Linshang Chemical
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Benzeneacetic Acid, 4-Chloro-3-Nitro-
Linshang Chemical
|
HS Code |
540007 |
| Chemical Formula | C8H6ClNO4 |
| Molar Mass | 215.59 g/mol |
| Appearance | Solid (usually a powder) |
| Physical State At Room Temp | Solid |
| Melting Point | Typically in a certain range (data - specific) |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
| Odor | Odorless or faint odor |
| Color | Off - white to yellowish |
| Density | Data - specific value |
| Pka Value | Data - specific for acidic hydrogen |
As an accredited Benzeneacetic Acid, 4-Chloro-3-Nitro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram pack of 4 - chloro - 3 - nitro - benzeneacetic acid in a sealed chemical - grade container. |
| Storage | Store 4 - chloro - 3 - nitro - benzeneacetic acid in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption and evaporation. Separate from oxidizing agents, reducing agents, and bases to avoid chemical reactions. Label the storage clearly for easy identification and safety. |
| Shipping | 4 - chloro - 3 - nitro - benzeneacetic acid is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and handling to prevent spills and ensure safety during transit. |
Competitive Benzeneacetic Acid, 4-Chloro-3-Nitro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What is the chemistry of this 4-chloro-3-nitrophenylacetic acid?
4-Ammonia-3-nitrophenylacetic acid, this is an organic compound. Its chemical properties are unique, combining the characteristics of ammonia, nitro and phenylacetic acid.
As far as the ammonia part is concerned, the amino group itself has a certain alkalinity and can react with the acid to form the corresponding salt. In 4-ammonia-3-nitrophenylacetic acid, the amino group can be neutralized with inorganic acids such as hydrochloric acid, sulfuric acid, etc., or organic acids under suitable conditions, thereby changing the ionic state and solubility of the compound.
The presence of nitro groups greatly affects the chemical activity of the compound. Nitro is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring, which will make the benzene ring more prone to electrophilic substitution reaction, and the reaction check point is mostly affected by the localization effect of nitro and amino groups. Generally speaking, the electron-absorbing action of nitro groups will reduce the density of adjacent and para-position electron clouds relatively more, and the density of meta-position electron clouds is relatively high, so the electrophilic substitution reaction tends to occur in the meta-position. At the same time, nitro can be reduced under certain conditions. For example, under the action of suitable catalysts and reducing agents, it can be gradually reduced to nitroso, hydroxylamine groups, and finally reduced to amino groups. This process can be used to synthesize other nitrogenous compounds.
Phenylacetic acid part, its carboxyl group has typical carboxylic acid It can neutralize with bases to form carboxylates and water, and can also esterify with alcohols under acid catalysis to form corresponding ester compounds. Moreover, due to the conjugation of benzene ring and carboxyl group, the acidity of carboxyl group is slightly stronger than that of general fatty acid.
In summary, 4-ammonia-3-nitrophenylacetic acid exhibits rich and diverse chemical properties due to its ammonia, nitro and phenylacetic acid groups, and has important application potential in organic synthesis, medicinal chemistry and other fields.
As far as the ammonia part is concerned, the amino group itself has a certain alkalinity and can react with the acid to form the corresponding salt. In 4-ammonia-3-nitrophenylacetic acid, the amino group can be neutralized with inorganic acids such as hydrochloric acid, sulfuric acid, etc., or organic acids under suitable conditions, thereby changing the ionic state and solubility of the compound.
The presence of nitro groups greatly affects the chemical activity of the compound. Nitro is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring, which will make the benzene ring more prone to electrophilic substitution reaction, and the reaction check point is mostly affected by the localization effect of nitro and amino groups. Generally speaking, the electron-absorbing action of nitro groups will reduce the density of adjacent and para-position electron clouds relatively more, and the density of meta-position electron clouds is relatively high, so the electrophilic substitution reaction tends to occur in the meta-position. At the same time, nitro can be reduced under certain conditions. For example, under the action of suitable catalysts and reducing agents, it can be gradually reduced to nitroso, hydroxylamine groups, and finally reduced to amino groups. This process can be used to synthesize other nitrogenous compounds.
