Linshang Chemical
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Benzeneacetic Acid, 2-(Chloromethyl)-
Linshang Chemical
|
HS Code |
248266 |
| Chemical Formula | C9H9ClO2 |
| Molar Mass | 184.62 g/mol |
| Appearance | Solid |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
As an accredited Benzeneacetic Acid, 2-(Chloromethyl)- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 2-(chloromethyl)benzeneacetic acid chemical. |
| Storage | **Storage of 2-(Chloromethyl)benzeneacetic Acid** Store 2-(Chloromethyl)benzeneacetic Acid in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent exposure to air and moisture. Since it's a chemical, segregate it from incompatible substances like oxidizing agents and bases to avoid potential reactions. |
| Shipping | Benzeneacetic Acid, 2-(chloromethyl)- should be shipped in accordance with strict hazardous chemical regulations. Use appropriate, leak - proof containers. Label clearly and ensure transportation in a well - ventilated vehicle to maintain safety. |
Competitive Benzeneacetic Acid, 2-(Chloromethyl)- prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of Benzeneacetic Acid, 2- (chloromethyl) -
2 - (chloromethyl) phenylacetic acid is one of the organic compounds. Its physical properties are quite unique.
Looking at its appearance, it often takes the form of white to off-white crystalline powder, which is easy to observe and handle.
Talking about the melting point, it is about 108-112 ° C. As an important physical constant of a substance, the melting point is of great significance for its identification and purity judgment. In this temperature range, the substance gradually changes from solid to liquid, reflecting the change of intermolecular forces.
In terms of solubility, it exhibits certain solubility in organic solvents such as ethanol and acetone. The polarity and molecular structure of organic solvents such as ethanol and acetone interact with 2- (chloromethyl) phenylacetic acid, so that the substance can be dispersed in it. However, the solubility in water is relatively poor. The polarity of water is strong, and it does not match the intermolecular force of 2- (chloromethyl) phenylacetic acid, resulting in it is difficult to dissolve in water in large quantities.
In addition, the substance has certain stability, but under specific conditions, such as high temperature, strong acid and strong base environment, its structure may change. Because it contains active groups such as chloromethyl and carboxyl groups, these groups can participate in a variety of chemical reactions, which in turn affects the stability of its physical properties. During storage and use, appropriate conditions must be selected based on these physical characteristics to ensure their quality and performance.
Looking at its appearance, it often takes the form of white to off-white crystalline powder, which is easy to observe and handle.
Talking about the melting point, it is about 108-112 ° C. As an important physical constant of a substance, the melting point is of great significance for its identification and purity judgment. In this temperature range, the substance gradually changes from solid to liquid, reflecting the change of intermolecular forces.
In terms of solubility, it exhibits certain solubility in organic solvents such as ethanol and acetone. The polarity and molecular structure of organic solvents such as ethanol and acetone interact with 2- (chloromethyl) phenylacetic acid, so that the substance can be dispersed in it. However, the solubility in water is relatively poor. The polarity of water is strong, and it does not match the intermolecular force of 2- (chloromethyl) phenylacetic acid, resulting in it is difficult to dissolve in water in large quantities.
In addition, the substance has certain stability, but under specific conditions, such as high temperature, strong acid and strong base environment, its structure may change. Because it contains active groups such as chloromethyl and carboxyl groups, these groups can participate in a variety of chemical reactions, which in turn affects the stability of its physical properties. During storage and use, appropriate conditions must be selected based on these physical characteristics to ensure their quality and performance.
Benzeneacetic Acid, 2- (chloromethyl) - What are the chemical properties of
Phenylacetic acid, 2 - (chloromethyl) -, the chemical properties of this substance are as follows:
It is acidic, because it contains a carboxyl group (-COOH), the carboxyl group can ionize hydrogen ions, so it can neutralize with bases, such as reacting with sodium hydroxide to form sodium phenylacetate and water, which is a common case of acid-base neutralization.
