Linshang Chemical
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Benzeneacetic Acid, 5-Chloro-2-Fluoro-
Linshang Chemical
|
HS Code |
809468 |
| Chemical Formula | C8H6ClFO2 |
| Molar Mass | 188.583 g/mol |
| Appearance | Solid (likely white or off - white powder) |
| Physical State At Room Temperature | Solid |
| Solubility In Water | Low, due to non - polar benzene ring and limited hydrogen - bonding ability |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Acidity | Weakly acidic due to the carboxylic acid group |
As an accredited Benzeneacetic Acid, 5-Chloro-2-Fluoro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 5 - chloro - 2 - fluoro - benzeneacetic acid in sealed chemical - grade packaging. |
| Storage | 5 - chloro - 2 - fluoro - benzeneacetic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. Label the storage clearly to prevent misidentification, ensuring compliance with safety regulations for handling such chemicals. |
| Shipping | Shipping of 5 - chloro - 2 - fluoro - benzeneacetic acid requires careful handling. It must be packaged in appropriate, leak - proof containers. Shipment should comply with chemical transport regulations to ensure safety during transit. |
Competitive Benzeneacetic Acid, 5-Chloro-2-Fluoro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading Benzeneacetic Acid, 5-Chloro-2-Fluoro- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 5-chloro-2-fluorophenylacetic acid?
5-% -2-deuterium acetic acid is a chemical compound, and its physical properties are very special.
First, due to the molecular weight and the molecular weight of the phase, its melting and boiling weight are generally slightly higher than acetic acid. The atomic weight of deuterium is large, which increases the molecular weight and increases the molecular force. Therefore, more energy is required to make it from solid solution or liquid solution.
Secondary solubility, 5-% -2-deuterium acetic acid is soluble in water, ethanol, ethyl ether, etc. It is often soluble. Its molecule contains carboxyl groups, which can form water molecules and increase its solubility in water; and its part is soluble. It has good compatibility, so it can also be dissolved when it is soluble.
Furthermore, the density of 5-% -2-deuterated acetic acid is slightly higher than that of ordinary acetic acid due to the heavier weight of deuterium atoms than that of deuterium atoms. This difference is very small, but it is also important in refining analysis and specific scenarios.
The outer layer of 5-% -2-deuterium acetic acid is a chromogenic solution, which has a characteristic irritating smell of acetic acid. In case of open flame, high temperature or oxidation, there is still a risk of explosion.
The physical properties of 5-% -2-deuterium acetic acid are the manifestation of its chemical properties. They are of great importance in various fields such as chemical synthesis, chemical research, and isotopic display. Due to their special physical properties, scientists can deeply explore the process of chemical reactions and the pursuit of chemical substances, and promote the vigorous development of the chemical family.
First, due to the molecular weight and the molecular weight of the phase, its melting and boiling weight are generally slightly higher than acetic acid. The atomic weight of deuterium is large, which increases the molecular weight and increases the molecular force. Therefore, more energy is required to make it from solid solution or liquid solution.
Secondary solubility, 5-% -2-deuterium acetic acid is soluble in water, ethanol, ethyl ether, etc. It is often soluble. Its molecule contains carboxyl groups, which can form water molecules and increase its solubility in water; and its part is soluble. It has good compatibility, so it can also be dissolved when it is soluble.
Furthermore, the density of 5-% -2-deuterated acetic acid is slightly higher than that of ordinary acetic acid due to the heavier weight of deuterium atoms than that of deuterium atoms. This difference is very small, but it is also important in refining analysis and specific scenarios.
The outer layer of 5-% -2-deuterium acetic acid is a chromogenic solution, which has a characteristic irritating smell of acetic acid. In case of open flame, high temperature or oxidation, there is still a risk of explosion.
The physical properties of 5-% -2-deuterium acetic acid are the manifestation of its chemical properties. They are of great importance in various fields such as chemical synthesis, chemical research, and isotopic display. Due to their special physical properties, scientists can deeply explore the process of chemical reactions and the pursuit of chemical substances, and promote the vigorous development of the chemical family.
