Linshang Chemical
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Benzeneacetic Acid, 4-Bromo-2-Chloro-
Linshang Chemical
|
HS Code |
178305 |
| Chemical Formula | C8H6BrClO2 |
| Molar Mass | 249.5 g/mol |
| Appearance | Solid |
| Color | White to off - white |
| Melting Point | 115 - 119 °C |
| Solubility In Water | Low |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Density | Approx. 1.7 g/cm³ |
| Pka | Around 4.0 - 4.5 |
As an accredited Benzeneacetic Acid, 4-Bromo-2-Chloro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 2 - chloro - benzeneacetic acid packaged in a sealed plastic bottle. |
| Storage | 4 - bromo - 2 - chloro - benzeneacetic acid should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture absorption and evaporation. Store it separately from oxidizing agents, bases, and other incompatible substances to avoid chemical reactions. |
| Shipping | 4 - bromo - 2 - chloro - benzeneacetic acid is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations to prevent leakage, ensuring safe transport due to its potentially hazardous nature. |
Competitive Benzeneacetic Acid, 4-Bromo-2-Chloro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy Benzeneacetic Acid, 4-Bromo-2-Chloro- in China?
As a trusted Benzeneacetic Acid, 4-Bromo-2-Chloro- manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading Benzeneacetic Acid, 4-Bromo-2-Chloro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 4-bromo-2-chlorophenylacetic acid?
4-Hydroxy-2-chlorobenzoic acid is one of the organic compounds. Its physical properties are as follows:
Under normal temperature, it often takes the shape of white to light yellow crystalline powder, which is easy to observe and distinguish.
Smell its smell, which is almost odorless, but it is slightly smelled, or has a slightly specific light taste, but this taste is very light and cannot be felt without careful observation.
On its melting point, it is between 150 ° C and 154 ° C. The characteristics of the melting point are of great significance in material identification and purity determination. When the temperature gradually rises near the melting point, the compound gradually melts from a solid state to a liquid state, and the intermolecular force changes due to the increase in temperature, causing the state of the substance to change.
As for solubility, slightly soluble in water, but in organic solvents such as ethanol and ether, it has better solubility. Because water molecules are polar molecules, and 4-hydroxyl-2-chlorobenzoic acid contains polar groups, its molecular structure still contains non-polar parts, which are poorly matched with the polarity of water, so slightly soluble. The polarity and molecular structure of organic solvents such as ethanol and ether are more compatible with 4-hydroxyl-2-chlorobenzoic acid, so they can be better miscible.
Its density is about 1.52 g/cm ³. This value reflects the mass of a substance per unit volume and is an important parameter in chemical production, storage and transportation. If the density is established, the mass of a certain volume of the substance can be known, which is convenient for the planning and implementation of related operations.
The physical properties of 4-Hydroxy-2-chlorobenzoic acid are of critical significance in many fields such as chemical synthesis, pharmaceutical research and development, and materials science, and can provide an important basis for related research and applications.
Under normal temperature, it often takes the shape of white to light yellow crystalline powder, which is easy to observe and distinguish.
Smell its smell, which is almost odorless, but it is slightly smelled, or has a slightly specific light taste, but this taste is very light and cannot be felt without careful observation.
On its melting point, it is between 150 ° C and 154 ° C. The characteristics of the melting point are of great significance in material identification and purity determination. When the temperature gradually rises near the melting point, the compound gradually melts from a solid state to a liquid state, and the intermolecular force changes due to the increase in temperature, causing the state of the substance to change.
As for solubility, slightly soluble in water, but in organic solvents such as ethanol and ether, it has better solubility. Because water molecules are polar molecules, and 4-hydroxyl-2-chlorobenzoic acid contains polar groups, its molecular structure still contains non-polar parts, which are poorly matched with the polarity of water, so slightly soluble. The polarity and molecular structure of organic solvents such as ethanol and ether are more compatible with 4-hydroxyl-2-chlorobenzoic acid, so they can be better miscible.
Its density is about 1.52 g/cm ³. This value reflects the mass of a substance per unit volume and is an important parameter in chemical production, storage and transportation. If the density is established, the mass of a certain volume of the substance can be known, which is convenient for the planning and implementation of related operations.
