Linshang Chemical
PRODUCTS
Benzenemethanol,2-Amino-4-Chloro-
Linshang Chemical
|
HS Code |
520015 |
| Chemical Formula | C7H8ClNO |
| Molar Mass | 157.597 g/mol |
| Appearance | Solid (likely, based on similar compounds) |
| Solubility In Water | Limited solubility expected due to non - polar benzene ring and polar functional groups balance |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone (due to organic nature of benzene ring) |
| Vapor Pressure | Low vapor pressure (as a solid, expected to have low volatility) |
As an accredited Benzenemethanol,2-Amino-4-Chloro- factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottles of 2 - amino - 4 - chloro - benzenemethanol, well - sealed for protection. |
| Storage | **Storage of 2 - amino - 4 - chloro - benzenemethanol**: Store this chemical in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air. Since it may be reactive, separate it from oxidizing agents, acids, and bases. Label the storage container clearly for easy identification and safety. |
| Shipping | Benzenemethanol, 2 - amino - 4 - chloro - should be shipped in tightly sealed, corrosion - resistant containers. Ensure compliance with chemical transportation regulations. Ship via methods suitable for hazardous chemicals, avoiding exposure to heat and incompatible substances. |
Competitive Benzenemethanol,2-Amino-4-Chloro- prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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What are the chemical properties of 2-amino-4-chlorobenzyl alcohol?
2-% Amino-4-chlorophenylacetic acid is an organic compound with unique chemical properties. Its properties are mostly white to off-white crystalline powders, which are quite stable at room temperature and pressure.
This compound is weakly acidic, because the amino group is alkaline to a certain extent, and the carboxyl group is acidic. Under different acid and base environments, proton transfer may occur and exist in ionic or molecular states. Its acidity is weak. The acidity of the carboxyl group is affected by the benzene ring and the chlorine atom. The electron-absorbing action of the chlorine atom will enhance the acidity of the carboxyl group, while the action of the amino power supplier may reduce the acidity slightly.
2-% Amino-4-chlorophenylacetic acid can undergo a variety of chemical reactions. From the perspective of substitution reaction, the nitrogen atom of the amino group has lone pairs of electrons, which is nucleophilic and can undergo nucleophilic substitution reaction with electrophilic reagents such as halogenated hydrocarbons to form new C-N bonds; carboxyl groups can be esterified with alcohols under acid catalysis to form corresponding esters. This reaction is a reversible reaction. By controlling the reaction conditions, such as increasing the concentration of the reactants and removing the product water, etc., the reaction can proceed in the direction of generating esters.
Because of its benzene ring, the electrophilic substitution reaction on the benzene ring can also occur. The chlorine atom is an ortho-para-site locator, and the amino group is also an ortho-para-site locator. The superposition of the two localization effects makes the ortho-sites of the amino group and the chlorine atom on the benzene ring more vulnerable to electrophilic reagents, and reactions such as halogenation, nitrification, and sulfonation occur.
In terms of redox reactions, amino groups may be oxidized by specific oxidants, and the specific oxidation products depend on the type of oxidant and reaction conditions; while carboxyl groups are generally difficult to be reduced, and specific strong reducing agents and harsh conditions are required to reduce them to alcohols or aldoxides.
These chemical properties of 2-amino-4-chlorophenylacetic acid make it widely used in organic synthesis, pharmaceutical chemistry, and other fields. It can be used as a key intermediate for the synthesis of various bioactive compounds and drugs
This compound is weakly acidic, because the amino group is alkaline to a certain extent, and the carboxyl group is acidic. Under different acid and base environments, proton transfer may occur and exist in ionic or molecular states. Its acidity is weak. The acidity of the carboxyl group is affected by the benzene ring and the chlorine atom. The electron-absorbing action of the chlorine atom will enhance the acidity of the carboxyl group, while the action of the amino power supplier may reduce the acidity slightly.