Phenylacetic acid part, its carboxyl group has typical carboxylic acid It can neutralize with bases to form carboxylates and water, and can also esterify with alcohols under acid catalysis to form corresponding ester compounds. Moreover, due to the conjugation of benzene ring and carboxyl group, the acidity of carboxyl group is slightly stronger than that of general fatty acid.
In summary, 4-ammonia-3-nitrophenylacetic acid exhibits rich and diverse chemical properties due to its ammonia, nitro and phenylacetic acid groups, and has important application potential in organic synthesis, medicinal chemistry and other fields.
What are the main applications of 4-chloro-3-nitrophenylacetic acid?
4 + -Cyano3-pyridyl acetic acid, which has important applications in many fields such as medicine and pesticides.
In the field of medicine, it can be used as a key intermediate for the synthesis of a variety of drugs. For example, in the process of anti-tumor drug development, 4 + -cyano3-pyridyl acetic acid has a chemical structure that can be combined with other molecules through specific reactions to construct compounds with the activity of inhibiting tumor cell proliferation. It provides specific active groups for drug molecules to help drugs act more precisely on tumor cell targets, thereby enhancing drug efficacy and reducing damage to normal cells. In the field of cardiovascular drugs, it can also be used to participate in reactions to synthesize drugs that have a regulatory effect on the cardiovascular system, or can adjust blood pressure and improve cardiac function.
In the field of pesticides, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. Based on its chemical properties, the synthesized pesticides may have high selective toxicity to pests, but have little impact on beneficial insects and environmental organisms. For example, synthetic insecticides with high insecticidal activity can precisely act on the nervous system or metabolic pathways of specific pests, inhibit the growth and reproduction of pests, effectively control the number of pest populations, and reduce the negative impact on the ecological environment, contributing to the sustainable development of agriculture.
Furthermore, in the field of organic synthetic chemistry, 4 + -cyano- 3 -pyridylacetic acid is an important building block for the construction of complex organic molecules due to its unique functional group. Chemists can use the reactivity of cyano and carboxyl groups to construct organic compounds with diverse structures through a series of organic reactions, such as nucleophilic substitution, addition reactions, etc., laying the foundation for the research and development of new materials and fine chemicals.
In the field of medicine, it can be used as a key intermediate for the synthesis of a variety of drugs. For example, in the process of anti-tumor drug development, 4 + -cyano3-pyridyl acetic acid has a chemical structure that can be combined with other molecules through specific reactions to construct compounds with the activity of inhibiting tumor cell proliferation. It provides specific active groups for drug molecules to help drugs act more precisely on tumor cell targets, thereby enhancing drug efficacy and reducing damage to normal cells. In the field of cardiovascular drugs, it can also be used to participate in reactions to synthesize drugs that have a regulatory effect on the cardiovascular system, or can adjust blood pressure and improve cardiac function.
In the field of pesticides, it also plays an important role. It can be used as a raw material for the synthesis of new pesticides. Based on its chemical properties, the synthesized pesticides may have high selective toxicity to pests, but have little impact on beneficial insects and environmental organisms. For example, synthetic insecticides with high insecticidal activity can precisely act on the nervous system or metabolic pathways of specific pests, inhibit the growth and reproduction of pests, effectively control the number of pest populations, and reduce the negative impact on the ecological environment, contributing to the sustainable development of agriculture.
Furthermore, in the field of organic synthetic chemistry, 4 + -cyano- 3 -pyridylacetic acid is an important building block for the construction of complex organic molecules due to its unique functional group. Chemists can use the reactivity of cyano and carboxyl groups to construct organic compounds with diverse structures through a series of organic reactions, such as nucleophilic substitution, addition reactions, etc., laying the foundation for the research and development of new materials and fine chemicals.
What are the preparation methods of 4-chloro-3-nitrophenylacetic acid?
To prepare 4-hydroxy-3-aminophenylacetic acid, the method is as follows:
First, it can be obtained by reducing the corresponding nitro compound. First, with suitable raw materials, the nitro group is introduced into the benzene ring at the appropriate position through a series of reactions to construct a nitro-containing phenylacetic acid derivative. Then, a suitable reducing agent is selected, such as a combination of metal and acid (iron and hydrochloric acid, etc.), or a method of catalytic hydrogenation, under suitable reaction conditions, the nitro group is reduced to an amino group to obtain the target product 4-hydroxy-3-aminophenylacetic acid. This process requires careful control of reaction conditions, such as temperature, pH, and the ratio of reactants, to prevent side reactions from occurring.
