Linshang Chemical
PRODUCTS
Benzeneacetic Acid, 3,4-Dichloro-
Linshang Chemical
|
HS Code |
528351 |
| Name | 3,4 - Dichlorobenzeneacetic acid |
| Chemical Formula | C8H6Cl2O2 |
| Molar Mass | 205.04 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 132 - 136 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, acetone |
| Acidity Pka | Approximately 3.8 |
| Odor | Odorless or very faint odor |
As an accredited Benzeneacetic Acid, 3,4-Dichloro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3,4 - dichlorobenzeneacetic acid packaged in a sealed, labeled container. |
| Storage | 3,4 - Dichlorobenzeneacetic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and evaporation. Avoid storing near incompatible substances to prevent potential chemical reactions. |
| Shipping | 3,4 - Dichlorobenzeneacetic acid is a chemical. It should be shipped in accordance with hazardous chemical regulations. Use suitable, properly labeled containers to prevent leakage and ensure safe transportation during transit. |
Competitive Benzeneacetic Acid, 3,4-Dichloro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy Benzeneacetic Acid, 3,4-Dichloro- in China?
As a trusted Benzeneacetic Acid, 3,4-Dichloro- manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading Benzeneacetic Acid, 3,4-Dichloro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3,4-dichlorophenylacetic acid?
3,4-Difluorophenylacetic acid is also an organic compound. It has unique chemical properties and is important in the field of chemistry.
Looking at its physical properties, under normal temperature, or as a solid, it has a specific melting point and boiling point. The melting boiling point is determined by the intermolecular force. The fluorine atom in the molecule is quite electronegative, and the intermolecular force is special, making the melting point different from other phenylacetic acid derivatives.
When it comes to chemical properties, its acidity is the first. The carboxyl group of phenylacetic acid can ionize hydrogen ions, which is acidic. However, because the fluorine atom at the ortho position of the benzene ring has a strong electron-absorbing effect, the induction effect reduces the density of the carboxyl group electron cloud, and the hydrogen ion is easier to leave, so its acidity is stronger than that of phenylacetic acid.
Furthermore, its benzene ring can undergo electrophilic substitution reaction. Although fluorine atoms have electron-absorbing induction effects, due to their lone pair electrons, they have a certain electron conjugation effect on the benzene ring, so that the electron cloud density of the benzene ring is relatively high, and the electrophilic reagents are easy to attack the ortho and para-sites. For example, halogenation and nitrification reactions can occur with halogenating agents, nitrifying agents, etc., and corresponding substituents are introduced into the ortho and para-sites.
In addition, carboxyl groups can participate in a variety of reactions. It can react with alcohols under acid catalysis to form corresponding ester compounds. It can also react with bases to form carboxylic salts. At the same time, the reactivity of its side chain is also affected by the presence of fluorine atoms. In organic synthesis, unique reaction paths can be designed according to this to prepare organic compounds with specific structures and functions.
All these chemical properties make it important for many fields such as medicine, pesticides, materials, etc. It can be used as a pharmaceutical intermediate to chemically modify and synthesize drugs with specific pharmacological activities; in the field of pesticides, it can be used to create new pesticides with high efficiency and low toxicity; in materials science, it can participate in the synthesis of polymer materials with special properties.
Looking at its physical properties, under normal temperature, or as a solid, it has a specific melting point and boiling point. The melting boiling point is determined by the intermolecular force. The fluorine atom in the molecule is quite electronegative, and the intermolecular force is special, making the melting point different from other phenylacetic acid derivatives.
When it comes to chemical properties, its acidity is the first. The carboxyl group of phenylacetic acid can ionize hydrogen ions, which is acidic. However, because the fluorine atom at the ortho position of the benzene ring has a strong electron-absorbing effect, the induction effect reduces the density of the carboxyl group electron cloud, and the hydrogen ion is easier to leave, so its acidity is stronger than that of phenylacetic acid.
Furthermore, its benzene ring can undergo electrophilic substitution reaction. Although fluorine atoms have electron-absorbing induction effects, due to their lone pair electrons, they have a certain electron conjugation effect on the benzene ring, so that the electron cloud density of the benzene ring is relatively high, and the electrophilic reagents are easy to attack the ortho and para-sites. For example, halogenation and nitrification reactions can occur with halogenating agents, nitrifying agents, etc., and corresponding substituents are introduced into the ortho and para-sites.
In addition, carboxyl groups can participate in a variety of reactions. It can react with alcohols under acid catalysis to form corresponding ester compounds. It can also react with bases to form carboxylic salts. At the same time, the reactivity of its side chain is also affected by the presence of fluorine atoms. In organic synthesis, unique reaction paths can be designed according to this to prepare organic compounds with specific structures and functions.