2 - (chloromethyl) The chloromethyl part is active. Chlorine atoms, as functional groups, can undergo nucleophilic substitution reactions. For example, when reacting with sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds; in the case of sodium cyanide, chlorine atoms will be replaced by cyanyl groups, and carboxyl groups can be obtained after hydrolysis. This is a common means of growing carbon chains in organic synthesis.
When heated, the substance may undergo a specific decomposition reaction. If conditions are appropriate, the chemical bond between the carboxyl group and the chloromethyl group may break, triggering a complex thermal decomposition process and generating a variety of decomposition products. The specific products vary depending on the reaction conditions.
It has certain solubility in organic solvents, such as common organic solvents such as ethanol and ether, which can dissolve this substance well. This property is very critical in the reaction operation and separation and purification of organic synthesis.
Because of its chlorine atoms, harmful gases containing chlorine may be produced during combustion, so care should be taken to prevent the emission of such harmful gases during treatment and use to protect the environment and human health. In short, the chemical properties of this substance are determined by the carboxyl group and chloromethyl functional group it contains, and it has unique uses and reaction characteristics in organic synthesis and other fields.
It is acidic, because it contains a carboxyl group (-COOH), the carboxyl group can ionize hydrogen ions, so it can neutralize with bases, such as reacting with sodium hydroxide to form sodium phenylacetate and water, which is a common case of acid-base neutralization.
2 - (chloromethyl) The chloromethyl part is active. Chlorine atoms, as functional groups, can undergo nucleophilic substitution reactions. For example, when reacting with sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds; in the case of sodium cyanide, chlorine atoms will be replaced by cyanyl groups, and carboxyl groups can be obtained after hydrolysis. This is a common means of growing carbon chains in organic synthesis.
When heated, the substance may undergo a specific decomposition reaction. If conditions are appropriate, the chemical bond between the carboxyl group and the chloromethyl group may break, triggering a complex thermal decomposition process and generating a variety of decomposition products. The specific products vary depending on the reaction conditions.
It has certain solubility in organic solvents, such as common organic solvents such as ethanol and ether, which can dissolve this substance well. This property is very critical in the reaction operation and separation and purification of organic synthesis.
Because of its chlorine atoms, harmful gases containing chlorine may be produced during combustion, so care should be taken to prevent the emission of such harmful gases during treatment and use to protect the environment and human health. In short, the chemical properties of this substance are determined by the carboxyl group and chloromethyl functional group it contains, and it has unique uses and reaction characteristics in organic synthesis and other fields.
What is the main use of Benzeneacetic Acid, 2- (chloromethyl) -?
2 - (chloromethyl) phenylacetic acid, which has a wide range of uses. In the field of organic synthesis, it can be called a key raw material. First, it can be used to create many bioactive compounds. For example, in the field of medicinal chemistry, by modifying and modifying its structure, drugs with specific pharmacological effects can be synthesized. In the research and development process of some anti-cancer drugs and antibacterial drugs, 2 - (chloromethyl) phenylacetic acid is often used as a starting material. It undergoes a series of chemical reactions to shape the molecular structure of drugs that meet the needs, providing an important material basis for medical research.
Second, it also has significant uses in the synthesis of pesticides. A variety of high-efficiency pesticides can be prepared from it. Due to its structural characteristics, it can derive compounds with special mechanisms of action on pests, or interfere with the growth and development of pests, or damage their nervous system, thereby achieving good insecticidal effects and assisting agricultural production in pest control.
Furthermore, in the field of materials science, 2 - (chloromethyl) phenylacetic acid also plays a role. It can participate in the synthesis of some functional polymer materials, giving the material special properties. For example, it can make the material have better adsorption, ion exchange, etc., and then expand the application range of materials, showing potential application value in chemical industry, environmental protection and other fields. In short, 2 - (chloromethyl) phenylacetic acid has important uses in many fields that cannot be ignored.
