined, which jointly affects the reactivity and regioselectivity of the benzene ring.
As for chloromethyl, the electron-absorbing induction effect of the chlorine atom is significant, while the methylene can be used as a reaction check point. The chlorine atom is easy to leave, and nucleophilic substitution reactions can occur, such as with nucleophiles, chlorine is replaced to form new compounds.
The compound may participate in a variety of organic reactions, such as electrophilic substitution reaction. Due to the influence of fluorine and methoxy on the electron cloud density of the benzene ring, the electrophilic reagent attack check point has a specific selectivity. In the nucleophilic substitution reaction, the chlorine of chloromethyl can be replaced by other nucleophilic groups to achieve functional group transformation. Due to its unique chemical properties, it can be used as an important intermediate in the field of organic synthesis to create complex organic compounds, which contribute to organic synthesis chemistry.
What are the main uses of Benzene, 4- (chloromethyl) -1-fluoro-2-methoxy-
4- (chloromethyl) -1 -fluoro-2 -methoxybenzene has a wide range of uses. In the field of medicinal chemistry, this compound may be used as an important intermediate. To cover the synthesis of medicine, it is often necessary to rely on such substances with unique structures to construct molecules with specific pharmacological activities through ingenious reactions. The presence of fluorine atoms, chloromethyl groups and methoxy groups endows molecules with unique physical and chemical properties, which help to precisely combine with biological targets, or affect the metabolism and absorption of drugs, so it is often favored by chemists when creating new drugs.
In the field of materials science, 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene also has its uses. Due to its special structure, it may participate in polymerization reactions to form polymer materials with special properties. For example, if it is introduced into the polymer backbone, fluorine atoms can improve the weather resistance and chemical stability of the material; chloromethyl can be used as an active check point to further modify the surface of the material, giving it special functions such as hydrophilicity and adsorption, and is used in many aspects such as separation membranes and sensor materials.
Furthermore, in the field of fine chemicals, this compound can be used as a starting material for the synthesis of special fragrances and dyes. Its unique chemical structure can be converted into delicate fragrance molecules through a series of chemical reactions, giving the product a unique aroma; or to build dyes with specific colors and properties to meet the needs of high-quality dyes in textile, printing and dyeing industries.
In summary, 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is of great value in many fields such as medicine, materials, and fine chemicals, providing an indispensable chemical basis for the development of various fields.
In the field of materials science, 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene also has its uses. Due to its special structure, it may participate in polymerization reactions to form polymer materials with special properties. For example, if it is introduced into the polymer backbone, fluorine atoms can improve the weather resistance and chemical stability of the material; chloromethyl can be used as an active check point to further modify the surface of the material, giving it special functions such as hydrophilicity and adsorption, and is used in many aspects such as separation membranes and sensor materials.
Furthermore, in the field of fine chemicals, this compound can be used as a starting material for the synthesis of special fragrances and dyes. Its unique chemical structure can be converted into delicate fragrance molecules through a series of chemical reactions, giving the product a unique aroma; or to build dyes with specific colors and properties to meet the needs of high-quality dyes in textile, printing and dyeing industries.
In summary, 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene is of great value in many fields such as medicine, materials, and fine chemicals, providing an indispensable chemical basis for the development of various fields.
What is the synthesis method of Benzene, 4- (chloromethyl) -1-fluoro-2-methoxy-
To prepare 4- (chloromethyl) -1 -fluoro-2 -methoxybenzene, you can follow the following ancient method.
First take 2-methoxyphenol, which is often used as a starting material in organic synthesis. First mix it with a suitable base, such as potassium carbonate, in a suitable solvent, such as N, N -dimethylformamide (DMF). The action of the base is to deprotonate the phenolic hydroxyl group and enhance its nucleophilicity.