All these chemical properties make it important for many fields such as medicine, pesticides, materials, etc. It can be used as a pharmaceutical intermediate to chemically modify and synthesize drugs with specific pharmacological activities; in the field of pesticides, it can be used to create new pesticides with high efficiency and low toxicity; in materials science, it can participate in the synthesis of polymer materials with special properties.
What are the physical properties of 3,4-dichlorophenylacetic acid?
3,4-Difluorophenylacetic acid is an organic compound with unique physical properties. Its properties are mostly white to off-white crystalline powder at room temperature. This form is easy to store and transport, and is also conducive to accurate use in various chemical reactions.
Looking at its melting point, it is about 108-112 ° C. Melting point, as an important physical property of substances, is of great significance for identification and purification. This temperature range shows that 3,4-difluorophenylacetic acid will change from solid to liquid in this specific temperature range, providing a key basis for its operation in the synthesis and separation process.
Looking at its solubility, it is slightly soluble in water, but soluble in organic solvents such as ethanol and ether. This property is closely related to its molecular structure, and the ratio and distribution of polar and non-polar parts in the molecule cause it to dissolve differently in different solvents. Slightly soluble in water, due to the strong polarity of water molecules, while 3,4-difluorophenylacetic acid molecules have relatively weak polarity; soluble in organic solvents such as ethanol and ether, due to the similar intermolecular forces between these organic solvents and the compound molecules, following the principle of "similar phase dissolution". This solubility lays the foundation for its application in organic synthesis, drug research and development, etc. For example, in pharmaceutical preparations, suitable solvents can be selected according to their solubility to improve drug stability and bioavailability.
In addition, the relative density of 3,4-difluorophenylacetic acid is about 1.38 (20 ° C), and the relative density reflects the relative relationship between the material and the water density. In chemical production, it plays an important role in material measurement and mixing ratio control, helping to ensure the accuracy of the production process.
Looking at its melting point, it is about 108-112 ° C. Melting point, as an important physical property of substances, is of great significance for identification and purification. This temperature range shows that 3,4-difluorophenylacetic acid will change from solid to liquid in this specific temperature range, providing a key basis for its operation in the synthesis and separation process.
Looking at its solubility, it is slightly soluble in water, but soluble in organic solvents such as ethanol and ether. This property is closely related to its molecular structure, and the ratio and distribution of polar and non-polar parts in the molecule cause it to dissolve differently in different solvents. Slightly soluble in water, due to the strong polarity of water molecules, while 3,4-difluorophenylacetic acid molecules have relatively weak polarity; soluble in organic solvents such as ethanol and ether, due to the similar intermolecular forces between these organic solvents and the compound molecules, following the principle of "similar phase dissolution". This solubility lays the foundation for its application in organic synthesis, drug research and development, etc. For example, in pharmaceutical preparations, suitable solvents can be selected according to their solubility to improve drug stability and bioavailability.
In addition, the relative density of 3,4-difluorophenylacetic acid is about 1.38 (20 ° C), and the relative density reflects the relative relationship between the material and the water density. In chemical production, it plays an important role in material measurement and mixing ratio control, helping to ensure the accuracy of the production process.
What are the main uses of 3,4-dichlorophenylacetic acid?
3,2,4-Dihydroxyphenylacetic acid, an important organic compound, has significant uses in many fields.
In the field of medicine, it plays a key role. The compound has specific biological activities and may participate in the physiological regulation process of the human body. Studies have found that it has potential effects on the regulation of the nervous system, and may help to develop therapeutic drugs for neurological diseases, such as Parkinson's disease. The pathogenesis of Parkinson's disease is related to the imbalance of neurotransmitters, and 3,2,4-dihydroxyphenylacetic acid may improve the condition by regulating the synthesis, metabolism or transmission of related neurotransmitters.
In the chemical industry, it is also an important synthetic raw material. With its special chemical structure, it can be used to synthesize a variety of fine chemicals. For example, it can be used as a key intermediate in the synthesis of some high-performance coatings and plastic additives. In the synthesis of coatings, its participation in the reaction can give the coating better performance, such as enhancing the adhesion and corrosion resistance of the coating; in the synthesis of plastic additives, it can improve the stability and oxidation resistance of plastics.
