Linshang Chemical
PRODUCTS
Benzene, 4-(Chloromethyl)-2-Fluoro-1-Methoxy-
Linshang Chemical
|
HS Code |
995989 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 174.6 |
| Appearance | Typically a colorless to pale - yellow liquid |
| Boiling Point | Estimated to be in a certain range (data may vary, around 200 - 220°C under standard pressure) |
| Density | Data - dependent, but around 1.2 - 1.3 g/cm³ for similar aromatic compounds |
| Solubility | Soluble in organic solvents like dichloromethane, ethyl acetate; sparingly soluble in water |
| Vapor Pressure | Relatively low vapor pressure at room temperature |
| Flash Point | Estimated to be around 70 - 80°C (flammability hazard related value) |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited Benzene, 4-(Chloromethyl)-2-Fluoro-1-Methoxy- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(chloromethyl)-2-fluoro-1 -methoxy -benzene in sealed, labeled chemical containers. |
| Storage | Store “Benzene, 4-(chloromethyl)-2-fluoro-1-methoxy -” in a cool, dry, well - ventilated area. Keep it away from heat, sparks, and open flames as it may be flammable. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to degradation or unwanted reactions. Separate from oxidizing agents and incompatible substances. |
| Shipping | Shipment of "Benzene, 4-(chloromethyl)-2-fluoro-1-methoxy-" must follow strict chemical transport regulations. It should be properly packaged in corrosion - resistant containers, labeled clearly, and transported by carriers licensed for hazardous chemicals. |
Competitive Benzene, 4-(Chloromethyl)-2-Fluoro-1-Methoxy- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy Benzene, 4-(Chloromethyl)-2-Fluoro-1-Methoxy- in China?
As a trusted Benzene, 4-(Chloromethyl)-2-Fluoro-1-Methoxy- manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading Benzene, 4-(Chloromethyl)-2-Fluoro-1-Methoxy- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of Benzene, 4- (chloromethyl) -2-fluoro-1-methoxy-
4- (chloromethyl) -2-fluoro-1-methoxybenzene, this is an organic compound. Its chemical properties are unique, containing chloromethyl, fluorine atoms and methoxy groups, which give it different reactivity.
Let's talk about chloromethyl first, which has high reactivity and is easy to lead to nucleophilic substitution. Because chlorine atoms can be used as leaving groups and replaced by nucleophilic reagents, such as alcohols and amines, they can borrow nucleophilic substitution to form new compounds. Ether and amine derivatives come from this.
The introduction of fluorine atoms greatly affects the electron cloud distribution and spatial structure of molecules. Fluorine electronegativity is extremely high, which attracts electrons, changes the electron cloud density of the benzene ring, and affects the activity and check point selectivity of the electrophilic substitution reaction on the benzene ring. Usually, it will reduce the electron cloud density of the benzene ring, increase the difficulty of the electrophilic substitution reaction, and tend to interposition substitution.
Methoxy group is the power supply radical, which can increase the electron cloud density of the benzene ring and improve the electrophilic substitution reaction activity of the benzene ring, especially in the adjacent and para-positions. Coexisting with the electron-withdrawing effect of the fluorine atom, the two check and balance each other, making the reactivity and selectivity of the molecule more complex.
In the field of organic synthesis, 4- (chloromethyl) -2-fluoro-1-methoxybenzene can be used as a key intermediate. Through ingenious design of reaction paths and the use of functional group characteristics, complex structures and specific functions can be synthesized. Organic compounds are of great significance in the fields of medicinal chemistry and materials science.
Let's talk about chloromethyl first, which has high reactivity and is easy to lead to nucleophilic substitution. Because chlorine atoms can be used as leaving groups and replaced by nucleophilic reagents, such as alcohols and amines, they can borrow nucleophilic substitution to form new compounds. Ether and amine derivatives come from this.
The introduction of fluorine atoms greatly affects the electron cloud distribution and spatial structure of molecules. Fluorine electronegativity is extremely high, which attracts electrons, changes the electron cloud density of the benzene ring, and affects the activity and check point selectivity of the electrophilic substitution reaction on the benzene ring. Usually, it will reduce the electron cloud density of the benzene ring, increase the difficulty of the electrophilic substitution reaction, and tend to interposition substitution.
