Linshang Chemical
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Benzene, 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)-
Linshang Chemical
|
HS Code |
733442 |
| Chemical Formula | C8H5ClF4 |
| Molar Mass | 226.57 g/mol |
| Solubility In Water | Low, as it is an organic halogen - containing aromatic compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
As an accredited Benzene, 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-1-fluoro-2-(trifluoromethyl)benzene in sealed chemical - grade container. |
| Storage | Store "Benzene, 4-(chloromethyl)-1-fluoro-2-(trifluoromethyl)-" in a cool, dry, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly - sealed container to prevent leakage. Due to its potential toxicity and flammability, ensure the storage area is restricted and labeled clearly for proper handling and safety. |
| Shipping | The chemical "Benzene, 4-(chloromethyl)-1-fluoro-2-(trifluoromethyl)-" should be shipped in accordance with strict hazardous materials regulations. Use appropriate, well - sealed containers to prevent leakage during transit. |
Competitive Benzene, 4-(Chloromethyl)-1-Fluoro-2-(Trifluoromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of this product 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
The main use of this substance (4- (methoxy) -1 -ene-2- (trimethylsilyl) benzene) is used in many fields.
In the field of organic synthesis, it is often a key intermediate. The methoxy group and trimethylsilyl group contained in the molecule give unique reactivity and selectivity. With the power supply of methoxy group, it can affect the electron cloud density distribution of the benzene ring, making the specific position of the benzene ring more vulnerable to electrophilic attack, and then guide the reaction to the desired check point. The trimethylsilyl group, as a silicon protecting group, can protect specific functional groups during the organic synthesis step to prevent them from participating in the reaction at an inappropriate time. When the subsequent conditions are suitable, it can be removed through a specific reaction to restore the activity of the functional groups, thereby realizing the gradual construction of complex organic molecules.
In the field of materials science, it also has important functions. Due to its structural properties, it can be chemically modified into the main chain or side chain of polymer materials, giving the material novel physical and chemical properties. For example, to improve the thermal stability of the material, so that the material can still maintain the stability of structure and performance in high temperature environment; or to adjust the solubility of the material, enhance its solubility in specific organic solvents, facilitate the processing of materials, and prepare various functional materials, such as optical materials, electronic materials, etc., to meet the needs of different application scenarios.
In addition, in pharmaceutical chemistry research, or as a potential lead compound structural unit. By modifying and optimizing its structure, it is expected to obtain molecules with specific biological activities, such as drug molecules with good pharmacological activity and pharmacokinetic properties, providing an important foundation and direction for the research and development of new drugs.
In the field of organic synthesis, it is often a key intermediate. The methoxy group and trimethylsilyl group contained in the molecule give unique reactivity and selectivity. With the power supply of methoxy group, it can affect the electron cloud density distribution of the benzene ring, making the specific position of the benzene ring more vulnerable to electrophilic attack, and then guide the reaction to the desired check point. The trimethylsilyl group, as a silicon protecting group, can protect specific functional groups during the organic synthesis step to prevent them from participating in the reaction at an inappropriate time. When the subsequent conditions are suitable, it can be removed through a specific reaction to restore the activity of the functional groups, thereby realizing the gradual construction of complex organic molecules.
In the field of materials science, it also has important functions. Due to its structural properties, it can be chemically modified into the main chain or side chain of polymer materials, giving the material novel physical and chemical properties. For example, to improve the thermal stability of the material, so that the material can still maintain the stability of structure and performance in high temperature environment; or to adjust the solubility of the material, enhance its solubility in specific organic solvents, facilitate the processing of materials, and prepare various functional materials, such as optical materials, electronic materials, etc., to meet the needs of different application scenarios.
In addition, in pharmaceutical chemistry research, or as a potential lead compound structural unit. By modifying and optimizing its structure, it is expected to obtain molecules with specific biological activities, such as drug molecules with good pharmacological activity and pharmacokinetic properties, providing an important foundation and direction for the research and development of new drugs.
What are the physical properties of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
(Halomethyl) -1-ene-2- (trihalomethyl) benzene is a class of organic compounds. Its physical properties are quite characteristic, as follows:
Looking at its properties, under normal conditions, it may be a colorless to light yellow liquid, and some may also be crystalline solids. This varies depending on the type and number of halogen atoms in the molecular structure, the interaction of benzene rings and alkenyl groups. If the number of halogen atoms increases, the intermolecular force increases, and the substance tends to be a solid state; conversely, when there are fewer halogen atoms, it is mostly a liquid state.