What are the chemical properties of 5-chloro-2-fluorophenylacetic acid?
5-Bromo-2-pentenoic acid is an organic compound with the following chemical properties:
1. ** Acidic **: It contains a carboxyl group (-COOH), so it is acidic. It can neutralize with alkali substances, such as with sodium hydroxide (NaOH). The hydrogen atom in the carboxyl group will combine with hydroxide ion (OH) to form water, and itself becomes the corresponding carboxylate and water. The reaction equation is: $C_ {5} H_ {7} BrO_ {2} + OH Na\ longrightarrow C_ {5} H_ {6} BrO_ {2} Na + H_ {2} O $. This acidity allows it to participate in many acid-base related chemical reactions, which are used in organic synthesis to construct specific structures.
2. ** Addition reaction **: The carbon-carbon double bond (C = C) exists in the molecule, and an addition reaction can occur. For example, with the addition of bromine ($Br_ {2} $), the carbon-carbon double bond breaks, and two bromine atoms are added to the two carbon atoms connected to the original double bond to form a dibromine substitute. The reaction formula is: $C_ {5} H_ {7} BrO_ {2} + Br_ {2}\ longrightarrow C_ {5} H_ {7} Br_ {3} O_ {2} $. It can also be added with hydrogen ($H_ {2} $) under the action of a catalyst, and the double bond becomes a single bond to obtain a saturated carboxylic acid derivative.
3. ** Substitution Reaction **: The alpha-hydrogen atom of the carboxyl group (hydrogen on the carbon atom connected to the carboxyl group) is affected by the carboxyl group and has certain reactivity, which can be replaced by other atoms or groups. For example, under appropriate conditions, alpha-hydrogen can be further replaced by halogen atoms. In addition, bromine atoms can also undergo substitution reactions. Under the action of nucleophiles, bromine atoms can be replaced by nucleophilic groups.
4. ** Polymerization reaction **: Due to the carbon-carbon double bond, under suitable initiator and conditions, 5-bromo-2-pentenoic acid molecules can be additionally polymerized with each other through double bonds to form a polymer. This polymerization reaction can be used to prepare polymer materials with specific properties and has potential applications in the field of materials science.
1. ** Acidic **: It contains a carboxyl group (-COOH), so it is acidic. It can neutralize with alkali substances, such as with sodium hydroxide (NaOH). The hydrogen atom in the carboxyl group will combine with hydroxide ion (OH) to form water, and itself becomes the corresponding carboxylate and water. The reaction equation is: $C_ {5} H_ {7} BrO_ {2} + OH Na\ longrightarrow C_ {5} H_ {6} BrO_ {2} Na + H_ {2} O $. This acidity allows it to participate in many acid-base related chemical reactions, which are used in organic synthesis to construct specific structures.
2. ** Addition reaction **: The carbon-carbon double bond (C = C) exists in the molecule, and an addition reaction can occur. For example, with the addition of bromine ($Br_ {2} $), the carbon-carbon double bond breaks, and two bromine atoms are added to the two carbon atoms connected to the original double bond to form a dibromine substitute. The reaction formula is: $C_ {5} H_ {7} BrO_ {2} + Br_ {2}\ longrightarrow C_ {5} H_ {7} Br_ {3} O_ {2} $. It can also be added with hydrogen ($H_ {2} $) under the action of a catalyst, and the double bond becomes a single bond to obtain a saturated carboxylic acid derivative.
3. ** Substitution Reaction **: The alpha-hydrogen atom of the carboxyl group (hydrogen on the carbon atom connected to the carboxyl group) is affected by the carboxyl group and has certain reactivity, which can be replaced by other atoms or groups. For example, under appropriate conditions, alpha-hydrogen can be further replaced by halogen atoms. In addition, bromine atoms can also undergo substitution reactions. Under the action of nucleophiles, bromine atoms can be replaced by nucleophilic groups.