2-% Amino-4-chlorophenylacetic acid can undergo a variety of chemical reactions. From the perspective of substitution reaction, the nitrogen atom of the amino group has lone pairs of electrons, which is nucleophilic and can undergo nucleophilic substitution reaction with electrophilic reagents such as halogenated hydrocarbons to form new C-N bonds; carboxyl groups can be esterified with alcohols under acid catalysis to form corresponding esters. This reaction is a reversible reaction. By controlling the reaction conditions, such as increasing the concentration of the reactants and removing the product water, etc., the reaction can proceed in the direction of generating esters.
Because of its benzene ring, the electrophilic substitution reaction on the benzene ring can also occur. The chlorine atom is an ortho-para-site locator, and the amino group is also an ortho-para-site locator. The superposition of the two localization effects makes the ortho-sites of the amino group and the chlorine atom on the benzene ring more vulnerable to electrophilic reagents, and reactions such as halogenation, nitrification, and sulfonation occur.
In terms of redox reactions, amino groups may be oxidized by specific oxidants, and the specific oxidation products depend on the type of oxidant and reaction conditions; while carboxyl groups are generally difficult to be reduced, and specific strong reducing agents and harsh conditions are required to reduce them to alcohols or aldoxides.
These chemical properties of 2-amino-4-chlorophenylacetic acid make it widely used in organic synthesis, pharmaceutical chemistry, and other fields. It can be used as a key intermediate for the synthesis of various bioactive compounds and drugs
What are the physical properties of 2-amino-4-chlorobenzyl alcohol?
Ethyl 2-% hydroxy-4-mercaptobutyrate is an organic compound. Its physical properties have many characteristics.
Under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid with uniform texture and no visible impurities. This state is conducive to its uniform mixing with other substances in many reaction systems and participation in various chemical reactions.
When it comes to odor, it often emits a weak and special smell, which is not pungent or unpleasant, but is different from odorless things. This smell may be related to the specific functional groups contained in its molecular structure.
In terms of boiling point, it is about a certain temperature range, and the specific value may vary slightly due to factors such as the measurement environment. The characteristics of the boiling point enable it to be distinguished from other substances with different boiling points in separation, purification and other operations according to the control of temperature. When the mixed system containing this compound is heated to a specific temperature, the substance will vaporize into steam, which can then be collected by means of condensation and other means to achieve the purpose of separation.
Melting point also has corresponding values. The existence of the melting point indicates that under specific low temperature conditions, this compound will change from liquid to solid state. This property is of great significance in storage and transportation. If the storage temperature is lower than its melting point, the compound is in a solid state, which is easier to store and transport, reducing the risk of leakage caused by liquid flow.
Its solubility is also an important physical property. In common organic solvents, such as ethanol, ether, etc., it exhibits good solubility. This is because the compound molecule and the organic solvent molecule can form specific interaction forces, such as van der Waals force, hydrogen bond, etc., so that it can be uniformly dispersed in the solvent. In water, the solubility is relatively weak, which is related to the polarity of the compound molecule and the polar interaction of the water molecule. This difference in solubility can be used to select suitable solvents for reaction, extraction and other operations in chemical experiments and industrial production.
Under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid with uniform texture and no visible impurities. This state is conducive to its uniform mixing with other substances in many reaction systems and participation in various chemical reactions.
When it comes to odor, it often emits a weak and special smell, which is not pungent or unpleasant, but is different from odorless things. This smell may be related to the specific functional groups contained in its molecular structure.
In terms of boiling point, it is about a certain temperature range, and the specific value may vary slightly due to factors such as the measurement environment. The characteristics of the boiling point enable it to be distinguished from other substances with different boiling points in separation, purification and other operations according to the control of temperature. When the mixed system containing this compound is heated to a specific temperature, the substance will vaporize into steam, which can then be collected by means of condensation and other means to achieve the purpose of separation.
Melting point also has corresponding values. The existence of the melting point indicates that under specific low temperature conditions, this compound will change from liquid to solid state. This property is of great significance in storage and transportation. If the storage temperature is lower than its melting point, the compound is in a solid state, which is easier to store and transport, reducing the risk of leakage caused by liquid flow.