Second, it also has significant uses in the synthesis of pesticides. A variety of high-efficiency pesticides can be prepared from it. Due to its structural characteristics, it can derive compounds with special mechanisms of action on pests, or interfere with the growth and development of pests, or damage their nervous system, thereby achieving good insecticidal effects and assisting agricultural production in pest control.
Furthermore, in the field of materials science, 2 - (chloromethyl) phenylacetic acid also plays a role. It can participate in the synthesis of some functional polymer materials, giving the material special properties. For example, it can make the material have better adsorption, ion exchange, etc., and then expand the application range of materials, showing potential application value in chemical industry, environmental protection and other fields. In short, 2 - (chloromethyl) phenylacetic acid has important uses in many fields that cannot be ignored.
What are the synthesis methods of Benzeneacetic Acid, 2- (chloromethyl) -
The method of preparing 2 - (chloromethyl) phenylacetic acid has various paths.
First, it can be obtained by chloromethylation of phenylacetonitrile and then hydrolysis. First, phenylacetonitrile is taken and chloromethylated with formaldehyde and hydrogen chloride in a suitable solvent in the presence of a catalyst such as anhydrous zinc chloride. This process requires temperature control and time control to allow the reaction to proceed smoothly. 2 - (chloromethyl) phenylacetonitrile can be obtained. Subsequently, the obtained 2 - (chloromethyl) phenylacetonitrile is catalyzed by acid or base hydrolysis. If acid catalysis is used, strong acids such as sulfuric acid are commonly used. Under heating conditions, the nitrile group is gradually converted into a carboxyl group. After post-treatment such as extraction, distillation, recrystallization, etc., pure 2- (chloromethyl) phenylacetic acid can be obtained.
Second, phenylacetic acid is used as the starting material and directly prepared by chloromethylation. The phenylacetic acid is dissolved in a suitable organic solvent, an appropriate catalyst is added, formaldehyde and hydrogen chloride gas are introduced, and chloromethylation occurs. The key to this reaction lies in the precise regulation of the reaction conditions. Due to the reactivity and selectivity, the temperature, the proportion of reactants, and the amount of catalyst need to be carefully considered. After the reaction is completed, the impurities are removed and the product is obtained through separation
Third, benzyl halide can be reacted with cyanide to form benzyl nitrile, and then benzyl nitrile can be chloromethylated and hydrolyzed to obtain the target product. First, the benzyl halide is reacted with cyanides such as sodium cyanide or potassium cyanide in a suitable solvent under the action of a phase transfer catalyst to form benzyl nitrile. Then, according to the above chloromethylation and hydrolysis steps, the final product is 2 - (chloromethyl) phenylacetic acid. Each method has its own advantages and disadvantages. In practical application, it is selected according to factors such as raw material availability, cost, and product purity requirements.
First, it can be obtained by chloromethylation of phenylacetonitrile and then hydrolysis. First, phenylacetonitrile is taken and chloromethylated with formaldehyde and hydrogen chloride in a suitable solvent in the presence of a catalyst such as anhydrous zinc chloride. This process requires temperature control and time control to allow the reaction to proceed smoothly. 2 - (chloromethyl) phenylacetonitrile can be obtained. Subsequently, the obtained 2 - (chloromethyl) phenylacetonitrile is catalyzed by acid or base hydrolysis. If acid catalysis is used, strong acids such as sulfuric acid are commonly used. Under heating conditions, the nitrile group is gradually converted into a carboxyl group. After post-treatment such as extraction, distillation, recrystallization, etc., pure 2- (chloromethyl) phenylacetic acid can be obtained.