4. ** Polymerization reaction **: Due to the carbon-carbon double bond, under suitable initiator and conditions, 5-bromo-2-pentenoic acid molecules can be additionally polymerized with each other through double bonds to form a polymer. This polymerization reaction can be used to prepare polymer materials with specific properties and has potential applications in the field of materials science.
What are the main uses of 5-chloro-2-fluorophenylacetic acid?
5-Bromo-2-pentenoic acid is an organic compound that has important uses in many fields.
First, in the field of organic synthesis, this is a key intermediate. It can react with alcohols to form corresponding ester compounds through many chemical reactions, such as esterification. Such esters are widely used in flavors, coatings and other industries, such as the synthesis of some special fragrances. After esterification of 5-bromo-2-pentenoic acid, its products may impart a unique flavor to the fragrance. At the same time, through the nucleophilic substitution of halogenated hydrocarbons, bromine atoms can be replaced by other functional groups, such as by amino groups, to form nitrogen-containing organic compounds, which is of great significance in drug synthesis.
Second, in the field of medicinal chemistry, its use cannot be underestimated. Because of its unique chemical structure, or with certain biological activities. Taking the development of some anti-cancer drugs as an example, researchers hope to synthesize new drugs with specific inhibitory effects on cancer cells by modifying and modifying the structure of 5-bromo-2-pentenoic acid. The double bonds and bromine atoms in its structure provide the possibility for the interaction of drug molecules with cancer cell targets, or by binding to specific proteins in cancer cells, interfere with the normal physiological activities of cancer cells, so as to achieve the purpose of inhibiting tumor growth.
Third, in the field of materials science, 5-bromo-2-pentenoic acid also shows potential value. In the preparation of functional polymer materials, it can be introduced into the polymer chain as a monomer or modifier. Its double bond can participate in the polymerization reaction, so that the polymer material has special properties, such as improving the mechanical properties, thermal stability or optical properties of the material. For example, in the preparation of optical materials, the introduction of this compound may enable the material to have unique light response characteristics, which can be used in light-controlled switching, optical storage and other fields.
First, in the field of organic synthesis, this is a key intermediate. It can react with alcohols to form corresponding ester compounds through many chemical reactions, such as esterification. Such esters are widely used in flavors, coatings and other industries, such as the synthesis of some special fragrances. After esterification of 5-bromo-2-pentenoic acid, its products may impart a unique flavor to the fragrance. At the same time, through the nucleophilic substitution of halogenated hydrocarbons, bromine atoms can be replaced by other functional groups, such as by amino groups, to form nitrogen-containing organic compounds, which is of great significance in drug synthesis.
Second, in the field of medicinal chemistry, its use cannot be underestimated. Because of its unique chemical structure, or with certain biological activities. Taking the development of some anti-cancer drugs as an example, researchers hope to synthesize new drugs with specific inhibitory effects on cancer cells by modifying and modifying the structure of 5-bromo-2-pentenoic acid. The double bonds and bromine atoms in its structure provide the possibility for the interaction of drug molecules with cancer cell targets, or by binding to specific proteins in cancer cells, interfere with the normal physiological activities of cancer cells, so as to achieve the purpose of inhibiting tumor growth.
Third, in the field of materials science, 5-bromo-2-pentenoic acid also shows potential value. In the preparation of functional polymer materials, it can be introduced into the polymer chain as a monomer or modifier. Its double bond can participate in the polymerization reaction, so that the polymer material has special properties, such as improving the mechanical properties, thermal stability or optical properties of the material. For example, in the preparation of optical materials, the introduction of this compound may enable the material to have unique light response characteristics, which can be used in light-controlled switching, optical storage and other fields.
What are the synthesis methods of 5-chloro-2-fluorophenylacetic acid?