Methoxy group is the power supply radical, which can increase the electron cloud density of the benzene ring and improve the electrophilic substitution reaction activity of the benzene ring, especially in the adjacent and para-positions. Coexisting with the electron-withdrawing effect of the fluorine atom, the two check and balance each other, making the reactivity and selectivity of the molecule more complex.
In the field of organic synthesis, 4- (chloromethyl) -2-fluoro-1-methoxybenzene can be used as a key intermediate. Through ingenious design of reaction paths and the use of functional group characteristics, complex structures and specific functions can be synthesized. Organic compounds are of great significance in the fields of medicinal chemistry and materials science.
What are the main uses of Benzene, 4- (chloromethyl) -2-fluoro-1-methoxy-
4- (chloromethyl) -2 -fluoro-1 -methoxybenzene, which has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of specific drugs. Due to its molecular structure, chloromethyl, fluorine atoms and methoxy groups each have unique chemical activities, which can be cleverly spliced with other compounds through various chemical reactions, so complex molecules with specific pharmacological activities can be constructed, which is very helpful for disease treatment and drug development.
In the field of materials science, it also has its uses. It can be chemically modified to make it a cornerstone for the construction of special functional materials. For example, by virtue of its structural properties, or by participating in the preparation of materials with special optical and electrical properties, it can contribute to the creation of new materials.
In the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., as the starting material, carefully construct more complex organic molecules, greatly enrich the types and structures of organic compounds, and provide an important material basis for the in-depth exploration and development of organic chemistry. In short, 4- (chloromethyl) -2-fluoro-1-methoxy benzene has shown indispensable value in many fields and has made a lot of contributions to the progress of scientific research and industrial production.
In the field of materials science, it also has its uses. It can be chemically modified to make it a cornerstone for the construction of special functional materials. For example, by virtue of its structural properties, or by participating in the preparation of materials with special optical and electrical properties, it can contribute to the creation of new materials.
In the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., as the starting material, carefully construct more complex organic molecules, greatly enrich the types and structures of organic compounds, and provide an important material basis for the in-depth exploration and development of organic chemistry. In short, 4- (chloromethyl) -2-fluoro-1-methoxy benzene has shown indispensable value in many fields and has made a lot of contributions to the progress of scientific research and industrial production.
What is the synthesis method of Benzene, 4- (chloromethyl) -2-fluoro-1-methoxy-
To prepare 4 - (chloromethyl) -2 -fluoro-1 -methoxybenzene, you can follow the following ancient method.
First, 2-fluoro-1 -methoxybenzoic acid is used as the starting material, and it is first converted into the corresponding acyl chloride. Take an appropriate amount of 2-fluoro-1 -methoxybenzoic acid, place it in a reactor, add an appropriate amount of sulfoxide chloride, use a few drops of N, N -dimethylformamide as the catalyst, and heat it to reflux. The thionyl chloride reacts with the carboxyl group. After a few hours, the carboxyl group is converted into an acyl chloride to obtain 2-fluoro-1 -methoxybenzoyl chloride. The beauty of this reaction is that thionyl chloride is active, reacts efficiently with carboxyl groups and has few side reactions.
The resulting 2-fluoro-1-methoxybenzoyl chloride is reduced for chlorination. Add an appropriate amount of lithium aluminum hydride and anhydrous tetrahydrofuran to the reaction system, and slowly add the tetrahydrofuran solution of 2-fluoro-1-methoxybenzoyl chloride dropwise at low temperature. Lithium aluminum hydride is a strong reducing agent, which can reduce the acid chloride to an aldehyde group, and then the aldehyde group is converted into chloromethyl group by the action of chlorination reagents such as phosphorus trichloride or dichlorosulfoxide to obtain 4- (chloromethyl) -2 -fluoro-1 -methoxybenzene. This step requires attention to low temperature operation to control the reaction rate and avoid side reactions.