Add fluorinated reagents, such as potassium fluoride, for the first time. In this environment, the oxygen nucleophilic of the phenolic hydroxyl group attacks the fluorine atom, and through the nucleophilic substitution reaction, 2-methoxy-1 -fluorobenzene is obtained. This step requires temperature control and monitoring of the reaction process to ensure a smooth reaction.
After 2-methoxy-1-fluorobenzene is obtained, chloromethyl is introduced. Place 2-methoxy-1-fluorobenzene in an anhydrous environment and add paraformaldehyde and a reagent composed of zinc chloride and concentrated hydrochloric acid. Under the catalysis of zinc chloride and concentrated hydrochloric acid, paraformaldehyde decomposes to produce formaldehyde, which reacts with hydrogen chloride to form chloromethyl positive ions. The benzene ring of 2-methoxy-1-fluorobenzene is affected by the localization effect of methoxy and fluorine atoms, and has high ortho-site activity. Chloromethyl positive ions attack ortho-sites and undergo electrophilic substitution reaction to obtain 4- (chloromethyl) -1 -fluoro-2 -methoxylbenzene.
The whole process of synthesis needs to pay attention to anhydrous and anaerobic operation, and after each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to remove impurities and obtain high-purity products
First take 2-methoxyphenol, which is often used as a starting material in organic synthesis. First mix it with a suitable base, such as potassium carbonate, in a suitable solvent, such as N, N -dimethylformamide (DMF). The action of the base is to deprotonate the phenolic hydroxyl group and enhance its nucleophilicity.
Add fluorinated reagents, such as potassium fluoride, for the first time. In this environment, the oxygen nucleophilic of the phenolic hydroxyl group attacks the fluorine atom, and through the nucleophilic substitution reaction, 2-methoxy-1 -fluorobenzene is obtained. This step requires temperature control and monitoring of the reaction process to ensure a smooth reaction.
After 2-methoxy-1-fluorobenzene is obtained, chloromethyl is introduced. Place 2-methoxy-1-fluorobenzene in an anhydrous environment and add paraformaldehyde and a reagent composed of zinc chloride and concentrated hydrochloric acid. Under the catalysis of zinc chloride and concentrated hydrochloric acid, paraformaldehyde decomposes to produce formaldehyde, which reacts with hydrogen chloride to form chloromethyl positive ions. The benzene ring of 2-methoxy-1-fluorobenzene is affected by the localization effect of methoxy and fluorine atoms, and has high ortho-site activity. Chloromethyl positive ions attack ortho-sites and undergo electrophilic substitution reaction to obtain 4- (chloromethyl) -1 -fluoro-2 -methoxylbenzene.
The whole process of synthesis needs to pay attention to anhydrous and anaerobic operation, and after each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to remove impurities and obtain high-purity products
What are the environmental effects of Benzene, 4- (chloromethyl) -1-fluoro-2-methoxy-
The environmental effects of benzene, 4- (chloromethyl) -1 -fluoro-2 -methoxy need to be studied in detail.
Looking at its chemical structure, it contains chloromethyl, fluorine and methoxy functional groups. Chloromethyl has certain activity and may participate in many chemical reactions in the environment. Chlorine atoms are highly active, and chloride ions may be released due to hydrolysis, substitution and other reactions, which in turn affect the chemical properties of surrounding water bodies and soils. If it enters the water body, or changes the pH of the water body, and the increase of chloride ions may interfere with the physiological functions of aquatic organisms, affecting their key physiological processes such as osmotic pressure regulation.
Although fluorine atoms are relatively stable, their existence will also change the overall properties of compounds. Fluorinated compounds are difficult to degrade in the environment and are easy to accumulate. They may enter the body of organisms, pass through the food chain and accumulate, and ultimately affect advanced organisms and even human health. Previous studies have shown that some fluorinated organics can interfere with the endocrine system of organisms and have negative effects on important physiological activities such as reproduction and development. The presence of methoxy groups also affects the polarity and stability of compounds. It can make compounds more soluble in certain organic solvents, which increases the possibility of their migration and diffusion in the environment. Once in the soil, or due to interaction with soil organic matter, soil structure and function are changed.