Second, phenolic compounds can also be used as starting materials. After phenols protect hydroxyl groups with specific protective groups, the substitution of carboxyl groups and amino precursors is introduced through the Fu-gram reaction. After that, the protective group is removed, and the substituent is properly converted to finally generate 4-hydroxy-3-aminophenylacetic acid. In this path, the selection and removal conditions of the protective group are very critical, not only to ensure that the protective group is stable during the reaction process, but also to be easily removed at the right time without affecting other groups.
Third, the transformation of some natural products can also be used. Some natural products contain a partial skeleton similar to the target product. By chemical modification, such as hydrolysis, oxidation, reduction, and substitution, the structure is gradually modified to convert it into 4-hydroxy-3-aminophenylacetic acid. This approach requires in-depth understanding of the origin and properties of natural products, and the reaction steps may be complicated, but sometimes the special structural advantages of natural products can be used to simplify part of the reaction process.
First, it can be obtained by reducing the corresponding nitro compound. First, with suitable raw materials, the nitro group is introduced into the benzene ring at the appropriate position through a series of reactions to construct a nitro-containing phenylacetic acid derivative. Then, a suitable reducing agent is selected, such as a combination of metal and acid (iron and hydrochloric acid, etc.), or a method of catalytic hydrogenation, under suitable reaction conditions, the nitro group is reduced to an amino group to obtain the target product 4-hydroxy-3-aminophenylacetic acid. This process requires careful control of reaction conditions, such as temperature, pH, and the ratio of reactants, to prevent side reactions from occurring.
Second, phenolic compounds can also be used as starting materials. After phenols protect hydroxyl groups with specific protective groups, the substitution of carboxyl groups and amino precursors is introduced through the Fu-gram reaction. After that, the protective group is removed, and the substituent is properly converted to finally generate 4-hydroxy-3-aminophenylacetic acid. In this path, the selection and removal conditions of the protective group are very critical, not only to ensure that the protective group is stable during the reaction process, but also to be easily removed at the right time without affecting other groups.
Third, the transformation of some natural products can also be used. Some natural products contain a partial skeleton similar to the target product. By chemical modification, such as hydrolysis, oxidation, reduction, and substitution, the structure is gradually modified to convert it into 4-hydroxy-3-aminophenylacetic acid. This approach requires in-depth understanding of the origin and properties of natural products, and the reaction steps may be complicated, but sometimes the special structural advantages of natural products can be used to simplify part of the reaction process.
What are the precautions for 4-chloro-3-nitrophenylacetic acid in storage and transportation?
4 + -Deuterium-3-aminobutyric acid must pay attention to many key matters during storage and transportation.
Deuterium, as a stable isotope of hydrogen, has special physical and chemical properties. The presence of deuterium in this substance may affect its physical and chemical properties. During storage and transportation, temperature regulation is crucial. If the temperature is too high, it may cause molecular structure changes, accelerate chemical reactions, and damage the stability of the substance. If the temperature is too low, it may cause freezing and other conditions, which is not conducive to its preservation. Therefore, it is necessary to accurately maintain the appropriate temperature range according to the characteristics of the substance.
3-aminobutyric acid itself has certain chemical activity. During storage, it is necessary to avoid contact with strong oxidants, strong acids and alkalis and other substances that are prone to chemical reactions to prevent oxidation, acid-base neutralization and other reactions, and change their chemical composition and properties. The choice of packaging materials should not be underestimated. Materials with stable chemical properties and no reaction with the substance must be selected, and the packaging must be well sealed to isolate air and moisture. Oxygen in the air may cause oxidation, moisture may cause reactions such as hydrolysis.
During transportation, road bumps, vibrations and other factors cannot be ignored. Excessive vibration may cause changes in the internal structure of the substance, or even cause package damage. Therefore, proper shock absorption and protection measures should be taken. At the same time, the environmental conditions in the transportation vehicle, such as temperature and humidity control, must also strictly meet the storage requirements of the substance. In addition, follow the relevant regulations and safety standards, complete transportation procedures to ensure safety compliance throughout the transportation process, and must not be negligent to avoid safety accidents or material deterioration.