When it comes to boiling points, due to the high electronegativity of halogen atoms, there is a strong dipole-dipole interaction between molecules, and some halogen atoms can also form hydrogen bonds, so their boiling points are usually higher than the corresponding hydrocarbons. And the number of halogen atoms increases, the relative molecular weight increases, and the boiling point also increases. For example, chlorine-containing (halomethyl) -1-ene-2- (trihalomethyl) benzene, the boiling point is often higher than that of fluorine-containing ones, because the relative molecular weight of chlorine atoms is greater than that of fluorine atoms. The melting point of
is also closely related to the molecular structure. Molecular symmetry is good, the crystal lattice is arranged regularly, the intermolecular force can be effectively exerted, and the melting point is high; while the structure is irregular, the intermolecular is difficult to be closely arranged, and the melting point is relatively low.
In terms of solubility, this kind of compound has a certain polarity due to the halogen atom, alkenyl group and benzene ring, and has good solubility in organic solvents such as dichloromethane, chloroform, ether, etc. This is because of the principle of "similar miscibility". Organic solvents have a certain polarity and can form intermolecular forces with (halomethyl) -1-ene-2- (trihalomethyl) benzene molecules to promote dissolution. However, in water, because its polarity is not enough to overcome the hydrogen bond between water molecules, the solubility is poor.
The density is usually higher than that of water. Due to the larger weight of halogen atoms relative to atoms, the molecular weight increases, and the mass per unit volume increases, so the density is higher than that of water.
In summary, the physical properties of (halomethyl) -1-ene-2- (trihalomethyl) benzene are determined by its unique molecular structure, and are closely related to its physical properties in the fields of organic synthesis and materials science.
Looking at its properties, under normal conditions, it may be a colorless to light yellow liquid, and some may also be crystalline solids. This varies depending on the type and number of halogen atoms in the molecular structure, the interaction of benzene rings and alkenyl groups. If the number of halogen atoms increases, the intermolecular force increases, and the substance tends to be a solid state; conversely, when there are fewer halogen atoms, it is mostly a liquid state.
When it comes to boiling points, due to the high electronegativity of halogen atoms, there is a strong dipole-dipole interaction between molecules, and some halogen atoms can also form hydrogen bonds, so their boiling points are usually higher than the corresponding hydrocarbons. And the number of halogen atoms increases, the relative molecular weight increases, and the boiling point also increases. For example, chlorine-containing (halomethyl) -1-ene-2- (trihalomethyl) benzene, the boiling point is often higher than that of fluorine-containing ones, because the relative molecular weight of chlorine atoms is greater than that of fluorine atoms. The melting point of
is also closely related to the molecular structure. Molecular symmetry is good, the crystal lattice is arranged regularly, the intermolecular force can be effectively exerted, and the melting point is high; while the structure is irregular, the intermolecular is difficult to be closely arranged, and the melting point is relatively low.
In terms of solubility, this kind of compound has a certain polarity due to the halogen atom, alkenyl group and benzene ring, and has good solubility in organic solvents such as dichloromethane, chloroform, ether, etc. This is because of the principle of "similar miscibility". Organic solvents have a certain polarity and can form intermolecular forces with (halomethyl) -1-ene-2- (trihalomethyl) benzene molecules to promote dissolution. However, in water, because its polarity is not enough to overcome the hydrogen bond between water molecules, the solubility is poor.
The density is usually higher than that of water. Due to the larger weight of halogen atoms relative to atoms, the molecular weight increases, and the mass per unit volume increases, so the density is higher than that of water.
In summary, the physical properties of (halomethyl) -1-ene-2- (trihalomethyl) benzene are determined by its unique molecular structure, and are closely related to its physical properties in the fields of organic synthesis and materials science.
What are the chemical properties of 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
(4- (methoxy) -1 -ene-2- (trimethylsilyl) benzene, its chemical properties are as follows:
In this compound, both methoxy and trimethylsilyl have an effect on the electron cloud density and reactivity of the benzene ring. Methoxy has a conjugation effect of electron donor, which can increase the electron cloud density of the adjacent and para-sites of the benzene ring. Therefore, in the electrophilic substitution reaction, it can guide electrophilic reagents to attack the adjacent and para-sites of the benzene ring. For example, during the halogenation reaction, halogen atoms will mostly introduce the adjacent and para-sites of methoxy groups.
And trimethylsilyl, although its steric resistance is large, it also has certain electron donor properties. In some reactions, its large steric resistance may affect the selectivity of the reaction. For example, when the nucleophilic substitution reaction occurs, the space around the trimethylsilyl group is relatively crowded, and the nucleophilic reagent is difficult to attack from its direction, thus affecting the process of the reaction and the structure of the product.