The physical properties of 4-Hydroxy-2-chlorobenzoic acid are of critical significance in many fields such as chemical synthesis, pharmaceutical research and development, and materials science, and can provide an important basis for related research and applications.
What are the chemical properties of 4-bromo-2-chlorophenylacetic acid?
4-Hydroxy-2-mercaptobutyric acid is an organic compound with unique chemical properties.
First, acidity. This compound contains a carboxyl group (-COOH), which can partially ionize hydrogen ions (H 🥰) in water and is acidic. Its acidity enables neutralization with bases, such as with sodium hydroxide (NaOH), where hydrogen ions in the carboxyl group combine with hydroxide ions (OH) to form water, resulting in corresponding carboxylate and water. The reaction formula is: 4-hydroxy- 2-mercaptobutyric acid + NaOH → 4-hydroxy- 2-mercaptobutyrate sodium + H2O O.
Second, hydroxyl reactivity. Molecules contain hydroxyl groups (-OH) and can undergo a variety of reactions. Can participate in esterification reactions, catalyzed by concentrated sulfuric acid and heated under conditions, react with carboxylic acids to form esters and water. For example, react with acetic acid to form 4-hydroxyl-2-mercaptobutyl acetate and water. This reaction is a reversible reaction, and the reaction can be promoted to form esters by controlling conditions.
Third, the characteristics of thiol groups. Mercapto (-SH) has high reactivity. Easily oxidized, it can be gradually oxidized in air to form disulfide bonds (-S-S-). Under the action of appropriate oxidants, the thiol group of two molecules of 4-hydroxyl-2-mercaptobutyric acid can be oxidized to form compounds containing disulfide bonds. In addition, the thiol group can form stable complexes with heavy metal ions, and this property can be used to treat wastewater containing heavy metal ions or to separate and detect heavy metals from mixtures.
Fourth, hydrophilicity. The intra-molecular carboxyl group, hydroxy group and thiol group are all hydrophilic groups, making them hydrophilic and partially soluble in water. This hydrophilicity is of great significance for their transportation and metabolism in organisms. Due to the multi-water environment of organisms, the hydrophilicity of compounds is conducive to their participation in various physiological processes in organisms.
First, acidity. This compound contains a carboxyl group (-COOH), which can partially ionize hydrogen ions (H 🥰) in water and is acidic. Its acidity enables neutralization with bases, such as with sodium hydroxide (NaOH), where hydrogen ions in the carboxyl group combine with hydroxide ions (OH) to form water, resulting in corresponding carboxylate and water. The reaction formula is: 4-hydroxy- 2-mercaptobutyric acid + NaOH → 4-hydroxy- 2-mercaptobutyrate sodium + H2O O.
Second, hydroxyl reactivity. Molecules contain hydroxyl groups (-OH) and can undergo a variety of reactions. Can participate in esterification reactions, catalyzed by concentrated sulfuric acid and heated under conditions, react with carboxylic acids to form esters and water. For example, react with acetic acid to form 4-hydroxyl-2-mercaptobutyl acetate and water. This reaction is a reversible reaction, and the reaction can be promoted to form esters by controlling conditions.
Third, the characteristics of thiol groups. Mercapto (-SH) has high reactivity. Easily oxidized, it can be gradually oxidized in air to form disulfide bonds (-S-S-). Under the action of appropriate oxidants, the thiol group of two molecules of 4-hydroxyl-2-mercaptobutyric acid can be oxidized to form compounds containing disulfide bonds. In addition, the thiol group can form stable complexes with heavy metal ions, and this property can be used to treat wastewater containing heavy metal ions or to separate and detect heavy metals from mixtures.
Fourth, hydrophilicity. The intra-molecular carboxyl group, hydroxy group and thiol group are all hydrophilic groups, making them hydrophilic and partially soluble in water. This hydrophilicity is of great significance for their transportation and metabolism in organisms. Due to the multi-water environment of organisms, the hydrophilicity of compounds is conducive to their participation in various physiological processes in organisms.
What are the main uses of 4-bromo-2-chlorophenylacetic acid?
For 4-2-benzoic acid, it is mainly used for anti-inflammatory purposes.