Deuterium, as a stable isotope of hydrogen, has special physical and chemical properties. The presence of deuterium in this substance may affect its physical and chemical properties. During storage and transportation, temperature regulation is crucial. If the temperature is too high, it may cause molecular structure changes, accelerate chemical reactions, and damage the stability of the substance. If the temperature is too low, it may cause freezing and other conditions, which is not conducive to its preservation. Therefore, it is necessary to accurately maintain the appropriate temperature range according to the characteristics of the substance.
3-aminobutyric acid itself has certain chemical activity. During storage, it is necessary to avoid contact with strong oxidants, strong acids and alkalis and other substances that are prone to chemical reactions to prevent oxidation, acid-base neutralization and other reactions, and change their chemical composition and properties. The choice of packaging materials should not be underestimated. Materials with stable chemical properties and no reaction with the substance must be selected, and the packaging must be well sealed to isolate air and moisture. Oxygen in the air may cause oxidation, moisture may cause reactions such as hydrolysis.
During transportation, road bumps, vibrations and other factors cannot be ignored. Excessive vibration may cause changes in the internal structure of the substance, or even cause package damage. Therefore, proper shock absorption and protection measures should be taken. At the same time, the environmental conditions in the transportation vehicle, such as temperature and humidity control, must also strictly meet the storage requirements of the substance. In addition, follow the relevant regulations and safety standards, complete transportation procedures to ensure safety compliance throughout the transportation process, and must not be negligent to avoid safety accidents or material deterioration.
What are the effects of 4-chloro-3-nitrophenylacetic acid on the environment and the human body?
4 + -Xenon-3-aminophenylacetic acid, the impact on the environment and human body, I should be the one to analyze.
Xenon is a rare gas with stable chemical properties. In ordinary environments, xenon rarely reacts with other substances, so in general, it is rarely directly harmful to the environment and human body. And it often exists in the atmosphere, the content is very small, and it is difficult to cause obvious environmental effects.
As for 3-aminophenylacetic acid, if the release of this substance in the environment is small, it may gradually dissipate through natural degradation pathways, such as microbial decomposition. However, if a large amount is dumped into the environment, it may affect the ecology of soil and water bodies. In soil, or cause changes in the structure of soil microbial community, hinder the normal function of soil and material circulation; in water, or change the chemical properties of water, affect the survival and reproduction of aquatic organisms.
On the human body, if 3-aminophenylacetic acid enters the body through the respiratory tract, skin or digestive tract, there may be a latent risk. It may irritate the respiratory tract and skin, causing discomfort, such as cough, skin itching, redness and swelling. If ingested in the body, absorbed by the digestive system, or metabolized in the body, affecting the physiological functions of the human body. Or interfere with the biochemical reactions of the human body, involving the liver, kidneys and other organs, because it may need to be metabolized and excreted by these organs.
It is important to note that although xenon is relatively harmless, the environmental and human effects of 3-aminophenylacetic acid depend on its presence and exposure. It should be handled with caution to prevent excessive damage.
Xenon is a rare gas with stable chemical properties. In ordinary environments, xenon rarely reacts with other substances, so in general, it is rarely directly harmful to the environment and human body. And it often exists in the atmosphere, the content is very small, and it is difficult to cause obvious environmental effects.
As for 3-aminophenylacetic acid, if the release of this substance in the environment is small, it may gradually dissipate through natural degradation pathways, such as microbial decomposition. However, if a large amount is dumped into the environment, it may affect the ecology of soil and water bodies. In soil, or cause changes in the structure of soil microbial community, hinder the normal function of soil and material circulation; in water, or change the chemical properties of water, affect the survival and reproduction of aquatic organisms.
On the human body, if 3-aminophenylacetic acid enters the body through the respiratory tract, skin or digestive tract, there may be a latent risk. It may irritate the respiratory tract and skin, causing discomfort, such as cough, skin itching, redness and swelling. If ingested in the body, absorbed by the digestive system, or metabolized in the body, affecting the physiological functions of the human body. Or interfere with the biochemical reactions of the human body, involving the liver, kidneys and other organs, because it may need to be metabolized and excreted by these organs.
It is important to note that although xenon is relatively harmless, the environmental and human effects of 3-aminophenylacetic acid depend on its presence and exposure. It should be handled with caution to prevent excessive damage.
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