In the oxidation reaction, the compound has a unique check point and difficulty of oxidation due to the influence of the substituent on the benzene ring. Methoxy groups increase the electron cloud density of the benzene ring and are relatively easy to be oxidized. However, the existence of trimethylsilyl groups may change the reaction route. Due to the special properties of silicon-carbon bonds, under some oxidation conditions, the silicon group part may be converted first, which in turn affects the subsequent oxidation reaction of the benzene ring.
In the reduction reaction, the compound also exhibits specific reactivity due to the action of the substituent. The electron-giving effect of the methoxy group makes the benzene ring more susceptible to electrons and is reduced. However, the steric resistance of the trimethylsilyl group may hinder the proximity of the reducing agent to the benzene ring, so the reaction conditions need to be adjusted appropriately to achieve the desired reduction effect.
Overall, 4- (methoxy) -1-ene-2- (trimethylsilyl) benzene exhibits chemical properties that are different from ordinary benzene derivatives in various chemical reactions due to its unique substituent structure, and has special application and research value in organic synthesis and other fields.)
In this compound, both methoxy and trimethylsilyl have an effect on the electron cloud density and reactivity of the benzene ring. Methoxy has a conjugation effect of electron donor, which can increase the electron cloud density of the adjacent and para-sites of the benzene ring. Therefore, in the electrophilic substitution reaction, it can guide electrophilic reagents to attack the adjacent and para-sites of the benzene ring. For example, during the halogenation reaction, halogen atoms will mostly introduce the adjacent and para-sites of methoxy groups.
And trimethylsilyl, although its steric resistance is large, it also has certain electron donor properties. In some reactions, its large steric resistance may affect the selectivity of the reaction. For example, when the nucleophilic substitution reaction occurs, the space around the trimethylsilyl group is relatively crowded, and the nucleophilic reagent is difficult to attack from its direction, thus affecting the process of the reaction and the structure of the product.
In the oxidation reaction, the compound has a unique check point and difficulty of oxidation due to the influence of the substituent on the benzene ring. Methoxy groups increase the electron cloud density of the benzene ring and are relatively easy to be oxidized. However, the existence of trimethylsilyl groups may change the reaction route. Due to the special properties of silicon-carbon bonds, under some oxidation conditions, the silicon group part may be converted first, which in turn affects the subsequent oxidation reaction of the benzene ring.
In the reduction reaction, the compound also exhibits specific reactivity due to the action of the substituent. The electron-giving effect of the methoxy group makes the benzene ring more susceptible to electrons and is reduced. However, the steric resistance of the trimethylsilyl group may hinder the proximity of the reducing agent to the benzene ring, so the reaction conditions need to be adjusted appropriately to achieve the desired reduction effect.
Overall, 4- (methoxy) -1-ene-2- (trimethylsilyl) benzene exhibits chemical properties that are different from ordinary benzene derivatives in various chemical reactions due to its unique substituent structure, and has special application and research value in organic synthesis and other fields.)
What is the process for producing 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
To prepare 4- (methoxy) -1 -ene-2- (trimethoxy) benzene, the process is as follows:
First take an appropriate amount of starting material, after fine weighing to ensure the accuracy of the amount, this is the basis for a smooth reaction. The purity of the raw material must be high, if impurities exist, or disturb the reaction process and cause the product to be impure.
Then, place the raw material in a suitable reaction vessel. This vessel must be temperature and pressure resistant, and there is no chemical reaction with the reactants. The material should be glass or a specific metal alloy, depending on the reaction characteristics.
The catalyst is indispensable for the progress of the reaction. Select the appropriate catalyst and precisely control its dosage according to its catalytic mechanism and activity. The catalyst can reduce the activation energy of the reaction, promote the efficient occurrence of the reaction, and then cause excess or side reactions to breed.
The reaction temperature and time are also critical. After repeated experiments and theoretical deduction, the optimal reaction temperature range is found, and the precise temperature control equipment is adjusted in real time to keep the temperature constant. If the temperature is too high, it may cause the decomposition of the reactants and the intensification of side reactions; if it is too low, the reaction rate will be slow and take a long time. At the same time, according to the reaction process and product generation, the reaction time can be accurately controlled to ensure that the reaction is complete and not excessive.
The pH of the reaction system also needs to be carefully regulated. According to the reaction mechanism, either acid or base is added to maintain a suitable pH value, which has a great impact on the direction and rate of the reaction.
After the reaction is completed, the separation and purification of the product is the top priority. First, the method of distillation is used to initially separate according to the difference in the boiling point of each component. Later, extraction, recrystallization and other techniques are used to remove impurities to obtain high-purity products.
The whole process, the operation must be rigorous and standardized, and all links are closely interlocked. A slight difference in the pool will affect the quality and yield of the product. Only by carefully controlling each element can we obtain high-quality 4- (methoxy) -1-ene-2- (trimethoxy) benzene.