Its solubility is also an important physical property. In common organic solvents, such as ethanol, ether, etc., it exhibits good solubility. This is because the compound molecule and the organic solvent molecule can form specific interaction forces, such as van der Waals force, hydrogen bond, etc., so that it can be uniformly dispersed in the solvent. In water, the solubility is relatively weak, which is related to the polarity of the compound molecule and the polar interaction of the water molecule. This difference in solubility can be used to select suitable solvents for reaction, extraction and other operations in chemical experiments and industrial production.
What are the main uses of 2-amino-4-chlorobenzyl alcohol?
2-% hydroxy-4-bromoacetophenone is a crucial intermediate in the field of organic synthesis, and has a wide range of uses in many fields. Details are as follows:
- ** Pharmaceutical Synthesis **: This is one of its important application fields. In the creation of antibacterial drugs, 2-% hydroxy-4-bromoacetophenone can act as a key intermediate, and can construct molecular structures with specific antibacterial activities through a series of chemical reactions. In the synthesis of cardiovascular drugs, it can participate in the construction of key fragments of drug molecules due to its unique chemical properties, which contributes greatly to optimizing drug efficacy and reducing side effects. In the process of research and development of many new drugs, 2-% hydroxy-4-bromoacetophenone can be found, which contributes to the development of human health.
- ** Pesticide preparation **: In the field of pesticides, 2-% hydroxy-4-bromoacetophenone also plays an indispensable role. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. By means of chemical synthesis, it is converted into pesticide ingredients with insecticidal, bactericidal or herbicidal effects. The pesticides made in this way have a significant effect on the control of crop diseases and pests, and can reduce environmental pollution and harm to non-target organisms, which is in line with the needs of modern green agriculture development.
- ** Fragrance production **: This compound also occupies a place in the fragrance industry. Because of its special odor and chemical stability, it can be used to prepare unique fragrances. In the synthesis of some floral or fruity fragrances, 2-% hydroxy-4-bromoacetophenone can be used as an important additive to give fragrances a richer and longer-lasting aroma, improve the quality and uniqueness of fragrances, and is widely used in perfumes, cosmetics and food fragrances.
- ** Pharmaceutical Synthesis **: This is one of its important application fields. In the creation of antibacterial drugs, 2-% hydroxy-4-bromoacetophenone can act as a key intermediate, and can construct molecular structures with specific antibacterial activities through a series of chemical reactions. In the synthesis of cardiovascular drugs, it can participate in the construction of key fragments of drug molecules due to its unique chemical properties, which contributes greatly to optimizing drug efficacy and reducing side effects. In the process of research and development of many new drugs, 2-% hydroxy-4-bromoacetophenone can be found, which contributes to the development of human health.
- ** Pesticide preparation **: In the field of pesticides, 2-% hydroxy-4-bromoacetophenone also plays an indispensable role. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. By means of chemical synthesis, it is converted into pesticide ingredients with insecticidal, bactericidal or herbicidal effects. The pesticides made in this way have a significant effect on the control of crop diseases and pests, and can reduce environmental pollution and harm to non-target organisms, which is in line with the needs of modern green agriculture development.
- ** Fragrance production **: This compound also occupies a place in the fragrance industry. Because of its special odor and chemical stability, it can be used to prepare unique fragrances. In the synthesis of some floral or fruity fragrances, 2-% hydroxy-4-bromoacetophenone can be used as an important additive to give fragrances a richer and longer-lasting aroma, improve the quality and uniqueness of fragrances, and is widely used in perfumes, cosmetics and food fragrances.
What are the synthesis methods of 2-amino-4-chlorobenzyl alcohol?
The synthesis method of 2-% hydroxy-4-bromoacetophenone has been known in ancient times and is detailed as follows.