In summary, benzene, 4 - (chloromethyl) - 1 - fluoro - 2 - methoxy, due to its special chemical structure, may cause many complex effects in the environment, whether it is on water ecology, soil environment, or metabolism in organisms, all need to be carefully evaluated and studied to prevent its potential harm to ecological balance and human well-being.
Looking at its chemical structure, it contains chloromethyl, fluorine and methoxy functional groups. Chloromethyl has certain activity and may participate in many chemical reactions in the environment. Chlorine atoms are highly active, and chloride ions may be released due to hydrolysis, substitution and other reactions, which in turn affect the chemical properties of surrounding water bodies and soils. If it enters the water body, or changes the pH of the water body, and the increase of chloride ions may interfere with the physiological functions of aquatic organisms, affecting their key physiological processes such as osmotic pressure regulation.
Although fluorine atoms are relatively stable, their existence will also change the overall properties of compounds. Fluorinated compounds are difficult to degrade in the environment and are easy to accumulate. They may enter the body of organisms, pass through the food chain and accumulate, and ultimately affect advanced organisms and even human health. Previous studies have shown that some fluorinated organics can interfere with the endocrine system of organisms and have negative effects on important physiological activities such as reproduction and development. The presence of methoxy groups also affects the polarity and stability of compounds. It can make compounds more soluble in certain organic solvents, which increases the possibility of their migration and diffusion in the environment. Once in the soil, or due to interaction with soil organic matter, soil structure and function are changed.
In summary, benzene, 4 - (chloromethyl) - 1 - fluoro - 2 - methoxy, due to its special chemical structure, may cause many complex effects in the environment, whether it is on water ecology, soil environment, or metabolism in organisms, all need to be carefully evaluated and studied to prevent its potential harm to ecological balance and human well-being.
Benzene, 4- (chloromethyl) -1-fluoro-2-methoxy- what are the precautions when storing and transporting
4 - (chloromethyl) - 1 - fluoro - 2 - methoxybenzene, when storing and transporting, there are many key things to pay attention to.
First, it is related to storage. Because of its chemical properties, it should be found in a cool, dry and well ventilated place. If placed in a high temperature or humid place, it may cause changes in the properties of the substance. Cover high temperature or cause chemical reactions to accelerate, and moisture may cause it to deteriorate, which may even affect its quality and stability. And it must be separated from oxidants, acids, bases and other substances to prevent dangerous chemical reactions. Because its structure contains functional groups such as chloromethyl, fluorine and methoxy, it is easy to react with specific chemicals and cause safety accidents.
Second, as for transportation. The transportation container must be well sealed to prevent leakage. Leakage will not only damage the substance itself, but also cause pollution to the environment, and the substance may be toxic and irritating, endangering the surrounding organisms. During transportation, avoid violent vibration and collision, which may cause damage to the container and cause leakage. At the same time, the transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can deal with it in a timely manner to ensure the safety of transportation.
First, it is related to storage. Because of its chemical properties, it should be found in a cool, dry and well ventilated place. If placed in a high temperature or humid place, it may cause changes in the properties of the substance. Cover high temperature or cause chemical reactions to accelerate, and moisture may cause it to deteriorate, which may even affect its quality and stability. And it must be separated from oxidants, acids, bases and other substances to prevent dangerous chemical reactions. Because its structure contains functional groups such as chloromethyl, fluorine and methoxy, it is easy to react with specific chemicals and cause safety accidents.
Second, as for transportation. The transportation container must be well sealed to prevent leakage. Leakage will not only damage the substance itself, but also cause pollution to the environment, and the substance may be toxic and irritating, endangering the surrounding organisms. During transportation, avoid violent vibration and collision, which may cause damage to the container and cause leakage. At the same time, the transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of emergencies, they can deal with it in a timely manner to ensure the safety of transportation.
Scan to WhatsApp