5-Bromo-2-chlorobenzoic acid is a key intermediate in organic synthesis. The synthesis method is as follows:
1. ** Using benzoic acid as the starting material **:
- The benzoic acid can be brominated first. The benzoic acid can be placed in an appropriate solvent, such as dichloromethane, and an appropriate amount of brominating reagents, such as N-bromosuccinimide (NBS), and the initiator azobisisobutyronitrile (AIBN), under the condition of heating or light, a brominated reaction will occur at a specific position on the benzene ring of the benzoic acid to generate a bromobenzoic acid derivative. The principle of this reaction is to use NBS to provide bromine free radicals. Under the action of the initiator, the free radicals attack the benzene ring and realize the substitution of bromine atoms.
- The obtained product is then chlorinated. The bromobenzoic acid derivative is placed in another reaction system, a chlorination reagent is added, such as sulfoxide chloride (SOCl ²), and a catalyst is added, such as anhydrous aluminum trichloride (AlCl 🥰), and the reaction is heated to reintroduce chlorine atoms into the benzene ring to obtain 5-bromo-2-chlorobenzoic acid. In this chlorination reaction, sulfoxide chloride provides a chlorine source, and under the action of a catalyst, the specific position of the benzene ring is replaced by chlorine atoms.
2 ** Using o-chlorobenzoic acid as raw material **:
- Let the o-chlorobenzoic acid react with the brominating agent. Dissolve the o-chlorobenzoic acid in a suitable organic solvent, such as carbon tetrachloride, add bromine (Br ²) and iron powder (Fe) as catalysts, and heat the reaction. Because the chlorine atom on the benzene ring is an ortho-site locator, the bromine atom will mainly replace its ortho-site. Through this reaction, 5-bromo-2-chlorobenzoic acid can be obtained. In this process, bromine is catalyzed by iron powder to generate positive bromide ions, which attack the benzene ring and undergo electrophilic substitution.
3. ** Using p-bromobenzoic acid as raw material **:
- p-bromobenzoic acid re Put p-bromobenzoic acid into a reaction vessel, add chlorinated reagents such as chlorine (Cl ²), and react under heating conditions with anhydrous iron trichloride (FeCl < unk >) as a catalyst. Due to the positioning effect of bromine atoms, chlorine atoms will replace hydrogen at a specific position on the benzene ring to form 5-bromo-2-chlorobenzoic acid. This reaction is the formation of chlorine positive ions under the action of chlorine gas under the catalyst, and electrophilic substitution of the benzene ring.
1. ** Using benzoic acid as the starting material **:
- The benzoic acid can be brominated first. The benzoic acid can be placed in an appropriate solvent, such as dichloromethane, and an appropriate amount of brominating reagents, such as N-bromosuccinimide (NBS), and the initiator azobisisobutyronitrile (AIBN), under the condition of heating or light, a brominated reaction will occur at a specific position on the benzene ring of the benzoic acid to generate a bromobenzoic acid derivative. The principle of this reaction is to use NBS to provide bromine free radicals. Under the action of the initiator, the free radicals attack the benzene ring and realize the substitution of bromine atoms.
- The obtained product is then chlorinated. The bromobenzoic acid derivative is placed in another reaction system, a chlorination reagent is added, such as sulfoxide chloride (SOCl ²), and a catalyst is added, such as anhydrous aluminum trichloride (AlCl 🥰), and the reaction is heated to reintroduce chlorine atoms into the benzene ring to obtain 5-bromo-2-chlorobenzoic acid. In this chlorination reaction, sulfoxide chloride provides a chlorine source, and under the action of a catalyst, the specific position of the benzene ring is replaced by chlorine atoms.
2 ** Using o-chlorobenzoic acid as raw material **:
- Let the o-chlorobenzoic acid react with the brominating agent. Dissolve the o-chlorobenzoic acid in a suitable organic solvent, such as carbon tetrachloride, add bromine (Br ²) and iron powder (Fe) as catalysts, and heat the reaction. Because the chlorine atom on the benzene ring is an ortho-site locator, the bromine atom will mainly replace its ortho-site. Through this reaction, 5-bromo-2-chlorobenzoic acid can be obtained. In this process, bromine is catalyzed by iron powder to generate positive bromide ions, which attack the benzene ring and undergo electrophilic substitution.