First take an appropriate amount of starting material, after fine weighing to ensure the accuracy of the amount, this is the basis for a smooth reaction. The purity of the raw material must be high, if impurities exist, or disturb the reaction process and cause the product to be impure.
Then, place the raw material in a suitable reaction vessel. This vessel must be temperature and pressure resistant, and there is no chemical reaction with the reactants. The material should be glass or a specific metal alloy, depending on the reaction characteristics.
The catalyst is indispensable for the progress of the reaction. Select the appropriate catalyst and precisely control its dosage according to its catalytic mechanism and activity. The catalyst can reduce the activation energy of the reaction, promote the efficient occurrence of the reaction, and then cause excess or side reactions to breed.
The reaction temperature and time are also critical. After repeated experiments and theoretical deduction, the optimal reaction temperature range is found, and the precise temperature control equipment is adjusted in real time to keep the temperature constant. If the temperature is too high, it may cause the decomposition of the reactants and the intensification of side reactions; if it is too low, the reaction rate will be slow and take a long time. At the same time, according to the reaction process and product generation, the reaction time can be accurately controlled to ensure that the reaction is complete and not excessive.
The pH of the reaction system also needs to be carefully regulated. According to the reaction mechanism, either acid or base is added to maintain a suitable pH value, which has a great impact on the direction and rate of the reaction.
After the reaction is completed, the separation and purification of the product is the top priority. First, the method of distillation is used to initially separate according to the difference in the boiling point of each component. Later, extraction, recrystallization and other techniques are used to remove impurities to obtain high-purity products.
The whole process, the operation must be rigorous and standardized, and all links are closely interlocked. A slight difference in the pool will affect the quality and yield of the product. Only by carefully controlling each element can we obtain high-quality 4- (methoxy) -1-ene-2- (trimethoxy) benzene.
What are the precautions for using 4- (chloromethyl) -1-fluoro-2- (trifluoromethyl) benzene?
4- (cyanomethyl) -1 -cyanomethyl-2- (tricyanomethyl) benzene is also a chemical substance. During use, pay attention to many matters.
First, this substance is toxic and is related to personal safety. During operation, professional protective gear must be worn, such as protective clothing, gloves, goggles and gas masks, etc., to prevent it from contacting the human body and avoid it from invading the body through the respiratory tract, skin and other channels, causing poisoning.
Second, its chemical properties are active, under specific conditions, or react violently, so when storing and using, keep away from fire sources, heat sources and strong oxidants, etc., to prevent accidents such as fire and explosion. Store in a cool and well-ventilated place, and store it properly according to regulations, and place it separately from other chemicals to avoid interaction.
Third, the operating environment should be well ventilated, and effective ventilation devices should be installed to drain volatile gaseous substances in time, reduce their concentration in the air, and reduce the risk of poisoning and explosion. If used in a laboratory, it should be operated in a fume hood to ensure the safety of the experimenter.
Fourth, the user must have professional training and be familiar with the nature, hazards and safe operation procedures of this substance. When operating, strictly follow the established procedures and must not be changed without authorization. After use, properly dispose of the remaining materials and waste, follow relevant environmental protection regulations, and must not be discarded at will to prevent environmental pollution.
In short, the use of 4- (cyanomethyl) -1-cyanomethyl-2- (tricyanomethyl) benzene, safety is paramount, and all precautions must be strictly followed to ensure personal and environmental safety.
First, this substance is toxic and is related to personal safety. During operation, professional protective gear must be worn, such as protective clothing, gloves, goggles and gas masks, etc., to prevent it from contacting the human body and avoid it from invading the body through the respiratory tract, skin and other channels, causing poisoning.
Second, its chemical properties are active, under specific conditions, or react violently, so when storing and using, keep away from fire sources, heat sources and strong oxidants, etc., to prevent accidents such as fire and explosion. Store in a cool and well-ventilated place, and store it properly according to regulations, and place it separately from other chemicals to avoid interaction.
Third, the operating environment should be well ventilated, and effective ventilation devices should be installed to drain volatile gaseous substances in time, reduce their concentration in the air, and reduce the risk of poisoning and explosion. If used in a laboratory, it should be operated in a fume hood to ensure the safety of the experimenter.
Fourth, the user must have professional training and be familiar with the nature, hazards and safe operation procedures of this substance. When operating, strictly follow the established procedures and must not be changed without authorization. After use, properly dispose of the remaining materials and waste, follow relevant environmental protection regulations, and must not be discarded at will to prevent environmental pollution.
In short, the use of 4- (cyanomethyl) -1-cyanomethyl-2- (tricyanomethyl) benzene, safety is paramount, and all precautions must be strictly followed to ensure personal and environmental safety.
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