First, benzoic acid plays an important role in the field of medicine. For example, this ingredient is often contained in part of the pain relief. Because it has a certain anti-inflammatory and pain effect, it can help relieve the pain caused by inflammation, such as pain, pain, etc. Its function is to reduce the generation and release of certain chemical substances, and to reduce pain and anti-inflammatory purposes.
Second, in the field of chemical synthesis, benzoic acid is an important part of the synthesis. With it as the starting material, a wide range of anti-inflammatory compounds can be synthesized. For example, it can react to other compounds containing specific functions to form molecules with special properties. This molecule is widely used in materials science, chemical research, and other aspects.
Third, in the fragrance industry, benzoic acid also has a place. It can be used as a raw material for the synthesis of fragrances, and can be serialized to generate fragrance components with special fragrance. These fragrances can be used in perfumes, chemicals, food additives, etc., to add a pleasant taste and enhance the sensory taste of the product.
Therefore, 4-2-benzoic acid, due to its various characteristics, plays an important role in the synthesis, chemical synthesis, fragrance, etc., and promotes the development of the product.
First, benzoic acid plays an important role in the field of medicine. For example, this ingredient is often contained in part of the pain relief. Because it has a certain anti-inflammatory and pain effect, it can help relieve the pain caused by inflammation, such as pain, pain, etc. Its function is to reduce the generation and release of certain chemical substances, and to reduce pain and anti-inflammatory purposes.
Second, in the field of chemical synthesis, benzoic acid is an important part of the synthesis. With it as the starting material, a wide range of anti-inflammatory compounds can be synthesized. For example, it can react to other compounds containing specific functions to form molecules with special properties. This molecule is widely used in materials science, chemical research, and other aspects.
Third, in the fragrance industry, benzoic acid also has a place. It can be used as a raw material for the synthesis of fragrances, and can be serialized to generate fragrance components with special fragrance. These fragrances can be used in perfumes, chemicals, food additives, etc., to add a pleasant taste and enhance the sensory taste of the product.
Therefore, 4-2-benzoic acid, due to its various characteristics, plays an important role in the synthesis, chemical synthesis, fragrance, etc., and promotes the development of the product.
What are the synthesis methods of 4-bromo-2-chlorophenylacetic acid?
4-Bromo-2-fluorobenzoic acid is a key intermediate in organic synthesis. There are many synthesis methods. The following are common methods:
1. ** Bromination method with 2-fluorobenzoic acid as the starting material **:
- ** Reaction principle **: React 2-fluorobenzoic acid with a brominating reagent to introduce bromine atoms at a specific position in the benzene ring. The commonly used brominating reagent is bromine (Br ²), and under the action of an appropriate catalyst, the bromination reaction on the benzene ring can be realized. Generally speaking, Lewis acid is required as a catalyst, such as iron trichloride (FeCl <), aluminum tribromide (AlBr <), etc.
- ** Reaction steps **: In the reaction vessel, first add 2-fluorobenzoic acid and an appropriate amount of catalyst, and then slowly add bromine dropwise at low temperature. After the dropwise addition is completed, gradually heat up to a suitable temperature and continue to stir the reaction. After the reaction is completed, pure 4-bromo-2-fluorobenzoic acid is obtained through conventional post-processing operations, such as dilution with water, extraction, distillation, recrystallization, etc. The advantage of this method is that the starting material is relatively easy to obtain, and the reaction conditions are relatively mild. However, by-products may be produced during the reaction process, which requires higher control of the reaction conditions.
2. ** Nucleophilic Substitution Method Using Halogenated Aromatic Hydrocarbons as Raw Materials **:
- ** Reaction Principle **: Select a suitable halogenated aromatic hydrocarbon with a halogen atom (such as chlorine, bromine, etc.) on its benzene ring, and reserve a check point that can be replaced by a nucleophilic reagent at a specific position. Using fluoride as a nucleophilic reagent, the original halogen atom on the benzene ring is replaced by a fluorine atom, and a carboxyl group is introduced at the same time, and 4-bromo-2-fluorobenzoic acid is finally synthesized through a series of reactions. Common nucleophilic reagents are potassium fluoride (KF), etc., which often need to be reacted in the presence of
- ** Reaction steps **: First, the halogenated aromatics are reacted with nucleophiles in specific solvents and phase transfer catalysts to form fluorine-containing intermediates. After that, carboxyl groups are introduced on the intermediates by suitable methods, such as reacting with carbon dioxide by Grignard reagents. Finally, the target product is obtained through separation, purification and other steps. The advantage of this method is that the position of the substituents on the benzene ring can be precisely controlled, and the product purity is high, but the reaction steps are relatively cumbersome, and the reaction conditions and operation techniques are strictly required.