Second, phenylacetic acid is used as the starting material and directly prepared by chloromethylation. The phenylacetic acid is dissolved in a suitable organic solvent, an appropriate catalyst is added, formaldehyde and hydrogen chloride gas are introduced, and chloromethylation occurs. The key to this reaction lies in the precise regulation of the reaction conditions. Due to the reactivity and selectivity, the temperature, the proportion of reactants, and the amount of catalyst need to be carefully considered. After the reaction is completed, the impurities are removed and the product is obtained through separation
Third, benzyl halide can be reacted with cyanide to form benzyl nitrile, and then benzyl nitrile can be chloromethylated and hydrolyzed to obtain the target product. First, the benzyl halide is reacted with cyanides such as sodium cyanide or potassium cyanide in a suitable solvent under the action of a phase transfer catalyst to form benzyl nitrile. Then, according to the above chloromethylation and hydrolysis steps, the final product is 2 - (chloromethyl) phenylacetic acid. Each method has its own advantages and disadvantages. In practical application, it is selected according to factors such as raw material availability, cost, and product purity requirements.
Benzeneacetic Acid, 2- (chloromethyl) - Precautions during use
The use of 2 - (chloromethyl) phenylacetic acid in the chemical industry involves many precautions and must be treated with caution.
This substance is toxic and irritating to a certain extent. When operating, you must wear complete protective equipment, such as gas masks, protective gloves and protective clothing, to prevent it from coming into contact with the skin, eyes, or inhaling through the respiratory tract, causing damage to the body. Operate in a well-ventilated place. If conditions permit, it should be carried out in a fume hood to ensure the timely discharge of harmful gases, reduce the concentration in the air, and ensure the safety of operators.
Storage is also particular. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, and avoid direct sunlight. And should be stored separately from oxidants, alkalis, etc., do not mix storage to prevent dangerous chemical reactions. At the same time, the storage area should be equipped with suitable containment materials to deal with possible leakage conditions.
During use, precise control of dosage and reaction conditions is essential. Strictly follow established operating procedures and process requirements, and control parameters such as temperature, pressure, and reaction time to prevent the reaction from getting out of control and leading to accidents. In case of accidental leakage, irrelevant personnel should be quickly evacuated to a safe area and isolated. Emergency personnel need to wear protective equipment. According to the amount of leakage and the actual situation, appropriate methods should be taken to collect and clean up to prevent the spread of pollution.
After use, properly dispose of the remaining materials and waste, and must not be discarded at will. Follow relevant environmental regulations and choose appropriate treatment methods to ensure that the environment is not polluted. Only by paying attention everywhere and operating in strict accordance with regulations can 2- (chloromethyl) phenylacetic acid be used safely and effectively.
This substance is toxic and irritating to a certain extent. When operating, you must wear complete protective equipment, such as gas masks, protective gloves and protective clothing, to prevent it from coming into contact with the skin, eyes, or inhaling through the respiratory tract, causing damage to the body. Operate in a well-ventilated place. If conditions permit, it should be carried out in a fume hood to ensure the timely discharge of harmful gases, reduce the concentration in the air, and ensure the safety of operators.
Storage is also particular. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, and avoid direct sunlight. And should be stored separately from oxidants, alkalis, etc., do not mix storage to prevent dangerous chemical reactions. At the same time, the storage area should be equipped with suitable containment materials to deal with possible leakage conditions.
During use, precise control of dosage and reaction conditions is essential. Strictly follow established operating procedures and process requirements, and control parameters such as temperature, pressure, and reaction time to prevent the reaction from getting out of control and leading to accidents. In case of accidental leakage, irrelevant personnel should be quickly evacuated to a safe area and isolated. Emergency personnel need to wear protective equipment. According to the amount of leakage and the actual situation, appropriate methods should be taken to collect and clean up to prevent the spread of pollution.
After use, properly dispose of the remaining materials and waste, and must not be discarded at will. Follow relevant environmental regulations and choose appropriate treatment methods to ensure that the environment is not polluted. Only by paying attention everywhere and operating in strict accordance with regulations can 2- (chloromethyl) phenylacetic acid be used safely and effectively.
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