First, acetophenone is used as the starting material, and the bromination reaction is used to introduce bromine atoms, and then the target product is obtained through the step of hydroxylation. First, acetophenone is placed in a suitable reaction vessel, and an appropriate amount of brominating reagent, such as liquid bromine or N-bromosuccinimide (NBS), is added, and a suitable catalyst, such as iron powder or iron tribromide, is supplemented. Under suitable reaction conditions, such as controlling temperature, reaction time, etc., a bromination reaction occurs at a specific position on the benzene ring of acetophenone to generate 4-bromoacetophenone. Subsequently, for the hydroxylation reaction of 4-bromoacetophenone, a suitable hydroxylation reagent, such as sodium hydroxide aqueous solution, can be selected. Under certain reaction conditions, the bromine atom is replaced by a hydroxyl group to obtain 2-hydroxy-4-bromoacetophenone. The steps of this method are relatively clear, but the selectivity of the bromination reaction and the control of the conditions of the hydroxylation reaction require fine operation to obtain a higher yield.
Second, using phenol as the starting material, through the acylation reaction, 4-acetylphenol is first prepared. Phenol is acylated with a suitable acylating agent, such as acetyl chloride or acetic anhydride, under the action of a catalyst such as aluminum trichloride, to produce 4-acetylphenol. After that, 4-acetylphenol is brominated. Similar to the above bromination reaction, a suitable brominating agent and reaction conditions are selected to introduce bromine atoms at a specific position in the phenyl ring of 4-acetylphenol to synthesize 2-hydroxy-4-bromoacetophenone. This approach uses common phenol as the starting material, and the raw material is easy to obtain. However, the optimization of acylation and bromination reaction conditions is also crucial, which is related to the purity and yield of the product.
Third, other more complex organic synthesis strategies can be used, such as using some aromatic hydrocarbons containing specific substituents as the starting material, and gradually building the structure of the target molecule through multi-step reactions. Although these methods can solve specific synthesis problems, they often have many steps, harsh reaction conditions, high requirements for reaction equipment and operation technology, and high cost, which may be inconvenient for large-scale preparation.
The above synthesis methods have their own advantages and disadvantages, and should be selected according to actual needs, such as the availability of raw materials, cost considerations, product purity requirements, and other factors.
First, acetophenone is used as the starting material, and the bromination reaction is used to introduce bromine atoms, and then the target product is obtained through the step of hydroxylation. First, acetophenone is placed in a suitable reaction vessel, and an appropriate amount of brominating reagent, such as liquid bromine or N-bromosuccinimide (NBS), is added, and a suitable catalyst, such as iron powder or iron tribromide, is supplemented. Under suitable reaction conditions, such as controlling temperature, reaction time, etc., a bromination reaction occurs at a specific position on the benzene ring of acetophenone to generate 4-bromoacetophenone. Subsequently, for the hydroxylation reaction of 4-bromoacetophenone, a suitable hydroxylation reagent, such as sodium hydroxide aqueous solution, can be selected. Under certain reaction conditions, the bromine atom is replaced by a hydroxyl group to obtain 2-hydroxy-4-bromoacetophenone. The steps of this method are relatively clear, but the selectivity of the bromination reaction and the control of the conditions of the hydroxylation reaction require fine operation to obtain a higher yield.
Second, using phenol as the starting material, through the acylation reaction, 4-acetylphenol is first prepared. Phenol is acylated with a suitable acylating agent, such as acetyl chloride or acetic anhydride, under the action of a catalyst such as aluminum trichloride, to produce 4-acetylphenol. After that, 4-acetylphenol is brominated. Similar to the above bromination reaction, a suitable brominating agent and reaction conditions are selected to introduce bromine atoms at a specific position in the phenyl ring of 4-acetylphenol to synthesize 2-hydroxy-4-bromoacetophenone. This approach uses common phenol as the starting material, and the raw material is easy to obtain. However, the optimization of acylation and bromination reaction conditions is also crucial, which is related to the purity and yield of the product.