3. ** Using p-bromobenzoic acid as raw material **:
- p-bromobenzoic acid re Put p-bromobenzoic acid into a reaction vessel, add chlorinated reagents such as chlorine (Cl ²), and react under heating conditions with anhydrous iron trichloride (FeCl < unk >) as a catalyst. Due to the positioning effect of bromine atoms, chlorine atoms will replace hydrogen at a specific position on the benzene ring to form 5-bromo-2-chlorobenzoic acid. This reaction is the formation of chlorine positive ions under the action of chlorine gas under the catalyst, and electrophilic substitution of the benzene ring.
What are the precautions for 5-chloro-2-fluorophenylacetic acid in storage and transportation?
For 5-% ammonia-2-hydroxybutyric acid, many matters should be paid attention to during storage and transportation.
The first thing to pay attention to is its chemical properties. This is a material with a specific chemical structure, ammonia and hydroxyl coexist, and the chemical activity is unique. When storing, avoid co-location with substances that are prone to chemical reactions, such as strong oxidants, strong acids and alkalis. Contact with it may trigger violent chemical reactions, cause material deterioration, and even cause safety accidents. If strong oxidants are encountered, it may cause dangerous conditions such as combustion and explosion.
Times and storage environment. It should be stored in a cool, dry and well-ventilated place. If the temperature is too high, it may increase its volatilization rate, damage the quality of the material, and also increase the safety risk; if the humidity is too high, it is easy to cause moisture absorption and deliquescence, which affects the purity and performance. And poor ventilation, volatile gas accumulation, or abnormal gas composition in the space, endangering the safety of personnel.
Furthermore, when transporting, the packaging must be strong and tight. Choose suitable packaging materials to ensure that they can withstand vibration, collision and temperature changes during transportation. To prevent material leakage due to package damage. If it leaks into the environment, it will not only waste materials, pollute the environment, but also cause harm to surrounding organisms and ecosystems.
In addition, personnel operation is also critical. Those involved in storage and transportation, when professionally trained, are familiar with the characteristics, risks and emergency treatment methods of 5-% ammonia-2-hydroxybutyric acid. The operation process must be strict compliance, such as handling with care during loading and unloading, to avoid package damage caused by brutal operation. In case of unexpected situations such as material leakage, it can be handled quickly and properly according to the established emergency plan to minimize losses and hazards.
The first thing to pay attention to is its chemical properties. This is a material with a specific chemical structure, ammonia and hydroxyl coexist, and the chemical activity is unique. When storing, avoid co-location with substances that are prone to chemical reactions, such as strong oxidants, strong acids and alkalis. Contact with it may trigger violent chemical reactions, cause material deterioration, and even cause safety accidents. If strong oxidants are encountered, it may cause dangerous conditions such as combustion and explosion.
Times and storage environment. It should be stored in a cool, dry and well-ventilated place. If the temperature is too high, it may increase its volatilization rate, damage the quality of the material, and also increase the safety risk; if the humidity is too high, it is easy to cause moisture absorption and deliquescence, which affects the purity and performance. And poor ventilation, volatile gas accumulation, or abnormal gas composition in the space, endangering the safety of personnel.
Furthermore, when transporting, the packaging must be strong and tight. Choose suitable packaging materials to ensure that they can withstand vibration, collision and temperature changes during transportation. To prevent material leakage due to package damage. If it leaks into the environment, it will not only waste materials, pollute the environment, but also cause harm to surrounding organisms and ecosystems.
In addition, personnel operation is also critical. Those involved in storage and transportation, when professionally trained, are familiar with the characteristics, risks and emergency treatment methods of 5-% ammonia-2-hydroxybutyric acid. The operation process must be strict compliance, such as handling with care during loading and unloading, to avoid package damage caused by brutal operation. In case of unexpected situations such as material leakage, it can be handled quickly and properly according to the established emergency plan to minimize losses and hazards.
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