3. ** Synthesis method using diazonium salt as intermediate **:
- ** Reaction principle **: First, the compound containing amino group is converted into diazonium salt through diazotization reaction, and then the activity of diazonium salt is used to react with different reagents to achieve the introduction of bromine atoms and fluorine atoms and the construction of carboxyl groups. For example, compounds containing amino groups and the position of benzene ring substituents meeting the requirements of the target product can be prepared first, and then made into diazonium salts. After reacting with reagents such as cuprous bromide, bromine atoms are introduced, and then fluorine atoms and carboxyl groups are introduced through other reactions.
- ** Reaction steps **: First, the amino-containing compound is dissolved in an appropriate acid solution, and the sodium nitrite solution is slowly added at low temperature for diazotization reaction to generate a diazonium salt solution. After that, corresponding reagents are added to the diazonium salt solution, and bromine, fluorine and carboxyl groups are introduced in sequence according to the established reaction route. After the reaction is completed, high-purity 4-bromo-2-fluorobenzoic acid is obtained through multi-step separation and purification operations, such as column chromatography, crystallization, etc. This method is highly flexible and can design different reaction routes according to needs, but the diazotization reaction is highly dangerous and requires extremely high reaction conditions and safety measures.
1. ** Bromination method with 2-fluorobenzoic acid as the starting material **:
- ** Reaction principle **: React 2-fluorobenzoic acid with a brominating reagent to introduce bromine atoms at a specific position in the benzene ring. The commonly used brominating reagent is bromine (Br ²), and under the action of an appropriate catalyst, the bromination reaction on the benzene ring can be realized. Generally speaking, Lewis acid is required as a catalyst, such as iron trichloride (FeCl <), aluminum tribromide (AlBr <), etc.
- ** Reaction steps **: In the reaction vessel, first add 2-fluorobenzoic acid and an appropriate amount of catalyst, and then slowly add bromine dropwise at low temperature. After the dropwise addition is completed, gradually heat up to a suitable temperature and continue to stir the reaction. After the reaction is completed, pure 4-bromo-2-fluorobenzoic acid is obtained through conventional post-processing operations, such as dilution with water, extraction, distillation, recrystallization, etc. The advantage of this method is that the starting material is relatively easy to obtain, and the reaction conditions are relatively mild. However, by-products may be produced during the reaction process, which requires higher control of the reaction conditions.
2. ** Nucleophilic Substitution Method Using Halogenated Aromatic Hydrocarbons as Raw Materials **:
- ** Reaction Principle **: Select a suitable halogenated aromatic hydrocarbon with a halogen atom (such as chlorine, bromine, etc.) on its benzene ring, and reserve a check point that can be replaced by a nucleophilic reagent at a specific position. Using fluoride as a nucleophilic reagent, the original halogen atom on the benzene ring is replaced by a fluorine atom, and a carboxyl group is introduced at the same time, and 4-bromo-2-fluorobenzoic acid is finally synthesized through a series of reactions. Common nucleophilic reagents are potassium fluoride (KF), etc., which often need to be reacted in the presence of
- ** Reaction steps **: First, the halogenated aromatics are reacted with nucleophiles in specific solvents and phase transfer catalysts to form fluorine-containing intermediates. After that, carboxyl groups are introduced on the intermediates by suitable methods, such as reacting with carbon dioxide by Grignard reagents. Finally, the target product is obtained through separation, purification and other steps. The advantage of this method is that the position of the substituents on the benzene ring can be precisely controlled, and the product purity is high, but the reaction steps are relatively cumbersome, and the reaction conditions and operation techniques are strictly required.
3. ** Synthesis method using diazonium salt as intermediate **:
- ** Reaction principle **: First, the compound containing amino group is converted into diazonium salt through diazotization reaction, and then the activity of diazonium salt is used to react with different reagents to achieve the introduction of bromine atoms and fluorine atoms and the construction of carboxyl groups. For example, compounds containing amino groups and the position of benzene ring substituents meeting the requirements of the target product can be prepared first, and then made into diazonium salts. After reacting with reagents such as cuprous bromide, bromine atoms are introduced, and then fluorine atoms and carboxyl groups are introduced through other reactions.