Third, other more complex organic synthesis strategies can be used, such as using some aromatic hydrocarbons containing specific substituents as the starting material, and gradually building the structure of the target molecule through multi-step reactions. Although these methods can solve specific synthesis problems, they often have many steps, harsh reaction conditions, high requirements for reaction equipment and operation technology, and high cost, which may be inconvenient for large-scale preparation.
The above synthesis methods have their own advantages and disadvantages, and should be selected according to actual needs, such as the availability of raw materials, cost considerations, product purity requirements, and other factors.
What are the precautions for the use of 2-amino-4-chlorobenzyl alcohol?
2-% hydroxy-4-methoxyacetophenone is a commonly used organic compound. During use, there are many precautions to be paid attention to:
First, safety protection is essential. This compound is irritating to a certain extent and may cause discomfort when it comes into contact with the skin, eyes or inhales its dust and vapor. Therefore, when operating, be sure to wear appropriate protective equipment, such as protective gloves, protective glasses and masks, to avoid direct contact. In case of accidental contact, rinse with plenty of water immediately and seek medical assistance according to the specific situation.
Second, storage conditions should not be ignored. Store it in a cool, dry and well-ventilated place, away from fire and oxidants. Because it is an organic compound, in case of open flame, hot topic or contact with strong oxidant, there is a risk of igniting combustion and explosion. At the same time, it should be sealed and stored to prevent moisture and deterioration, affecting its quality and performance.
Third, accurately control the dosage when using. According to the specific reaction requirements and experimental design, strictly and accurately weigh the dosage. Too much dosage, or cause excessive reaction, generate unnecessary by-products, increase the difficulty of subsequent separation and purification; too little dosage may make the reaction incomplete and fail to achieve the desired effect.
Fourth, be familiar with the reaction characteristics. When 2-hydroxy-4-methoxyacetophenone participates in the reaction, it is necessary to fully understand its reaction activity, reaction conditions and possible products. Different reaction conditions, such as temperature, pH, reaction time, etc., have a significant impact on the reaction results. Therefore, it is necessary to determine the best reaction conditions through preliminary experimental exploration and literature research to ensure the smooth progress of the reaction.
Fifth, properly dispose of waste. Waste containing this compound is generated during the experiment or production process, and cannot be discarded at will. It should be collected and treated by classification in accordance with relevant environmental protection regulations. Because it may cause pollution to the environment, it needs to be professionally treated to reduce environmental hazards.
First, safety protection is essential. This compound is irritating to a certain extent and may cause discomfort when it comes into contact with the skin, eyes or inhales its dust and vapor. Therefore, when operating, be sure to wear appropriate protective equipment, such as protective gloves, protective glasses and masks, to avoid direct contact. In case of accidental contact, rinse with plenty of water immediately and seek medical assistance according to the specific situation.
Second, storage conditions should not be ignored. Store it in a cool, dry and well-ventilated place, away from fire and oxidants. Because it is an organic compound, in case of open flame, hot topic or contact with strong oxidant, there is a risk of igniting combustion and explosion. At the same time, it should be sealed and stored to prevent moisture and deterioration, affecting its quality and performance.
Third, accurately control the dosage when using. According to the specific reaction requirements and experimental design, strictly and accurately weigh the dosage. Too much dosage, or cause excessive reaction, generate unnecessary by-products, increase the difficulty of subsequent separation and purification; too little dosage may make the reaction incomplete and fail to achieve the desired effect.
Fourth, be familiar with the reaction characteristics. When 2-hydroxy-4-methoxyacetophenone participates in the reaction, it is necessary to fully understand its reaction activity, reaction conditions and possible products. Different reaction conditions, such as temperature, pH, reaction time, etc., have a significant impact on the reaction results. Therefore, it is necessary to determine the best reaction conditions through preliminary experimental exploration and literature research to ensure the smooth progress of the reaction.
Fifth, properly dispose of waste. Waste containing this compound is generated during the experiment or production process, and cannot be discarded at will. It should be collected and treated by classification in accordance with relevant environmental protection regulations. Because it may cause pollution to the environment, it needs to be professionally treated to reduce environmental hazards.
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