In addition, in biochemical research, 3,2,4-dihydroxyphenylacetic acid is also of great significance as a biomarker. The content of this substance in organisms may reflect the physiological or pathological state of the body. Researchers can monitor its content to deeply explore the metabolic process in organisms and the mechanism of the occurrence and development of diseases, providing a strong basis for the early diagnosis and treatment of diseases. From this perspective, 3,2,4-dihydroxyphenylacetic acid is indispensable in many fields such as medicine, chemical industry, and biochemistry, and is of great significance to promoting the development of various fields.
In the field of medicine, it plays a key role. The compound has specific biological activities and may participate in the physiological regulation process of the human body. Studies have found that it has potential effects on the regulation of the nervous system, and may help to develop therapeutic drugs for neurological diseases, such as Parkinson's disease. The pathogenesis of Parkinson's disease is related to the imbalance of neurotransmitters, and 3,2,4-dihydroxyphenylacetic acid may improve the condition by regulating the synthesis, metabolism or transmission of related neurotransmitters.
In the chemical industry, it is also an important synthetic raw material. With its special chemical structure, it can be used to synthesize a variety of fine chemicals. For example, it can be used as a key intermediate in the synthesis of some high-performance coatings and plastic additives. In the synthesis of coatings, its participation in the reaction can give the coating better performance, such as enhancing the adhesion and corrosion resistance of the coating; in the synthesis of plastic additives, it can improve the stability and oxidation resistance of plastics.
In addition, in biochemical research, 3,2,4-dihydroxyphenylacetic acid is also of great significance as a biomarker. The content of this substance in organisms may reflect the physiological or pathological state of the body. Researchers can monitor its content to deeply explore the metabolic process in organisms and the mechanism of the occurrence and development of diseases, providing a strong basis for the early diagnosis and treatment of diseases. From this perspective, 3,2,4-dihydroxyphenylacetic acid is indispensable in many fields such as medicine, chemical industry, and biochemistry, and is of great significance to promoting the development of various fields.
What is the preparation method of 3,4-dichlorophenylacetic acid?
The preparation of 3,4-difluorophenylacetic acid is an important matter for chemical synthesis. The method is as follows:
Starting with 3,4-difluorobenzene as the base material, this material is easy to obtain and has specific chemical activity. First, it reacts with haloacetate in a suitable alkaline environment. The alkaline environment can be created by strong bases such as sodium hydroxide or potassium carbonate. In this environment, the hydrogen atoms on the benzene ring of 3,4-difluorobenzene are replaced by haloacetate to form 3,4-difluorophenylacetate. This reaction requires precise temperature control, usually between room temperature and 50 degrees Celsius. If the temperature is too high, side reactions will easily occur, and if it is too low, the reaction rate will be slow.
Then, the prepared 3,4-difluorophenylacetate is hydrolyzed. The method of hydrolysis is mostly a dilute acid or a dilute base as a catalyst. If a dilute base, such as a dilute sodium hydroxide solution, is used under the condition of heating and refluxing, the ester group can be hydrolyzed into a carboxyl group to obtain a sodium salt of 3,4-difluorophenylacetate. This process requires careful observation of the reaction process to ensure complete hydrolysis.
Then neutralize the sodium salt of 3,4-difluorophenylacetate with acid, commonly used hydrochloric acid or sulfuric acid. After neutralization, 3,4-difluorophenylacetate precipitates from the solution. At this time, the product can be collected by filtration, and then washed with an appropriate amount of organic solvent to remove impurities. Finally, through a drying process, pure 3,4-difluorophenylacetic acid can be obtained.
Or it can be prepared by other methods. With 3,4-difluorobenzoic acid as the starting material, after a reduction reaction, the carboxyl group is reduced to hydroxymethyl group to obtain 3,4-difluorobenzyl alcohol. This reduction reaction can be used as a reducing agent such as sodium borohydride or lithium aluminum hydride. Then, 3,4-difluorobenzyl alcohol is oxidized to oxidize the hydroxymethyl group to a carboxyl group. This oxidation reaction can be used as an oxidizing agent such as potassium permanganate or potassium dichromate, and finally 3,4-difluorobenzyl acetic acid can be obtained. Although the preparation process is different, it is necessary to adhere to the chemical principle and precisely control the reaction conditions in order to obtain a pure product.
Starting with 3,4-difluorobenzene as the base material, this material is easy to obtain and has specific chemical activity. First, it reacts with haloacetate in a suitable alkaline environment. The alkaline environment can be created by strong bases such as sodium hydroxide or potassium carbonate. In this environment, the hydrogen atoms on the benzene ring of 3,4-difluorobenzene are replaced by haloacetate to form 3,4-difluorophenylacetate. This reaction requires precise temperature control, usually between room temperature and 50 degrees Celsius. If the temperature is too high, side reactions will easily occur, and if it is too low, the reaction rate will be slow.