- ** Reaction steps **: First, the amino-containing compound is dissolved in an appropriate acid solution, and the sodium nitrite solution is slowly added at low temperature for diazotization reaction to generate a diazonium salt solution. After that, corresponding reagents are added to the diazonium salt solution, and bromine, fluorine and carboxyl groups are introduced in sequence according to the established reaction route. After the reaction is completed, high-purity 4-bromo-2-fluorobenzoic acid is obtained through multi-step separation and purification operations, such as column chromatography, crystallization, etc. This method is highly flexible and can design different reaction routes according to needs, but the diazotization reaction is highly dangerous and requires extremely high reaction conditions and safety measures.
What are the precautions for 4-bromo-2-chlorophenylacetic acid in storage and transportation?
4-Chlorophenylacetic acid is an important chemical compound. It is necessary to control the phase of the storage and storage, and pay attention to the general situation in order to ensure the safety of its products.
First of all, the storage environment is very important. This compound should be stored in a good place. Because of the tide, it is easy to cause its hydrolysis and other reactions, and it will affect the product. If the environment is tidal, water molecules or their molecules interact with each other, breaking the original and changing the original, resulting in the change of its properties. Therefore, it is necessary to control the phase of the storage and emptiness. Generally speaking, it should be maintained at 40% - 60%. Furthermore, the density should not be ignored. High density may cause its decomposition or accelerate its reaction rate. Usually, the storage capacity is between 2 and 8 degrees Celsius. At this temperature, its chemical properties are determined, which can effectively extend the shelf life.
Secondly, in terms of performance, the packaging is guaranteed to be tight and leakage. The packaging material is resistant to corrosion to match the chemical properties of 4-2-chlorophenylacetic acid. If the material is used without packaging, or is corroded and leaked, it is more likely to endanger the safety of people and the surrounding environment. On the way, avoid strong shock collisions. Due to severe shock or the exposure of the molecules of the compound, it will not be reversed in time. It is also necessary to pay attention to the environmental control of the environment, such as keeping the temperature and temperature constant, and reducing the amount due to the impact of environmental chemicals.
In addition, if there is a problem or a problem, it will be stored in isolation. Due to its chemical activity, this material is not connected, and it is easy to produce oxidation and original reactions, which may lead to serious accidents such as combustion and explosion. Workers also need to be well-versed in its dangerous characteristics and emergency treatment measures. In case of leakage and other emergencies, they can be quickly and appropriately placed to reduce harm.
First of all, the storage environment is very important. This compound should be stored in a good place. Because of the tide, it is easy to cause its hydrolysis and other reactions, and it will affect the product. If the environment is tidal, water molecules or their molecules interact with each other, breaking the original and changing the original, resulting in the change of its properties. Therefore, it is necessary to control the phase of the storage and emptiness. Generally speaking, it should be maintained at 40% - 60%. Furthermore, the density should not be ignored. High density may cause its decomposition or accelerate its reaction rate. Usually, the storage capacity is between 2 and 8 degrees Celsius. At this temperature, its chemical properties are determined, which can effectively extend the shelf life.
Secondly, in terms of performance, the packaging is guaranteed to be tight and leakage. The packaging material is resistant to corrosion to match the chemical properties of 4-2-chlorophenylacetic acid. If the material is used without packaging, or is corroded and leaked, it is more likely to endanger the safety of people and the surrounding environment. On the way, avoid strong shock collisions. Due to severe shock or the exposure of the molecules of the compound, it will not be reversed in time. It is also necessary to pay attention to the environmental control of the environment, such as keeping the temperature and temperature constant, and reducing the amount due to the impact of environmental chemicals.
In addition, if there is a problem or a problem, it will be stored in isolation. Due to its chemical activity, this material is not connected, and it is easy to produce oxidation and original reactions, which may lead to serious accidents such as combustion and explosion. Workers also need to be well-versed in its dangerous characteristics and emergency treatment measures. In case of leakage and other emergencies, they can be quickly and appropriately placed to reduce harm.
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