There are other methods, which can be started from 2-fluoro-1-methoxybenzene. First, the chloromethylation reaction is carried out with paraformaldehyde and hydrogen chloride gas under the catalysis of anhydrous zinc chloride. Place 2-fluoro-1-methoxybenzene in the reaction vessel, add an appropriate amount of anhydrous zinc chloride, and add hydrogen chloride gas and paraformaldehyde. Anhydrous zinc chloride has high catalytic activity, which can promote the replacement of hydrogen on the benzene ring with chloromethyl to obtain 4- (chloromethyl) -2-fluoro-1-methoxybenzene. This approach is relatively simple, but it is necessary to pay attention to the control of reaction conditions to increase the purity and yield of the product.
All methods have their own advantages and disadvantages. When implementing, it is necessary to choose the appropriate method according to the availability of raw materials, cost considerations, and product requirements, so as to achieve the best results.
First, 2-fluoro-1 -methoxybenzoic acid is used as the starting material, and it is first converted into the corresponding acyl chloride. Take an appropriate amount of 2-fluoro-1 -methoxybenzoic acid, place it in a reactor, add an appropriate amount of sulfoxide chloride, use a few drops of N, N -dimethylformamide as the catalyst, and heat it to reflux. The thionyl chloride reacts with the carboxyl group. After a few hours, the carboxyl group is converted into an acyl chloride to obtain 2-fluoro-1 -methoxybenzoyl chloride. The beauty of this reaction is that thionyl chloride is active, reacts efficiently with carboxyl groups and has few side reactions.
The resulting 2-fluoro-1-methoxybenzoyl chloride is reduced for chlorination. Add an appropriate amount of lithium aluminum hydride and anhydrous tetrahydrofuran to the reaction system, and slowly add the tetrahydrofuran solution of 2-fluoro-1-methoxybenzoyl chloride dropwise at low temperature. Lithium aluminum hydride is a strong reducing agent, which can reduce the acid chloride to an aldehyde group, and then the aldehyde group is converted into chloromethyl group by the action of chlorination reagents such as phosphorus trichloride or dichlorosulfoxide to obtain 4- (chloromethyl) -2 -fluoro-1 -methoxybenzene. This step requires attention to low temperature operation to control the reaction rate and avoid side reactions.
There are other methods, which can be started from 2-fluoro-1-methoxybenzene. First, the chloromethylation reaction is carried out with paraformaldehyde and hydrogen chloride gas under the catalysis of anhydrous zinc chloride. Place 2-fluoro-1-methoxybenzene in the reaction vessel, add an appropriate amount of anhydrous zinc chloride, and add hydrogen chloride gas and paraformaldehyde. Anhydrous zinc chloride has high catalytic activity, which can promote the replacement of hydrogen on the benzene ring with chloromethyl to obtain 4- (chloromethyl) -2-fluoro-1-methoxybenzene. This approach is relatively simple, but it is necessary to pay attention to the control of reaction conditions to increase the purity and yield of the product.
All methods have their own advantages and disadvantages. When implementing, it is necessary to choose the appropriate method according to the availability of raw materials, cost considerations, and product requirements, so as to achieve the best results.
Benzene, 4- (chloromethyl) -2-fluoro-1-methoxy- what to pay attention to when storing
When storing 4- (chloromethyl) -2-fluoro-1-methoxybenzene, be sure to pay attention to many matters. This substance has certain chemical activity, so it should be avoided from co-storage with strong oxidants, strong acids, strong bases and other substances to prevent violent chemical reactions and risk safety.
Because of its flammability, it should be placed in a cool and ventilated place, away from fire and heat sources, and must not be placed in a high temperature environment to avoid fire. In addition, this compound may be harmful to the human body, and the storage place should be clearly marked to prevent others from accidentally touching or eating it.
The container used for storage should be well sealed and made of suitable materials to prevent it from leaking or reacting with the material of the container. The condition of the container should also be checked regularly on a daily basis. If there are signs of leakage, appropriate measures should be taken immediately. And the humidity of the storage environment should also be paid attention to. If the humidity is too high or it affects its stability.
In addition, the storage area should be equipped with corresponding emergency treatment equipment and protective equipment. If something happens, it can be responded to in time. During the storage process, it should also be operated in accordance with relevant laws and standards, and all information stored should be recorded in detail, such as quantity, time of entry and exit of the warehouse, etc., for traceability and management. In this way, the safety and stability of the storage of 4- (chloromethyl) -2-fluoro-1-methoxybenzene are guaranteed.