Then, the prepared 3,4-difluorophenylacetate is hydrolyzed. The method of hydrolysis is mostly a dilute acid or a dilute base as a catalyst. If a dilute base, such as a dilute sodium hydroxide solution, is used under the condition of heating and refluxing, the ester group can be hydrolyzed into a carboxyl group to obtain a sodium salt of 3,4-difluorophenylacetate. This process requires careful observation of the reaction process to ensure complete hydrolysis.
Then neutralize the sodium salt of 3,4-difluorophenylacetate with acid, commonly used hydrochloric acid or sulfuric acid. After neutralization, 3,4-difluorophenylacetate precipitates from the solution. At this time, the product can be collected by filtration, and then washed with an appropriate amount of organic solvent to remove impurities. Finally, through a drying process, pure 3,4-difluorophenylacetic acid can be obtained.
Or it can be prepared by other methods. With 3,4-difluorobenzoic acid as the starting material, after a reduction reaction, the carboxyl group is reduced to hydroxymethyl group to obtain 3,4-difluorobenzyl alcohol. This reduction reaction can be used as a reducing agent such as sodium borohydride or lithium aluminum hydride. Then, 3,4-difluorobenzyl alcohol is oxidized to oxidize the hydroxymethyl group to a carboxyl group. This oxidation reaction can be used as an oxidizing agent such as potassium permanganate or potassium dichromate, and finally 3,4-difluorobenzyl acetic acid can be obtained. Although the preparation process is different, it is necessary to adhere to the chemical principle and precisely control the reaction conditions in order to obtain a pure product.
What are the precautions for storing and transporting 3,4-dichlorophenylacetic acid?
3% 2C4-difluorophenylacetic acid, when storing and transporting, it is necessary to pay attention to many key matters.
Bear the brunt, the storage place must be cool, dry and well ventilated. This is due to the nature of the substance or affected by temperature and humidity and air circulation. If the storage environment is warm and humid, it may cause chemical reactions to occur, which will damage the quality. For example, if placed in a high temperature and humid place, it may cause deliquescence and deterioration, and lose its original efficacy.
Furthermore, keep away from fire and heat sources. Because it may be flammable or contact with fire or heat will cause dangerous reactions. If it is close to the source of fire, it may cause combustion or even explosion, endangering the safety of the surrounding area.
When transporting, the packaging must be tight. Suitable packaging materials must be selected to ensure that there is no risk of leakage during transportation. If the packaging is omitted and the substance leaks, it will not only pollute the environment, but also pose a threat to the health of the transportation personnel and surrounding people.
At the same time, the transportation vehicle should also meet the safety standards. Vehicles should be equipped with fire and explosion-proof safety facilities, and the transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In the event of an emergency on the way, it can be responded to quickly and properly to minimize the harm.
In addition, whether it is stored or transported, it should be stored or transported separately from oxidants, acids, alkalis and other substances. Because the substance may react violently with the above substances, serious consequences will be caused.
In conclusion, 3% 2C4-difluorophenylacetic acid needs to be treated strictly in all aspects of storage and transportation, and operated according to safety regulations to ensure the safety of personnel and the integrity of materials.
Bear the brunt, the storage place must be cool, dry and well ventilated. This is due to the nature of the substance or affected by temperature and humidity and air circulation. If the storage environment is warm and humid, it may cause chemical reactions to occur, which will damage the quality. For example, if placed in a high temperature and humid place, it may cause deliquescence and deterioration, and lose its original efficacy.
Furthermore, keep away from fire and heat sources. Because it may be flammable or contact with fire or heat will cause dangerous reactions. If it is close to the source of fire, it may cause combustion or even explosion, endangering the safety of the surrounding area.
When transporting, the packaging must be tight. Suitable packaging materials must be selected to ensure that there is no risk of leakage during transportation. If the packaging is omitted and the substance leaks, it will not only pollute the environment, but also pose a threat to the health of the transportation personnel and surrounding people.
At the same time, the transportation vehicle should also meet the safety standards. Vehicles should be equipped with fire and explosion-proof safety facilities, and the transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In the event of an emergency on the way, it can be responded to quickly and properly to minimize the harm.
In addition, whether it is stored or transported, it should be stored or transported separately from oxidants, acids, alkalis and other substances. Because the substance may react violently with the above substances, serious consequences will be caused.
In conclusion, 3% 2C4-difluorophenylacetic acid needs to be treated strictly in all aspects of storage and transportation, and operated according to safety regulations to ensure the safety of personnel and the integrity of materials.
Scan to WhatsApp