Because of its flammability, it should be placed in a cool and ventilated place, away from fire and heat sources, and must not be placed in a high temperature environment to avoid fire. In addition, this compound may be harmful to the human body, and the storage place should be clearly marked to prevent others from accidentally touching or eating it.
The container used for storage should be well sealed and made of suitable materials to prevent it from leaking or reacting with the material of the container. The condition of the container should also be checked regularly on a daily basis. If there are signs of leakage, appropriate measures should be taken immediately. And the humidity of the storage environment should also be paid attention to. If the humidity is too high or it affects its stability.
In addition, the storage area should be equipped with corresponding emergency treatment equipment and protective equipment. If something happens, it can be responded to in time. During the storage process, it should also be operated in accordance with relevant laws and standards, and all information stored should be recorded in detail, such as quantity, time of entry and exit of the warehouse, etc., for traceability and management. In this way, the safety and stability of the storage of 4- (chloromethyl) -2-fluoro-1-methoxybenzene are guaranteed.
What are the environmental effects of Benzene, 4- (chloromethyl) -2-fluoro-1-methoxy-
The influence of 4- (chloromethyl) -2-fluoro-1-methoxybenzene on the environment is worthy of in-depth investigation.
Looking at its chemical structure, chloromethyl is active and can participate in various chemical reactions in the environment. It releases chloride ions in water bodies or due to hydrolysis. If it accumulates too much, it may cause the salinity of water bodies to rise, affecting the survival and reproduction of aquatic organisms. Aquatic organisms are sensitive to changes in salinity. Abnormal salinity or imbalance of their osmotic pressure can cause physiological dysfunction.
The presence of fluorine atoms also affects. Fluorine-containing compounds are highly stable in the environment and difficult to be degraded naturally. They may accumulate in organisms and pass along the food chain, resulting in toxic effects on high trophic organisms. For example, it affects the normal functions of the nervous system and endocrine system of organisms.
Although the methoxyl group is relatively stable, it may also undergo transformation under specific environmental conditions. This compound enters the soil environment, or affects the structure and function of the soil microbial community. Soil microorganisms are crucial to soil fertility and material circulation, and their communities change or cause imbalance in the soil ecosystem, affecting plant growth.
And the compound has certain volatility. After entering the atmosphere, it may participate in photochemical reactions and affect the air quality. Or interact with other pollutants in the atmosphere to generate secondary pollutants, endangering human health and the ecological environment.
In summary, 4- (chloromethyl) -2-fluoro-1-methoxybenzene in various environmental media has a complex impact on the ecosystem through various pathways, which requires close attention and in-depth study to understand its harm and find countermeasures.
Looking at its chemical structure, chloromethyl is active and can participate in various chemical reactions in the environment. It releases chloride ions in water bodies or due to hydrolysis. If it accumulates too much, it may cause the salinity of water bodies to rise, affecting the survival and reproduction of aquatic organisms. Aquatic organisms are sensitive to changes in salinity. Abnormal salinity or imbalance of their osmotic pressure can cause physiological dysfunction.
The presence of fluorine atoms also affects. Fluorine-containing compounds are highly stable in the environment and difficult to be degraded naturally. They may accumulate in organisms and pass along the food chain, resulting in toxic effects on high trophic organisms. For example, it affects the normal functions of the nervous system and endocrine system of organisms.
Although the methoxyl group is relatively stable, it may also undergo transformation under specific environmental conditions. This compound enters the soil environment, or affects the structure and function of the soil microbial community. Soil microorganisms are crucial to soil fertility and material circulation, and their communities change or cause imbalance in the soil ecosystem, affecting plant growth.
And the compound has certain volatility. After entering the atmosphere, it may participate in photochemical reactions and affect the air quality. Or interact with other pollutants in the atmosphere to generate secondary pollutants, endangering human health and the ecological environment.
In summary, 4- (chloromethyl) -2-fluoro-1-methoxybenzene in various environmental media has a complex impact on the ecosystem through various pathways, which requires close attention and in-depth study to understand its harm and find countermeasures.
Scan to WhatsApp
